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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5274-5282

Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl] piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors

(11) Ontoria, Jesus M a Bufi, Laura Llauger a Torrisi, Caterina a Bresciani, Alberto a Giomini, Claudia a Rowley, Michael a Serafini, Sergio a Bin, Hu b Hao, Wu b Steinkühler, Christian a Jones, Philip a,c

a IRBM (Italy)

b WUXI APPTEC (China)

c DANA FARBER CANCER INSTITUTE (United States)

Author keywords

Hedgehog inhibitor; Hedgehog pathway; Smoothened antagonist

Indexed keywords

4 [3 (QUINOLIN 2 YL) 1,2,4 OXADIAZOL 5 YL]PIPERAZINYLUREA DERIVATIVE; PROTEIN INHIBITOR; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEDGEHOG PROTEINS; HUMANS; MICROSOMES; MOLECULAR STRUCTURE; RATS; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

CANIS FAMILIARIS; ERINACEIDAE; RATTUS;

EID: 80051942180 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.031 Document Type: Article

Times cited : (28)

References (21)

1
- 33751549095
- L.L. Rubin, and F.J. de Sauvage Nat. Rev. Drug Disc. 5 2006 1026
- (2006) Nat. Rev. Drug Disc. , vol.5 , pp. 1026
- Rubin, L.L.¹ De Sauvage, F.J.²

2
- 40849096112
- J. Xie Curr. Oncol. Rep. 10 2008 107
- (2008) Curr. Oncol. Rep. , vol.10 , pp. 107
- Xie, J.¹

3
- 67649126684
- P. Gallinari, G. Filocamo, P. Jones, S. Pazzaglia, and C. Steinkuhler Exp. Opin. Drug Discov. 4 2009 525
- (2009) Exp. Opin. Drug Discov. , vol.4 , pp. 525
- Gallinari, P.¹ Filocamo, G.² Jones, P.³ Pazzaglia, S.⁴ Steinkuhler, C.⁵

4
- 0035577854
- P.W. Ingham, and A.P. McMahon Genes Dev. 15 2001 3059
- (2001) Genes Dev. , vol.15 , pp. 3059
- Ingham, P.W.¹ McMahon, A.P.²

5
- 77950647110
- S. Peukert, and K. Miller-Moslin ChemMedChem 5 2010 500
- (2010) ChemMedChem , vol.5 , pp. 500
- Peukert, S.¹ Miller-Moslin, K.²

6
- 69949084378
- K.D. Robarge, S.A. Brunton, G.M. Castanedo, Y. Cui, M.S. Dina, R. Goldsmith, S.E. Gould, O. Guichert, J.L. Gunzner, J. Halladay, W. Jia, C. Khojasteh, M.F.T. Koehler, K. Kotkow, H. La, R.L. LaLonde, K. Lau, L. Lee, D. Marshall, J.C. Marsters, L.J. Murray, C. Qian, L.L. Rubin, L. Salphati, M.S. Stanley, J.H.A. Stibbard, D.P. Sutherlin, S. Ubhayaker, S. Wang, S. Wong, and M. Xie Bioorg. Med. Chem. Lett. 19 2009 5576
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5576
- Robarge, K.D.¹ Brunton, S.A.² Castanedo, G.M.³ Cui, Y.⁴ Dina, M.S.⁵ Goldsmith, R.⁶ Gould, S.E.⁷ Guichert, O.⁸ Gunzner, J.L.⁹ Halladay, J.¹⁰ Jia, W.¹¹ Khojasteh, C.¹² Koehler, M.F.T.¹³ Kotkow, K.¹⁴ La, H.¹⁵ Lalonde, R.L.¹⁶ Lau, K.¹⁷ Lee, L.¹⁸ Marshall, D.¹⁹ Marsters, J.C.²⁰ more..

7
- 70349238733
- D.D. Von Hoff, P.M. LoRusso, C.M. Rudin, J.C. Reddy, R.L. Yauch, R. Tibes, G.J. Weiss, M.J. Borad, C.L. Hann, J.R. Brahmer, H.M. Mackey, B.L. Lum, W.C. Darbonne, J.C. Marsters Jr., F.J. de Sauvage, and J.A. Low New Eng. J. Med. 361 2009 1164
- (2009) New Eng. J. Med. , vol.361 , pp. 1164
- Von Hoff, D.D.¹ Lorusso, P.M.² Rudin, C.M.³ Reddy, J.C.⁴ Yauch, R.L.⁵ Tibes, R.⁶ Weiss, G.J.⁷ Borad, M.J.⁸ Hann, C.L.⁹ Brahmer, J.R.¹⁰ MacKey, H.M.¹¹ Lum, B.L.¹² Darbonne, W.C.¹³ Marsters, Jr.J.C.¹⁴ De Sauvage, F.J.¹⁵ Low, J.A.¹⁶

8
- 79960351998
- 10.1016/j.bmcl.2011.06.024
- S. Malancona, S. Altamura, G. Filocamo, O. Kinzel, J.I. Martin Hernando, M. Rowley, R. Scarpelli, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 2011 10.1016/j.bmcl.2011.06.024
- (2011) Bioorg. Med. Chem. Lett.
- Malancona, S.¹ Altamura, S.² Filocamo, G.³ Kinzel, O.⁴ Martin Hernando, J.I.⁵ Rowley, M.⁶ Scarpelli, R.⁷ Steinkühler, C.⁸ Jones, P.⁹

9
- 79960349060
- 10.1016/j.bmcl.2011.06.023
- O. Kinzel, A. Alfieri, S. Altamura, M. Brunetti, S. Bufali, F. Colaceci, F. Ferrigno, G. Filocamo, M. Fonsi, P. Gallinari, S. Malancona, J.I. Martin Hernando, E. Monteagudo, M.V. Orsale, M.C. Palumbi, V. Pucci, M. Rowley, R. Sasso, R. Scarpelli, C. Steinkühler, and P. Jones Bioorg. Med. Chem. Lett. 2011 10.1016/j.bmcl.2011.06.023
- (2011) Bioorg. Med. Chem. Lett.
- Kinzel, O.¹ Alfieri, A.² Altamura, S.³ Brunetti, M.⁴ Bufali, S.⁵ Colaceci, F.⁶ Ferrigno, F.⁷ Filocamo, G.⁸ Fonsi, M.⁹ Gallinari, P.¹⁰ Malancona, S.¹¹ Martin Hernando, J.I.¹² Monteagudo, E.¹³ Orsale, M.V.¹⁴ Palumbi, M.C.¹⁵ Pucci, V.¹⁶ Rowley, M.¹⁷ Sasso, R.¹⁸ Scarpelli, R.¹⁹ Steinkühler, C.²⁰ Jones, P.²¹ more..

10
- 60249088794
- B.Z. Stanton, L.F. Peng, N. Maloof, K. Nakai, X. Wang, J.L. Duffner, K.M. Taveras, J.M. Hyman, S.W. Lee, A.N. Koehler, J.K. Chen, J.L. Fox, A. Mandinova, and S.L. Schreiber Nature Chem. Biol. 5 2009 154
- (2009) Nature Chem. Biol. , vol.5 , pp. 154
- Stanton, B.Z.¹ Peng, L.F.² Maloof, N.³ Nakai, K.⁴ Wang, X.⁵ Duffner, J.L.⁶ Taveras, K.M.⁷ Hyman, J.M.⁸ Lee, S.W.⁹ Koehler, A.N.¹⁰ Chen, J.K.¹¹ Fox, J.L.¹² Mandinova, A.¹³ Schreiber, S.L.¹⁴

11
- 34249867843
- M. Lauth, A. Bergström, T. Shimokawa, and R. Toftgrd Proc. Natl. Acad. Sci. U.S.A. 104 2007 8455
- (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 8455
- Lauth, M.¹ Bergström, A.² Shimokawa, T.³ Toftgrd, R.⁴

12
- 69549138464
- J.M. Hyman, A.J. Firestone, V.M. Heine, Y. Zhao, C.A. Ocasio, K. Han, M. Sun, P.G. Rack, S. Sinha, J.J. Wu, D.E. Solow-Cordero, J. Jiang, D.H. Rowitch, and J.K. Chen Proc. Natl. Acad. Sci. U.S.A. 106 2009 14132
- (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 14132
- Hyman, J.M.¹ Firestone, A.J.² Heine, V.M.³ Zhao, Y.⁴ Ocasio, C.A.⁵ Han, K.⁶ Sun, M.⁷ Rack, P.G.⁸ Sinha, S.⁹ Wu, J.J.¹⁰ Solow-Cordero, D.E.¹¹ Jiang, J.¹² Rowitch, D.H.¹³ Chen, J.K.¹⁴

13
- 78651225643
- Y. Rifai, M.A. Arai, S.K. Sadhu, F. Ahmed, and M. Ishibashi Bioorg. Med. Chem. Lett. 21 2011 718
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 718
- Rifai, Y.¹ Arai, M.A.² Sadhu, S.K.³ Ahmed, F.⁴ Ishibashi, M.⁵

14
- 0034738979
- J. Taipale, J.K. Chen, M.K. Cooper, B. Wang, R.K. Mann, L. Milenkovic, M.P. Scotts, and P.A. Beachy Nature 406 2000 1005
- (2000) Nature , vol.406 , pp. 1005
- Taipale, J.¹ Chen, J.K.² Cooper, M.K.³ Wang, B.⁴ Mann, R.K.⁵ Milenkovic, L.⁶ Scotts, M.P.⁷ Beachy, P.A.⁸

15
- 18644368453
- M. Frank-Kamenetsky, X.M. Zhang, S. Bottega, O. Guicherit, H. Wichterle, H. Dudek, D. Bumcrot, F.Y. Wang, S. Jones, J. Shulok, L.L. Rubin, and J.A. Porter J. Biol. 1 2002 10
- (2002) J. Biol. , vol.1 , pp. 10
- Frank-Kamenetsky, M.¹ Zhang, X.M.² Bottega, S.³ Guicherit, O.⁴ Wichterle, H.⁵ Dudek, H.⁶ Bumcrot, D.⁷ Wang, F.Y.⁸ Jones, S.⁹ Shulok, J.¹⁰ Rubin, L.L.¹¹ Porter, J.A.¹²

16
- 0036829397
- J.K. Chen, J. Taipale, M.K. Cooper, and P.A. Beachy Genes Dev. 16 2002 2743
- (2002) Genes Dev. , vol.16 , pp. 2743
- Chen, J.K.¹ Taipale, J.² Cooper, M.K.³ Beachy, P.A.⁴

17
- 80051947776
- WO2010/013037
- Dessole, G.; Jones, P.; Llauger Bufi, L.; Muraglia, E.; Ontoria Ontoria, J. M.; Torrisi, C. WO2010/013037, 2010.
- (2010)
- Dessole, G.¹ Jones, P.² Llauger Bufi, L.³ Muraglia, E.⁴ Ontoria Ontoria, J.M.⁵ Torrisi, C.⁶

18
- 0035911020
- A.R. Gangloff, J. Litvak, E.J. Shelton, D. Sperandio, V.R. Wang, and K.D. Rice Tetrahedron Lett. 42 2001 1441
- (2001) Tetrahedron Lett. , vol.42 , pp. 1441
- Gangloff, A.R.¹ Litvak, J.² Shelton, E.J.³ Sperandio, D.⁴ Wang, V.R.⁵ Rice, K.D.⁶

19
- 41649105269
- S.A. Brunton, J.H.A. Stibbard, L.L. Rubin, L.I. Kruse, O.M. Guicherit, E.A. Boyd, and S. Price J. Med. Chem. 51 2008 1108
- (2008) J. Med. Chem. , vol.51 , pp. 1108
- Brunton, S.A.¹ Stibbard, J.H.A.² Rubin, L.L.³ Kruse, L.I.⁴ Guicherit, O.M.⁵ Boyd, E.A.⁶ Price, S.⁷

20
- 77957245263
- F. Manetti, H. Faure, H. Roudaut, T. Gorojankina, E. Traiffort, A. Schoenfelder, A. Mann, A. Solinas, M. Taddei, and M. Ruat Mol. Pharmacol. 78 2010 658
- (2010) Mol. Pharmacol. , vol.78 , pp. 658
- Manetti, F.¹ Faure, H.² Roudaut, H.³ Gorojankina, T.⁴ Traiffort, E.⁵ Schoenfelder, A.⁶ Mann, A.⁷ Solinas, A.⁸ Taddei, M.⁹ Ruat, M.¹⁰

21
- 79951974372
- H. Roudaut, E. Traiffort, T. Gorojankina, L. Vincent, H. Faure, A. Schoenfelder, A. Mann, F. Manetti, A. Solinas, M. Taddei, and M. Ruat Mol. Pharmacol 79 2011 453
- (2011) Mol. Pharmacol , vol.79 , pp. 453
- Roudaut, H.¹ Traiffort, E.² Gorojankina, T.³ Vincent, L.⁴ Faure, H.⁵ Schoenfelder, A.⁶ Mann, A.⁷ Manetti, F.⁸ Solinas, A.⁹ Taddei, M.¹⁰ Ruat, M.¹¹

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