-
1
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
Knudson AG Jr,. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971; 68: 820-823.
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 820-823
-
-
Knudson, Jr.A.G.1
-
2
-
-
0022506980
-
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
-
Friend SH, Bernards R, Rogelj S, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986; 323: 643-646.
-
(1986)
Nature
, vol.323
, pp. 643-646
-
-
Friend, S.H.1
Bernards, R.2
Rogelj, S.3
-
3
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell PC,. The clonal evolution of tumor cell populations. Science. 1976; 194: 23-28.
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
4
-
-
0015458408
-
The spontaneous azaguanine-resistant mutants of diploid human fibroblasts
-
DeMars R, Held KR,. The spontaneous azaguanine-resistant mutants of diploid human fibroblasts. Humangenetik. 1972; 16: 87-110.
-
(1972)
Humangenetik
, vol.16
, pp. 87-110
-
-
Demars, R.1
Held, K.R.2
-
5
-
-
0023135430
-
Mutation rate of normal and malignant human lymphocytes
-
Seshadri R, Kutlaca RJ, Trainor K, Matthews C, Morley AA,. Mutation rate of normal and malignant human lymphocytes. Cancer Res. 1987; 47: 407-409.
-
(1987)
Cancer Res
, vol.47
, pp. 407-409
-
-
Seshadri, R.1
Kutlaca, R.J.2
Trainor, K.3
Matthews, C.4
Morley, A.A.5
-
6
-
-
0035890321
-
Haplo-insufficiency? Let me count the ways
-
Quon KC, Berns A,. Haplo-insufficiency? Let me count the ways. Genes Dev. 2001; 15: 2917-2921.
-
(2001)
Genes Dev
, vol.15
, pp. 2917-2921
-
-
Quon, K.C.1
Berns, A.2
-
7
-
-
0034643955
-
Accommodating haploinsufficient tumor suppressor genes in Knudson's model
-
Cook WD, McCaw BJ,. Accommodating haploinsufficient tumor suppressor genes in Knudson's model. Oncogene. 2000; 19: 3434-3438.
-
(2000)
Oncogene
, vol.19
, pp. 3434-3438
-
-
Cook, W.D.1
McCaw, B.J.2
-
9
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW,. Cancer genes and the pathways they control. Nat Med. 2004; 10: 789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
10
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW,. Cancer genome landscapes. Science. 2013; 339: 1546-1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, Jr.L.A.5
Kinzler, K.W.6
-
11
-
-
84885129618
-
Comprehensive identification of mutational cancer driver genes across 12 tumor types
-
Tamborero D, Gonzalez-Perez A, Perez-Llamas C, et al. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep. 2013; 3: 2650.
-
(2013)
Sci Rep
, vol.3
, pp. 2650
-
-
Tamborero, D.1
Gonzalez-Perez, A.2
Perez-Llamas, C.3
-
12
-
-
84885008220
-
Pan-cancer patterns of somatic copy number alteration
-
Zack TI, Schumacher SE, Carter SL, et al. Pan-cancer patterns of somatic copy number alteration. Nat Genet. 2013; 45: 1134-1140.
-
(2013)
Nat Genet
, vol.45
, pp. 1134-1140
-
-
Zack, T.I.1
Schumacher, S.E.2
Carter, S.L.3
-
13
-
-
84862636275
-
Mutant p53: One name, many proteins
-
Freed-Pastor WA, Prives C,. Mutant p53: one name, many proteins. Genes Dev. 2012; 26: 1268-1286.
-
(2012)
Genes Dev
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
14
-
-
0025894713
-
P53 mutations in human cancers
-
Hollstein M, Sidransky D, Vogelstein B, Harris CC,. p53 mutations in human cancers. Science. 1991; 253: 49-53.
-
(1991)
Science
, vol.253
, pp. 49-53
-
-
Hollstein, M.1
Sidransky, D.2
Vogelstein, B.3
Harris, C.C.4
-
16
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012; 2: 401-404.
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
-
17
-
-
0025111068
-
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
-
Michalovitz D, Halevy O, Oren M,. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell. 1990; 62: 671-680.
-
(1990)
Cell
, vol.62
, pp. 671-680
-
-
Michalovitz, D.1
Halevy, O.2
Oren, M.3
-
18
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang GA, Iwakuma T, Suh YA, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004; 119: 861-872.
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.A.3
-
19
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI,. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature. 2006; 443: 214-217.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
20
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007; 445: 656-660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
-
21
-
-
77955354374
-
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
-
Kenzelmann Broz D, Attardi LD,. In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis. 2010; 31: 1311-1318.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1311-1318
-
-
Kenzelmann Broz, D.1
Attardi, L.D.2
-
22
-
-
79952234403
-
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
-
Wang Y, Suh YA, Fuller MY, et al. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011; 121: 893-904.
-
(2011)
J Clin Invest
, vol.121
, pp. 893-904
-
-
Wang, Y.1
Suh, Y.A.2
Fuller, M.Y.3
-
23
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008; 13: 454-463.
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
-
24
-
-
58349104143
-
Identification of nuclear export inhibitors with potent anticancer activity in vivo
-
Mutka SC, Yang WQ, Dong SD, et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009; 69: 510-517.
-
(2009)
Cancer Res
, vol.69
, pp. 510-517
-
-
Mutka, S.C.1
Yang, W.Q.2
Dong, S.D.3
-
25
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004; 303: 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
-
26
-
-
84895779578
-
Drugging the p53 pathway: Understanding the route to clinical efficacy
-
Khoo KH, Verma CS, Lane DP,. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014; 13: 217-236.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 217-236
-
-
Khoo, K.H.1
Verma, C.S.2
Lane, D.P.3
-
27
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie PH, Gorina S, Marechal V, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science. 1996; 274: 948-953.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
-
28
-
-
0034716943
-
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines
-
Chene P, Fuchs J, Bohn J, Garcia-Echeverria C, Furet P, Fabbro D,. A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines. J Mol Biol. 2000; 299: 245-253.
-
(2000)
J Mol Biol
, vol.299
, pp. 245-253
-
-
Chene, P.1
Fuchs, J.2
Bohn, J.3
Garcia-Echeverria, C.4
Furet, P.5
Fabbro, D.6
-
29
-
-
41649102468
-
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
-
Shangary S, Qin D, McEachern D, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A. 2008; 105: 3933-3938.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3933-3938
-
-
Shangary, S.1
Qin, D.2
McEachern, D.3
-
30
-
-
84856098041
-
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
-
Michaelis M, Rothweiler F, Barth S, et al. Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis. 2011; 2: e243.
-
(2011)
Cell Death Dis
, vol.2
, pp. e243
-
-
Michaelis, M.1
Rothweiler, F.2
Barth, S.3
-
31
-
-
84908148515
-
SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression
-
Wang S, Sun W, Zhao Y, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014; 74: 5855-5865.
-
(2014)
Cancer Res
, vol.74
, pp. 5855-5865
-
-
Wang, S.1
Sun, W.2
Zhao, Y.3
-
32
-
-
84867615093
-
Targeting p53 in vivo: A first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
-
Lehmann S, Bykov VJ, Ali D, et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J Clin Oncol. 2012; 30: 3633-3639.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3633-3639
-
-
Lehmann, S.1
Bykov, V.J.2
Ali, D.3
-
33
-
-
17344365479
-
A phase i study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer
-
Schuler M, Rochlitz C, Horowitz JA, et al. A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer. Hum Gene Ther. 1998; 9: 2075-2082.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2075-2082
-
-
Schuler, M.1
Rochlitz, C.2
Horowitz, J.A.3
-
34
-
-
0033526357
-
Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
-
Swisher SG, Roth JA, Nemunaitis J, et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst. 1999; 91: 763-771.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 763-771
-
-
Swisher, S.G.1
Roth, J.A.2
Nemunaitis, J.3
-
35
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
-
Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH,. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med. 1997; 3: 639-645.
-
(1997)
Nat Med
, vol.3
, pp. 639-645
-
-
Heise, C.1
Sampson-Johannes, A.2
Williams, A.3
McCormick, F.4
Von Hoff, D.D.5
Kirn, D.H.6
-
36
-
-
0037109013
-
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy
-
Lamfers ML, Grill J, Dirven CM, et al. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res. 2002; 62: 5736-5742.
-
(2002)
Cancer Res
, vol.62
, pp. 5736-5742
-
-
Lamfers, M.L.1
Grill, J.2
Dirven, C.M.3
-
37
-
-
0033831080
-
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
-
Khuri FR, Nemunaitis J, Ganly I, et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med. 2000; 6: 879-885.
-
(2000)
Nat Med
, vol.6
, pp. 879-885
-
-
Khuri, F.R.1
Nemunaitis, J.2
Ganly, I.3
-
38
-
-
0033693231
-
Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial
-
Nemunaitis J, Ganly I, Khuri F, et al. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial. Cancer Res. 2000; 60: 6359-6366.
-
(2000)
Cancer Res
, vol.60
, pp. 6359-6366
-
-
Nemunaitis, J.1
Ganly, I.2
Khuri, F.3
-
39
-
-
34249043939
-
Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: Implications of p53 mutation or isoform expression on breast cancer cell invasion
-
Mehta SA, Christopherson KW, Bhat-Nakshatri P, et al. Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Oncogene. 2007; 26: 3329-3337.
-
(2007)
Oncogene
, vol.26
, pp. 3329-3337
-
-
Mehta, S.A.1
Christopherson, K.W.2
Bhat-Nakshatri, P.3
-
40
-
-
84898614449
-
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling
-
Weissmueller S, Manchado E, Saborowski M, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. Cell. 2014; 157: 382-394.
-
(2014)
Cell
, vol.157
, pp. 382-394
-
-
Weissmueller, S.1
Manchado, E.2
Saborowski, M.3
-
41
-
-
70249141312
-
Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial
-
Leffers N, Lambeck AJ, Gooden MJ, et al. Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial. Int J Cancer. 2009; 125: 2104-2113.
-
(2009)
Int J Cancer
, vol.125
, pp. 2104-2113
-
-
Leffers, N.1
Lambeck, A.J.2
Gooden, M.J.3
-
42
-
-
77952135152
-
INGN-225: A dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: Observed association between immune response and enhanced chemotherapy effect
-
Chiappori AA, Soliman H, Janssen WE, Antonia SJ, Gabrilovich DI,. INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther. 2010; 10: 983-991.
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 983-991
-
-
Chiappori, A.A.1
Soliman, H.2
Janssen, W.E.3
Antonia, S.J.4
Gabrilovich, D.I.5
-
43
-
-
84899728764
-
Phase i dendritic cell p53 peptide vaccine for head and neck cancer
-
Schuler PJ, Harasymczuk M, Visus C, et al. Phase I dendritic cell p53 peptide vaccine for head and neck cancer. Clin Cancer Res. 2014; 20: 2433-2444.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2433-2444
-
-
Schuler, P.J.1
Harasymczuk, M.2
Visus, C.3
-
44
-
-
51849097348
-
The role of PTEN signaling perturbations in cancer and in targeted therapy
-
Keniry M, Parsons R,. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene. 2008; 27: 5477-5485.
-
(2008)
Oncogene
, vol.27
, pp. 5477-5485
-
-
Keniry, M.1
Parsons, R.2
-
45
-
-
14444269482
-
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
-
Teng DH, Hu R, Lin H, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 1997; 57: 5221-5225.
-
(1997)
Cancer Res
, vol.57
, pp. 5221-5225
-
-
Teng, D.H.1
Hu, R.2
Lin, H.3
-
46
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
-
Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci U S A. 1998; 95: 13513-13518.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
-
47
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998; 95: 29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
-
48
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997; 91: 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
49
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC,. AKT/PKB signaling: navigating downstream. Cell. 2007; 129: 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
50
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter CJ, Pedraza LG, Xu T,. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol. 2002; 4: 658-665.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
51
-
-
13844251972
-
Lack of PTEN sequesters CHK1 and initiates genetic instability
-
Puc J, Keniry M, Li HS, et al. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005; 7: 193-204.
-
(2005)
Cancer Cell
, vol.7
, pp. 193-204
-
-
Puc, J.1
Keniry, M.2
Li, H.S.3
-
52
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL,. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
54
-
-
77950243447
-
Drugging the PI3 kinome: From chemical tools to drugs in the clinic
-
Workman P, Clarke PA, Raynaud FI, van Montfort RL,. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer Res. 2010; 70: 2146-2157.
-
(2010)
Cancer Res
, vol.70
, pp. 2146-2157
-
-
Workman, P.1
Clarke, P.A.2
Raynaud, F.I.3
Van Montfort, R.L.4
-
55
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
Haruta T, Uno T, Kawahara J, et al. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol. 2000; 14: 783-794.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 783-794
-
-
Haruta, T.1
Uno, T.2
Kawahara, J.3
-
56
-
-
78651458656
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
-
Chandarlapaty S, Sawai A, Scaltriti M, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell. 2011; 19: 58-71.
-
(2011)
Cancer Cell
, vol.19
, pp. 58-71
-
-
Chandarlapaty, S.1
Sawai, A.2
Scaltriti, M.3
-
57
-
-
84897133359
-
Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer
-
Tao JJ, Castel P, Radosevic-Robin N, et al. Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. Sci Signal. 2014; 7: ra29.
-
(2014)
Sci Signal
, vol.7
, pp. ra29
-
-
Tao, J.J.1
Castel, P.2
Radosevic-Robin, N.3
-
58
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia A, Elledge SJ,. The DNA damage response: making it safe to play with knives. Mol Cell. 2010; 40: 179-204.
-
(2010)
Mol Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
59
-
-
38049115657
-
The mechanism of human nonhomologous DNA end joining
-
Lieber MR,. The mechanism of human nonhomologous DNA end joining. J Biol Chem. 2008; 283: 1-5.
-
(2008)
J Biol Chem
, vol.283
, pp. 1-5
-
-
Lieber, M.R.1
-
60
-
-
62349120246
-
DNA repair in mammalian cells: Base excision repair: The long and short of it
-
Robertson AB, Klungland A, Rognes T, Leiros I,. DNA repair in mammalian cells: base excision repair: the long and short of it. Cell Mol Life Sci. 2009; 66: 981-993.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 981-993
-
-
Robertson, A.B.1
Klungland, A.2
Rognes, T.3
Leiros, I.4
-
61
-
-
38049125557
-
Mechanisms and functions of DNA mismatch repair
-
Li GM,. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008; 18: 85-98.
-
(2008)
Cell Res
, vol.18
, pp. 85-98
-
-
Li, G.M.1
-
62
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005; 434: 913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
63
-
-
0034667921
-
Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1
-
Vodenicharov MD, Sallmann FR, Satoh MS, Poirier GG,. Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1. Nucleic Acids Res. 2000; 28: 3887-3896.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 3887-3896
-
-
Vodenicharov, M.D.1
Sallmann, F.R.2
Satoh, M.S.3
Poirier, G.G.4
-
64
-
-
84889595095
-
Appraising iniparib, the PARP inhibitor that never was-what must we learn?
-
Mateo J, Ong M, Tan DS, Gonzalez MA, de Bono JS,. Appraising iniparib, the PARP inhibitor that never was-what must we learn? Nat Rev Clin Oncol. 2013; 10: 688-696.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 688-696
-
-
Mateo, J.1
Ong, M.2
Tan, D.S.3
Gonzalez, M.A.4
De Bono, J.S.5
-
65
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple-negative breast cancer
-
O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med. 2011; 364: 205-214.
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
O'Shaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
-
66
-
-
80054748797
-
The use of PARP inhibitors in cancer therapy: Use as adjuvant with chemotherapy or radiotherapy; Use as a single agent in susceptible patients; Techniques used to identify susceptible patients
-
Shall S, Gaymes T, Farzaneh F, Curtin N, Mufti GJ,. The use of PARP inhibitors in cancer therapy: use as adjuvant with chemotherapy or radiotherapy; use as a single agent in susceptible patients; techniques used to identify susceptible patients. Methods Mol Biol. 2011; 780: 239-266.
-
(2011)
Methods Mol Biol
, vol.780
, pp. 239-266
-
-
Shall, S.1
Gaymes, T.2
Farzaneh, F.3
Curtin, N.4
Mufti, G.J.5
-
67
-
-
68049097111
-
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
-
Gupta A, Yang Q, Pandita RK, et al. Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle. 2009; 8: 2198-2210.
-
(2009)
Cell Cycle
, vol.8
, pp. 2198-2210
-
-
Gupta, A.1
Yang, Q.2
Pandita, R.K.3
-
68
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012; 490: 61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
69
-
-
77955770116
-
DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
-
Rodriguez AA, Makris A, Wu MF, et al. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat. 2010; 123: 189-196.
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 189-196
-
-
Rodriguez, A.A.1
Makris, A.2
Wu, M.F.3
-
70
-
-
4944229642
-
Hallmarks of 'BRCAness' in sporadic cancers
-
Turner N, Tutt A, Ashworth A,. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer. 2004; 4: 814-819.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 814-819
-
-
Turner, N.1
Tutt, A.2
Ashworth, A.3
-
71
-
-
33847355994
-
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer
-
Lee MN, Tseng RC, Hsu HS, et al. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin Cancer Res. 2007; 13: 832-838.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 832-838
-
-
Lee, M.N.1
Tseng, R.C.2
Hsu, H.S.3
-
72
-
-
78649321855
-
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
-
Weston VJ, Oldreive CE, Skowronska A, et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood. 2010; 116: 4578-4587.
-
(2010)
Blood
, vol.116
, pp. 4578-4587
-
-
Weston, V.J.1
Oldreive, C.E.2
Skowronska, A.3
-
73
-
-
0027417017
-
Pathway correcting DNA replication errors in Saccharomyces cerevisiae
-
Morrison A, Johnson AL, Johnston LH, Sugino A,. Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J. 1993; 12: 1467-1473.
-
(1993)
EMBO J
, vol.12
, pp. 1467-1473
-
-
Morrison, A.1
Johnson, A.L.2
Johnston, L.H.3
Sugino, A.4
-
74
-
-
77649311945
-
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
-
Martin SA, McCabe N, Mullarkey M, et al. DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell. 2010; 17: 235-248.
-
(2010)
Cancer Cell
, vol.17
, pp. 235-248
-
-
Martin, S.A.1
McCabe, N.2
Mullarkey, M.3
-
75
-
-
69249240178
-
The combined status of ATM and p53 link tumor development with therapeutic response
-
Jiang H, Reinhardt HC, Bartkova J, et al. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 2009; 23: 1895-1909.
-
(2009)
Genes Dev
, vol.23
, pp. 1895-1909
-
-
Jiang, H.1
Reinhardt, H.C.2
Bartkova, J.3
-
76
-
-
33744924482
-
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
-
Zhao Y, Thomas HD, Batey MA, et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 2006; 66: 5354-5362.
-
(2006)
Cancer Res
, vol.66
, pp. 5354-5362
-
-
Zhao, Y.1
Thomas, H.D.2
Batey, M.A.3
-
77
-
-
67649710471
-
Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
-
Mizuarai S, Yamanaka K, Itadani H, et al. Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor. Mol Cancer. 2009; 8: 34.
-
(2009)
Mol Cancer
, vol.8
, pp. 34
-
-
Mizuarai, S.1
Yamanaka, K.2
Itadani, H.3
-
78
-
-
79960339454
-
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
-
De Witt Hamer PC, Mir SE, Noske D, Van Noorden CJ, Wurdinger T,. WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe. Clin Cancer Res. 2011; 17: 4200-4207.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4200-4207
-
-
De Witt Hamer, P.C.1
Mir, S.E.2
Noske, D.3
Van Noorden, C.J.4
Wurdinger, T.5
-
80
-
-
84877303028
-
Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping
-
Laufer C, Fischer B, Billmann M, Huber W, Boutros M,. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nat Methods. 2013; 10: 427-431.
-
(2013)
Nat Methods
, vol.10
, pp. 427-431
-
-
Laufer, C.1
Fischer, B.2
Billmann, M.3
Huber, W.4
Boutros, M.5
-
81
-
-
79551629227
-
Searching for synthetic lethality in cancer
-
Brough R, Frankum JR, Costa-Cabral S, Lord CJ, Ashworth A,. Searching for synthetic lethality in cancer. Curr Opin Genet Dev. 2011; 21: 34-41.
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 34-41
-
-
Brough, R.1
Frankum, J.R.2
Costa-Cabral, S.3
Lord, C.J.4
Ashworth, A.5
-
82
-
-
84907333139
-
Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
-
Jerby-Arnon L, Pfetzer N, Waldman YY, et al. Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell. 2014; 158: 1199-1209.
-
(2014)
Cell
, vol.158
, pp. 1199-1209
-
-
Jerby-Arnon, L.1
Pfetzer, N.2
Waldman, Y.Y.3
-
83
-
-
84865134914
-
Passenger deletions generate therapeutic vulnerabilities in cancer
-
Muller FL, Colla S, Aquilanti E, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012; 488: 337-342.
-
(2012)
Nature
, vol.488
, pp. 337-342
-
-
Muller, F.L.1
Colla, S.2
Aquilanti, E.3
-
84
-
-
77249123407
-
Signatures of mutation and selection in the cancer genome
-
Bignell GR, Greenman CD, Davies H, et al. Signatures of mutation and selection in the cancer genome. Nature. 2010; 463: 893-898.
-
(2010)
Nature
, vol.463
, pp. 893-898
-
-
Bignell, G.R.1
Greenman, C.D.2
Davies, H.3
-
85
-
-
84863770814
-
Cancer genetics and epigenetics: Two sides of the same coin?
-
You JS, Jones PA,. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 2012; 22: 9-20.
-
(2012)
Cancer Cell
, vol.22
, pp. 9-20
-
-
You, J.S.1
Jones, P.A.2
-
86
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin SB, Jones PA,. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer. 2011; 11: 726-734.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
87
-
-
79958769268
-
Epigenetic aberrations during oncogenesis
-
Hatziapostolou M, Iliopoulos D,. Epigenetic aberrations during oncogenesis. Cell Mol Life Sci. 2011; 68: 1681-1702.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 1681-1702
-
-
Hatziapostolou, M.1
Iliopoulos, D.2
-
88
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M,. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 2007; 8: 286-298.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
89
-
-
84863756127
-
Wnt signaling, stem cells, and cancer of the gastrointestinal tract
-
Schepers A, Clevers H,. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol. 2012; 4: a007989.
-
(2012)
Cold Spring Harb Perspect Biol
, vol.4
, pp. a007989
-
-
Schepers, A.1
Clevers, H.2
-
90
-
-
84856549042
-
Genome-scale analysis of aberrant DNA methylation in colorectal cancer
-
Hinoue T, Weisenberger DJ, Lange CP, et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 2012; 22: 271-282.
-
(2012)
Genome Res
, vol.22
, pp. 271-282
-
-
Hinoue, T.1
Weisenberger, D.J.2
Lange, C.P.3
-
91
-
-
10344260184
-
CpG island methylator phenotype in cancer
-
Issa JP,. CpG island methylator phenotype in cancer. Nat Rev Cancer. 2004; 4: 988-993.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 988-993
-
-
Issa, J.P.1
-
92
-
-
79953123510
-
Breast cancer methylomes establish an epigenomic foundation for metastasis
-
Fang F, Turcan S, Rimner A, et al. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med. 2011; 3: 75ra25.
-
(2011)
Sci Transl Med
, vol.3
, pp. 75ra25
-
-
Fang, F.1
Turcan, S.2
Rimner, A.3
-
93
-
-
0037456636
-
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
-
Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S,. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett. 2003; 192: 75-82.
-
(2003)
Cancer Lett
, vol.192
, pp. 75-82
-
-
Kanai, Y.1
Ushijima, S.2
Nakanishi, Y.3
Sakamoto, M.4
Hirohashi, S.5
-
94
-
-
77954089584
-
Array-based genomic resequencing of human leukemia
-
Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene. 2010; 29: 3723-3731.
-
(2010)
Oncogene
, vol.29
, pp. 3723-3731
-
-
Yamashita, Y.1
Yuan, J.2
Suetake, I.3
-
95
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010; 363: 2424-2433.
-
(2010)
N Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
96
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
International Vidaza High-Risk MDS Survival Study Group
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. International Vidaza High-Risk MDS Survival Study Group. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009; 10: 223-232.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
97
-
-
84908247072
-
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
-
Bejar R, Lord A, Stevenson K, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 2014; 124: 2705-2712.
-
(2014)
Blood
, vol.124
, pp. 2705-2712
-
-
Bejar, R.1
Lord, A.2
Stevenson, K.3
-
98
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012; 483: 479-483.
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
99
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012; 483: 474-478.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
-
100
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; 340: 626-630.
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
-
101
-
-
84884545211
-
Induction of sarcomas by mutant IDH2
-
Lu C, Venneti S, Akalin A, et al. Induction of sarcomas by mutant IDH2. Genes Dev. 2013; 27: 1986-1998.
-
(2013)
Genes Dev
, vol.27
, pp. 1986-1998
-
-
Lu, C.1
Venneti, S.2
Akalin, A.3
-
102
-
-
84886741979
-
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
-
Borodovsky A, Salmasi V, Turcan S, et al. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget. 2013; 4: 1737-1747.
-
(2013)
Oncotarget
, vol.4
, pp. 1737-1747
-
-
Borodovsky, A.1
Salmasi, V.2
Turcan, S.3
-
103
-
-
84886744421
-
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine
-
Turcan S, Fabius AW, Borodovsky A, et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine. Oncotarget. 2013; 4: 1729-1736.
-
(2013)
Oncotarget
, vol.4
, pp. 1729-1736
-
-
Turcan, S.1
Fabius, A.W.2
Borodovsky, A.3
-
104
-
-
34250171437
-
Histone deacetylase inhibitors: Signalling towards p21cip1/waf1
-
Ocker M, Schneider-Stock R,. Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int J Biochem Cell Biol. 2007; 39: 1367-1374.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1367-1374
-
-
Ocker, M.1
Schneider-Stock, R.2
-
105
-
-
84892942381
-
New and emerging HDAC inhibitors for cancer treatment
-
West AC, Johnstone RW,. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest. 2014; 124: 30-39.
-
(2014)
J Clin Invest
, vol.124
, pp. 30-39
-
-
West, A.C.1
Johnstone, R.W.2
-
106
-
-
34547799203
-
Cancer genetics of epigenetic genes
-
Miremadi A, Oestergaard MZ, Pharoah PD, Caldas C,. Cancer genetics of epigenetic genes. Hum Mol Genet. 2007; 16 (spec no 1): R28-R49.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.SPEC NO 1
, pp. R28-R49
-
-
Miremadi, A.1
Oestergaard, M.Z.2
Pharoah, P.D.3
Caldas, C.4
-
107
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007; 109: 31-39.
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
-
108
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2009; 27: 5410-5417.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
-
109
-
-
77957154350
-
Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins
-
Mills AA,. Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer. 2010; 10: 669-682.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 669-682
-
-
Mills, A.A.1
-
110
-
-
79955513100
-
Aberrations of EZH2 in cancer
-
Chase A, Cross NC,. Aberrations of EZH2 in cancer. Clin Cancer Res. 2011; 17: 2613-2618.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2613-2618
-
-
Chase, A.1
Cross, N.C.2
-
111
-
-
62149122634
-
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
-
Ezhkova E, Pasolli HA, Parker JS, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009; 136: 1122-1135.
-
(2009)
Cell
, vol.136
, pp. 1122-1135
-
-
Ezhkova, E.1
Pasolli, H.A.2
Parker, J.S.3
-
112
-
-
34247625135
-
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
-
Tan J, Yang X, Zhuang L, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007; 21: 1050-1063.
-
(2007)
Genes Dev
, vol.21
, pp. 1050-1063
-
-
Tan, J.1
Yang, X.2
Zhuang, L.3
-
113
-
-
84884532954
-
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
-
Kim W, Bird GH, Neff T, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013; 9: 643-650.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 643-650
-
-
Kim, W.1
Bird, G.H.2
Neff, T.3
-
114
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013; 369: 122-133.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
115
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012; 366: 2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
116
-
-
84904472602
-
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
-
Rajasagi M, Shukla SA, Fritsch EF, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014; 124: 453-462.
-
(2014)
Blood
, vol.124
, pp. 453-462
-
-
Rajasagi, M.1
Shukla, S.A.2
Fritsch, E.F.3
-
117
-
-
33746550675
-
Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents
-
Wang H, Han H, Mousses S, Von Hoff DD,. Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents. Semin Oncol. 2006; 33: 513-520.
-
(2006)
Semin Oncol
, vol.33
, pp. 513-520
-
-
Wang, H.1
Han, H.2
Mousses, S.3
Von Hoff, D.D.4
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