메뉴 건너뛰기




Volumn 121, Issue 9, 2015, Pages 1357-1368

Therapeutic targeting of tumor suppressor genes

Author keywords

cancer; oncogene; therapeutic targeting; tumor suppressor gene

Indexed keywords

B RAF KINASE; BRCA1 PROTEIN; BRCA2 PROTEIN; CANCER VACCINE; DNA METHYLTRANSFERASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTONE DEACETYLASE INHIBITOR; ISOCITRATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; POLYCOMB GROUP PROTEIN; PROTEIN KINASE B INHIBITOR; PROTEIN MDM2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE INHIBITOR; SIRTUIN; ANTINEOPLASTIC AGENT; TP53 PROTEIN, HUMAN;

EID: 84928242556     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.29140     Document Type: Review
Times cited : (133)

References (117)
  • 1
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG Jr,. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971; 68: 820-823.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson, Jr.A.G.1
  • 2
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend SH, Bernards R, Rogelj S, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986; 323: 643-646.
    • (1986) Nature , vol.323 , pp. 643-646
    • Friend, S.H.1    Bernards, R.2    Rogelj, S.3
  • 3
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC,. The clonal evolution of tumor cell populations. Science. 1976; 194: 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 4
    • 0015458408 scopus 로고
    • The spontaneous azaguanine-resistant mutants of diploid human fibroblasts
    • DeMars R, Held KR,. The spontaneous azaguanine-resistant mutants of diploid human fibroblasts. Humangenetik. 1972; 16: 87-110.
    • (1972) Humangenetik , vol.16 , pp. 87-110
    • Demars, R.1    Held, K.R.2
  • 6
    • 0035890321 scopus 로고    scopus 로고
    • Haplo-insufficiency? Let me count the ways
    • Quon KC, Berns A,. Haplo-insufficiency? Let me count the ways. Genes Dev. 2001; 15: 2917-2921.
    • (2001) Genes Dev , vol.15 , pp. 2917-2921
    • Quon, K.C.1    Berns, A.2
  • 7
    • 0034643955 scopus 로고    scopus 로고
    • Accommodating haploinsufficient tumor suppressor genes in Knudson's model
    • Cook WD, McCaw BJ,. Accommodating haploinsufficient tumor suppressor genes in Knudson's model. Oncogene. 2000; 19: 3434-3438.
    • (2000) Oncogene , vol.19 , pp. 3434-3438
    • Cook, W.D.1    McCaw, B.J.2
  • 9
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW,. Cancer genes and the pathways they control. Nat Med. 2004; 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 11
    • 84885129618 scopus 로고    scopus 로고
    • Comprehensive identification of mutational cancer driver genes across 12 tumor types
    • Tamborero D, Gonzalez-Perez A, Perez-Llamas C, et al. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep. 2013; 3: 2650.
    • (2013) Sci Rep , vol.3 , pp. 2650
    • Tamborero, D.1    Gonzalez-Perez, A.2    Perez-Llamas, C.3
  • 12
    • 84885008220 scopus 로고    scopus 로고
    • Pan-cancer patterns of somatic copy number alteration
    • Zack TI, Schumacher SE, Carter SL, et al. Pan-cancer patterns of somatic copy number alteration. Nat Genet. 2013; 45: 1134-1140.
    • (2013) Nat Genet , vol.45 , pp. 1134-1140
    • Zack, T.I.1    Schumacher, S.E.2    Carter, S.L.3
  • 13
    • 84862636275 scopus 로고    scopus 로고
    • Mutant p53: One name, many proteins
    • Freed-Pastor WA, Prives C,. Mutant p53: one name, many proteins. Genes Dev. 2012; 26: 1268-1286.
    • (2012) Genes Dev , vol.26 , pp. 1268-1286
    • Freed-Pastor, W.A.1    Prives, C.2
  • 15
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine AJ, Momand J, Finlay CA,. The p53 tumour suppressor gene. Nature. 1991; 351: 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 16
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012; 2: 401-404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 17
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz D, Halevy O, Oren M,. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell. 1990; 62: 671-680.
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 18
    • 13644260907 scopus 로고    scopus 로고
    • Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    • Lang GA, Iwakuma T, Suh YA, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004; 119: 861-872.
    • (2004) Cell , vol.119 , pp. 861-872
    • Lang, G.A.1    Iwakuma, T.2    Suh, Y.A.3
  • 19
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI,. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature. 2006; 443: 214-217.
    • (2006) Nature , vol.443 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 20
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007; 445: 656-660.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3
  • 21
    • 77955354374 scopus 로고    scopus 로고
    • In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
    • Kenzelmann Broz D, Attardi LD,. In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis. 2010; 31: 1311-1318.
    • (2010) Carcinogenesis , vol.31 , pp. 1311-1318
    • Kenzelmann Broz, D.1    Attardi, L.D.2
  • 22
    • 79952234403 scopus 로고    scopus 로고
    • Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
    • Wang Y, Suh YA, Fuller MY, et al. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011; 121: 893-904.
    • (2011) J Clin Invest , vol.121 , pp. 893-904
    • Wang, Y.1    Suh, Y.A.2    Fuller, M.Y.3
  • 23
    • 42949114938 scopus 로고    scopus 로고
    • Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
    • Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008; 13: 454-463.
    • (2008) Cancer Cell , vol.13 , pp. 454-463
    • Lain, S.1    Hollick, J.J.2    Campbell, J.3
  • 24
    • 58349104143 scopus 로고    scopus 로고
    • Identification of nuclear export inhibitors with potent anticancer activity in vivo
    • Mutka SC, Yang WQ, Dong SD, et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009; 69: 510-517.
    • (2009) Cancer Res , vol.69 , pp. 510-517
    • Mutka, S.C.1    Yang, W.Q.2    Dong, S.D.3
  • 25
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004; 303: 844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 26
    • 84895779578 scopus 로고    scopus 로고
    • Drugging the p53 pathway: Understanding the route to clinical efficacy
    • Khoo KH, Verma CS, Lane DP,. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014; 13: 217-236.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 217-236
    • Khoo, K.H.1    Verma, C.S.2    Lane, D.P.3
  • 27
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie PH, Gorina S, Marechal V, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science. 1996; 274: 948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3
  • 28
    • 0034716943 scopus 로고    scopus 로고
    • A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines
    • Chene P, Fuchs J, Bohn J, Garcia-Echeverria C, Furet P, Fabbro D,. A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines. J Mol Biol. 2000; 299: 245-253.
    • (2000) J Mol Biol , vol.299 , pp. 245-253
    • Chene, P.1    Fuchs, J.2    Bohn, J.3    Garcia-Echeverria, C.4    Furet, P.5    Fabbro, D.6
  • 29
    • 41649102468 scopus 로고    scopus 로고
    • Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
    • Shangary S, Qin D, McEachern D, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A. 2008; 105: 3933-3938.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3933-3938
    • Shangary, S.1    Qin, D.2    McEachern, D.3
  • 30
    • 84856098041 scopus 로고    scopus 로고
    • Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
    • Michaelis M, Rothweiler F, Barth S, et al. Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis. 2011; 2: e243.
    • (2011) Cell Death Dis , vol.2 , pp. e243
    • Michaelis, M.1    Rothweiler, F.2    Barth, S.3
  • 31
    • 84908148515 scopus 로고    scopus 로고
    • SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression
    • Wang S, Sun W, Zhao Y, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014; 74: 5855-5865.
    • (2014) Cancer Res , vol.74 , pp. 5855-5865
    • Wang, S.1    Sun, W.2    Zhao, Y.3
  • 32
    • 84867615093 scopus 로고    scopus 로고
    • Targeting p53 in vivo: A first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
    • Lehmann S, Bykov VJ, Ali D, et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J Clin Oncol. 2012; 30: 3633-3639.
    • (2012) J Clin Oncol , vol.30 , pp. 3633-3639
    • Lehmann, S.1    Bykov, V.J.2    Ali, D.3
  • 33
    • 17344365479 scopus 로고    scopus 로고
    • A phase i study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer
    • Schuler M, Rochlitz C, Horowitz JA, et al. A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer. Hum Gene Ther. 1998; 9: 2075-2082.
    • (1998) Hum Gene Ther , vol.9 , pp. 2075-2082
    • Schuler, M.1    Rochlitz, C.2    Horowitz, J.A.3
  • 34
    • 0033526357 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
    • Swisher SG, Roth JA, Nemunaitis J, et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst. 1999; 91: 763-771.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 763-771
    • Swisher, S.G.1    Roth, J.A.2    Nemunaitis, J.3
  • 35
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH,. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med. 1997; 3: 639-645.
    • (1997) Nat Med , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6
  • 36
    • 0037109013 scopus 로고    scopus 로고
    • Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy
    • Lamfers ML, Grill J, Dirven CM, et al. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res. 2002; 62: 5736-5742.
    • (2002) Cancer Res , vol.62 , pp. 5736-5742
    • Lamfers, M.L.1    Grill, J.2    Dirven, C.M.3
  • 37
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • Khuri FR, Nemunaitis J, Ganly I, et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med. 2000; 6: 879-885.
    • (2000) Nat Med , vol.6 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3
  • 38
    • 0033693231 scopus 로고    scopus 로고
    • Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial
    • Nemunaitis J, Ganly I, Khuri F, et al. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial. Cancer Res. 2000; 60: 6359-6366.
    • (2000) Cancer Res , vol.60 , pp. 6359-6366
    • Nemunaitis, J.1    Ganly, I.2    Khuri, F.3
  • 39
    • 34249043939 scopus 로고    scopus 로고
    • Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: Implications of p53 mutation or isoform expression on breast cancer cell invasion
    • Mehta SA, Christopherson KW, Bhat-Nakshatri P, et al. Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Oncogene. 2007; 26: 3329-3337.
    • (2007) Oncogene , vol.26 , pp. 3329-3337
    • Mehta, S.A.1    Christopherson, K.W.2    Bhat-Nakshatri, P.3
  • 40
    • 84898614449 scopus 로고    scopus 로고
    • Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling
    • Weissmueller S, Manchado E, Saborowski M, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. Cell. 2014; 157: 382-394.
    • (2014) Cell , vol.157 , pp. 382-394
    • Weissmueller, S.1    Manchado, E.2    Saborowski, M.3
  • 41
    • 70249141312 scopus 로고    scopus 로고
    • Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial
    • Leffers N, Lambeck AJ, Gooden MJ, et al. Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial. Int J Cancer. 2009; 125: 2104-2113.
    • (2009) Int J Cancer , vol.125 , pp. 2104-2113
    • Leffers, N.1    Lambeck, A.J.2    Gooden, M.J.3
  • 42
    • 77952135152 scopus 로고    scopus 로고
    • INGN-225: A dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: Observed association between immune response and enhanced chemotherapy effect
    • Chiappori AA, Soliman H, Janssen WE, Antonia SJ, Gabrilovich DI,. INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther. 2010; 10: 983-991.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 983-991
    • Chiappori, A.A.1    Soliman, H.2    Janssen, W.E.3    Antonia, S.J.4    Gabrilovich, D.I.5
  • 43
    • 84899728764 scopus 로고    scopus 로고
    • Phase i dendritic cell p53 peptide vaccine for head and neck cancer
    • Schuler PJ, Harasymczuk M, Visus C, et al. Phase I dendritic cell p53 peptide vaccine for head and neck cancer. Clin Cancer Res. 2014; 20: 2433-2444.
    • (2014) Clin Cancer Res , vol.20 , pp. 2433-2444
    • Schuler, P.J.1    Harasymczuk, M.2    Visus, C.3
  • 44
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M, Parsons R,. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene. 2008; 27: 5477-5485.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 45
    • 14444269482 scopus 로고    scopus 로고
    • MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
    • Teng DH, Hu R, Lin H, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 1997; 57: 5221-5225.
    • (1997) Cancer Res , vol.57 , pp. 5221-5225
    • Teng, D.H.1    Hu, R.2    Lin, H.3
  • 46
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
    • Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci U S A. 1998; 95: 13513-13518.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13513-13518
    • Myers, M.P.1    Pass, I.2    Batty, I.H.3
  • 47
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998; 95: 29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    De La Pompa, J.L.3
  • 48
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997; 91: 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 49
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC,. AKT/PKB signaling: navigating downstream. Cell. 2007; 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 50
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T,. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol. 2002; 4: 658-665.
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 51
    • 13844251972 scopus 로고    scopus 로고
    • Lack of PTEN sequesters CHK1 and initiates genetic instability
    • Puc J, Keniry M, Li HS, et al. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005; 7: 193-204.
    • (2005) Cancer Cell , vol.7 , pp. 193-204
    • Puc, J.1    Keniry, M.2    Li, H.S.3
  • 52
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL,. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002; 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 53
  • 54
    • 77950243447 scopus 로고    scopus 로고
    • Drugging the PI3 kinome: From chemical tools to drugs in the clinic
    • Workman P, Clarke PA, Raynaud FI, van Montfort RL,. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer Res. 2010; 70: 2146-2157.
    • (2010) Cancer Res , vol.70 , pp. 2146-2157
    • Workman, P.1    Clarke, P.A.2    Raynaud, F.I.3    Van Montfort, R.L.4
  • 55
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta T, Uno T, Kawahara J, et al. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol. 2000; 14: 783-794.
    • (2000) Mol Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3
  • 56
    • 78651458656 scopus 로고    scopus 로고
    • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
    • Chandarlapaty S, Sawai A, Scaltriti M, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell. 2011; 19: 58-71.
    • (2011) Cancer Cell , vol.19 , pp. 58-71
    • Chandarlapaty, S.1    Sawai, A.2    Scaltriti, M.3
  • 57
    • 84897133359 scopus 로고    scopus 로고
    • Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer
    • Tao JJ, Castel P, Radosevic-Robin N, et al. Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. Sci Signal. 2014; 7: ra29.
    • (2014) Sci Signal , vol.7 , pp. ra29
    • Tao, J.J.1    Castel, P.2    Radosevic-Robin, N.3
  • 58
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A, Elledge SJ,. The DNA damage response: making it safe to play with knives. Mol Cell. 2010; 40: 179-204.
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 59
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining
    • Lieber MR,. The mechanism of human nonhomologous DNA end joining. J Biol Chem. 2008; 283: 1-5.
    • (2008) J Biol Chem , vol.283 , pp. 1-5
    • Lieber, M.R.1
  • 60
    • 62349120246 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: Base excision repair: The long and short of it
    • Robertson AB, Klungland A, Rognes T, Leiros I,. DNA repair in mammalian cells: base excision repair: the long and short of it. Cell Mol Life Sci. 2009; 66: 981-993.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 981-993
    • Robertson, A.B.1    Klungland, A.2    Rognes, T.3    Leiros, I.4
  • 61
    • 38049125557 scopus 로고    scopus 로고
    • Mechanisms and functions of DNA mismatch repair
    • Li GM,. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008; 18: 85-98.
    • (2008) Cell Res , vol.18 , pp. 85-98
    • Li, G.M.1
  • 62
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005; 434: 913-917.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 63
    • 0034667921 scopus 로고    scopus 로고
    • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1
    • Vodenicharov MD, Sallmann FR, Satoh MS, Poirier GG,. Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1. Nucleic Acids Res. 2000; 28: 3887-3896.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3887-3896
    • Vodenicharov, M.D.1    Sallmann, F.R.2    Satoh, M.S.3    Poirier, G.G.4
  • 64
    • 84889595095 scopus 로고    scopus 로고
    • Appraising iniparib, the PARP inhibitor that never was-what must we learn?
    • Mateo J, Ong M, Tan DS, Gonzalez MA, de Bono JS,. Appraising iniparib, the PARP inhibitor that never was-what must we learn? Nat Rev Clin Oncol. 2013; 10: 688-696.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 688-696
    • Mateo, J.1    Ong, M.2    Tan, D.S.3    Gonzalez, M.A.4    De Bono, J.S.5
  • 65
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med. 2011; 364: 205-214.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 66
    • 80054748797 scopus 로고    scopus 로고
    • The use of PARP inhibitors in cancer therapy: Use as adjuvant with chemotherapy or radiotherapy; Use as a single agent in susceptible patients; Techniques used to identify susceptible patients
    • Shall S, Gaymes T, Farzaneh F, Curtin N, Mufti GJ,. The use of PARP inhibitors in cancer therapy: use as adjuvant with chemotherapy or radiotherapy; use as a single agent in susceptible patients; techniques used to identify susceptible patients. Methods Mol Biol. 2011; 780: 239-266.
    • (2011) Methods Mol Biol , vol.780 , pp. 239-266
    • Shall, S.1    Gaymes, T.2    Farzaneh, F.3    Curtin, N.4    Mufti, G.J.5
  • 67
    • 68049097111 scopus 로고    scopus 로고
    • Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
    • Gupta A, Yang Q, Pandita RK, et al. Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle. 2009; 8: 2198-2210.
    • (2009) Cell Cycle , vol.8 , pp. 2198-2210
    • Gupta, A.1    Yang, Q.2    Pandita, R.K.3
  • 68
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012; 490: 61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 69
    • 77955770116 scopus 로고    scopus 로고
    • DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
    • Rodriguez AA, Makris A, Wu MF, et al. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat. 2010; 123: 189-196.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 189-196
    • Rodriguez, A.A.1    Makris, A.2    Wu, M.F.3
  • 70
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • Turner N, Tutt A, Ashworth A,. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer. 2004; 4: 814-819.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 71
    • 33847355994 scopus 로고    scopus 로고
    • Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer
    • Lee MN, Tseng RC, Hsu HS, et al. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin Cancer Res. 2007; 13: 832-838.
    • (2007) Clin Cancer Res , vol.13 , pp. 832-838
    • Lee, M.N.1    Tseng, R.C.2    Hsu, H.S.3
  • 72
    • 78649321855 scopus 로고    scopus 로고
    • The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
    • Weston VJ, Oldreive CE, Skowronska A, et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood. 2010; 116: 4578-4587.
    • (2010) Blood , vol.116 , pp. 4578-4587
    • Weston, V.J.1    Oldreive, C.E.2    Skowronska, A.3
  • 73
    • 0027417017 scopus 로고
    • Pathway correcting DNA replication errors in Saccharomyces cerevisiae
    • Morrison A, Johnson AL, Johnston LH, Sugino A,. Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J. 1993; 12: 1467-1473.
    • (1993) EMBO J , vol.12 , pp. 1467-1473
    • Morrison, A.1    Johnson, A.L.2    Johnston, L.H.3    Sugino, A.4
  • 74
    • 77649311945 scopus 로고    scopus 로고
    • DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
    • Martin SA, McCabe N, Mullarkey M, et al. DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell. 2010; 17: 235-248.
    • (2010) Cancer Cell , vol.17 , pp. 235-248
    • Martin, S.A.1    McCabe, N.2    Mullarkey, M.3
  • 75
    • 69249240178 scopus 로고    scopus 로고
    • The combined status of ATM and p53 link tumor development with therapeutic response
    • Jiang H, Reinhardt HC, Bartkova J, et al. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 2009; 23: 1895-1909.
    • (2009) Genes Dev , vol.23 , pp. 1895-1909
    • Jiang, H.1    Reinhardt, H.C.2    Bartkova, J.3
  • 76
    • 33744924482 scopus 로고    scopus 로고
    • Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    • Zhao Y, Thomas HD, Batey MA, et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 2006; 66: 5354-5362.
    • (2006) Cancer Res , vol.66 , pp. 5354-5362
    • Zhao, Y.1    Thomas, H.D.2    Batey, M.A.3
  • 77
    • 67649710471 scopus 로고    scopus 로고
    • Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
    • Mizuarai S, Yamanaka K, Itadani H, et al. Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor. Mol Cancer. 2009; 8: 34.
    • (2009) Mol Cancer , vol.8 , pp. 34
    • Mizuarai, S.1    Yamanaka, K.2    Itadani, H.3
  • 78
    • 79960339454 scopus 로고    scopus 로고
    • WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
    • De Witt Hamer PC, Mir SE, Noske D, Van Noorden CJ, Wurdinger T,. WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe. Clin Cancer Res. 2011; 17: 4200-4207.
    • (2011) Clin Cancer Res , vol.17 , pp. 4200-4207
    • De Witt Hamer, P.C.1    Mir, S.E.2    Noske, D.3    Van Noorden, C.J.4    Wurdinger, T.5
  • 79
    • 75649111192 scopus 로고    scopus 로고
    • The genetic landscape of a cell
    • Costanzo M, Baryshnikova A, Bellay J, et al. The genetic landscape of a cell. Science. 2010; 327: 425-431.
    • (2010) Science , vol.327 , pp. 425-431
    • Costanzo, M.1    Baryshnikova, A.2    Bellay, J.3
  • 80
    • 84877303028 scopus 로고    scopus 로고
    • Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping
    • Laufer C, Fischer B, Billmann M, Huber W, Boutros M,. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nat Methods. 2013; 10: 427-431.
    • (2013) Nat Methods , vol.10 , pp. 427-431
    • Laufer, C.1    Fischer, B.2    Billmann, M.3    Huber, W.4    Boutros, M.5
  • 82
    • 84907333139 scopus 로고    scopus 로고
    • Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
    • Jerby-Arnon L, Pfetzer N, Waldman YY, et al. Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell. 2014; 158: 1199-1209.
    • (2014) Cell , vol.158 , pp. 1199-1209
    • Jerby-Arnon, L.1    Pfetzer, N.2    Waldman, Y.Y.3
  • 83
    • 84865134914 scopus 로고    scopus 로고
    • Passenger deletions generate therapeutic vulnerabilities in cancer
    • Muller FL, Colla S, Aquilanti E, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012; 488: 337-342.
    • (2012) Nature , vol.488 , pp. 337-342
    • Muller, F.L.1    Colla, S.2    Aquilanti, E.3
  • 84
    • 77249123407 scopus 로고    scopus 로고
    • Signatures of mutation and selection in the cancer genome
    • Bignell GR, Greenman CD, Davies H, et al. Signatures of mutation and selection in the cancer genome. Nature. 2010; 463: 893-898.
    • (2010) Nature , vol.463 , pp. 893-898
    • Bignell, G.R.1    Greenman, C.D.2    Davies, H.3
  • 85
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: Two sides of the same coin?
    • You JS, Jones PA,. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 2012; 22: 9-20.
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 86
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome-biological and translational implications
    • Baylin SB, Jones PA,. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer. 2011; 11: 726-734.
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 87
    • 79958769268 scopus 로고    scopus 로고
    • Epigenetic aberrations during oncogenesis
    • Hatziapostolou M, Iliopoulos D,. Epigenetic aberrations during oncogenesis. Cell Mol Life Sci. 2011; 68: 1681-1702.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1681-1702
    • Hatziapostolou, M.1    Iliopoulos, D.2
  • 88
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M,. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 2007; 8: 286-298.
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 89
    • 84863756127 scopus 로고    scopus 로고
    • Wnt signaling, stem cells, and cancer of the gastrointestinal tract
    • Schepers A, Clevers H,. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol. 2012; 4: a007989.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , pp. a007989
    • Schepers, A.1    Clevers, H.2
  • 90
    • 84856549042 scopus 로고    scopus 로고
    • Genome-scale analysis of aberrant DNA methylation in colorectal cancer
    • Hinoue T, Weisenberger DJ, Lange CP, et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 2012; 22: 271-282.
    • (2012) Genome Res , vol.22 , pp. 271-282
    • Hinoue, T.1    Weisenberger, D.J.2    Lange, C.P.3
  • 91
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa JP,. CpG island methylator phenotype in cancer. Nat Rev Cancer. 2004; 4: 988-993.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 92
    • 79953123510 scopus 로고    scopus 로고
    • Breast cancer methylomes establish an epigenomic foundation for metastasis
    • Fang F, Turcan S, Rimner A, et al. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med. 2011; 3: 75ra25.
    • (2011) Sci Transl Med , vol.3 , pp. 75ra25
    • Fang, F.1    Turcan, S.2    Rimner, A.3
  • 93
    • 0037456636 scopus 로고    scopus 로고
    • Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
    • Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S,. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett. 2003; 192: 75-82.
    • (2003) Cancer Lett , vol.192 , pp. 75-82
    • Kanai, Y.1    Ushijima, S.2    Nakanishi, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 94
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene. 2010; 29: 3723-3731.
    • (2010) Oncogene , vol.29 , pp. 3723-3731
    • Yamashita, Y.1    Yuan, J.2    Suetake, I.3
  • 95
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010; 363: 2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 96
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • International Vidaza High-Risk MDS Survival Study Group
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. International Vidaza High-Risk MDS Survival Study Group. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009; 10: 223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 97
    • 84908247072 scopus 로고    scopus 로고
    • TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
    • Bejar R, Lord A, Stevenson K, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 2014; 124: 2705-2712.
    • (2014) Blood , vol.124 , pp. 2705-2712
    • Bejar, R.1    Lord, A.2    Stevenson, K.3
  • 98
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012; 483: 479-483.
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 99
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012; 483: 474-478.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 100
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; 340: 626-630.
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3
  • 101
    • 84884545211 scopus 로고    scopus 로고
    • Induction of sarcomas by mutant IDH2
    • Lu C, Venneti S, Akalin A, et al. Induction of sarcomas by mutant IDH2. Genes Dev. 2013; 27: 1986-1998.
    • (2013) Genes Dev , vol.27 , pp. 1986-1998
    • Lu, C.1    Venneti, S.2    Akalin, A.3
  • 102
    • 84886741979 scopus 로고    scopus 로고
    • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
    • Borodovsky A, Salmasi V, Turcan S, et al. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget. 2013; 4: 1737-1747.
    • (2013) Oncotarget , vol.4 , pp. 1737-1747
    • Borodovsky, A.1    Salmasi, V.2    Turcan, S.3
  • 103
    • 84886744421 scopus 로고    scopus 로고
    • Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine
    • Turcan S, Fabius AW, Borodovsky A, et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine. Oncotarget. 2013; 4: 1729-1736.
    • (2013) Oncotarget , vol.4 , pp. 1729-1736
    • Turcan, S.1    Fabius, A.W.2    Borodovsky, A.3
  • 104
    • 34250171437 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Signalling towards p21cip1/waf1
    • Ocker M, Schneider-Stock R,. Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int J Biochem Cell Biol. 2007; 39: 1367-1374.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1367-1374
    • Ocker, M.1    Schneider-Stock, R.2
  • 105
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West AC, Johnstone RW,. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest. 2014; 124: 30-39.
    • (2014) J Clin Invest , vol.124 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 107
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007; 109: 31-39.
    • (2007) Blood , vol.109 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3
  • 108
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2009; 27: 5410-5417.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3
  • 109
    • 77957154350 scopus 로고    scopus 로고
    • Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins
    • Mills AA,. Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer. 2010; 10: 669-682.
    • (2010) Nat Rev Cancer , vol.10 , pp. 669-682
    • Mills, A.A.1
  • 110
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase A, Cross NC,. Aberrations of EZH2 in cancer. Clin Cancer Res. 2011; 17: 2613-2618.
    • (2011) Clin Cancer Res , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 111
    • 62149122634 scopus 로고    scopus 로고
    • Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    • Ezhkova E, Pasolli HA, Parker JS, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009; 136: 1122-1135.
    • (2009) Cell , vol.136 , pp. 1122-1135
    • Ezhkova, E.1    Pasolli, H.A.2    Parker, J.S.3
  • 112
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007; 21: 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 113
    • 84884532954 scopus 로고    scopus 로고
    • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
    • Kim W, Bird GH, Neff T, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013; 9: 643-650.
    • (2013) Nat Chem Biol , vol.9 , pp. 643-650
    • Kim, W.1    Bird, G.H.2    Neff, T.3
  • 114
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013; 369: 122-133.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 115
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012; 366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 116
    • 84904472602 scopus 로고    scopus 로고
    • Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
    • Rajasagi M, Shukla SA, Fritsch EF, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014; 124: 453-462.
    • (2014) Blood , vol.124 , pp. 453-462
    • Rajasagi, M.1    Shukla, S.A.2    Fritsch, E.F.3
  • 117
    • 33746550675 scopus 로고    scopus 로고
    • Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents
    • Wang H, Han H, Mousses S, Von Hoff DD,. Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents. Semin Oncol. 2006; 33: 513-520.
    • (2006) Semin Oncol , vol.33 , pp. 513-520
    • Wang, H.1    Han, H.2    Mousses, S.3    Von Hoff, D.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.