5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

Oncotarget

Volumn 4, Issue 10, 2013, Pages 1737-1747

  Borodovsky, Alexandra ^a   Salmasi, Vafi ^a   Turcan, Sevin ^b   Fabius, Armida W M ^b   Baia, Gilson S ^a   Eberhart, Charles G ^a   Weingart, Jon D ^a   Gallia, Gary L ^a   Baylin, Stephen B ^a   Chan, Timothy A ^b   Riggins, Gregory J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

5 azacytidine; Astrocytoma; IDH; Methylation; Progressive glioma; Xenograft

Indexed keywords

AZACITIDINE; ISOCITRATE DEHYDROGENASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GLIOBLASTOMA; HISTOPATHOLOGY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PROMOTER REGION; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DNA METHYLATION; FEMALE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; ISOCITRATE DEHYDROGENASE; MALE; MICE; MICE, NUDE; MUTATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886741979     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1408     Document Type: Article

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