Haplo-insufficiency? Let me count the ways

Genes and Development

Volumn 15, Issue 22, 2001, Pages 2917-2921

  Quon, K C ^a   Berns, A ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; GENE MUTATION; HAPLOTYPE; HUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; LOSS OF HETEROZYGOSITY; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTATION; NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0035890321     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.949001     Document Type: Review

References (26)

1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)
2. Accommodating haploin-sufficient tumor suppressor genes in Knudson's model
3. Breast cancer
4. E1A signaling to p53 involves the p19(ARF) tumor suppressor
5. Disruption of the Arf-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
6. A genetic model for colorectal tumorigenesis
7. The murine gene p27Kip1 is haplo-insufficient for tumour suppression
8. Creation of human tumour cells with defined genetic elements
9. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1
10. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism
11. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
12. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis
13. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
14. Cancer epigenetics comes of age
15. Hereditary cancer, oncogenes, and antioncogenes
16. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
17. BRCA2 mutations in primary breast and ovarian cancers
18. Genetic instabilities in human cancers
19. 1 phase of the cell cycle
20. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
21. Involvement of Brca2 in DNA repair
22. How many mutations are required for tumorigenesis? Implications from human cancer data
23. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
24. Mutation rate of normal and malignant human lymphocytes
25. Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
26. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization