A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

Journal of Molecular Biology

Volumn 299, Issue 1, 2000, Pages 245-253

  Chène, Patrick ^a   Fuchs, Jean ^a   Bohn, Jacqueline ^a   García Echeverría, Carlos ^a   Furet, Pascal ^a   Fabbro, Doriano ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Hdm2; Mdm2; P53; Peptide; Protein protein interaction

Indexed keywords

AP PEPTIDE; CISPLATIN; GENE PRODUCT; MUTANT PROTEIN; PEPTIDE; PROTEIN INHIBITOR; PROTEIN P53; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

EID: 0034716943     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3738     Document Type: Article

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