-
1
-
-
0015994548
-
Intracytoplasmic junctions in cardiac muscle cells
-
Buja LM, Ferrans VJ, Maron BJ, et al. Intracytoplasmic junctions in cardiac muscle cells. Am J Pathol. 1974;74:613-647.
-
(1974)
Am J Pathol.
, vol.74
, pp. 613-647
-
-
Buja, L.M.1
Ferrans, V.J.2
Maron, B.J.3
-
2
-
-
31444448021
-
Controversies in ventricular remodelling
-
Opie LH, Commerford PJ, Gersh BJ, et al. Controversies in ventricular remodelling. Lancet. 2006;367:356-367.
-
(2006)
Lancet
, vol.367
, pp. 356-367
-
-
Opie, L.H.1
Commerford, P.J.2
Gersh, B.J.3
-
3
-
-
84880748603
-
Pathological ventricular remodeling: Mechanisms: Part 1 of 2
-
Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: Mechanisms: part 1 of 2. Circulation. 2013;128:388-400.
-
(2013)
Circulation
, vol.128
, pp. 388-400
-
-
Burchfield, J.S.1
Xie, M.2
Hill, J.A.3
-
4
-
-
0026748322
-
Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
-
Ganau A, Devereux RB, Roman MJ, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19:1550-1558.
-
(1992)
J Am Coll Cardiol.
, vol.19
, pp. 1550-1558
-
-
Ganau, A.1
Devereux, R.B.2
Roman, M.J.3
-
5
-
-
0025837599
-
Architecture of myocardial cells in human cardiac ventricles with concentric and eccentric hypertrophy as demonstrated by quantitative scanning electron microscopy
-
Sawada K, Kawamura K. Architecture of myocardial cells in human cardiac ventricles with concentric and eccentric hypertrophy as demonstrated by quantitative scanning electron microscopy. Heart Vessels. 1991;6:129-142.
-
(1991)
Heart Vessels
, vol.6
, pp. 129-142
-
-
Sawada, K.1
Kawamura, K.2
-
6
-
-
0026693383
-
Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy
-
Gerdes AM, Kellerman SE, Moore JA, et al. Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. Circulation. 1992;86:426-430.
-
(1992)
Circulation
, vol.86
, pp. 426-430
-
-
Gerdes, A.M.1
Kellerman, S.E.2
Moore, J.A.3
-
7
-
-
0028960907
-
Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure
-
Gerdes AM, Capasso JM. Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure. J Mol Cell Cardiol. 1995; 27:849-856.
-
(1995)
J Mol Cell Cardiol.
, vol.27
, pp. 849-856
-
-
Gerdes, A.M.1
Capasso, J.M.2
-
8
-
-
84869171054
-
Myocyte shape regulates lateral registry of sarcomeres and contractility
-
Kuo PL, Lee H, Bray MA, et al. Myocyte shape regulates lateral registry of sarcomeres and contractility. Am J Pathol. 2012;181:2030-2037.
-
(2012)
Am J Pathol.
, vol.181
, pp. 2030-2037
-
-
Kuo, P.L.1
Lee, H.2
Bray, M.A.3
-
9
-
-
0025266820
-
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications
-
Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81:1161-1172.
-
(1990)
Circulation
, vol.81
, pp. 1161-1172
-
-
Pfeffer, M.A.1
Braunwald, E.2
-
10
-
-
0038380271
-
Phenotyping hypertrophy: Eschew obfuscation
-
Dorn GW, Robbins J, Sugden PH. Phenotyping hypertrophy: eschew obfuscation. Circ Res. 2003;92:1171-1175.
-
(2003)
Circ Res.
, vol.92
, pp. 1171-1175
-
-
Dorn, G.W.1
Robbins, J.2
Sugden, P.H.3
-
11
-
-
0016681078
-
Wall stress and patterns of hypertrophy in the human left ventricle
-
Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest. 1975;56:56-64.
-
(1975)
J Clin Invest.
, vol.56
, pp. 56-64
-
-
Grossman, W.1
Jones, D.2
Mclaurin, L.P.3
-
12
-
-
0025612373
-
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
-
Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-1566.
-
(1990)
N Engl J Med.
, vol.322
, pp. 1561-1566
-
-
Levy, D.1
Garrison, R.J.2
Savage, D.D.3
-
13
-
-
0035203498
-
Left ventricular mass and cardiovascular morbidity in essential hypertension: The MAVI study
-
Verdecchia P, Carini G, Circo A, et al. Left ventricular mass and cardiovascular morbidity in essential hypertension: The MAVI study. J Am Coll Cardiol. 2001;38:1829-1835.
-
(2001)
J Am Coll Cardiol.
, vol.38
, pp. 1829-1835
-
-
Verdecchia, P.1
Carini, G.2
Circo, A.3
-
14
-
-
2942603215
-
Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients
-
Lonn E, Mathew J, Pogue J, et al. Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients. Eur J Cardiovasc Prev Rehabil. 2003;10:420-428.
-
(2003)
Eur J Cardiovasc Prev Rehabil.
, vol.10
, pp. 420-428
-
-
Lonn, E.1
Mathew, J.2
Pogue, J.3
-
15
-
-
0026092229
-
Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension
-
Koren MJ, Devereux RB, Casale PN, et al. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med. 1991;114:345-352.
-
(1991)
Ann Intern Med.
, vol.114
, pp. 345-352
-
-
Koren, M.J.1
Devereux, R.B.2
Casale, P.N.3
-
16
-
-
24044532613
-
Left ventricular hypertrophy in aortic valve stenosis: Preventive or promotive of systolic dysfunction and heart failure?
-
Kupari M, Turto H, Lommi J. Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur Heart J. 2005;26:1790-1796.
-
(2005)
Eur Heart J.
, vol.26
, pp. 1790-1796
-
-
Kupari, M.1
Turto, H.2
Lommi, J.3
-
17
-
-
80052783805
-
Progression from normal to reduced left ventricular ejection fraction in patients with concentric left ventricular hypertrophy after long-term follow-up
-
Krishnamoorthy A, Brown T, Ayers CR, et al. Progression from normal to reduced left ventricular ejection fraction in patients with concentric left ventricular hypertrophy after long-term follow-up. Am J Cardiol. 2011;108:997-1001.
-
(2011)
Am J Cardiol.
, vol.108
, pp. 997-1001
-
-
Krishnamoorthy, A.1
Brown, T.2
Ayers, C.R.3
-
18
-
-
79551475805
-
Decreasing trends in the incidence of heart failure after acute myocardial infarction from 1993- 2004: A study of 175, 216 patients with a first acute myocardial infarction in Sweden
-
Shafazand M, Rosengren A, Lappas G, et al. Decreasing trends in the incidence of heart failure after acute myocardial infarction from 1993- 2004: A study of 175, 216 patients with a first acute myocardial infarction in Sweden. Eur J Heart Fail. 2011;13:135-141.
-
(2011)
Eur J Heart Fail.
, vol.13
, pp. 135-141
-
-
Shafazand, M.1
Rosengren, A.2
Lappas, G.3
-
19
-
-
21044446833
-
Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up
-
Pellikka PA, Sarano ME, Nishimura RA, et al. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation. 2005;111:3290-3295.
-
(2005)
Circulation
, vol.111
, pp. 3290-3295
-
-
Pellikka, P.A.1
Sarano, M.E.2
Nishimura, R.A.3
-
20
-
-
0346492726
-
Metabolic remodelling of the failing heart: The cardiac burn-out syndrome?
-
van Bilsen M, Smeets PJ, Gilde AJ, et al. Metabolic remodelling of the failing heart: The cardiac burn-out syndrome? Cardiovasc Res. 2004;61: 218-226.
-
(2004)
Cardiovasc Res.
, vol.61
, pp. 218-226
-
-
Van Bilsen, M.1
Smeets, P.J.2
Gilde, A.J.3
-
21
-
-
77955172275
-
Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects
-
Mohammed SF, Ohtani T, Korinek J, et al. Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects". Circulation. 2010;122:370-378.
-
(2010)
Circulation
, vol.122
, pp. 370-378
-
-
Mohammed, S.F.1
Ohtani, T.2
Korinek, J.3
-
22
-
-
33847759508
-
Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure
-
Graham HK, Trafford AW. Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure. Am J Physiol Heart Circ Physiol. 2007;292 1364-1372.
-
(2007)
Am J Physiol Heart Circ Physiol.
, vol.292
, pp. 1364-1372
-
-
Graham, H.K.1
Trafford, A.W.2
-
23
-
-
84875806579
-
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
-
Skrbic B, Bjornstad JL, Marstein HS, et al. Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload. Matrix Biol. 2013;32:133-142.
-
(2013)
Matrix Biol.
, vol.32
, pp. 133-142
-
-
Skrbic, B.1
Bjornstad, J.L.2
Marstein, H.S.3
-
24
-
-
79955115054
-
VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation
-
Xu XH, Xu J, Xue L, et al. VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation. J Cardiothorac Surg. 2011;6:54.
-
(2011)
J Cardiothorac Surg.
, vol.6
, pp. 54
-
-
Xu, X.H.1
Xu, J.2
Xue, L.3
-
25
-
-
0016746520
-
Precursors of sudden coronary death. Factors related to the incidence of sudden death
-
Kannel WB, Doyle JT, McNamara PM, et al. Precursors of sudden coronary death. Factors related to the incidence of sudden death. Circulation. 1975;51:606-613.
-
(1975)
Circulation
, vol.51
, pp. 606-613
-
-
Kannel, W.B.1
Doyle, J.T.2
Mcnamara, P.M.3
-
26
-
-
0032212316
-
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
-
Haider AW, Larson MG, Benjamin EJ, et al. Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol. 1998;32:1454-1459.
-
(1998)
J Am Coll Cardiol.
, vol.32
, pp. 1454-1459
-
-
Haider, A.W.1
Larson, M.G.2
Benjamin, E.J.3
-
27
-
-
54349095394
-
Influence of the type and degree of left ventricular hypertrophy on the prevalence of ventricular arrhythmias in patients with hypertensive heart disease
-
Kunisek J, Zaputovic L, Mavric Z, et al. Influence of the type and degree of left ventricular hypertrophy on the prevalence of ventricular arrhythmias in patients with hypertensive heart disease. Med Klin (Munich). 2008;103:705-711.
-
(2008)
Med Klin (Munich)
, vol.103
, pp. 705-711
-
-
Kunisek, J.1
Zaputovic, L.2
Mavric, Z.3
-
28
-
-
0028801293
-
Cardiac arrhythmias and left ventricular hypertrophy in systemic hypertension and their influences on prognosis
-
Bayes-Genis A, Guindo J, Vinolas X, et al. Cardiac arrhythmias and left ventricular hypertrophy in systemic hypertension and their influences on prognosis. Am J Cardiol. 1995;76:54-59.
-
(1995)
Am J Cardiol.
, vol.76
, pp. 54-59
-
-
Bayes-Genis, A.1
Guindo, J.2
Vinolas, X.3
-
29
-
-
84866495060
-
Pressure overload induces early morphological changes in the heart
-
Souders CA, Borg TK, Banerjee I, et al. Pressure overload induces early morphological changes in the heart. Am J Pathol. 2012;181:1226-1235.
-
(2012)
Am J Pathol.
, vol.181
, pp. 1226-1235
-
-
Souders, C.A.1
Borg, T.K.2
Banerjee, I.3
-
30
-
-
47149111304
-
Mechanisms of post-infarct left ventricular remodeling
-
French BA, Kramer CM. Mechanisms of post-infarct left ventricular remodeling. Drug Discov Today Dis Mech. 2007;4:185-196.
-
(2007)
Drug Discov Today Dis Mech.
, vol.4
, pp. 185-196
-
-
French, B.A.1
Kramer, C.M.2
-
31
-
-
0034691296
-
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
-
Hill JA, Karimi M, Kutschke W, et al. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation. 2000;101:2863-2869.
-
(2000)
Circulation
, vol.101
, pp. 2863-2869
-
-
Hill, J.A.1
Karimi, M.2
Kutschke, W.3
-
32
-
-
3042608187
-
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
-
McMullen JR, Sherwood MC, Tarnavski O, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation. 2004;109:3050-3055.
-
(2004)
Circulation
, vol.109
, pp. 3050-3055
-
-
Mcmullen, J.R.1
Sherwood, M.C.2
Tarnavski, O.3
-
33
-
-
0036143851
-
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
-
Esposito G, Rapacciuolo A, Naga Prasad SV, et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 2002;105:85-92.
-
(2002)
Circulation
, vol.105
, pp. 85-92
-
-
Esposito, G.1
Rapacciuolo, A.2
Naga Prasad, S.V.3
-
34
-
-
0028945136
-
Reverse remodeling from cardiomyoplasty in human heart failure. External constraint versus active assist
-
Kass DA, Baughman KL, Pak PH, et al. Reverse remodeling from cardiomyoplasty in human heart failure. External constraint versus active assist. Circulation. 1995;91:2314-2318.
-
(1995)
Circulation
, vol.91
, pp. 2314-2318
-
-
Kass, D.A.1
Baughman, K.L.2
Pak, P.H.3
-
35
-
-
84857641624
-
Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy
-
Sachse FB, Torres NS, Savio-Galimberti E, et al. Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res. 2012;110:588-597.
-
(2012)
Circ Res.
, vol.110
, pp. 588-597
-
-
Sachse, F.B.1
Torres, N.S.2
Savio-Galimberti, E.3
-
36
-
-
84866423739
-
Regression of ECG-LVH is associated with lower risk of new-onset heart failure and mortality in patients with isolated systolic hypertension; the LIFE study
-
Larstorp AC, Okin PM, Devereux RB, et al. Regression of ECG-LVH is associated with lower risk of new-onset heart failure and mortality in patients with isolated systolic hypertension; the LIFE study. Am J Hypertens. 2012;25:1101-1109.
-
(2012)
Am J Hypertens.
, vol.25
, pp. 1101-1109
-
-
Larstorp, A.C.1
Okin, P.M.2
Devereux, R.B.3
-
37
-
-
8544226268
-
Prognostic significance of left ventricular mass change during treatment of hypertension
-
Devereux RB, Wachtell K, Gerdts E, et al. Prognostic significance of left ventricular mass change during treatment of hypertension. JAMA. 2004;292:2350-2356.
-
(2004)
JAMA
, vol.292
, pp. 2350-2356
-
-
Devereux, R.B.1
Wachtell, K.2
Gerdts, E.3
-
38
-
-
0035797832
-
Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril
-
Mathew J, Sleight P, Lonn E, et al. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation. 2001;104:1615-1621.
-
(2001)
Circulation
, vol.104
, pp. 1615-1621
-
-
Mathew, J.1
Sleight, P.2
Lonn, E.3
-
39
-
-
8544223585
-
Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events
-
Okin PM, Devereux RB, Jern S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. JAMA. 2004;292: 2343-2349.
-
(2004)
JAMA
, vol.292
, pp. 2343-2349
-
-
Okin, P.M.1
Devereux, R.B.2
Jern, S.3
-
40
-
-
33645750695
-
Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: The losartan intervention for endpoint (LIFE) reduction in hypertension study
-
Okin PM, Devereux RB, Gerdts E, et al. Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study. Circulation. 2006;113:1588-1596.
-
(2006)
Circulation
, vol.113
, pp. 1588-1596
-
-
Okin, P.M.1
Devereux, R.B.2
Gerdts, E.3
-
41
-
-
79957720871
-
Communication signals between cardiac fibroblasts and cardiac myocytes
-
Ottaviano FG, Yee KO. Communication signals between cardiac fibroblasts and cardiac myocytes. J Cardiovasc Pharmacol. 2011;57: 513-521.
-
(2011)
J Cardiovasc Pharmacol.
, vol.57
, pp. 513-521
-
-
Ottaviano, F.G.1
Yee, K.O.2
-
42
-
-
33847347313
-
ECM remodeling in hypertensive heart disease
-
Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest. 2007;117:568-575.
-
(2007)
J Clin Invest.
, vol.117
, pp. 568-575
-
-
Berk, B.C.1
Fujiwara, K.2
Lehoux, S.3
-
43
-
-
35748974863
-
Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function
-
Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function. Physiol Rev. 2007;87: 1285-1342.
-
(2007)
Physiol Rev.
, vol.87
, pp. 1285-1342
-
-
Spinale, F.G.1
-
44
-
-
79251617662
-
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth
-
Kehat I, Davis J, Tiburcy M, et al. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res. 2011;108:176-183.
-
(2011)
Circ Res.
, vol.108
, pp. 176-183
-
-
Kehat, I.1
Davis, J.2
Tiburcy, M.3
-
45
-
-
84883491199
-
Differential cardiac remodeling in preload versus afterload
-
Toischer K, Rokita AG, Unsold B, et al. Differential cardiac remodeling in preload versus afterload. Circulation. 2010;122:993-1003.
-
(2010)
Circulation
, vol.122
, pp. 993-1003
-
-
Toischer, K.1
Rokita, A.G.2
Unsold, B.3
-
46
-
-
0142043899
-
Predictors of late development of heart failure in stable survivors of myocardial infarction: The CARE study
-
Lewis EF, Moye LA, Rouleau JL, et al. Predictors of late development of heart failure in stable survivors of myocardial infarction: The CARE study. J Am Coll Cardiol. 2003;42:1446-1453.
-
(2003)
J Am Coll Cardiol.
, vol.42
, pp. 1446-1453
-
-
Lewis, E.F.1
Moye, L.A.2
Rouleau, J.L.3
-
47
-
-
84856142828
-
Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren
-
Shah AM, Shin SH, Takeuchi M, et al. Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren. Eur J Heart Fail. 2012;14:185-192.
-
(2012)
Eur J Heart Fail
, vol.14
, pp. 185-192
-
-
Shah, A.M.1
Shin, S.H.2
Takeuchi, M.3
-
48
-
-
77951155887
-
Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NFkappaB activation and cardiac hypertrophy
-
Hingtgen SD, Li Z, Kutschke W, et al. Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NFkappaB activation and cardiac hypertrophy. Physiol Genomics. 2010; 41:127-136.
-
(2010)
Physiol Genomics.
, vol.41
, pp. 127-136
-
-
Hingtgen, S.D.1
Li, Z.2
Kutschke, W.3
-
49
-
-
77950286813
-
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
-
Nikolaev VO, Moshkov A, Lyon AR, et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327:1653-1657.
-
(2010)
Science
, vol.327
, pp. 1653-1657
-
-
Nikolaev, V.O.1
Moshkov, A.2
Lyon, A.R.3
-
50
-
-
79551580284
-
PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: Results of a 1-year, prospective, randomized, placebo-controlled study
-
Guazzi M, Vicenzi M, Arena R, et al. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail. 2011;4:8-17.
-
(2011)
Circ Heart Fail
, vol.4
, pp. 8-17
-
-
Guazzi, M.1
Vicenzi, M.2
Arena, R.3
-
51
-
-
84861234413
-
Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: A randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging
-
Giannetta E, Isidori AM, Galea N, et al. Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: A randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging. Circulation. 2012;125:2323-2333.
-
(2012)
Circulation
, vol.125
, pp. 2323-2333
-
-
Giannetta, E.1
Isidori, A.M.2
Galea, N.3
-
53
-
-
78650121847
-
Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies
-
Bernardo BC, Weeks KL, Pretorius L, et al. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther. 2010;128:191-227.
-
(2010)
Pharmacol Ther.
, vol.128
, pp. 191-227
-
-
Bernardo, B.C.1
Weeks, K.L.2
Pretorius, L.3
-
54
-
-
33745185351
-
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
-
Perrino C, Naga Prasad SV, Mao L, et al. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006;116:1547-1560.
-
(2006)
J Clin Invest.
, vol.116
, pp. 1547-1560
-
-
Perrino, C.1
Naga PrasaS., V.2
Mao, L.3
-
55
-
-
84864621624
-
Phosphoinositide 3-kinase p110alpha is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction
-
Weeks KL, Gao X, Du XJ, et al. Phosphoinositide 3-kinase p110alpha is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction. Circ Heart Fail. 2012;5: 523-534.
-
(2012)
Circ Heart Fail
, vol.5
, pp. 523-534
-
-
Weeks, K.L.1
Gao, X.2
Du, X.J.3
-
56
-
-
0034636832
-
Reverse remodeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system
-
Tamura T, Said S, Harris J, et al. Reverse remodeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system. Circulation. 2000;102:253-259.
-
(2000)
Circulation
, vol.102
, pp. 253-259
-
-
Tamura, T.1
Said, S.2
Harris, J.3
-
57
-
-
42049107348
-
Telmisartan, ramipril, or both in patients at high risk for vascular events
-
Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547-1559.
-
(2008)
N Engl J Med.
, vol.358
, pp. 1547-1559
-
-
Yusuf, S.1
Teo, K.K.2
Pogue, J.3
-
58
-
-
79960392722
-
Combination inhibition of the renin-angiotensin system: Is more better?
-
Krause MW, Fonseca VA, Shah SV. Combination inhibition of the renin-angiotensin system: Is more better? Kidney Int. 2011;80:245-255.
-
(2011)
Kidney Int.
, vol.80
, pp. 245-255
-
-
Krause, M.W.1
Fonseca, V.A.2
Shah, S.V.3
-
59
-
-
80052795644
-
Beta-arrestin: A signaling molecule and potential therapeutic target for heart failure
-
Noor N, Patel CB, Rockman HA. Beta-arrestin: A signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol. 2011;51:534-541.
-
(2011)
J Mol Cell Cardiol.
, vol.51
, pp. 534-541
-
-
Noor, N.1
Patel, C.B.2
Rockman, H.A.3
-
60
-
-
84885056564
-
First clinical experience with TRV027: Pharmacokinetics and pharmacodynamics in healthy volunteers
-
Soergel DG, Subach RA, Cowan CL, et al. First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2013;53:892-899.
-
(2013)
J Clin Pharmacol.
, vol.53
, pp. 892-899
-
-
Soergel, D.G.1
Subach, R.A.2
Cowan, C.L.3
-
61
-
-
84884409614
-
The beta-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium
-
Monasky MM, Taglieri DM, Henze M, et al. The beta-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. Am J Physiol Heart Circ Physiol. 2013;305:856-866.
-
(2013)
Am J Physiol Heart Circ Physiol.
, vol.305
, pp. 856-866
-
-
Monasky, M.M.1
Taglieri, D.M.2
Henze, M.3
-
62
-
-
34547555364
-
Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure
-
Chan AK, Sanderson JE, Wang T, et al. Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure. J Am Coll Cardiol. 2007;50:591-596.
-
(2007)
J Am Coll Cardiol.
, vol.50
, pp. 591-596
-
-
Chan, A.K.1
Sanderson, J.E.2
Wang, T.3
-
63
-
-
0142085752
-
Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
-
Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study. Circulation. 2003;108:1831-1838.
-
(2003)
Circulation
, vol.108
, pp. 1831-1838
-
-
Pitt, B.1
Reichek, N.2
Willenbrock, R.3
-
64
-
-
0242543981
-
Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
-
Fraccarollo D, Galuppo P, Hildemann S, et al. Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction. J Am Coll Cardiol. 2003;42:1666-1673.
-
(2003)
J Am Coll Cardiol.
, vol.42
, pp. 1666-1673
-
-
Fraccarollo, D.1
Galuppo, P.2
Hildemann, S.3
-
65
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
-
Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999; 341:709-717.
-
(1999)
N Engl J Med.
, vol.341
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
-
66
-
-
78650399880
-
Eplerenone in patients with systolic heart failure and mild symptoms
-
Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11-21.
-
(2011)
N Engl J Med.
, vol.364
, pp. 11-21
-
-
Zannad, F.1
Mcmurray, J.J.2
Krum, H.3
-
67
-
-
0037869353
-
Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure
-
Cittadini A, Monti MG, Isgaard J, et al. Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure. Cardiovasc Res. 2003;58:555-564.
-
(2003)
Cardiovasc Res.
, vol.58
, pp. 555-564
-
-
Cittadini, A.1
Monti, M.G.2
Isgaard, J.3
-
68
-
-
84901272015
-
PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy
-
Orena S, Maurer TS, She L, et al. PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy. Front Pharmacol. 2013;4:115.
-
(2013)
Front Pharmacol
, vol.4
, pp. 115
-
-
Orena, S.1
Maurer, T.S.2
She, L.3
-
69
-
-
84861554853
-
Discovery of BAY 94-8862: A nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases
-
Barfacker L, Kuhl A, Hillisch A, et al. Discovery of BAY 94-8862: A nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7:1385-1403.
-
(2012)
ChemMedChem.
, vol.7
, pp. 1385-1403
-
-
Barfacker, L.1
Kuhl, A.2
Hillisch, A.3
-
70
-
-
84876974185
-
CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3Kalpha-Akt signaling
-
Yang L, Cai X, Liu J, et al. CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3Kalpha-Akt signaling. PLoS One. 2013;8:62373-.
-
(2013)
PLoS One
, vol.8
, pp. 62373
-
-
Yang, L.1
Cai, X.2
Liu, J.3
-
71
-
-
40549135974
-
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
-
Morimoto T, Sunagawa Y, Kawamura T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest. 2008;118:868-878.
-
(2008)
J Clin Invest.
, vol.118
, pp. 868-878
-
-
Morimoto, T.1
Sunagawa, Y.2
Kawamura, T.3
-
72
-
-
77954620098
-
Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice
-
Calvert JW, Elston M, Nicholson CK, et al. Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice. Circulation. 2010;122:11-19.
-
(2010)
Circulation
, vol.122
, pp. 11-19
-
-
Calvert, J.W.1
Elston, M.2
Nicholson, C.K.3
-
73
-
-
84884719159
-
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin
-
Liu W, Zi M, Tsui H, et al. A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circ Heart Fail. 2013;6:833-844.
-
(2013)
Circ Heart Fail
, vol.6
, pp. 833-844
-
-
Liu, W.1
Zi, M.2
Tsui, H.3
-
74
-
-
84872002780
-
Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure
-
Erdmann E, Semigran MJ, Nieminen MS, et al. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. Eur Heart J. 2013;34:57-67.
-
(2013)
Eur Heart J.
, vol.34
, pp. 57-67
-
-
Erdmann, E.1
Semigran, M.J.2
Nieminen, M.S.3
-
75
-
-
84885119071
-
Reduced hemodynamic load aids low-dose resveratrol in reversing cardiovascular defects in hypertensive rats
-
Thandapilly SJ, Louis XL, Behbahani J, et al. Reduced hemodynamic load aids low-dose resveratrol in reversing cardiovascular defects in hypertensive rats. Hypertens Res. 2013;36:866-872.
-
(2013)
Hypertens Res.
, vol.36
, pp. 866-872
-
-
Thandapilly, S.J.1
Louis, X.L.2
Behbahani, J.3
-
76
-
-
79959525058
-
Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
-
Dai DF, Chen T, et al. Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. J Am Coll Cardiol. 2011; 58:73-82.
-
(2011)
J Am Coll Cardiol.
, vol.58
, pp. 73-82
-
-
Dai, D.F.1
Chen, T.2
-
77
-
-
84880721470
-
Riociguat for the treatment of pulmonary arterial hypertension
-
Ghofrani HA, Galie N, Grimminger F, et al. Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med. 2013;369:330-340.
-
(2013)
N Engl J Med.
, vol.369
, pp. 330-340
-
-
Ghofrani, H.A.1
Galie, N.2
Grimminger, F.3
-
78
-
-
84868668210
-
TRV120027, a novel betaarrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
-
Boerrigter G, Soergel DG, Violin JD, et al. TRV120027, a novel betaarrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circ Heart Fail. 2012;5:627-634.
-
(2012)
Circ Heart Fail
, vol.5
, pp. 627-634
-
-
Boerrigter, G.1
Soergel, D.G.2
Violin, J.D.3
-
79
-
-
3242660757
-
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure
-
Lai NC, Roth DM, Gao MH, et al. Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation. 2004;110:330-336.
-
(2004)
Circulation
, vol.110
, pp. 330-336
-
-
Lai, N.C.1
Roth, D.M.2
Gao, M.H.3
-
80
-
-
84879098362
-
Dual neurohormonal intervention in CV disease: Angiotensin receptor and neprilysin inhibition
-
Segura J, Salazar J, Ruilope LM. Dual neurohormonal intervention in CV disease: Angiotensin receptor and neprilysin inhibition. Expert Opin Investig Drugs. 2013;22:915-925.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, pp. 915-925
-
-
Segura, J.1
Salazar, J.2
Ruilope, L.M.3
-
81
-
-
84880113102
-
An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential
-
Jay SM, Murthy AC, Hawkins JF, et al. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013;128:152-161.
-
(2013)
Circulation
, vol.128
, pp. 152-161
-
-
Jay, S.M.1
Murthy, A.C.2
Hawkins, J.F.3
-
82
-
-
84871986523
-
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): A randomised, placebo-controlled trial
-
Teerlink JR, Cotter G, Davison BA, et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): A randomised, placebo-controlled trial. Lancet. 2013;381:29-39.
-
(2013)
Lancet
, vol.381
, pp. 29-39
-
-
Teerlink, J.R.1
Cotter, G.2
Davison, B.A.3
-
83
-
-
84882415231
-
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: A randomized, double-blind trial
-
Pitt B, Kober L, Ponikowski P, et al. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: A randomized, double-blind trial. Eur Heart J. 2013;34:2453-2463.
-
(2013)
Eur Heart J.
, vol.34
, pp. 2453-2463
-
-
Pitt, B.1
Kober, L.2
Ponikowski, P.3
-
84
-
-
50849123772
-
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: A comparison with spironolactone
-
Mulder P, Mellin V, Favre J, et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: A comparison with spironolactone. Eur Heart J. 2008;29:2171-2179.
-
(2008)
Eur Heart J.
, vol.29
, pp. 2171-2179
-
-
Mulder, P.1
Mellin, V.2
Favre, J.3
-
85
-
-
80255141746
-
Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: Results of a randomized, double-blind, placebo- And active-controlled phase 2 trial
-
Calhoun DA, White WB, Krum H, et al. Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- And active-controlled phase 2 trial. Circulation. 2011;124:1945-1955.
-
(2011)
Circulation
, vol.124
, pp. 1945-1955
-
-
Calhoun, D.A.1
White, W.B.2
Krum, H.3
-
86
-
-
37549047239
-
Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: Discordant enantioselectivity versus reduction of plasma aldosterone
-
Minnaard-Huiban M, Emmen JM, Roumen L, et al. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology. 2008;149:28-31.
-
(2008)
Endocrinology
, vol.149
, pp. 28-31
-
-
Minnaard-Huiban, M.1
Emmen, J.M.2
Roumen, L.3
-
87
-
-
84884359989
-
Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy
-
Schumacher CD, Steele RE, Brunner HR. Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy. J Hypertens. 2013;31:2085-2093.
-
(2013)
J Hypertens.
, vol.31
, pp. 2085-2093
-
-
Schumacher, C.D.1
Steele, R.E.2
Brunner, H.R.3
-
88
-
-
84865760148
-
The effects of aldosterone synthase inhibition on aldosterone and cortisol in patients with hypertension: A phase II, randomized, double-blind, placebo-controlled, multicenter study
-
Andersen K, Hartman D, Peppard T, et al. The effects of aldosterone synthase inhibition on aldosterone and cortisol in patients with hypertension: A phase II, randomized, double-blind, placebo-controlled, multicenter study. J Clin Hypertens (Greenwich). 2012;14:580-587.
-
(2012)
J Clin Hypertens (Greenwich)
, vol.14
, pp. 580-587
-
-
Andersen, K.1
Hartman, D.2
Peppard, T.3
-
89
-
-
83455201665
-
Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension
-
Pouleur AC, Uno H, Prescott MF, et al. Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2011;12:483-490.
-
(2011)
J Renin Angiotensin Aldosterone Syst.
, vol.12
, pp. 483-490
-
-
Pouleur, A.C.1
Uno, H.2
Prescott, M.F.3
-
90
-
-
79955463305
-
Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
-
Solomon SD, Shin SH, Shah A, et al. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur Heart J. 2011;32:1227-1234.
-
(2011)
Eur Heart J.
, vol.32
, pp. 1227-1234
-
-
Solomon, S.D.1
Shin, S.H.2
Shah, A.3
-
91
-
-
84875176312
-
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: The ASTRONAUT randomized trial
-
Gheorghiade M, Bohm M, Greene SJ, et al. Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: The ASTRONAUT randomized trial. JAMA. 2013;309:1125-1135.
-
(2013)
JAMA
, vol.309
, pp. 1125-1135
-
-
Gheorghiade, M.1
Bohm, M.2
Greene, S.J.3
-
92
-
-
84869492851
-
Cardiorenal end points in a trial of aliskiren for type 2 diabetes
-
Parving HH, Brenner BM, McMurray JJ, et al. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012;367: 2204-2213.
-
(2012)
N Engl J Med.
, vol.367
, pp. 2204-2213
-
-
Parving, H.H.1
Brenner, B.M.2
Mcmurray, J.J.3
-
93
-
-
84874405559
-
Cardiovascular effects of a novel selective Rho kinase inhibitor, 2-(1H-indazole-5-yl)amino-4-methoxy- 6-piperazino triazine (DW1865)
-
Oh KS, Oh BK, Park CH, et al. Cardiovascular effects of a novel selective Rho kinase inhibitor, 2-(1H-indazole-5-yl)amino-4-methoxy- 6-piperazino triazine (DW1865). Eur J Pharmacol. 2013;702:218-226.
-
(2013)
Eur J Pharmacol.
, vol.702
, pp. 218-226
-
-
Oh, K.S.1
Oh, B.K.2
Park, C.H.3
-
94
-
-
84887608131
-
RASSF1A: A potential novel therapeutic target against cardiac hypertrophy
-
Duan C, Liu M, Zhang J, et al. RASSF1A: A potential novel therapeutic target against cardiac hypertrophy. Prog Biophys Mol Biol. 2013;113: 284-288.
-
(2013)
Prog Biophys Mol Biol.
, vol.113
, pp. 284-288
-
-
Duan, C.1
Liu, M.2
Zhang, J.3
-
95
-
-
70449730792
-
Regression of left ventricular mass by antihypertensive treatment: A meta-analysis of randomized comparative studies
-
Fagard RH, Celis H, Thijs L, et al. Regression of left ventricular mass by antihypertensive treatment: A meta-analysis of randomized comparative studies. Hypertension. 2009;54:1084-1091.
-
(2009)
Hypertension
, vol.54
, pp. 1084-1091
-
-
Fagard, R.H.1
Celis, H.2
Thijs, L.3
-
96
-
-
36749094552
-
A unique mechanism of betablocker action: Carvedilol stimulates beta-arrestin signaling
-
Wisler JW, DeWire SM, Whalen EJ, et al. A unique mechanism of betablocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007;104:16657-16662.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, pp. 16657-16662
-
-
Wisler, J.W.1
Dewire, S.M.2
Whalen, E.J.3
-
97
-
-
84855358922
-
Nebivolol: An endothelium-friendly selective beta1-adrenoceptor blocker
-
Gao Y, Vanhoutte PM. Nebivolol: An endothelium-friendly selective beta1-adrenoceptor blocker. J Cardiovasc Pharmacol. 2012;59:16-21.
-
(2012)
J Cardiovasc Pharmacol
, vol.59
, pp. 16-21
-
-
Gao, Y.1
Vanhoutte, P.M.2
-
98
-
-
59049097977
-
Myocardial adenoassociated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
-
Rengo G, Lymperopoulos A, Zincarelli C, et al. Myocardial adenoassociated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation. 2009;119:89-98.
-
(2009)
Circulation
, vol.119
, pp. 89-98
-
-
Rengo, G.1
Lymperopoulos, A.2
Zincarelli, C.3
-
99
-
-
77956226186
-
Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure
-
Casey LM, Pistner AR, Belmonte SL, et al. Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure. Circ Res. 2010;107:532-539.
-
(2010)
Circ Res.
, vol.107
, pp. 532-539
-
-
Casey, L.M.1
Pistner, A.R.2
Belmonte, S.L.3
-
100
-
-
84860350915
-
AAV6.betaARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model
-
Raake PW, Schlegel P, Ksienzyk J, et al. AAV6.betaARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. Eur Heart J. 2013;34:1437-1447.
-
(2013)
Eur Heart J.
, vol.34
, pp. 1437-1447
-
-
Raake, P.W.1
Schlegel, P.2
Ksienzyk, J.3
-
101
-
-
78149361376
-
Proinflammatory cytokines in heart failure: Double-edged swords
-
HedayatM, Mahmoudi MJ, Rose NR, et al. Proinflammatory cytokines in heart failure: double-edged swords. Heart Fail Rev. 2010;15:543-562.
-
(2010)
Heart Fail Rev.
, vol.15
, pp. 543-562
-
-
Hedayat, M.1
Mahmoudi, M.J.2
Rose, N.R.3
-
102
-
-
77955500182
-
Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
-
Melendez GC, McLarty JL, Levick SP, et al. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension. 2010;56:225-231.
-
(2010)
Hypertension
, vol.56
, pp. 225-231
-
-
Melendez, G.C.1
Mclarty, J.L.2
Levick, S.P.3
-
103
-
-
77954242107
-
TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure
-
Kleinbongard P, Heusch G, Schulz R. TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther. 2010;127:295-314.
-
(2010)
Pharmacol Ther.
, vol.127
, pp. 295-314
-
-
Kleinbongard, P.1
Heusch, G.2
Schulz, R.3
-
104
-
-
84877633753
-
Etanercept normalises left ventricular mass in patients with rheumatoid arthritis
-
Daien CI, Fesler P, du CG, et al. Etanercept normalises left ventricular mass in patients with rheumatoid arthritis. Ann Rheum Dis. 2013;72: 881-887.
-
(2013)
Ann Rheum Dis.
, vol.72
, pp. 881-887
-
-
Daien, C.I.1
Fesler, P.2
Du, C.G.3
-
105
-
-
11144355760
-
Targeted anticytokine therapy in patients with chronic heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
-
Mann DL, McMurray JJ, Packer M, et al. Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation. 2004;109: 1594-1602.
-
(2004)
Circulation
, vol.109
, pp. 1594-1602
-
-
Mann, D.L.1
Mcmurray, J.J.2
Packer, M.3
-
106
-
-
0038755661
-
Randomized, double-blind, placebo- controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: Results of the anti-TNF therapy against congestive heart failure (ATTACH) trial
-
Chung ES, Packer M, Lo KH, et al. Randomized, double-blind, placebo- controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF therapy against congestive heart failure (ATTACH) trial. Circulation. 2003;107:3133-3140.
-
(2003)
Circulation
, vol.107
, pp. 3133-3140
-
-
Chung, E.S.1
Packer, M.2
Lo, K.H.3
-
107
-
-
84868553979
-
Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice
-
Lai NC, Gao MH, Tang E, et al. Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice. Lab Invest. 2012;92:1518-1526.
-
(2012)
Lab Invest.
, vol.92
, pp. 1518-1526
-
-
Lai, N.C.1
Gao, M.H.2
Tang, E.3
-
108
-
-
79960916464
-
Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway
-
Manukyan MC, Alvernaz CH, Poynter JA, et al. Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery. 2011;150:231-239.
-
(2011)
Surgery
, vol.150
, pp. 231-239
-
-
Manukyan, M.C.1
Alvernaz, C.H.2
Poynter, J.A.3
-
109
-
-
84862177457
-
Inflammatory cytokines in heart failure: Mediators and markers
-
Gullestad L, Ueland T, Vinge LE, et al. Inflammatory cytokines in heart failure: Mediators and markers. Cardiology. 2012;122:23-35.
-
(2012)
Cardiology
, vol.122
, pp. 23-35
-
-
Gullestad, L.1
Ueland, T.2
Vinge, L.E.3
-
110
-
-
84893395842
-
Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart
-
Zouein FA, Kurdi M, Booz GW. Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart. JAKSTAT. 2013;2:24352.
-
(2013)
JAKSTAT
, vol.2
, pp. 24352
-
-
Zouein, F.A.1
Kurdi, M.2
Booz, G.W.3
-
111
-
-
79952068475
-
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload
-
Liu W, Zi M, Chi H, et al. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. J Mol Cell Cardiol. 2011;50:702-711.
-
(2011)
J Mol Cell Cardiol.
, vol.50
, pp. 702-711
-
-
Liu, W.1
Zi, M.2
Chi, H.3
-
112
-
-
0032489550
-
Cardiac hypertrophy induced by mitogenactivated protein kinase kinase 7, a specific activator for c-Jun NH2- Terminal kinase in ventricular muscle cells
-
Wang Y, Su B, Sah VP, et al. Cardiac hypertrophy induced by mitogenactivated protein kinase kinase 7, a specific activator for c-Jun NH2- Terminal kinase in ventricular muscle cells. J Biol Chem. 1998;273: 5423-5426.
-
(1998)
J Biol Chem.
, vol.273
, pp. 5423-5426
-
-
Wang, Y.1
Su, B.2
Sah, V.P.3
-
113
-
-
0038651918
-
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
-
Braz JC, Bueno OF, Liang Q, et al. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003;111:1475-1486.
-
(2003)
J Clin Invest.
, vol.111
, pp. 1475-1486
-
-
Braz, J.C.1
Bueno, O.F.2
Liang, Q.3
-
114
-
-
0035834071
-
The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy
-
Liao P, Georgakopoulos D, Kovacs A, et al. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A. 2001;98:12283-12288.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12283-12288
-
-
Liao, P.1
Georgakopoulos, D.2
Kovacs, A.3
-
115
-
-
77955690900
-
Protein kinases as drug development targets for heart disease therapy
-
Dhalla NS, Mueller AL. Protein kinases as drug development targets for heart disease therapy. Pharmaceuticals. 2010;3:2111-2145.
-
(2010)
Pharmaceuticals
, vol.3
, pp. 2111-2145
-
-
Dhalla, N.S.1
Mueller, A.L.2
-
116
-
-
84868602480
-
The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): Design and rationale
-
Melloni C, Sprecher DL, Sarov-Blat L, et al. The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale. Am Heart J. 2012;164:646-653.
-
(2012)
Am Heart J.
, vol.164
, pp. 646-653
-
-
Melloni, C.1
Sprecher, D.L.2
Sarov-Blat, L.3
-
117
-
-
0027722248
-
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
-
Sadoshima J, Xu Y, Slayter HS, et al. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-984.
-
(1993)
Cell
, vol.75
, pp. 977-984
-
-
Sadoshima, J.1
Xu, Y.2
Slayter, H.S.3
-
119
-
-
0026709274
-
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy
-
Sadoshima J, Jahn L, Takahashi T, et al. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 1992;267: 10551-10560.
-
(1992)
J Biol Chem.
, vol.267
, pp. 10551-10560
-
-
Sadoshima, J.1
Jahn, L.2
Takahashi, T.3
-
120
-
-
57149121154
-
Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction
-
Schnitzler M, Storch U, Meibers S, et al. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008;27:3092-3103.
-
(2008)
EMBO J.
, vol.27
, pp. 3092-3103
-
-
Schnitzler, M.1
Storch, U.2
Meibers, S.3
-
121
-
-
0037453074
-
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy
-
Geier C, Perrot A, Ozcelik C, et al. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003;107:1390-1395.
-
(2003)
Circulation
, vol.107
, pp. 1390-1395
-
-
Geier, C.1
Perrot, A.2
Ozcelik, C.3
-
122
-
-
84863157243
-
Beta1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses
-
Li R, Wu Y, Manso AM, et al. Beta1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012;180:952-962.
-
(2012)
Am J Pathol.
, vol.180
, pp. 952-962
-
-
Li, R.1
Wu, Y.2
Manso, A.M.3
-
123
-
-
79953144790
-
Cilengitide: An RGD pentapeptide alphanubeta3 and alphanubeta5 integrin inhibitor in development for glioblastoma and other malignancies
-
Reardon DA, Neyns B, Weller M, et al. Cilengitide: An RGD pentapeptide alphanubeta3 and alphanubeta5 integrin inhibitor in development for glioblastoma and other malignancies. Future Oncol. 2011;7:339-354.
-
(2011)
Future Oncol.
, vol.7
, pp. 339-354
-
-
Reardon, D.A.1
Neyns, B.2
Weller, M.3
-
124
-
-
33750802650
-
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
-
Spassova MA, Hewavitharana T, Xu W, et al. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A. 2006;103:16586-16591.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 16586-16591
-
-
Spassova, M.A.1
Hewavitharana, T.2
Xu, W.3
-
125
-
-
13944263659
-
TRPC1 forms the stretch-activated cation channel in vertebrate cells
-
Maroto R, Raso A, Wood TG, et al. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol. 2005;7:179-185.
-
(2005)
Nat Cell Biol.
, vol.7
, pp. 179-185
-
-
Maroto, R.1
Raso, A.2
Wood, T.G.3
-
126
-
-
35448982353
-
Pressure-induced and storeoperated cation influx in vascular smooth muscle cells is independent of TRPC1
-
Dietrich A, Kalwa H, Storch U, et al. Pressure-induced and storeoperated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch. 2007;455:465-477.
-
(2007)
Pflugers Arch.
, vol.455
, pp. 465-477
-
-
Dietrich, A.1
Kalwa, H.2
Storch, U.3
-
127
-
-
38649133202
-
Revisiting TRPC1 and TRPC6 mechanosensitivity
-
Gottlieb P, Folgering J, Maroto R, et al. Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch. 2008;455:1097-1103.
-
(2008)
Pflugers Arch.
, vol.455
, pp. 1097-1103
-
-
Gottlieb, P.1
Folgering, J.2
Maroto, R.3
-
128
-
-
79960617636
-
PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes
-
Poteser M, Schleifer H, Lichtenegger M, et al. PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes. Proc Natl Acad Sci U S A. 2011;108:10556-10561.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 10556-10561
-
-
Poteser, M.1
Schleifer, H.2
Lichtenegger, M.3
-
129
-
-
84870500198
-
Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways
-
Schleifer H, Doleschal B, Lichtenegger M, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012;167: 1712-1722.
-
(2012)
Br J Pharmacol.
, vol.167
, pp. 1712-1722
-
-
Schleifer, H.1
Doleschal, B.2
Lichtenegger, M.3
-
130
-
-
65249173997
-
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
-
Kiyonaka S, Kato K, Nishida M, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009;106:5400-5405.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5400-5405
-
-
Kiyonaka, S.1
Kato, K.2
Nishida, M.3
-
131
-
-
33746045297
-
Integration of calcium with the signaling network in cardiac myocytes
-
Schaub MC, Hefti MA, Zaugg M. Integration of calcium with the signaling network in cardiac myocytes. J Mol Cell Cardiol. 2006;41: 183-214.
-
(2006)
J Mol Cell Cardiol.
, vol.41
, pp. 183-214
-
-
Schaub, M.C.1
Hefti, M.A.2
Zaugg, M.3
-
132
-
-
84862825070
-
A caveolae-targeted L-type Ca(2)+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility
-
Makarewich CA, Correll RN, Gao H, et al. A caveolae-targeted L-type Ca(2)+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circ Res. 2012;110:669-674.
-
(2012)
Circ Res.
, vol.110
, pp. 669-674
-
-
Makarewich, C.A.1
Correll, R.N.2
Gao, H.3
-
133
-
-
0038642326
-
A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
-
Klingbeil AU, Schneider M, Martus P, et al. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med. 2003;115:41-46.
-
(2003)
Am J Med.
, vol.115
, pp. 41-46
-
-
Klingbeil, A.U.1
Schneider, M.2
Martus, P.3
-
134
-
-
0035845677
-
Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: The prospective randomized enalapril study evaluating regression of ventricular enlargement (preserve) trial
-
Devereux RB, Palmieri V, Sharpe N, et al. Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: The prospective randomized enalapril study evaluating regression of ventricular enlargement (preserve) trial. Circulation. 2001;104:1248-1254.
-
(2001)
Circulation
, vol.104
, pp. 1248-1254
-
-
Devereux, R.B.1
Palmieri, V.2
Sharpe, N.3
-
135
-
-
0033973435
-
Efficacy and safety of calcium channel blockers in heart failure: Focus on recent trials with second-generation dihydropyridines
-
de Vries RJ, van Veldhuisen DJ, Dunselman PH. Efficacy and safety of calcium channel blockers in heart failure: focus on recent trials with second-generation dihydropyridines. Am Heart J. 2000;139:185-194.
-
(2000)
Am Heart J.
, vol.139
, pp. 185-194
-
-
De Vries, R.J.1
Van Veldhuisen, D.J.2
Dunselman, P.H.3
-
136
-
-
33747382766
-
Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial
-
Leenen FH, Nwachuku CE, Black HR, et al. Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension. 2006;48:374-384.
-
(2006)
Hypertension
, vol.48
, pp. 374-384
-
-
Leenen, F.H.1
Nwachuku, C.E.2
Black, H.R.3
-
137
-
-
0034640113
-
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
-
Marx SO, Reiken S, Hisamatsu Y, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365-376.
-
(2000)
Cell
, vol.101
, pp. 365-376
-
-
Marx, S.O.1
Reiken, S.2
Hisamatsu, Y.3
-
138
-
-
84866022419
-
JTV519 (K201) reduces sarcoplasmic reticulum Ca(2)(+) leak and improves diastolic function in vitro in murine and human non-failing myocardium
-
Sacherer M, Sedej S, Wakula P, et al. JTV519 (K201) reduces sarcoplasmic reticulum Ca(2)(+) leak and improves diastolic function in vitro in murine and human non-failing myocardium. Br J Pharmacol. 2012; 167:493-504.
-
(2012)
Br J Pharmacol.
, vol.167
, pp. 493-504
-
-
Sacherer, M.1
Sedej, S.2
Wakula, P.3
-
139
-
-
33646739318
-
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias
-
Lehnart SE, Terrenoire C, Reiken S, et al. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006;103:7906-7910.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7906-7910
-
-
Lehnart, S.E.1
Terrenoire, C.2
Reiken, S.3
-
140
-
-
77950470200
-
Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model
-
van Oort RJ, Respress JL, Li N, et al. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010;55:932-938.
-
(2010)
Hypertension
, vol.55
, pp. 932-938
-
-
Van Oort, R.J.1
Respress, J.L.2
Li, N.3
-
141
-
-
84901929088
-
Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload
-
Sedej S, Schmidt A, Denegri M, et al. Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload. J Am Coll Cardiol. 2014;63:1569-1579.
-
(2014)
J Am Coll Cardiol.
, vol.63
, pp. 1569-1579
-
-
Sedej, S.1
Schmidt, A.2
Denegri, M.3
-
142
-
-
68449103544
-
Pharmacological characteristics and clinical applications of K201
-
Kaneko N, Matsuda R, Hata Y, et al. Pharmacological characteristics and clinical applications of K201. Curr Clin Pharmacol. 2009;4: 126-131.
-
(2009)
Curr Clin Pharmacol.
, vol.4
, pp. 126-131
-
-
Kaneko, N.1
Matsuda, R.2
Hata, Y.3
-
143
-
-
69249212388
-
S100A1 in cardiovascular health and disease: Closing the gap between basic science and clinical therapy
-
Kraus C, Rohde D, Weidenhammer C, et al. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. J Mol Cell Cardiol. 2009;47:445-455.
-
(2009)
J Mol Cell Cardiol.
, vol.47
, pp. 445-455
-
-
Kraus, C.1
Rohde, D.2
Weidenhammer, C.3
-
144
-
-
79960696509
-
Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model
-
Pleger ST, Shan C, Ksienzyk J, et al. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci Transl Med. 2011;3:92-64.
-
(2011)
Sci Transl Med.
, vol.3
, pp. 64-92
-
-
Pleger, S.T.1
Shan, C.2
Ksienzyk, J.3
-
145
-
-
77957914859
-
Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation
-
Beeri R, Chaput M, Guerrero JL, et al. Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation. Circ Heart Fail. 2010;3:627-634.
-
(2010)
Circ Heart Fail
, vol.3
, pp. 627-634
-
-
Beeri, R.1
Chaput, M.2
Guerrero, J.L.3
-
146
-
-
79961032369
-
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
-
Jessup M, Greenberg B, Mancini D, et al. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 2011;124:304-313.
-
(2011)
Circulation
, vol.124
, pp. 304-313
-
-
Jessup, M.1
Greenberg, B.2
Mancini, D.3
-
147
-
-
76349112911
-
Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: Hit or miss
-
Sipido KR, Vangheluwe P. Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: Hit or miss. Circ Res. 2010;106:230-233.
-
(2010)
Circ Res.
, vol.106
, pp. 230-233
-
-
Sipido, K.R.1
Vangheluwe, P.2
-
148
-
-
2442438896
-
[Na(+)] in the subsarcolemmal "fuzzy" space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes
-
Verdonck F, Mubagwa K, Sipido KR. [Na(+)] in the subsarcolemmal "fuzzy" space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes. Cell Calcium. 2004;35:603-612.
-
(2004)
Cell Calcium.
, vol.35
, pp. 603-612
-
-
Verdonck, F.1
Mubagwa, K.2
Sipido, K.R.3
-
149
-
-
42749083194
-
The role of NHE-1 in myocardial hypertrophy and remodelling
-
Karmazyn M, Kilic A, Javadov S. The role of NHE-1 in myocardial hypertrophy and remodelling. J Mol Cell Cardiol. 2008;44:647-653.
-
(2008)
J Mol Cell Cardiol.
, vol.44
, pp. 647-653
-
-
Karmazyn, M.1
Kilic, A.2
Javadov, S.3
-
150
-
-
40749126460
-
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: Results of the EXPEDITION study
-
Mentzer RM Jr, Bartels C, Bolli R, et al. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg. 2008;85:1261-1270.
-
(2008)
Ann Thorac Surg.
, vol.85
, pp. 1261-1270
-
-
Mentzer, R.M.1
Bartels, C.2
Bolli, R.3
-
151
-
-
40649117625
-
Targeting Na+/H+ exchanger regulation for cardiac protection: A RSKy approach?
-
Avkiran M, Cook AR, Cuello F. Targeting Na+/H+ exchanger regulation for cardiac protection: A RSKy approach? Curr Opin Pharmacol. 2008;8:133-140.
-
(2008)
Curr Opin Pharmacol.
, vol.8
, pp. 133-140
-
-
Avkiran, M.1
Cook, A.R.2
Cuello, F.3
-
152
-
-
84856442152
-
Role of ranolazine in angina, heart failure, arrhythmias, and diabetes
-
Sossalla S, Maier LS. Role of ranolazine in angina, heart failure, arrhythmias, and diabetes. Pharmacol Ther. 2012;133:311-323.
-
(2012)
Pharmacol Ther.
, vol.133
, pp. 311-323
-
-
Sossalla, S.1
Maier, L.S.2
-
153
-
-
57049182027
-
Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure
-
Rastogi S, Sharov VG, Mishra S, et al. Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol. 2008;295:2149-2155.
-
(2008)
Am J Physiol Heart Circ Physiol.
, vol.295
, pp. 2149-2155
-
-
Rastogi, S.1
Sharov, V.G.2
Mishra, S.3
-
154
-
-
84876326824
-
The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?
-
Fischer TH, Neef S, Maier LS. The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies? J Mol Cell Cardiol. 2013;58:182-187.
-
(2013)
J Mol Cell Cardiol.
, vol.58
, pp. 182-187
-
-
Fischer, T.H.1
Neef, S.2
Maier, L.S.3
-
155
-
-
0037162697
-
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
-
Zhang CL, McKinsey TA, Chang S, et al. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002; 110:479-488.
-
(2002)
Cell
, vol.110
, pp. 479-488
-
-
Zhang, C.L.1
Mckinsey, T.A.2
Chang, S.3
-
156
-
-
76349122643
-
Protein acetylation in the cardiorenal axis: The promise of histone deacetylase inhibitors
-
Bush EW, McKinsey TA. Protein acetylation in the cardiorenal axis: The promise of histone deacetylase inhibitors. Circ Res. 2010;106:272-284.
-
(2010)
Circ Res.
, vol.106
, pp. 272-284
-
-
Bush, E.W.1
Mckinsey, T.A.2
-
157
-
-
33644861578
-
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding
-
Kee HJ, Sohn IS, Nam KI, et al. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation. 2006;113:51-59.
-
(2006)
Circulation
, vol.113
, pp. 51-59
-
-
Kee, H.J.1
Sohn, I.S.2
Nam, K.I.3
-
158
-
-
84886307237
-
Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure
-
Kao YH, Liou JP, Chung CC, et al. Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. Int J Cardiol. 2013;168:4178-4183.
-
(2013)
Int J Cardiol.
, vol.168
, pp. 4178-4183
-
-
Kao, Y.H.1
Liou, J.P.2
Chung, C.C.3
-
160
-
-
80052814243
-
Isoform-selective HDAC inhibitors: Closing in o n translational medicine for the heart
-
McKinsey TA. Isoform-selective HDAC inhibitors: closing in o n translational medicine for the heart. J Mol Cell Cardiol. 2011;51:491-496.
-
(2011)
J Mol Cell Cardiol.
, vol.51
, pp. 491-496
-
-
Mckinsey, T.A.1
-
161
-
-
33847038668
-
MicroRNAs play an essential role in the development of cardiac hypertrophy
-
Sayed D, Hong C, Chen IY, et al. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res. 2007;100:416-424.
-
(2007)
Circ Res.
, vol.100
, pp. 416-424
-
-
Sayed, D.1
Hong, C.2
Chen, I.Y.3
-
162
-
-
34249279050
-
MicroRNA-133 controls cardiac hypertrophy
-
Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13:613-618.
-
(2007)
Nat Med.
, vol.13
, pp. 613-618
-
-
Care, A.1
Catalucci, D.2
Felicetti, F.3
-
163
-
-
78649843756
-
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling
-
da Costa Martins PA, Salic K, GladkaMM, et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol. 2010;12:1220-1227.
-
(2010)
Nat Cell Biol.
, vol.12
, pp. 1220-1227
-
-
Da Costa Martins, P.A.1
Salic, K.2
Gladka, M.M.3
-
164
-
-
84855244103
-
MicroRNA therapeutics in cardiovascular medicine
-
Thum T. MicroRNA therapeutics in cardiovascular medicine. EMBO Mol Med. 2012;4:3-14.
-
(2012)
EMBO Mol Med.
, vol.4
, pp. 3-14
-
-
Thum, T.1
-
165
-
-
84867903854
-
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
-
Bernardo BC, Gao XM, Winbanks CE, et al. Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci U S A. 2012;109: 17615-17620.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 17615-17620
-
-
Bernardo, B.C.1
Gao, X.M.2
Winbanks, C.E.3
-
166
-
-
84880816481
-
Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling
-
Karakikes I, Chaanine AH, Kang S, et al. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J Am Heart Assoc. 2013;2: 000078.
-
(2013)
J Am Heart Assoc.
, vol.2
, pp. 000078
-
-
Karakikes, I.1
Chaanine, A.H.2
Kang, S.3
-
167
-
-
33846418746
-
Role of oxidative stress in cardiac hypertrophy and remodeling
-
Takimoto E, Kass DA. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension. 2007;49:241-248.
-
(2007)
Hypertension
, vol.49
, pp. 241-248
-
-
Takimoto, E.1
Kass, D.A.2
-
168
-
-
20044383911
-
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial
-
Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial. JAMA. 2005;293:1338-1347.
-
(2005)
JAMA
, vol.293
, pp. 1338-1347
-
-
Lonn, E.1
Bosch, J.2
Yusuf, S.3
-
169
-
-
0345157579
-
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease
-
Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334:1145-1149.
-
(1996)
N Engl J Med.
, vol.334
, pp. 1145-1149
-
-
Hennekens, C.H.1
Buring, J.E.2
Manson, J.E.3
-
170
-
-
0034688195
-
Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
-
Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342: 154-160.
-
(2000)
N Engl J Med.
, vol.342
, pp. 154-160
-
-
Yusuf, S.1
Dagenais, G.2
Pogue, J.3
-
171
-
-
85039880852
-
-
Deleted in proof
-
Deleted in proof.
-
-
-
-
172
-
-
0141924553
-
A novel pleiotropic effect of statins: Prevention of cardiac hypertrophy by cholesterol-independent mechanisms
-
Nakagami H, Jensen KS, Liao JK. A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms. Ann Med. 2003;35:398-403.
-
(2003)
Ann Med.
, vol.35
, pp. 398-403
-
-
Nakagami, H.1
Jensen, K.S.2
Liao, J.K.3
-
173
-
-
82455210559
-
The effects of simvastatin on left ventricular hypertrophy and left ventricular function in patients with essential hypertension
-
Pan XD, Zeng ZH, Liang LY, et al. The effects of simvastatin on left ventricular hypertrophy and left ventricular function in patients with essential hypertension. Clin Exp Hypertens. 2011;33:558-564.
-
(2011)
Clin Exp Hypertens.
, vol.33
, pp. 558-564
-
-
Pan, X.D.1
Zeng, Z.H.2
Liang, L.Y.3
-
174
-
-
78049476990
-
No effect of rosuvastatin on left ventricular hypertrophy in patients with hypertension: A prospective randomised open-label study with blinded endpoint assessment
-
Folkeringa RJ, de VC, Pinto YM, et al. No effect of rosuvastatin on left ventricular hypertrophy in patients with hypertension: A prospective randomised open-label study with blinded endpoint assessment. Int J Cardiol. 2010;145:156-158.
-
(2010)
Int J Cardiol.
, vol.145
, pp. 156-158
-
-
Folkeringa, R.J.1
De, V.C.2
Pinto, Y.M.3
-
175
-
-
35648967680
-
HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: A randomized placebo-controlled pilot study
-
Bauersachs J, Stork S, Kung M, et al. HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: A randomized placebo-controlled pilot study. Eur J Clin Invest. 2007;37:852-859.
-
(2007)
Eur J Clin Invest.
, vol.37
, pp. 852-859
-
-
Bauersachs, J.1
Stork, S.2
Kung, M.3
-
176
-
-
84874081484
-
NADPH oxidases in heart failure: Poachers or gamekeepers?
-
Zhang M, Perino A, Ghigo A, et al. NADPH oxidases in heart failure: poachers or gamekeepers? Antioxid Redox Signal. 2013;18:1024-1041.
-
(2013)
Antioxid Redox Signal
, vol.18
, pp. 1024-1041
-
-
Zhang, M.1
Perino, A.2
Ghigo, A.3
-
177
-
-
84875422028
-
Rationale and design of the EMBRACE STEMI study: A phase 2a, randomized, double-blind, placebo- controlled trial to evaluate the safety, tolerability and efficacy of intravenous bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction
-
Chakrabarti AK, Feeney K, Abueg C, et al. Rationale and design of the EMBRACE STEMI study: A phase 2a, randomized, double-blind, placebo- controlled trial to evaluate the safety, tolerability and efficacy of intravenous bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction. Am Heart J. 2013;165:509-514.
-
(2013)
Am Heart J.
, vol.165
, pp. 509-514
-
-
Chakrabarti, A.K.1
Feeney, K.2
Abueg, C.3
-
178
-
-
84879563896
-
Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice
-
Dolinsky VW, Chakrabarti S, Pereira TJ, et al. Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim Biophys Acta. 2013;1832:1723-1733.
-
(2013)
Biochim Biophys Acta
, vol.1832
, pp. 1723-1733
-
-
Dolinsky, V.W.1
Chakrabarti, S.2
Pereira, T.J.3
-
179
-
-
70449718779
-
Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO∗ and beyond
-
Ritchie RH, Irvine JC, Rosenkranz AC, et al. Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO∗ and beyond. Pharmacol Ther. 2009;124:279-300.
-
(2009)
Pharmacol Ther.
, vol.124
, pp. 279-300
-
-
Ritchie, R.H.1
Irvine, J.C.2
Rosenkranz, A.C.3
-
180
-
-
0037143710
-
Inhibition of calcineurin- NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes
-
Fiedler B, Lohmann SM, Smolenski A, et al. Inhibition of calcineurin- NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci U S A. 2002;99:11363-11368.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11363-11368
-
-
Fiedler, B.1
Lohmann, S.M.2
Smolenski, A.3
-
181
-
-
84875078987
-
Increased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodeling
-
Vandenwijngaert S, Pokreisz P, Hermans H, et al. Increased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodeling. PLoS One. 2013;8:58841.
-
(2013)
PLoS One
, vol.8
, pp. 58841
-
-
Vandenwijngaert, S.1
Pokreisz, P.2
Hermans, H.3
-
182
-
-
34248147132
-
Novel therapeutic directions for the natriuretic peptides in cardiovascular diseases: What is on the horizon
-
Burnett JC Jr. Novel therapeutic directions for the natriuretic peptides in cardiovascular diseases: What is on the horizon. J Cardiol. 2006;48: 235-241.
-
(2006)
J Cardiol.
, vol.48
, pp. 235-241
-
-
Burnett, J.C.1
-
183
-
-
0037306002
-
Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: Importance of cyclic GMP
-
Rosenkranz AC, Woods RL, Dusting GJ, et al. Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: Importance of cyclic GMP. Cardiovasc Res. 2003;57:515-522.
-
(2003)
Cardiovasc Res.
, vol.57
, pp. 515-522
-
-
Rosenkranz, A.C.1
Woods, R.L.2
Dusting, G.J.3
-
184
-
-
84857036386
-
Natriuretic peptides in therapy for decompensated heart failure
-
Gassanov N, Biesenbach E, Caglayan E, et al. Natriuretic peptides in therapy for decompensated heart failure. Eur J Clin Pharmacol. 2012; 68:223-230.
-
(2012)
Eur J Clin Pharmacol
, vol.68
, pp. 223-230
-
-
Gassanov, N.1
Biesenbach, E.2
Caglayan, E.3
-
185
-
-
84867887876
-
Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure
-
Birner C, Ulucan C, Bratfisch M, et al. Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2012; 385:1117-1125.
-
(2012)
Naunyn Schmiedebergs Arch Pharmacol.
, vol.385
, pp. 1117-1125
-
-
Birner, C.1
Ulucan, C.2
Bratfisch, M.3
-
186
-
-
1642452758
-
Omapatrilat and enalapril in patients with hypertension: The Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial
-
Kostis JB, Packer M, Black HR, et al. Omapatrilat and enalapril in patients with hypertension: The Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial. Am J Hypertens. 2004;17:103-111.
-
(2004)
Am J Hypertens
, vol.17
, pp. 103-111
-
-
Kostis, J.B.1
Packer, M.2
Black, H.R.3
-
187
-
-
84859871006
-
Angiotensin-converting enzyme 2: The first decade
-
Clarke NE, Turner AJ. Angiotensin-converting enzyme 2: The first decade. Int J Hypertens. 2012;2012:307315.
-
(2012)
Int J Hypertens
, vol.2012
, pp. 307315
-
-
Clarke, N.E.1
Turner, A.J.2
-
188
-
-
77956817833
-
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
-
Gu J, Noe A, Chandra P, et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 2010;50:401-414.
-
(2010)
J Clin Pharmacol.
, vol.50
, pp. 401-414
-
-
Gu, J.1
Noe, A.2
Chandra, P.3
-
189
-
-
84867745957
-
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: A phase 2 double-blind randomised controlled trial
-
Solomon SD, Zile M, Pieske B, et al. The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: A phase 2 double-blind randomised controlled trial. Lancet. 2012;380: 1387-1395.
-
(2012)
Lancet
, vol.380
, pp. 1387-1395
-
-
Solomon, S.D.1
Zile, M.2
Pieske, B.3
-
190
-
-
0027468571
-
Long-term oral nitrate therapy prevents chronic ventricular remodeling in the dog
-
McDonald KM, Francis GS, Matthews J, et al. Long-term oral nitrate therapy prevents chronic ventricular remodeling in the dog. J Am Coll Cardiol. 1993;21:514-522.
-
(1993)
J Am Coll Cardiol.
, vol.21
, pp. 514-522
-
-
McDonald, K.M.1
Francis, G.S.2
Matthews, J.3
-
191
-
-
77957271700
-
Nitric oxide pathway in hypertrophied heart: New therapeutic uses of nitric oxide donors
-
Ruiz-Hurtado G, Delgado C. Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors. J Hypertens. 2010; 28(suppl 1):56-61.
-
(2010)
J Hypertens
, vol.28
, pp. 56-61
-
-
Ruiz-Hurtado, G.1
Delgado, C.2
-
192
-
-
84880984684
-
HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyo- cytes: Potential therapeutic advantages of HNO over NO
-
Irvine JC, Cao N, Gossain S, et al. HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyo- cytes: potential therapeutic advantages of HNO over NO. Am J Physiol Heart Circ Physiol. 2013;305:365-377.
-
(2013)
Am J Physiol Heart Circ Physiol.
, vol.305
, pp. 365-377
-
-
Irvine, J.C.1
Cao, N.2
Gossain, S.3
-
193
-
-
77952749684
-
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
-
Lee DI, Vahebi S, Tocchetti CG, et al. PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol. 2010;105:337-347.
-
(2010)
Basic Res Cardiol.
, vol.105
, pp. 337-347
-
-
Lee, D.I.1
Vahebi, S.2
Tocchetti, C.G.3
-
194
-
-
84861487927
-
Cardioprotective effect of beta-3 adrenergic receptor agonism: Role of neuronal nitric oxide synthase
-
Niu X, Watts VL, Cingolani OH, et al. Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol. 2012;59:1979-1987.
-
(2012)
J Am Coll Cardiol.
, vol.59
, pp. 1979-1987
-
-
Niu, X.1
Watts, V.L.2
Cingolani, O.H.3
-
195
-
-
84861505171
-
Alterations in beta3-adrenergic cardiac innervation and nitric oxide signaling in heart failure
-
Kulandavelu S, Hare JM. Alterations in beta3-adrenergic cardiac innervation and nitric oxide signaling in heart failure. J Am Coll Cardiol. 2012;59:1988-1990.
-
(2012)
J Am Coll Cardiol.
, vol.59
, pp. 1988-1990
-
-
Kulandavelu, S.1
Hare, J.M.2
-
196
-
-
33748312096
-
NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential
-
Evgenov OV, Pacher P, Schmidt PM, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5:755-768.
-
(2006)
Nat Rev Drug Discov.
, vol.5
, pp. 755-768
-
-
Evgenov, O.V.1
Pacher, P.2
Schmidt, P.M.3
-
197
-
-
79960599350
-
Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats
-
Geschka S, Kretschmer A, Sharkovska Y, et al. Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats. PLoS One. 2011;6:21853.
-
(2011)
PLoS One
, vol.6
, pp. 21853
-
-
Geschka, S.1
Kretschmer, A.2
Sharkovska, Y.3
-
198
-
-
67650547955
-
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
-
Masuyama H, Tsuruda T, Sekita Y, et al. Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart. Hypertens Res. 2009;32:597-603.
-
(2009)
Hypertens Res.
, vol.32
, pp. 597-603
-
-
Masuyama, H.1
Tsuruda, T.2
Sekita, Y.3
-
199
-
-
84868689779
-
The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy
-
Irvine JC, Ganthavee V, et al. The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy. PLoS One. 2012;7:44481.
-
(2012)
PLoS One
, vol.7
, pp. 44481
-
-
Irvine, J.C.1
Ganthavee, V.2
-
200
-
-
20044363270
-
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
-
Takimoto E, Champion HC, Li M, et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med. 2005;11:214-222.
-
(2005)
Nat Med.
, vol.11
, pp. 214-222
-
-
Takimoto, E.1
Champion, H.C.2
Li, M.3
-
201
-
-
84880544313
-
Protein kinase g ialpha inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo
-
Blanton RM, Takimoto E, Lane AM, et al. Protein kinase g ialpha inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo. J Am Heart Assoc. 2012;1:003731.
-
(2012)
J Am Heart Assoc.
, vol.1
, pp. 003731
-
-
Blanton, R.M.1
Takimoto, E.2
Lane, A.M.3
-
202
-
-
84868219699
-
Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo
-
Westermann D, Becher PM, Lindner D, et al. Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo. Basic Res Cardiol. 2012;107:308.
-
(2012)
Basic Res Cardiol.
, vol.107
, pp. 308
-
-
Westermann, D.1
Becher, P.M.2
Lindner, D.3
-
203
-
-
84865426471
-
The ability of phosphodiesterase-5 inhibitors sildenafil and ordonafil to reverse L-NAME induced cardiac hypertrophy in the rabbit: Possible role of calcineurin and p38
-
Zeidan A, Siam A, Al KA, et al. The ability of phosphodiesterase-5 inhibitors sildenafil and ordonafil to reverse L-NAME induced cardiac hypertrophy in the rabbit: possible role of calcineurin and p38. Can J Physiol Pharmacol. 2012;90:1247-1255.
-
(2012)
Can J Physiol Pharmacol.
, vol.90
, pp. 1247-1255
-
-
Zeidan, A.1
Siam, A.2
Al, K.A.3
-
204
-
-
34248232967
-
Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR
-
Kristek F, Koprdova R, Cebova M. Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR. J Physiol Pharmacol. 2007;58:33-43.
-
(2007)
J Physiol Pharmacol
, vol.58
, pp. 33-43
-
-
Kristek, F.1
Koprdova, R.2
Cebova, M.3
-
205
-
-
84875531214
-
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial
-
Redfield MM, Chen HH, Borlaug BA, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial. JAMA. 2013;309:1268-1277.
-
(2013)
JAMA
, vol.309
, pp. 1268-1277
-
-
Redfield, M.M.1
Chen, H.H.2
Borlaug, B.A.3
-
206
-
-
77955981900
-
Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
-
18
-
Zhong J, Basu R, Guo D, et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 2010;122:717-728, 18.
-
(2010)
Circulation
, vol.122
, pp. 717-728
-
-
Zhong, J.1
Basu, R.2
Guo, D.3
-
207
-
-
84883202259
-
Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects
-
Haschke M, Schuster M, Poglitsch M, et al. Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet. 2013;52:783-792.
-
(2013)
Clin Pharmacokinet
, vol.52
, pp. 783-792
-
-
Haschke, M.1
Schuster, M.2
Poglitsch, M.3
-
208
-
-
84867296931
-
Angiotensin-(1-7)-mediated signaling in cardiomyocytes
-
Gomes ER, Santos RA, Guatimosim S. Angiotensin-(1-7)-mediated signaling in cardiomyocytes. Int J Hypertens. 2012;2012:493129.
-
(2012)
Int J Hypertens
, vol.2012
, pp. 493129
-
-
Gomes, E.R.1
Santos, R.A.2
Guatimosim, S.3
-
209
-
-
84860643125
-
Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991
-
Zeng WT, Chen WY, Leng XY, et al. Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991. Cardiovasc Ther. 2012;30:152-161.
-
(2012)
Cardiovasc Ther.
, vol.30
, pp. 152-161
-
-
Zeng, W.T.1
Chen, W.Y.2
Leng, X.Y.3
-
210
-
-
79953243160
-
An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted and isoproterenol-treated rats
-
Marques FD, Ferreira AJ, Sinisterra RD, et al. An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted and isoproterenol-treated rats. Hypertension. 2011;57:477-483.
-
(2011)
Hypertension
, vol.57
, pp. 477-483
-
-
Marques, F.D.1
Ferreira, A.J.2
Sinisterra, R.D.3
-
211
-
-
84874563950
-
The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats
-
Savergnini SQ, Ianzer D, Carvalho MB, et al. The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats. PLoS One. 2013;8:57757.
-
(2013)
PLoS One
, vol.8
, pp. 57757
-
-
Savergnini, S.Q.1
Ianzer, D.2
Carvalho, M.B.3
-
212
-
-
84862808312
-
AMPK isoform expression in the normal and failing hearts
-
Kim M, Shen M, Ngoy S, et al. AMPK isoform expression in the normal and failing hearts. J Mol Cell Cardiol. 2012;52:1066-1073.
-
(2012)
J Mol Cell Cardiol.
, vol.52
, pp. 1066-1073
-
-
Kim, M.1
Shen, M.2
Ngoy, S.3
-
213
-
-
78650658243
-
Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats
-
Zhang CX, Pan SN, Meng RS, et al. Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats. Clin Exp Pharmacol Physiol. 2011;38:55-62.
-
(2011)
Clin Exp Pharmacol Physiol
, vol.38
, pp. 55-62
-
-
Zhang, C.X.1
Pan, S.N.2
Meng, R.S.3
-
214
-
-
33947574510
-
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overloadinduced cardiac hypertrophy
-
Li HL, Yin R, Chen D, et al. Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overloadinduced cardiac hypertrophy. J Cell Biochem. 2007;100:1086-1099.
-
(2007)
J Cell Biochem.
, vol.100
, pp. 1086-1099
-
-
Li, H.L.1
Yin, R.2
Chen, D.3
-
215
-
-
0036167225
-
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
-
Arad M, Benson DW, Perez-Atayde AR, et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest. 2002;109:357-362.
-
(2002)
J Clin Invest.
, vol.109
, pp. 357-362
-
-
Arad, M.1
Benson, D.W.2
Perez-Atayde, A.R.3
-
216
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
DeBosch B, Treskov I, Lupu TS, et al. Akt1 is required for physiological cardiac growth. Circulation. 2006;113:2097-2104.
-
(2006)
Circulation
, vol.113
, pp. 2097-2104
-
-
Debosch, B.1
Treskov, I.2
Lupu, T.S.3
-
217
-
-
33845703636
-
Akt2 regulates cardiac metabolism and cardiomyocyte survival
-
DeBosch B, Sambandam N, Weinheimer C, et al. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281: 32841-32851.
-
(2006)
J Biol Chem.
, vol.281
, pp. 32841-32851
-
-
Debosch, B.1
Sambandam, N.2
Weinheimer, C.3
-
218
-
-
0034107580
-
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps
-
Wang L, Wang X, Proud CG. Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps. Am J Physiol Heart Circ Physiol. 2000;278:1056-1068.
-
(2000)
Am J Physiol Heart Circ Physiol.
, vol.278
, pp. 1056-1068
-
-
Wang, L.1
Wang, X.2
Proud, C.G.3
-
219
-
-
0037154168
-
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo
-
Antos CL, McKinsey TA, Frey N, et al. Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2002;99:907-912.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 907-912
-
-
Antos, C.L.1
Mckinsey, T.A.2
Frey, N.3
-
220
-
-
0037423666
-
Insulin-like growth factor- 1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium
-
von Lewinski D, Voss K, Hulsmann S, et al. Insulin-like growth factor- 1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium. Circ Res. 2003;92:169-176.
-
(2003)
Circ Res.
, vol.92
, pp. 169-176
-
-
Von Lewinski, D.1
Voss, K.2
Hulsmann, S.3
-
221
-
-
33846318098
-
Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
-
McMullen JR, Amirahmadi F, Woodcock EA, et al. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2007;104:612-617.
-
(2007)
Proc Natl Acad Sci U S a
, vol.104
, pp. 612-617
-
-
McMullen, J.R.1
Amirahmadi, F.2
Woodcock, E.A.3
-
222
-
-
0036284578
-
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth
-
Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail Rev. 2002; 7:175-185.
-
(2002)
Heart Fail Rev.
, vol.7
, pp. 175-185
-
-
Lehman, J.J.1
Kelly, D.P.2
-
223
-
-
29244470231
-
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling
-
Cittadini A, Monti MG, Iaccarino G, et al. Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling. Gene Ther. 2006;13:8-19.
-
(2006)
Gene Ther.
, vol.13
, pp. 8-19
-
-
Cittadini, A.1
Monti, M.G.2
Iaccarino, G.3
-
224
-
-
84876240706
-
PI3K inhibitors as novel cancer therapies: Implications for cardiovascular medicine
-
McLean BA, Zhabyeyev P, Pituskin E, et al. PI3K inhibitors as novel cancer therapies: Implications for cardiovascular medicine. J Card Fail. 2013;19:268-282.
-
(2013)
J Card Fail
, vol.19
, pp. 268-282
-
-
McLean, B.A.1
Zhabyeyev, P.2
Pituskin, E.3
-
225
-
-
33746699629
-
Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
-
Gao XM, Wong G, Wang B, et al. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens. 2006; 24:1663-1670.
-
(2006)
J Hypertens.
, vol.24
, pp. 1663-1670
-
-
Gao, X.M.1
Wong, G.2
Wang, B.3
-
226
-
-
0037382861
-
Rapamycin attenuates loadinduced cardiac hypertrophy in mice
-
Shioi T, McMullen JR, Tarnavski O, et al. Rapamycin attenuates loadinduced cardiac hypertrophy in mice. Circulation. 2003;107:1664-1670.
-
(2003)
Circulation
, vol.107
, pp. 1664-1670
-
-
Shioi, T.1
McMullen, J.R.2
Tarnavski, O.3
-
227
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
228
-
-
77955928444
-
Everolimus: Efficacy and safety in cardiac transplantation
-
Schaffer SA, Ross HJ. Everolimus: efficacy and safety in cardiac transplantation. Expert Opin Drug Saf. 2010;9:843-854.
-
(2010)
Expert Opin Drug Saf.
, vol.9
, pp. 843-854
-
-
Schaffer, S.A.1
Ross, H.J.2
-
229
-
-
33846118941
-
Cardiac effects of growth hormone treatment in chronic heart failure: A meta-analysis
-
Le CP, Hittinger L, Chanson P, et al. Cardiac effects of growth hormone treatment in chronic heart failure: A meta-analysis. J Clin Endocrinol Metab. 2007;92:180-185.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 180-185
-
-
Le, C.P.1
Hittinger, L.2
Chanson, P.3
-
230
-
-
40649119926
-
Growth hormone therapy in congestive heart failure due to left ventricular systolic dysfunction: A meta-analysis
-
Tritos NA, Danias PG. Growth hormone therapy in congestive heart failure due to left ventricular systolic dysfunction: A meta-analysis. Endocr Pract. 2008;14:40-49.
-
(2008)
Endocr Pract.
, vol.14
, pp. 40-49
-
-
Tritos, N.A.1
Danias, P.G.2
-
231
-
-
24944519319
-
Reliability of ventricular remodeling as a surrogate for use in conjunction with clinical outcomes in heart failure
-
Konstam MA. Reliability of ventricular remodeling as a surrogate for use in conjunction with clinical outcomes in heart failure. Am J Cardiol. 2005;96:867-871.
-
(2005)
Am J Cardiol.
, vol.96
, pp. 867-871
-
-
Konstam, M.A.1
|