Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure

Cardiovascular Research

Volumn 58, Issue 3, 2003, Pages 555-564

  Cittadini, Antonio ^a   Monti, Maria Gaia ^a   Isgaard, Jörgen ^b   Casaburi, Cosma ^a   Strömer, Hinrik ^c   Di Gianni, Angela ^a   Serpico, Raffaella ^a   Saldamarco, Lavinia ^a   Vanasia, Massimo ^d   Saccà, Luigi ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d GiEnne Pharma   (Italy)

Author keywords

Antagonists; Connective tissue; Fibrosis; Heart failure; Ventricular arrhythmias

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ALDOSTERONE ANTAGONIST; ALDOSTERONE RECEPTOR; CANRENONE; DRUG METABOLITE; MESSENGER RNA; NORADRENALIN; PLACEBO; RAMIPRIL; SPIRONOLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DIASTOLE; DRESSLER SYNDROME; DRUG EFFECT; ECHOCARDIOGRAPHY; EXPERIMENTAL MODEL; FIBROSING ALVEOLITIS; GENERAL CONDITION IMPROVEMENT; HEART CATHETERIZATION; HEART DILATATION; HEART FAILURE; HEART INFARCTION SIZE; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE FILLING; HEART VENTRICLE REMODELING; HEMODYNAMICS; HISTOLOGY; ISOLATED HEART; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; RAT; SARCOPLASMIC RETICULUM; SYSTOLE; VASCULAR FIBROSIS;

ANIMALS; CALCIUM-TRANSPORTING ATPASES; CANRENONE; DRUG THERAPY, COMBINATION; HEART FAILURE, CONGESTIVE; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NOREPINEPHRINE; RAMIPRIL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ALDOSTERONE; RNA, MESSENGER; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 0037869353     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00251-7     Document Type: Article

References (27)

1. Pitt B., Zannad F., Remme W.J., et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. New Engl J Med. 341:1999;709-717.
2. Weber K.T. Aldosterone in congestive heart failure. New Engl J Med. 345:2001;1689-1697.
3. Silvestre J.-S., Robert V., Heymes C., et al. Myocardial production of aldosterone and corticosterone in the rat. J Biol Chem. 273:1998;4883-4891.
4. Silvestre J.-S., Heymes C., Oubenaïssa A., et al. Activation of cardiac aldosterone in rat myocardial infarction. Effects of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation. 99:1999;2694-2701.
5. Delyani J.A., Robinson E.L., Rudolph A.E. Effect of a selective aldosterone receptor antagonist in myocardial infarction. Am J Physiol. 50:2001;H647-H654.
6. Bauersachs J., Fraccarollo D., Ertl G., et al. Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE inhibition: mechanistic evidence to support RALES. Circulation. 102:2000;2325-2328.
7. Cittadini A., Grossman J.D., Napoli R., et al. Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocardial infarction. J Am Coll Cardiol. 29:1997;1109-1116.
8. Cittadini A., Casaburi C., Monti M.G., et al. Effects of canrenone on myocardial reactive fibrosis in a rat model of postinfarction heart failure. Cardiovasc Drug Ther. 16:2002;195-201.
9. Strömer H., Cittadini A., Szymanska G., Morgan J.P. Validation of different methods to compare isovolumic cardiac function in isolated hearts of varying sizes. Am J Physiol. 272:1997;H501-H510.
10. Kihara Y., Morgan J.P. Intracellular calcium and ventricular fibrillation. Studies in the aequorin-loaded isovolumic ferret heart. Circ Res. 68:1991;1378-1389.
11. Wei S., Chow L.T.C., Shum I.O.L., Qin L., Sanderson J.E. Left and right ventricular collagen type I-III ratios and remodeling post-myocardial infarction. J Card Fail. 5:1999;117-126.
12. Liu Y.H., Yang X.P., Sharov V.G., et al. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type I receptor antagonist in rats with heart failure. J Clin Invest. 99:1997;1926-1935.
13. Van Kerckhoven R., Kalkman E.A.J., Saxena P.R., Schoemaker R.G. Altered cardiac collagen and associated changes in diastolic function of infarcted rat hearts. Cardiovasc Res. 46:2000;316-323.
14. Nwogu J.I., Geenen D., Bean M., et al. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation. 104:2001;2216-2221.
15. Isgaard J., Wahlander H., Adams M.A., Friberg P. Increased expression of growth hormone receptor mRNA and insulin-like growth factor-I mRNA in volume-overloaded hearts. Hypertension. 23:1994;884-888.
16. Omerovic E., Bollano E., Mobini R., et al. Growth hormone improves bioenergetics and decreases catecholamines in postinfarct rat hearts. Endocrinology. 141:2000;4592-4599.
17. Swynghedauw B. Molecular mechanisms of myocardial remodelling. Physiol Rev. 79:1999;215-262.
18. Capasso J.M., Palackal T., Olivetti G., Anversa P. Left ventricular failure induced by long-term hypertension in rats. Circ Res. 66:1990;1400.
19. Conrad C.H., Brooks W.W., Hayes J.A., et al. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 91:1995;161-170.
20. Mihailidou A.S., Bundgaard H., Mardini M., et al. Hyperaldosteronemia in rabbits inhibits the cardiac sarcolemmal Na(+)-K(+) pump. Circ Res. 86:2000;37-42.
21. Ramires F.J., Mansur A., Coelho O., et al. Effects of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy. Am J Cardiol. 85:2000;1207-1211.
22. Towbin J.A., Bowles N.E. The failing heart. Nature. 415:2002;227-233.
23. Hatakeyama H., Miyamori I., Fijita T., et al. Vasuclar aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem. 269:1994;24316-24320.
24. Harada E., Yoshimura M., Yasue H., et al. Aldosterone induces angiotensin-converting enzyme gene expression in cultured neonatal rat cardiocytes. Circulation. 10:(104):2001;137-139.
25. Litwin S.E., Katz S.E., Morgan J.P., Douglas P.S. Long-term captopril treatment improves diastolic filling more than systolic performance in rats with large myocardial infarction. J Am Coll Cardiol. 28:1996;773-781.
26. Brilla C.G., Zhou G., Matsubara L., Weber K.T. Collagen metabolism in cultured adult rat cardiac fibroblast: response to angiotensin II and aldosterone. J Mol Cell Cardiol. 26:1994;809-820.
27. Takeishi Y., Bhagwat A., Ball N.A., et al. Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure. Am J Physiol. 276:1999;H53-H62.