Left ventricular hypertrophy in aortic valve stenosis: Preventive or promotive of systolic dysfunction and heart failure?

European Heart Journal

Volumn 26, Issue 17, 2005, Pages 1790-1796

  Kupari, Markku ^a   Turto, Heikki ^a   Lommi, Jyri ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Aortic valve stenosis; Heart failure; Left ventricular hypertrophy

Indexed keywords

ADULT; AGED; AORTA VALVE STENOSIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; ECHOCARDIOGRAPHY; EUROPE; FEMALE; HEART CATHETERIZATION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; FEMALE; HEART CATHETERIZATION; HEART FAILURE, CONGESTIVE; HEMODYNAMIC PROCESSES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; STROKE VOLUME;

EID: 24044532613     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1093/eurheartj/ehi290     Document Type: Article

References (40)

1. Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 1975;56:56-64.
2. Bonow RO, Carabello BA, deLeon AC Jr, Edmunds HL, Jr, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O'Gara PT, O'Rourke RA, Rahimtoola SH, Ritchie JL, Cheitlin ML, Eagle KA, Gardner TJ, Garson A, Jr, Gibbons RJ, Russell RO, Ryan TJ, Smith SC, Jr. Guidelines for the management of patients with valvular heart disease. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 1998;98:1949-1984.
3. Hill JA, Karimi M, Kutscke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation 2000;101:2863-2869.
4. G-Nitro-L-arginine methyl ester-induced hypertension. Novel molecular adaptation to systolic load in absence of hypertrophy. Circulation 2000;101:423-429.
5. Esposito G, Rapacciuolo A, Prasad SVN, Takaoka H, Thomas SA, Koch WJ, Rockman HA. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 2002;105:85-92.
6. Hill JA, Rothermel BA, Yoo K-D, Cabuay B, Demetroulis E, Weiss RM, Kutschke W, Bassel-Duby R, Williams RS. Targeted inhibition of calcineurin in pressure-overload hypertrophy: preservation of systolic function. J Biol Chem 2002;277:10251-10255.
7. Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, Richardson JA, Hill JA, Olson EN. Activated glycogen synthase-3 suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 2002;99:907-909.
8. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990;322:1561-1566.
9. Lips DJ, DeWindt LJ, van Kraaij, DJW, Doevendans PA. Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy. Eur Heart J 2003;24:883-896.
10. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart. A new therapeutic target? Circulation 2004;109:1580-1589.
11. Kupari M, Turto H, Lommi J. Diagnosing heart failure in aortic valve stenosis. J Intern Med 2004;256:381-388.
12. Helske S, Lindstedt K, Laine M, Mäyränpää M, Werkkala K, Lommi J, Turto H, Kupari M, Kovanen PT. Induction of local angiotensin II-producing systems in stenotic aortic valves. J Am Coll Cardiol 2004;44:1859-1866.
13. Lindroos M, Kupari M, Heikkila J, Tilvis R. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 1993;21:1220-1225.
14. Kupari M, Koskinen P, Virolainen J. Correlates of left ventricular mass in a population sample aged 36 to 37 years. Circulation 1994;89:1050-1059.
15. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450-458.
16. Devereux RB, Lutas EM, Casale PN, Kligfield P, Eisenberg RR, Hammond IW, Miller DH, Reis G, Alderman MH, Laragh JH. Standardization of M-mode echocardiographic left ventricular anatomic measurements. J Am Coll Cardiol 1984;4:1222-1230.
17. The Task Force on Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis of heart failure. Eur Heart J 1995;16:741-751.
18. Gunthers, Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation 1979;59:679-688.
19. Salcedo EE, Korzik DH, Currie PJ, Stewart WJ, Lever HM, Goormastic M. Determinants of left ventricular hypertrophy in aortic valve stenosis. Cleve Clin J Med 1989; 56:590-596.
20. Seiler C, Jenni R. Severe aortic stenosis without left ventricular hypertrophy: prevalence, predictors and short-term follow-up after aortic valve replacement. Heart 1996;76:250-255.
21. Dellgren G, Eriksson MJ, Blange I, Brodin L-Å, Rådegran K, Sylvén C. Angiotensin-converting enzyme gene polymorphism influences degree of left ventricular hypertrophy and its regression in patients undergoing operation for aortic stenosis. Am J Cardiol 1999;84:909-913.
22. Ortlepp JR, Breithardt O, Ohme F, Hanrath P, Hoffman R. Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis. Am Heart J 2001;141:471-483.
23. Carroll JD, Carroll EP, Feldman T, Ward DM, Lang RM, McGaughey D, Karpet RB. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation 1992;86:1099-1107.
24. Douglas PS, Otto CM, Mickel MC, Reid CL, Davis KB. Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry. Br Heart J 1995;73:548-554.
25. Wong KK, Summers KM, Burstow DJ, West MJ. Genetic variants of proteins from the renin angiotensin system are associated with pressure load cardiac hypertrophy. Clin Exp Pharmacol Physiol 1996;23:587-590.
26. Canterin-Antonini F, Huang G, Cervesato E, Faggiano P, Pavan D, Piazza R, Nicolosi GL. Symptomatic aortic stenosis. Does systemic hypertension play a role? Hypertension 2003;41:1268-1272.
27. Otto CM, Burwash IG, Legget ME, Munt BI, Fujioka M, Healy NL, Kraft CD, Miyake-Hull CY, Schwaegleret RG. Prospective study of asymptomatic valvular aortic stenosis. Circulation 1997;95:2262-2270.
28. Rosenhek R, Binder T, Porenta G, Lang I, Christ G, Schemper M, Maurer G, Baumgartner H. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 2000;343:611-617.
29. Pellikka PA, Nishimura RA, Bailey KR, Tajik AJ. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J Am Coll Cardiol 1990;15:1012-1017.
30. Brener SJ, Duffy CI, Thomas JD, Stewart WJ. Progression of aortic stenosis in 394 patients: relation to changes in myocardial and mitral valve dysfunction. J Am Coll Cardiol 1995;25:305-310.
31. Rossi A, Tomaino M, Golia G, Anselmi M, Fuca G, Zardini P. Echocardiographic prediction of clinical outcome in medically treated patients with aortic stenosis. Am Heart J 2000;140:766-771.
32. Aurigemma GP, Silver KH, Priest MA, Gaasch WH. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy. J Am Coll Cardiol 1995;26:195-202.
33. Weinberg EO, Schoen FJ, George D, Douglas PS, Litwin SE, Schunkert H, Benedict CR, Lorellet BH. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure oberload hypertrophy due to ascending aortic stenosis. Circulation 1994;90:1410-1422.
34. Litwin SE, Katz SE, Weinberg EO, Lorell BH, Aurigemma GP, Douglas PS. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Circulation 1995;91:2642-2654.
35. Bruckschlegel G, Holmer SR, Jandelait K, Grimm D, Muders F, Kromer EP, Riegger GAJ, Schunkert H. Blockade of the rennin-angiotensin system in cardiac pressure-overload hypertrophy in rats. Hypertension 1995;25:250-259.
36. Turcani M, Rupp H. Heart failure development in rats with ascending aortic constriction and angiotensin-converting enzyme inhibition. Br J Pharmacol 2000;130:1671-1677.
37. Routledge HC, Townend JN. ACE inhibition in aortic stenosis: dangerous medicine or golden opportunity? J Hum Hypertens 2001;15:659-667.
38. O'Brien KD, Zhao XQ, Shavelle DM, Caulfield MT, Letterer RA, Kapadia SR, Probstfield JL, Otto CM. Hemodynamic effects of the angiotensin-converting enzyme inhibitor, rampiril, in patients with mild to moderate aortic stenosis and preserved left ventricular function. J Investig Med 2004;52:185-191.
39. Chockalingam A, Venkatesan S, Supramaniam T, Jagannathan V, Elangovan S, Alagesan R, Gnanavelu G, Dorairajan S, Krishna BP, Chockalingam V. Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aortic Stenosis (SCOPE-AS). Am Heart J 2004;147:e19.
40. O'Brien KD, Shavelle DM, Caulfield MT, McDonald TO, Olin-Lewis K, Otto CM, Probstfieldt JL. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 2002;106:2224-2230.