Alterations in β3-adrenergic cardiac innervation and nitric oxide signaling in heart failure

Journal of the American College of Cardiology

Volumn 59, Issue 22, 2012, Pages 1988-1990

  Kulandavelu, Shathiyah ^a   Hare, Joshua M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

heart failure; hypertrophy; nitric oxide synthase; oxidative stress; 3 adrenergic receptor

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEBIVOLOL; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

AORTA CONSTRICTION; CARDIOMYOPATHY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME REGULATION; HEART FAILURE; HEART FUNCTION; HEART INNERVATION; HEART MUSCLE INJURY; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SARCOLEMMA; SIGNAL TRANSDUCTION;

EID: 84861505171     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.01.058     Document Type: Editorial

References (23)

1. J.M. Hare, M.M. Givertz, M.A. Creager Increased sensitivity to nitric oxide synthase inhibition in patients with heart failure: potentiation of beta-adrenergic inotropic responsiveness Circulation 97 1998 161 166
2. C. Gauthier, G. Tavernier, F. Charpentier Functional beta3-adrenoceptor in the human heart J Clin Invest 98 1996 556 562
3. C. Gauthier, V. Leblais, L. Kobzik The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle J Clin Invest 102 1998 1377 1384
4. P. Varghese, R.W. Harrison, R.A. Lofthouse Beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility J Clin Invest 106 2000 697 703
5. J.R. Arch beta(3)-Adrenoceptor agonists: potential, pitfalls and progress Eur J Pharmacol 440 2002 99 107
6. S. Moniotte, L. Kobzik, O. Feron Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium Circulation 103 2001 1649 1655
7. J.M. Hare, J.S. Stamler NOS: modulator, not mediator of cardiac performance Nat Med 5 1999 273 274
8. X. Niu, V.L. Watts, O.H. Cingolani Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase J Am Coll Cardiol 59 2012 1979 1987
9. J.M. Hare Nitroso-redox balance in the cardiovascular system N Engl J Med 351 2004 2112 2114
10. T. Damy, P. Ratajczak, E. Robidel Up-regulation of cardiac nitric oxide synthase 1-derived nitric oxide after myocardial infarction in senescent rats FASEB J 17 2003 1934 1936
11. T. Damy, P. Ratajczak, A.M. Shah Increased neuronal nitric oxide synthase-derived NO production in the failing human heart Lancet 363 2004 1365 1367
12. F. Beigi, B.N. Oskouei, M. Zheng Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON Nitric Oxide 21 2009 226 233
13. R.M. Saraiva, K.M. Minhas, S.V. Raju Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium Circulation 112 2005 3415 3422
14. D. Dawson, C.A. Lygate, M.H. Zhang nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction Circulation 112 2005 3729 3737
15. L.A. Barouch, R.W. Harrison, M.W. Skaf Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms Nature 416 2002 337 339
16. S.A. Khan, K. Lee, K.M. Minhas Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling Proc Natl Acad Sci U S A 101 2004 15944 15948
17. D.R. Gonzalez, F. Beigi, A.V. Treuer Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes Proc Natl Acad Sci U S A 104 2007 20612 20617
18. L. Xu, J.P. Eu, G. Meissner Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation Science 279 1998 234 237
19. J.M. Hare, J.S. Stamler NO/redox disequilibrium in the failing heart and cardiovascular system J Clin Invest 115 2005 509 517
20. S.B. Liggett, N.J. Freedman, D.A. Schwinn Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor Proc Natl Acad Sci U S A 90 1993 3665 3669
21. V. Sharma, H. Parsons, M.F. Allard Metoprolol increases the expression of beta(3)-adrenoceptors in the diabetic heart: effects on nitric oxide signaling and forkhead transcription factor-3 Eur J Pharmacol 595 2008 44 51
22. B. Rozec, M. Erfanian, K. Laurent Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart J Am Coll Cardiol 53 2009 1532 1538
23. S.A. Sorrentino, C. Doerries, C. Manes Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional beta1-blockade J Am Coll Cardiol 57 2011 601 611