NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential

Nature Reviews Drug Discovery

Volumn 5, Issue 9, 2006, Pages 755-768

  Evgenov, Oleg V ^a,b   Pacher, Pál ^c   Schmidt, Peter M ^d,e   Haskó, György ^f   Schmidt, Harald H H W ^d,e   Stasch, Johannes Peter ^g  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d MONASH UNIVERSITY   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^g BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL] 5 MORPHOLINO 4,6 PYRIMIDINEDIAMINE; 3 [2 (4 CHLOROPHENYLTHIO)PHENYL] N (4 DIMETHYLAMINOBUTYL)ACRYLAMIDE; 4 [[4 CARBOXYBUTYL[2 [(4 PHENETHYLBENZYL)OXY]PHENETHYL]AMINO]METHYL]BENZOIC ACID; 4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; BAY 60 2770; BAY W 1149; BAY W 1449; CFM 1571; DICARBOXYLIC ACID DERIVATIVE; ENZYME ACTIVATOR; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; GUANYLATE CYCLASE INHIBITOR; GUANYLATE CYCLASE STMULATING AGENT; HEME; HMR 1766; HYDRAZONE DERIVATIVE; INDAZOLE DERIVATIVE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PENTOXIFYLLINE; PHOSPHODIESTERASE V INHIBITOR; S 3448; SILDENAFIL; STREPTOZOCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASODILATOR AGENT;

ATHEROSCLEROSIS; BIOAVAILABILITY; BIOCHEMISTRY; CARDIOVASCULAR DISEASE; CHRONIC DRUG ADMINISTRATION; DOSE RESPONSE; DRUG BINDING; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERANCE; ENZYME ACTIVATION; ERECTILE DYSFUNCTION; HEART FAILURE; HUMAN; HYPERTENSION; HYPOTENSION; KIDNEY FAILURE; KIDNEY FIBROSIS; LIVER CIRRHOSIS; METHEMOGLOBINEMIA; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; DRUG DESIGN; ENZYME ACTIVATION; ENZYME ACTIVATORS; GUANYLATE CYCLASE; HUMANS; MOLECULAR STRUCTURE; NITRIC OXIDE;

EID: 33748312096     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2038     Document Type: Review

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