Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload

Journal of the American College of Cardiology

Volumn 63, Issue 15, 2014, Pages 1569-1579

  Sedej, Simon ^a,b   Schmidt, Albrecht ^a   Denegri, Marco ^c   Walther, Stefanie ^a   Matovina, Marinko ^a   Arnstein, Georg ^a   Gutschi, Eva Maria ^a,b   Windhager, Isabella ^a   Ljubojević, Senka ^a,b   Negri, Sara ^c   Heinzel, Frank R ^a,b   Bisping, Egbert ^a,b   Vos, Marc A ^d   Napolitano, Carlo ^c,e   Priori, Silvia G ^c,e   Kockskämper, Jens ^f   Pieske, Burkert ^a,b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

calcium; heart failure; hypertension; remodeling; sarcoplasmic reticulum

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; PHOSPHOPROTEIN PHOSPHATASE 1; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; CALCIUM; DANTROLENE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHOSPHOLAMBAN; RYANODINE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; GAIN OF FUNCTION MUTATION; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; MORTALITY; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SURVIVAL RATE; WILD TYPE; DISEASE ASSOCIATION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE HYPERTROPHY; OSMOTIC PUMP; PROTEIN PHOSPHORYLATION;

CALCIUM; HEART FAILURE; HYPERTENSION; REMODELING; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA; DNA MUTATIONAL ANALYSIS; HEART FAILURE; MICE; MICE, KNOCKOUT; MUTATION; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

EID: 84901929088     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.11.010     Document Type: Article

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