메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages

CpG-ODN Attenuates Pathological Cardiac Hypertrophy and Heart Failure by Activation of PI3Kα-Akt Signaling

Author keywords

[No Author keywords available]

Indexed keywords

C 274; CPG OLIGODEOXYNUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PROTEIN KINASE B; UNCLASSIFIED DRUG; CPG-OLIGONUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE;

EID: 84876974185     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062373     Document Type: Article
Times cited : (23)

References (31)
  • 2
    • 33846857559 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Friday G, Furie K, Go A, et al. (2007) Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115: e69-171.
    • (2007) Circulation , vol.115
    • Rosamond, W.1    Flegal, K.2    Friday, G.3    Furie, K.4    Go, A.5
  • 3
    • 33846966331 scopus 로고    scopus 로고
    • Differences between pathologic and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure
    • McMullen JR, Jennings GL, (2007) Differences between pathologic and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure. Clinical and experimental pharmacology & physiology 34: 255-262.
    • (2007) Clinical and Experimental Pharmacology & Physiology , vol.34 , pp. 255-262
    • McMullen, J.R.1    Jennings, G.L.2
  • 5
    • 34547665415 scopus 로고    scopus 로고
    • Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface
    • McKinsey TA, Kass DA, (2007) Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. Nat Rev Drug Discov 6: 617-635.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 617-635
    • McKinsey, T.A.1    Kass, D.A.2
  • 6
    • 81755181690 scopus 로고    scopus 로고
    • Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors
    • Li C, Li J, Cai X, Sun H, Jiao J, et al. (2011) Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. J Biol Chem 286: 40782-40791.
    • (2011) J Biol Chem , vol.286 , pp. 40782-40791
    • Li, C.1    Li, J.2    Cai, X.3    Sun, H.4    Jiao, J.5
  • 7
    • 62349105876 scopus 로고    scopus 로고
    • Cardiac regulation by phosphoinositide 3-kinases and PTEN
    • Oudit GY, Penninger JM, (2009) Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovascular research 82: 250-260.
    • (2009) Cardiovascular Research , vol.82 , pp. 250-260
    • Oudit, G.Y.1    Penninger, J.M.2
  • 8
    • 0242381308 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase γ-deficient mice are protected from isoproterenol-induced heart failure
    • Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, et al. (2003) Phosphoinositide 3-kinase γ-deficient mice are protected from isoproterenol-induced heart failure. Circulation 108: 2147-2152.
    • (2003) Circulation , vol.108 , pp. 2147-2152
    • Oudit, G.Y.1    Crackower, M.A.2    Eriksson, U.3    Sarao, R.4    Kozieradzki, I.5
  • 9
    • 34247877577 scopus 로고    scopus 로고
    • The fuzzy logic of physiological cardiac hypertrophy
    • Dorn GW 2nd, (2007) The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49: 962-970.
    • (2007) Hypertension , vol.49 , pp. 962-970
    • Dorn 2nd, G.W.1
  • 11
    • 77954936825 scopus 로고    scopus 로고
    • Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis
    • Davies EJ, Moxham T, Rees K, Singh S, Coats AJ, et al. (2010) Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis. European journal of heart failure 12: 706-715.
    • (2010) European Journal of Heart Failure , vol.12 , pp. 706-715
    • Davies, E.J.1    Moxham, T.2    Rees, K.3    Singh, S.4    Coats, A.J.5
  • 12
    • 78650121847 scopus 로고    scopus 로고
    • Molecular distinction between physiological and pathologic cardiac hypertrophy: experimental findings and therapeutic strategies
    • Bernardo BC, Weeks KL, Pretorius L, McMullen JR, (2010) Molecular distinction between physiological and pathologic cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacology & therapeutics 128: 191-227.
    • (2010) Pharmacology & Therapeutics , vol.128 , pp. 191-227
    • Bernardo, B.C.1    Weeks, K.L.2    Pretorius, L.3    McMullen, J.R.4
  • 13
    • 10744223902 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway
    • McMullen JR, Shioi T, Huang WY, Zhang L, Tarnavski O, et al. (2004) The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. The Journal of biological chemistry 279: 4782-4793.
    • (2004) The Journal of Biological Chemistry , vol.279 , pp. 4782-4793
    • McMullen, J.R.1    Shioi, T.2    Huang, W.Y.3    Zhang, L.4    Tarnavski, O.5
  • 14
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    • Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, et al. (2000) The conserved phosphoinositide 3-kinase pathway determines heart size in mice. The EMBO journal 19: 2537-2548.
    • (2000) The EMBO Journal , vol.19 , pp. 2537-2548
    • Shioi, T.1    Kang, P.M.2    Douglas, P.S.3    Hampe, J.4    Yballe, C.M.5
  • 15
    • 33846318098 scopus 로고    scopus 로고
    • Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
    • McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, et al. (2007) Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 104: 612-617.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 612-617
    • McMullen, J.R.1    Amirahmadi, F.2    Woodcock, E.A.3    Schinke-Braun, M.4    Bouwman, R.D.5
  • 16
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg AM, (2006) Therapeutic potential of Toll-like receptor 9 activation. Nature reviews Drug discovery 5: 471-484.
    • (2006) Nature Reviews Drug Discovery , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 17
    • 33750515851 scopus 로고    scopus 로고
    • Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
    • Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR, (2006) Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovascular research 72: 384-393.
    • (2006) Cardiovascular Research , vol.72 , pp. 384-393
    • Boyd, J.H.1    Mathur, S.2    Wang, Y.3    Bateman, R.M.4    Walley, K.R.5
  • 18
    • 41149145130 scopus 로고    scopus 로고
    • Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9
    • Knuefermann P, Schwederski M, Velten M, Krings P, Ehrentraut H, et al. (2008) Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9. Cardiovascular research 78: 26-35.
    • (2008) Cardiovascular Research , vol.78 , pp. 26-35
    • Knuefermann, P.1    Schwederski, M.2    Velten, M.3    Krings, P.4    Ehrentraut, H.5
  • 19
    • 34247163179 scopus 로고    scopus 로고
    • An Andersen-Tawil syndrome mutation in Kir2.1 (V302M) alters the G-loop cytoplasmic K+ conduction pathway
    • Ma D, Tang XD, Rogers TB, Welling PA, (2007) An Andersen-Tawil syndrome mutation in Kir2.1 (V302M) alters the G-loop cytoplasmic K+ conduction pathway. J Biol Chem 282: 5781-5789.
    • (2007) J Biol Chem , vol.282 , pp. 5781-5789
    • Ma, D.1    Tang, X.D.2    Rogers, T.B.3    Welling, P.A.4
  • 20
    • 77957349183 scopus 로고    scopus 로고
    • The calcium store sensor, STIM1, reciprocally controls Orai and Cav1.2 channels
    • Wang Y, Deng X, Mancarella S, Hendron E, Eguchi S, et al. (2010) The calcium store sensor, STIM1, reciprocally controls Orai and Cav1.2 channels. Science 330: 105-109.
    • (2010) Science , vol.330 , pp. 105-109
    • Wang, Y.1    Deng, X.2    Mancarella, S.3    Hendron, E.4    Eguchi, S.5
  • 21
    • 0141963861 scopus 로고    scopus 로고
    • Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels
    • Tang XD, Xu R, Reynolds MF, Garcia ML, Heinemann SH, et al. (2003) Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature 425: 531-535.
    • (2003) Nature , vol.425 , pp. 531-535
    • Tang, X.D.1    Xu, R.2    Reynolds, M.F.3    Garcia, M.L.4    Heinemann, S.H.5
  • 22
    • 52549127241 scopus 로고    scopus 로고
    • Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
    • Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, et al. (2008) Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway. Nature immunology 9: 1157-1164.
    • (2008) Nature Immunology , vol.9 , pp. 1157-1164
    • Cao, W.1    Manicassamy, S.2    Tang, H.3    Kasturi, S.P.4    Pirani, A.5
  • 23
    • 84890560911 scopus 로고    scopus 로고
    • The TLR9 agonist, CpG-ODN 1826, ameliorates cardiac dysfunction after trauma-hemorrhage
    • Zhang X, Gao M, Ha T, Kalbfleisch JH, Williams DL, et al. (2012) The TLR9 agonist, CpG-ODN 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock.
    • (2012) Shock
    • Zhang, X.1    Gao, M.2    Ha, T.3    Kalbfleisch, J.H.4    Williams, D.L.5
  • 24
    • 84868516625 scopus 로고    scopus 로고
    • CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling
    • Cao Z, Ren D, Ha T, Liu L, Wang X, et al. (2013) CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling. Biochimica et biophysica acta 1832: 96-104.
    • (2013) Biochimica Et Biophysica Acta , vol.1832 , pp. 96-104
    • Cao, Z.1    Ren, D.2    Ha, T.3    Liu, L.4    Wang, X.5
  • 25
    • 77955888865 scopus 로고    scopus 로고
    • TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    • Ha T, Hu Y, Liu L, Lu C, McMullen JR, et al. (2010) TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Cardiovascular research 87: 694-703.
    • (2010) Cardiovascular Research , vol.87 , pp. 694-703
    • Ha, T.1    Hu, Y.2    Liu, L.3    Lu, C.4    McMullen, J.R.5
  • 27
    • 34547121683 scopus 로고    scopus 로고
    • Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism
    • Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, et al. (2007) Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis: an international journal on programmed cell death 12: 1579-1588.
    • (2007) Apoptosis: An International Journal on Programmed Cell Death , vol.12 , pp. 1579-1588
    • Zhang, K.R.1    Liu, H.T.2    Zhang, H.F.3    Zhang, Q.J.4    Li, Q.X.5
  • 29
    • 41149165830 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction
    • Timmers L, Sluijter JP, van Keulen JK, Hoefer IE, Nederhoff MG, et al. (2008) Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circulation research 102: 257-264.
    • (2008) Circulation Research , vol.102 , pp. 257-264
    • Timmers, L.1    Sluijter, J.P.2    van Keulen, J.K.3    Hoefer, I.E.4    Nederhoff, M.G.5
  • 30
    • 0035665486 scopus 로고    scopus 로고
    • Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system
    • Leenen FH, White R, Yuan B, (2001) Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. Am J Physiol Heart Circ Physiol 281: H2410-2416.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Leenen, F.H.1    White, R.2    Yuan, B.3
  • 31
    • 74549187474 scopus 로고    scopus 로고
    • Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure
    • Galindo CL, Skinner MA, Errami M, Olson LD, Watson DA, et al. (2009) Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure. BMC physiology 9: 23.
    • (2009) BMC Physiology , vol.9 , pp. 23
    • Galindo, C.L.1    Skinner, M.A.2    Errami, M.3    Olson, L.D.4    Watson, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.