Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).

Journal of clinical pharmacology

Volumn 50, Issue 4, 2010, Pages 401-414

  Gu, Jessie ^a   Noe, Adele ^b   Chandra, Priya ^b   Al Fayoumi, Suliman ^b   Ligueros Saylan, Monica ^b   Sarangapani, Ramesh ^b   Maahs, Suzanne ^b   Ksander, Gary ^b   Rigel, Dean F ^b   Jeng, Arco Y ^b   Lin, Tsu Han ^b   Zheng, Weiyi ^b   Dole, William P ^b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 BIPHENYL 4 YLMETHYL 3 ETHOXYCARBONYL 1 BUTYLCARBAMOYL)PROPIONATE 3' METHYL 2' (PENTANOYL(2' (TETRAZOL 5 YLATE)BIPHENYL 4' YLMETHYL)AMINO)BUTYRATE; 3-(1-BIPHENYL-4-YLMETHYL-3-ETHOXYCARBONYL-1-BUTYLCARBAMOYL)PROPIONATE-3'-METHYL-2'-(PENTANOYL(2'-(TETRAZOL-5-YLATE)BIPHENYL-4'-YLMETHYL)AMINO)BUTYRATE; AMINOBUTYRIC ACID DERIVATIVE; ANGIOTENSIN RECEPTOR; MEMBRANE METALLOENDOPEPTIDASE; TETRAZOLE DERIVATIVE;

ADOLESCENT; ADULT; ANIMAL; ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOG; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG SCREENING; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RAT; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

ADOLESCENT; ADULT; AMINOBUTYRIC ACIDS; ANIMALS; COHORT STUDIES; CROSS-OVER STUDIES; DOGS; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MIDDLE AGED; NEPRILYSIN; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECEPTORS, ANGIOTENSIN; TETRAZOLES; YOUNG ADULT;

MLCS; MLOWN;

EID: 77956817833     PISSN: None     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009343932     Document Type: Article

References (0)