메뉴 건너뛰기




Volumn 59, Issue 1, 2012, Pages 16-21

Nebivolol: An endothelium-friendly selective β 1- adrenoceptor blocker

Author keywords

blocker; chronic heart failure; hypertension; nitric oxide; reactive oxygen species

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA 1 ADRENERGIC RECEPTOR; N(G),N(G) DIMETHYLARGININE; NEBIVOLOL; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

EID: 84855358922     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182073e27     Document Type: Review
Times cited : (31)

References (69)
  • 1
    • 0022508699 scopus 로고
    • Haemodynamic effects in man during exercise of a single oral dose of Narbivolol (R 67555), a new beta-1-adrenoceptor blocking agent: A comparative study with atenolol, pindolol, and propranolol
    • De Cree J, Geukens H, Leempoels J, et al. Haemodynamic effects in man during exercise of a single oral dose of nebivolol (R 67555), a new beta-1-adrenoceptor blocking agent: a comparative study with atenolol, pindolol and propranolol. Drug Dev Res. 1986;8:109-117. (Pubitemid 16078129)
    • (1986) Drug Development Research , vol.8 , Issue.1-4 , pp. 109-117
    • De Cree, J.1    Geukens, H.2    Leempoels, J.3    Verhaegen, H.4
  • 2
    • 0024211087 scopus 로고
    • The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers
    • Pauwels PJ, Gommeren W, Van Lommen G, et al. The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers. Mol Pharmacol. 1988;34:843-851. (Pubitemid 19014407)
    • (1988) Molecular Pharmacology , vol.34 , Issue.6 , pp. 843-851
    • Pauwels, P.J.1    Gommeren, W.2    Van Lommen, G.3    Janssen, P.A.J.4    Leysen, J.E.5
  • 3
    • 0023910662 scopus 로고
    • Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist
    • Van de Water A, Janssens W, Van Nueten J, et al. Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist. J Cardiovasc Pharmacol. 1988;11:552-563.
    • (1988) J Cardiovasc Pharmacol , vol.11 , pp. 552-563
    • Van De Water, A.1    Janssens, W.2    Van Nueten, J.3
  • 5
    • 0025948189 scopus 로고
    • Nebivolol induces endothelium-dependent relaxations of canine coronary arteries
    • Gao Y, Nagao T, Bond RA, et al. Nebivolol induces endothelium-dependent relaxations of canine coronary arteries. J Cardiovascular Pharmacol. 1991;17:964-969.
    • (1991) J Cardiovascular Pharmacol. , vol.17 , pp. 964-969
    • Gao, Y.1    Nagao, T.2    Bond, R.A.3
  • 6
    • 46849117086 scopus 로고    scopus 로고
    • Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol
    • DOI 10.1111/j.1527-3466.2008.00044.x
    • Ignarro LJ. Different pharmacological properties of two enantiomers in a unique β-blocker, nebivolol. Cardiovasc Ther. 2008;26:115-134. (Pubitemid 351952828)
    • (2008) Cardiovascular Therapeutics , vol.26 , Issue.2 , pp. 115-134
    • Ignarro, L.J.1
  • 7
    • 0142138775 scopus 로고    scopus 로고
    • Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium
    • DOI 10.1016/S0014-2999(03)02116-2
    • Bundkirchen A, Nguyen Q, Brixius K, et al. Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium. Eur J Pharmacol. 2003;476:97-105. (Pubitemid 37315541)
    • (2003) European Journal of Pharmacology , vol.476 , Issue.1-2 , pp. 97-105
    • Bundkirchen, A.1    Nguyen, Q.2    Brixius, K.3    Bolck, B.4    Mehlhorn, U.5    Schwinger, R.H.G.6
  • 8
    • 0034620523 scopus 로고    scopus 로고
    • beta-Adrenergic receptor blockade in chronic heart failure
    • Bristow MR. beta-adrenergic receptor blockade in chronic heart failure. Circulation. 2000;101:558-569. (Pubitemid 30080872)
    • (2000) Circulation , vol.101 , Issue.5 , pp. 558-569
    • Bristow, M.R.1
  • 9
    • 84855356103 scopus 로고    scopus 로고
    • Nebivolol induces lipolysis and uncoupling protein 1 expression in ex-vivo human visceral adipocytes
    • abstract
    • Bordicchia M, Lorena S, Marcucci P, et al. Nebivolol induces lipolysis and uncoupling protein 1 expression in ex-vivo human visceral adipocytes [abstract]. Circulation. 2009;120:S530-S531.
    • (2009) Circulation , vol.120
    • Bordicchia, M.1    Lorena, S.2    Marcucci, P.3
  • 10
    • 0034920596 scopus 로고    scopus 로고
    • Nebivolol induces calcium-independent signaling in endothelial cells by a possible beta-Adrenergic pathway
    • DOI 10.1097/00005344-200108000-00004
    • Gosgnach W, Boixel C, Nevo N, et al. Nebivolol induces calcium independent signaling in endothelial cells by a possible beta-adrenergic pathway. J Cardiovasc Pharmacol. 2001;38:191-199. (Pubitemid 32667145)
    • (2001) Journal of Cardiovascular Pharmacology , vol.38 , Issue.2 , pp. 191-199
    • Gosgnach, W.1    Boixel, C.2    Nevo, N.3    Poiraud, T.4    Michel, J.-B.5
  • 13
    • 65349146446 scopus 로고    scopus 로고
    • Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta
    • Tran Quang T, Rozec B, Audigane L, et al. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta. Br J Pharmacol. 2009;156:601-608.
    • (2009) Br J Pharmacol. , vol.156 , pp. 601-608
    • Tran Quang, T.1    Rozec, B.2    Audigane, L.3
  • 15
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • DOI 10.1007/s00210-003-0832-2
    • Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:23-37. (Pubitemid 38161221)
    • (2004) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.369 , Issue.1 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 16
    • 34247366467 scopus 로고    scopus 로고
    • The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension
    • DOI 10.1111/j.1365-2125.2006.02796.x
    • Lefebvre J, Poirier L, Poirier P, et al. The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension. Br J Clin Pharmacol. 2007;63:575-582. (Pubitemid 46632567)
    • (2007) British Journal of Clinical Pharmacology , vol.63 , Issue.5 , pp. 575-582
    • Lefebvre, J.1    Poirier, L.2    Poirier, P.3    Turgeon, J.4    Lacourciere, Y.5
  • 18
    • 84855351314 scopus 로고    scopus 로고
    • Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: Drug-drug interaction studies
    • Epub ahead of print
    • Lindamood C, Ortiz S, Shaw A, et al. Effects of commonly administered agents and genetics on nebivolol pharmacokinetics: drug-drug interaction studies. J Clin Pharmacol. 2010 [Epub ahead of print].
    • (2010) J Clin Pharmacol
    • Lindamood, C.1    Ortiz, S.2    Shaw, A.3
  • 19
    • 0029129670 scopus 로고
    • Nebivolol vasodilates human forearm vasculature: Evidence for an L-arginine/NO-dependent mechanism
    • Cockcroft JR, Chowienczyk PJ, Brett SE, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995;274:1067-1071.
    • (1995) J Pharmacol Exp Ther. , vol.274 , pp. 1067-1071
    • Cockcroft, J.R.1    Chowienczyk, P.J.2    Brett, S.E.3
  • 22
    • 0036749763 scopus 로고    scopus 로고
    • 1-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms
    • 1-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms. Nitric Oxide. 2002;7:75-82.
    • (2002) Nitric Oxide , vol.7 , pp. 75-82
    • Ignarro, L.J.1    Byrns, R.E.2    Trinh, K.3
  • 24
    • 0037904408 scopus 로고    scopus 로고
    • Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: A novel mechanism for antihypertensive action
    • Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, et al. Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action. Circulation. 2003;107:2747-2752. (Pubitemid 36667251)
    • (2003) Circulation , vol.107 , Issue.21 , pp. 2747-2752
    • Kalinowski, L.1    Dobrucki, L.W.2    Szczepanska-Konkel, M.3    Jankowski, M.4    Martyniec, L.5    Angielski, S.6    Malinski, T.7
  • 26
    • 34047229326 scopus 로고    scopus 로고
    • Effect of dl-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells
    • DOI 10.1016/j.phrs.2006.12.008, PII S1043661807000126
    • Evangelista S, Garbin U, Pasini AF, et al. Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells. Pharmacol Res. 2007;55:303-309. (Pubitemid 46533933)
    • (2007) Pharmacological Research , vol.55 , Issue.4 , pp. 303-309
    • Evangelista, S.1    Garbin, U.2    Pasini, A.F.3    Stranieri, C.4    Boccioletti, V.5    Cominacini, L.6
  • 27
    • 33747809601 scopus 로고    scopus 로고
    • Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity
    • DOI 10.1097/01.fjc.0000238593.67191.e2, PII 0000534420060700000010
    • Mason RP, Kubant R, Jacob RF, et al. Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: role of antioxidant activity. J Cardiovasc Pharmacol. 2006;48:862-869. (Pubitemid 44276465)
    • (2006) Journal of Cardiovascular Pharmacology , vol.48 , Issue.1 , pp. 862-869
    • Mason, R.P.1    Kubant, R.2    Jacob, R.F.3    Walter, M.F.4    Boychuk, B.5    Malinski, T.6
  • 30
    • 36349023095 scopus 로고    scopus 로고
    • 3-adrenergic receptors in endothelial no signaling
    • DOI 10.1074/jbc.M706815200
    • Kou R, Michel T. Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling. J Biol Chem. 2007;282:32719-32729. (Pubitemid 350159316)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 32719-32729
    • Kou, R.1    Michel, T.2
  • 33
    • 77952889195 scopus 로고    scopus 로고
    • The multiple actions of NO
    • Gao Y. The multiple actions of NO. Pflügers Archiv-Eur J Physiol. 2010;459:829-839.
    • (2010) Pflügers Archiv-Eur J Physiol , vol.459 , pp. 829-839
    • Gao, Y.1
  • 34
    • 2942577486 scopus 로고    scopus 로고
    • Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway
    • DOI 10.1161/01.ATV.0000128897.54893.26
    • Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004;24:1023-1030. (Pubitemid 38737826)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.6 , pp. 1023-1030
    • Vallance, P.1    Leiper, J.2
  • 35
    • 36248958181 scopus 로고    scopus 로고
    • Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity
    • DOI 10.1016/j.phrs.2007.09.015, PII S104366180700182X
    • Garbin U, Pasini AF, Stranieri C, et al. Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity. Pharmacol Res. 2007;56:515-521. (Pubitemid 350137774)
    • (2007) Pharmacological Research , vol.56 , Issue.6 , pp. 515-521
    • Garbin, U.1    Pasini, A.F.2    Stranieri, C.3    Manfro, S.4    Boccioletti, V.5    Cominacini, L.6
  • 37
    • 54249107160 scopus 로고    scopus 로고
    • Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients
    • Pasini AF, Garbin U, Stranieri C, et al. Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. Am J Hypertens. 2008;21:1251-1257.
    • (2008) Am J Hypertens. , vol.21 , pp. 1251-1257
    • Pasini, A.F.1    Garbin, U.2    Stranieri, C.3
  • 38
    • 0033038384 scopus 로고    scopus 로고
    • Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: Protective effects of nebivolol
    • DOI 10.1016/S0014-2999(98)00907-8, PII S0014299998009078
    • Janssen PM, Zeitz O, Hasenfuss G. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol. Eur J Pharmacol. 1999;366:223-232. (Pubitemid 29080786)
    • (1999) European Journal of Pharmacology , vol.366 , Issue.2-3 , pp. 223-232
    • Janssen, P.M.L.1    Zeitz, O.2    Hasenfuss, G.3
  • 39
    • 33644875667 scopus 로고    scopus 로고
    • Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans
    • DOI 10.1161/CIRCULATIONAHA.105.556233, PII 0000301720051213000020
    • Mason RP, Kalinowski L, Jacob RF, et al. Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans. Circulation. 2005;112:3795-3801. (Pubitemid 43739521)
    • (2005) Circulation , vol.112 , Issue.24 , pp. 3795-3801
    • Mason, R.P.1    Kalinowski, L.2    Jacob, R.F.3    Jacoby, A.M.4    Malinski, T.5
  • 40
    • 0033779308 scopus 로고    scopus 로고
    • Nebivolol decreases systemic oxidative stress in healthy volunteers
    • Troost R, Schwedhelm E, Rojczyk S, et al. Nebivolol decreases systemic oxidative stress in healthy volunteers. Br J Clin Pharmacol. 2000;50:377-379.
    • (2000) Br J Clin Pharmacol. , vol.50 , pp. 377-379
    • Troost, R.1    Schwedhelm, E.2    Rojczyk, S.3
  • 41
    • 0038351115 scopus 로고    scopus 로고
    • Epidemiology of hypertension and cardiovascular disease in African Americans
    • Flack JM, Ferdinand KC, Nasser SA. Epidemiology of hypertension and cardiovascular disease in African Americans. J Clin Hypertens. 2003;5(suppl 1):5-11.
    • (2003) J Clin Hypertens , vol.5 , Issue.SUPPL. 1 , pp. 5-11
    • Flack, J.M.1    Ferdinand, K.C.2    Nasser, S.A.3
  • 44
    • 33947111435 scopus 로고    scopus 로고
    • Antioxidant activity of carvedilol in cardiovascular disease
    • DOI 10.1097/HJH.0b013e3280127948, PII 0000487220070400000001
    • Dandona P, Ghanim H, Brooks DP. Antioxidant activity of carvedilol in cardiovascular disease. J Hypertens. 2007;25:731-741. (Pubitemid 46398866)
    • (2007) Journal of Hypertension , vol.25 , Issue.4 , pp. 731-741
    • Dandona, P.1    Ghanim, H.2    Brooks, D.P.3
  • 45
    • 33846818459 scopus 로고    scopus 로고
    • Basic Mechanisms of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Injury
    • DOI 10.1016/j.tcm.2006.11.005, PII S1050173806001782
    • Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc Med. 2007;17:48-54. (Pubitemid 46205327)
    • (2007) Trends in Cardiovascular Medicine , vol.17 , Issue.2 , pp. 48-54
    • Papaharalambus, C.A.1    Griendling, K.K.2
  • 46
    • 67650917880 scopus 로고    scopus 로고
    • An in-depth analysis of vasodilation in the management of hypertension: Focus on adrenergic blockade
    • Bakris G. An in-depth analysis of vasodilation in the management of hypertension: focus on adrenergic blockade. J Cardiovasc Pharmacol. 2009;53:379-387.
    • (2009) J Cardiovasc Pharmacol. , vol.53 , pp. 379-387
    • Bakris, G.1
  • 47
    • 77951667288 scopus 로고    scopus 로고
    • Why beta-blockers should not be used as first choice in uncomplicated hypertension
    • De Caterina AR, Leone AM. Why beta-blockers should not be used as first choice in uncomplicated hypertension. Am J Cardiol. 2010;105:1433-1438.
    • (2010) Am J Cardiol. , vol.105 , pp. 1433-1438
    • De Caterina, A.R.1    Leone, A.M.2
  • 48
    • 0035979349 scopus 로고    scopus 로고
    • Nebivolol reverses endothelial dysfunction in essential hypertention: A randomized, double crossover study
    • Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, doubleblind, crossover study. Circulation. 2001;104:511-514. (Pubitemid 32738117)
    • (2001) Circulation , vol.104 , Issue.5 , pp. 511-514
    • Tzemos, N.1    Lim, P.O.2    MacDonald, T.M.3
  • 49
    • 34547841522 scopus 로고    scopus 로고
    • Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension
    • DOI 10.1016/j.ejphar.2007.05.031, PII S0014299907006413
    • Georgescu A, Popov D, Dragan E, et al. Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. Eur J Pharmacol. 2007;570:149-158. (Pubitemid 47247683)
    • (2007) European Journal of Pharmacology , vol.570 , Issue.1-3 , pp. 149-158
    • Georgescu, A.1    Popov, D.2    Dragan, E.3    Dragomir, E.4    Badila, E.5
  • 51
    • 0034035071 scopus 로고    scopus 로고
    • Nebivolol inhibits human aortic smooth muscle cell growth: Effects on cell cycle regulatory proteins
    • DOI 10.1097/00005344-200006000-00003
    • Andre DE, Arnet U, Yang Z, et al. Nebivolol inhibits human aortic smooth muscle cell growth: effects of cell cycle regulatory proteins. J Cardiovasc Pharmacol. 2000;35:845-848. (Pubitemid 30327511)
    • (2000) Journal of Cardiovascular Pharmacology , vol.35 , Issue.6 , pp. 845-848
    • Andre, D.E.1    Arnet, U.2    Yang, Z.3    Luscher, T.F.4
  • 53
    • 0036749818 scopus 로고    scopus 로고
    • Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP
    • DOI 10.1016/S1089-8603(02)00113-1, PII S1089860302001131
    • Ignarro LJ, Sisodia M, Trinh K, et al. Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP. Nitric Oxide. 2002;7:83-90. (Pubitemid 35176999)
    • (2002) Nitric Oxide - Biology and Chemistry , vol.7 , Issue.2 , pp. 83-90
    • Ignarro, L.J.1    Sisodia, M.2    Trinh, K.3    Bedrood, S.4    Wu, G.5    Hua, W.L.6    Buga, G.M.7
  • 56
    • 44349118138 scopus 로고    scopus 로고
    • Beta-blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection
    • DOI 10.1038/ajh.2008.156, PII AJH2008156
    • Mahmud A, Feely J. Beta-blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection. Am J Hypertens. 2008;21:663-667. (Pubitemid 351733365)
    • (2008) American Journal of Hypertension , vol.21 , Issue.6 , pp. 663-667
    • Mahmud, A.1    Feely, J.2
  • 58
    • 73949111388 scopus 로고    scopus 로고
    • B-Adrenergic blockers for chronic heart failure
    • Javed U, Deedwania PC. b-Adrenergic blockers for chronic heart failure. Cardiol Rev. 2009;17:287-292.
    • (2009) Cardiol Rev. , vol.17 , pp. 287-292
    • Javed, U.1    Deedwania, P.C.2
  • 59
    • 19544370840 scopus 로고    scopus 로고
    • Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: Results of the ENECA study
    • DOI 10.1016/j.ejheart.2004.10.015, PII S1388984204002958
    • Edes I, Gasior Z, Wita K. Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study. Eur J Heart Fail. 2005;7:631-639. (Pubitemid 40732997)
    • (2005) European Journal of Heart Failure , vol.7 , Issue.4 , pp. 631-639
    • Edes, I.1    Gasior, Z.2    Wita, K.3
  • 61
    • 36148932514 scopus 로고    scopus 로고
    • Nebivolol in the treatment of chronic heart failure
    • Veverka A, L Salinas J. Nebivolol in the treatment of chronic heart failure. Vasc Health Risk Manag. 2007;3:647-654. (Pubitemid 350104120)
    • (2007) Vascular Health and Risk Management , vol.3 , Issue.5 , pp. 647-654
    • Veverka, A.1    Salinas, J.L.2
  • 62
    • 75149177591 scopus 로고    scopus 로고
    • Regional functions of the left ventricle in patients with coronary slow flow and the effects of nebivolol
    • Gunes Y, Tuncer M, Guntekin U, et al. Regional functions of the left ventricle in patients with coronary slow flow and the effects of nebivolol. Ther Adv Cardiovasc Dis. 2009;3:441-446.
    • (2009) Ther Adv Cardiovasc Dis. , vol.3 , pp. 441-446
    • Gunes, Y.1    Tuncer, M.2    Guntekin, U.3
  • 63
    • 34548824830 scopus 로고    scopus 로고
    • Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation
    • DOI 10.1161/HYPERTENSIONAHA.107.094458, PII 0000426820071000000014
    • Maffei A, Di Pardo A, Carangi R, et al. Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation. Hypertension. 2007;50:652-656. (Pubitemid 47442727)
    • (2007) Hypertension , vol.50 , Issue.4 , pp. 652-656
    • Maffei, A.1    Di, P.A.2    Carangi, R.3    Carullo, P.4    Poulet, R.5    Gentile, M.T.6    Vecchione, C.7    Lembo, G.8
  • 66
    • 46149088232 scopus 로고    scopus 로고
    • Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits
    • de Nigris F, Mancini FP, Balestrieri ML, et al. Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits. Nitric Oxide. 2008;19:57-63.
    • (2008) Nitric Oxide. , vol.19 , pp. 57-63
    • De Nigris, F.1    Mancini, F.P.2    Balestrieri, M.L.3
  • 67
    • 77951287071 scopus 로고    scopus 로고
    • Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    • Toblli J, Cao G, Rivas C, et al. Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats. J Hypertens. 2010;28:1007-1019.
    • (2010) J Hypertens. , vol.28 , pp. 1007-1019
    • Toblli, J.1    Cao, G.2    Rivas, C.3
  • 68
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840-844.
    • (2000) Circ Res. , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 69
    • 0025367154 scopus 로고
    • The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the d-enantiomer
    • DOI 10.1016/0014-2999(90)90087-M
    • Xhonneux R, Wouters L, Reneman RS, et al. The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the d-enantiomer. Eur J Pharmacol. 1990;181:261-265. (Pubitemid 20185899)
    • (1990) European Journal of Pharmacology , vol.181 , Issue.3 , pp. 261-265
    • Xhonneux, R.1    Wouters, L.2    Reneman, R.S.3    Janssen, P.A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.