-
1
-
-
0036733722
-
Treasures and traps in genome-wide data sets: Case examples from yeast
-
Grunenfelder, B. & Winzeler, E. A. Treasures and traps in genome-wide data sets: case examples from yeast. Nature Rev. Genet. 3, 653-661 (2002).
-
(2002)
Nature Rev. Genet
, vol.3
, pp. 653-661
-
-
Grunenfelder, B.1
Winzeler, E.A.2
-
2
-
-
0036250571
-
From sequence to phenotype: Reverse genetics in Drosophila melanogaster
-
Adams, M. D. & Sekelsky, J. J. From sequence to phenotype: reverse genetics in Drosophila melanogaster. Nature Rev. Genet. 3, 189-198 (2002).
-
(2002)
Nature Rev. Genet
, vol.3
, pp. 189-198
-
-
Adams, M.D.1
Sekelsky, J.J.2
-
3
-
-
0346728473
-
Systematic genome-wide screens of gene function
-
Carpenter, A. E. & Sabatini, D. M. Systematic genome-wide screens of gene function. Nature Rev. Genet. 5, 11-22 (2004).
-
(2004)
Nature Rev. Genet
, vol.5
, pp. 11-22
-
-
Carpenter, A.E.1
Sabatini, D.M.2
-
4
-
-
34250216344
-
Image-based multivariate profiling of drug responses from single cells
-
Loo, L.-H., Wu, L. F. & Altschuler, S. J. Image-based multivariate profiling of drug responses from single cells. Nature Methods 4, 445-453 (2007).
-
(2007)
Nature Methods
, vol.4
, pp. 445-453
-
-
Loo, L.-H.1
Wu, L.F.2
Altschuler, S.J.3
-
5
-
-
33749381471
-
Analysis of cell-based RNAi screens
-
Boutros, M., Bras, L. P. & Huber, W. Analysis of cell-based RNAi screens. Genome Biol. 7, R66 (2006).
-
(2006)
Genome Biol
, vol.7
, pp. R66
-
-
Boutros, M.1
Bras, L.P.2
Huber, W.3
-
6
-
-
45549089565
-
The art and design of genetic screens: RNA interference
-
Boutros, M. & Ahringer, J. The art and design of genetic screens: RNA interference. Nature Rev. Genet. 9, 554-566 (2008).
-
(2008)
Nature Rev. Genet
, vol.9
, pp. 554-566
-
-
Boutros, M.1
Ahringer, J.2
-
7
-
-
68349112682
-
Statistical methods for analysis of high-throughput RNA interference screens
-
Birmingham, A. et al. Statistical methods for analysis of high-throughput RNA interference screens. Nature Methods 6, 569-575 (2009).
-
(2009)
Nature Methods
, vol.6
, pp. 569-575
-
-
Birmingham, A.1
-
8
-
-
77955868506
-
Computational solutions to large-scale data management and analysis
-
Schadt, E. E., Linderman, M. D., Sorenson, J., Lee, L. & Nolan, G. P. Computational solutions to large-scale data management and analysis. Nature Rev. Genet. 11, 647-657 (2010).
-
(2010)
Nature Rev. Genet
, vol.11
, pp. 647-657
-
-
Schadt, E.E.1
Linderman, M.D.2
Sorenson, J.3
Lee, L.4
Nolan, G.P.5
-
9
-
-
5544306760
-
Genome-wide high-throughput screens in functional genomics
-
Friedman, A. & Perrimon, N. Genome-wide high-throughput screens in functional genomics. Curr. Opin. Genet. Dev. 14, 470-476 (2004).
-
(2004)
Curr. Opin. Genet. Dev
, vol.14
, pp. 470-476
-
-
Friedman, A.1
Perrimon, N.2
-
10
-
-
77953626646
-
Genomic screening with RNAi: Results and challenges
-
Mohr, S., Bakal, C. & Perrimon, N. Genomic screening with RNAi: results and challenges. Annu. Rev. Biochem. 79, 37-64 (2010).
-
(2010)
Annu. Rev. Biochem
, vol.79
, pp. 37-64
-
-
Mohr, S.1
Bakal, C.2
Perrimon, N.3
-
11
-
-
8444223104
-
Multidimensional drug profiling by automated microscopy
-
Perlman, Z. E. et al. Multidimensional drug profiling by automated microscopy. Science 306, 1194-1198 (2004).
-
(2004)
Science
, vol.306
, pp. 1194-1198
-
-
Perlman, Z.E.1
-
12
-
-
34250882643
-
Quantitative morphological signatures define local signaling networks regulating cell morphology
-
Bakal, C., Aach, J., Church, G. & Perrimon, N. Quantitative morphological signatures define local signaling networks regulating cell morphology. Science 316, 1753-1756 (2007).
-
(2007)
. Science
, vol.316
, pp. 1753-1756
-
-
Bakal, C.1
Aach, J.2
Church, G.3
Perrimon, N.4
-
13
-
-
70349613624
-
An approach for extensibly profiling the molecular states of cellular subpopulations
-
Loo, L.-H. et al. An approach for extensibly profiling the molecular states of cellular subpopulations. Nature Methods 6, 759-765 (2009).
-
(2009)
Nature Methods
, vol.6
, pp. 759-765
-
-
Loo, L.-H.1
-
14
-
-
84860187343
-
Single-cell analysis of population context advances RNAi screening at multiple levels
-
Snijder, B. et al. Single-cell analysis of population context advances RNAi screening at multiple levels. Mol. Systems Biol. 8, 579 (2012).
-
(2012)
Mol. Systems Biol
, vol.8
, pp. 579
-
-
Snijder, B.1
-
15
-
-
84880328076
-
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
-
Yin, Z. et al. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nature Cell Biol. 15, 860-871 (2013).
-
(2013)
. Nature Cell Biol
, vol.15
, pp. 860-871
-
-
Yin, Z.1
-
16
-
-
84902089978
-
A hierarchical map of regulatory genetic interactions in membrane trafficking
-
Liberali, P., Snijder, B. & Pelkmans, L. A hierarchical map of regulatory genetic interactions in membrane trafficking. Cell 157, 1473-1487 (2014).
-
(2014)
Cell
, vol.157
, pp. 1473-1487
-
-
Liberali, P.1
Snijder, B.2
Pelkmans, L.3
-
17
-
-
0018930046
-
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
-
Novick, P., Field, C. & Schekman, R. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21, 205-215 (1980).
-
(1980)
Cell
, vol.21
, pp. 205-215
-
-
Novick, P.1
Field, C.2
Schekman, R.3
-
18
-
-
0034676448
-
Functional genomic analysis of cell division in C. Elegans using RNAi of genes on chromosome III
-
Gonczy, P. et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331-336 (2000).
-
(2000)
Nature
, vol.408
, pp. 331-336
-
-
Gonczy, P.1
-
19
-
-
0034676457
-
Functional genomic analysis of C. Elegans chromosome i by systematic RNA interference
-
Fraser, A. G. et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
-
20
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
Lum, L. et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039-2045 (2003).
-
(2003)
Science
, vol.299
, pp. 2039-2045
-
-
Lum, L.1
-
21
-
-
0141750434
-
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
-
Aza-Blanc, P. et al. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627-637 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 627-637
-
-
Aza-Blanc, P.1
-
22
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
-
Brummelkamp, T. R., Nijman, S. M., Dirac, A. M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003).
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
23
-
-
0038737044
-
Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases
-
Heo, W. D. & Meyer, T. Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases. Cell 113, 315-328 (2003).
-
(2003)
Cell
, vol.113
, pp. 315-328
-
-
Heo, W.D.1
Meyer, T.2
-
24
-
-
0842309871
-
Genome-wide RNAi analysis of growth and viability in Drosophila cells
-
Boutros, M. et al. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303, 832-835 (2004).
-
(2004)
Science
, vol.303
, pp. 832-835
-
-
Boutros, M.1
-
25
-
-
12144288006
-
A resource for large-scale RNA-interference-based screens in mammals
-
Paddison, P. J. et al. A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427-431 (2004).
-
(2004)
Nature
, vol.428
, pp. 427-431
-
-
Paddison, P.J.1
-
26
-
-
77950387346
-
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
-
Neumann, B. et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464, 721-727 (2010).
-
(2010)
Nature
, vol.464
, pp. 721-727
-
-
Neumann, B.1
-
27
-
-
84863205689
-
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
-
Simpson, J. C. et al. Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nature Cell Biol. 14, 764-774 (2012).
-
(2012)
Nature Cell Biol
, vol.14
, pp. 764-774
-
-
Simpson, J.C.1
-
28
-
-
0035957433
-
A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes
-
Stevenson, L. F., Kennedy, B. K. & Harlow, E. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc. Natl Acad. Sci. USA 98, 3946-3951 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 3946-3951
-
-
Stevenson, L.F.1
Kennedy, B.K.2
Harlow, E.3
-
29
-
-
33646483183
-
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells
-
Pritsker, M., Ford, N. R., Jenq, H. T. & Lemischka, I. R. Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 6946-6951 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 6946-6951
-
-
Pritsker, M.1
Ford, N.R.2
Jenq, H.T.3
Lemischka, I.R.4
-
30
-
-
0034331004
-
Chemical genetics: Ligand-based discovery of gene function
-
Stockwell, B. R. Chemical genetics: ligand-based discovery of gene function. Nature Rev. Genet. 1, 116-125 (2000).
-
(2000)
Nature Rev. Genet
, vol.1
, pp. 116-125
-
-
Stockwell, B.R.1
-
31
-
-
27744530147
-
Zinc finger nucleases: Custom-designed molecular scissors for genome engineering of plant and mammalian cells
-
Durai, S. et al. Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res. 33, 5978-5990 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5978-5990
-
-
Durai, S.1
-
32
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller, J. C. et al. A TALE nuclease architecture for efficient genome editing. Nature Biotech. 29, 143-148 (2011).
-
(2011)
Nature Biotech
, vol.29
, pp. 143-148
-
-
Miller, J.C.1
-
33
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S. & Gregory, P. D. Genome editing with engineered zinc finger nucleases. Nature Rev. Genet. 11, 636-646 (2010).
-
(2010)
Nature Rev. Genet
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
34
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
35
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
36
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
-
37
-
-
84892749369
-
Genetic screens in human cells using the CRISPR- Cas9 system
-
Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR- Cas9 system. Science 343, 80-84 (2014).
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
38
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for Genome engineering
-
Hsu, P. D., Lander, E. S. & Zhang, F. Development and applications of CRISPR-Cas9 for Genome engineering. Cell 157, 1262-1278 (2014).
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
39
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi, L. S. et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173-1183 (2013).
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
-
40
-
-
84908352138
-
Genome-scale CRISPR-mediated control of gene repression and activation
-
Gilbert, L. A. et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159, 647-661 (2014).
-
(2014)
Cell
, vol.159
, pp. 647-661
-
-
Gilbert, L.A.1
-
41
-
-
33645520821
-
Small molecules in an RNAi world
-
Eggert, U. S., Field, C. M. & Mitchison, T. J. Small molecules in an RNAi world. Mol. BioSystems 2, 93 (2006).
-
(2006)
Mol. BioSystems
, vol.2
, pp. 93
-
-
Eggert, U.S.1
Field, C.M.2
Mitchison, T.J.3
-
42
-
-
36249031068
-
Recognizing and exploiting differences between RNAi and small-molecule inhibitors
-
Weiss, W. A., Taylor, S. S. & Shokat, K. M. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nature Chem. Biol. 3, 739-744 (2007).
-
(2007)
Nature Chem. Biol
, vol.3
, pp. 739-744
-
-
Weiss, W.A.1
Taylor, S.S.2
Shokat, K.M.3
-
43
-
-
54249117296
-
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds
-
Bakal, C. et al. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 322, 453-456 (2008).
-
(2008)
Science
, vol.322
, pp. 453-456
-
-
Bakal, C.1
-
44
-
-
21844440569
-
Genome-wide analysis of human kinases in clathrin-and caveolae/raft-mediated endocytosis
-
Pelkmans, L. et al. Genome-wide analysis of human kinases in clathrin-and caveolae/raft-mediated endocytosis. Nature 436, 78-86 (2005).
-
(2005)
Nature
, vol.436
, pp. 78-86
-
-
Pelkmans, L.1
-
45
-
-
77949424084
-
Systems survey of endocytosis by multiparametric image analysis
-
Collinet, C. et al. Systems survey of endocytosis by multiparametric image analysis. Nature 464, 243-249 (2010).
-
(2010)
Nature
, vol.464
, pp. 243-249
-
-
Collinet, C.1
-
46
-
-
84870856794
-
RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells
-
Chia, J. et al. RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells. Mol. Systems Biol. 8, 1-33 (2012).
-
(2012)
Mol. Systems Biol
, vol.8
, pp. 1-33
-
-
Chia, J.1
-
47
-
-
38849192515
-
Profiling essential genes in human mammary cells by multiplex RNAi screening
-
Silva, J. M. et al. Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 319, 617-620 (2008).
-
(2008)
Science
, vol.319
, pp. 617-620
-
-
Silva, J.M.1
-
48
-
-
84874113985
-
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
-
Bassik, M. C. et al. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell 152, 909-922 (2013).
-
(2013)
Cell
, vol.152
, pp. 909-922
-
-
Bassik, M.C.1
-
49
-
-
70849098603
-
Haploid genetic screens in human cells identify host factors used by pathogens
-
Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231-1235 (2009).
-
(2009)
Science
, vol.326
, pp. 1231-1235
-
-
Carette, J.E.1
-
50
-
-
0033529707
-
Functional characterization of the S. Cerevisiae genome by gene deletion and parallel analysis
-
Winzeler, E. A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (1999).
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
-
51
-
-
0037173615
-
Functional profiling of the Saccharomyces cerevisiae genome
-
Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391 (2002).
-
(2002)
Nature
, vol.418
, pp. 387-391
-
-
Giaever, G.1
-
52
-
-
77953255163
-
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
-
Kim, D. U. et al. Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nature Biotech. 28, 617-623 (2010).
-
(2010)
Nature Biotech
, vol.28
, pp. 617-623
-
-
Kim, D.U.1
-
53
-
-
77954491295
-
A mouse knockout library for secreted and transmembrane proteins
-
Tang, T. et al. A mouse knockout library for secreted and transmembrane proteins. Nature Biotech. 28, 749-755 (2010).
-
(2010)
Nature Biotech
, vol.28
, pp. 749-755
-
-
Tang, T.1
-
54
-
-
79959198088
-
Mouse library set to be knockout
-
Dolgin, E. Mouse library set to be knockout. Nature 474, 262-263 (2011).
-
(2011)
Nature
, vol.474
, pp. 262-263
-
-
Dolgin, E.1
-
55
-
-
79959210305
-
A conditional knockout resource for the genome-wide study of mouse gene function
-
Skarnes, W. C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337-342 (2011).
-
(2011)
Nature
, vol.474
, pp. 337-342
-
-
Skarnes, W.C.1
-
56
-
-
0344240244
-
Isolation and characterization of a near-haploid human cell line
-
Kotecki, M., Reddy, P. S. & Cochran, B. H. Isolation and characterization of a near-haploid human cell line. Exp. Cell Res. 252, 273-280 (1999).
-
(1999)
Exp. Cell Res
, vol.252
, pp. 273-280
-
-
Kotecki, M.1
Reddy, P.S.2
Cochran, B.H.3
-
57
-
-
80455174608
-
Derivation of haploid embryonic stem cells from mouse embryos
-
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. Nature 479, 131-134 (2011).
-
(2011)
Nature
, vol.479
, pp. 131-134
-
-
Leeb, M.1
Wutz, A.2
-
58
-
-
84884903662
-
A reversible gene trap collection empowers haploid genetics in human cells
-
Burckstummer, T. et al. A reversible gene trap collection empowers haploid genetics in human cells. Nature Methods 10, 965-971 (2013).
-
(2013)
Nature Methods
, vol.10
, pp. 965-971
-
-
Burckstummer, T.1
-
59
-
-
0035861532
-
Systematic genetic analysis with ordered arrays of yeast deletion mutants
-
Tong, A. H. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364-2368 (2001).
-
(2001)
Science
, vol.294
, pp. 2364-2368
-
-
Tong, A.H.1
-
60
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner, M. et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123, 507-519 (2005).
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
-
61
-
-
75649111192
-
The genetic landscape of a cell
-
Costanzo, M. et al. The genetic landscape of a cell. Science 327, 425-431 (2010).
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
-
62
-
-
12344288635
-
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
-
Eggert, U. S. et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, e379 (2004).
-
(2004)
PLoS Biol
, vol.2
, pp. e379
-
-
Eggert, U.S.1
-
63
-
-
78751567879
-
A mammalian functional-genetic approach to characterizing cancer therapeutics
-
Jiang, H., Pritchard, J. R., Williams, R. T., Lauffenburger, D. A. & Hemann, M. T. A mammalian functional-genetic approach to characterizing cancer therapeutics. Nature Chem. Biol. 7, 92-100 (2011).
-
(2011)
Nature Chem. Biol
, vol.7
, pp. 92-100
-
-
Jiang, H.1
Pritchard, J.R.2
Williams, R.T.3
Lauffenburger, D.A.4
Hemann, M.T.5
-
64
-
-
84877303028
-
Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping
-
Laufer, C., Fischer, B., Billmann, M., Huber, W. & Boutros, M. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nature Methods 10, 427-431 (2013).
-
(2013)
Nature Methods
, vol.10
, pp. 427-431
-
-
Laufer, C.1
Fischer, B.2
Billmann, M.3
Huber, W.4
Boutros, M.5
-
65
-
-
84877262605
-
Quantitative genetic-interaction mapping in mammalian cells
-
Roguev, A. et al. Quantitative genetic-interaction mapping in mammalian cells. Nature Methods 10, 432-437 (2013).
-
(2013)
. Nature Methods
, vol.10
, pp. 432-437
-
-
Roguev, A.1
-
66
-
-
79961054838
-
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin
-
Reiling, J. H. et al. A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc. Natl Acad. Sci. USA 108, 11756-11765 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11756-11765
-
-
Reiling, J.H.1
-
67
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie, D. A. et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112 (2009).
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
-
68
-
-
79953283356
-
Genetic interactions in cancer progression and treatment
-
Ashworth, A., Lord, C. J. & Reis, J. S. Genetic interactions in cancer progression and treatment. Cell 145, 30-38 (2011).
-
(2011)
Cell
, vol.145
, pp. 30-38
-
-
Ashworth, A.1
Lord, C.J.2
Reis, J.S.3
-
69
-
-
68849103521
-
Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
-
Bandura, D. R. et al. Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal. Chem. 81, 6813-6822 (2009).
-
(2009)
Anal. Chem
, vol.81
, pp. 6813-6822
-
-
Bandura, D.R.1
-
70
-
-
79955750055
-
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
-
Bendall, S. C. et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332, 687-696 (2011).
-
(2011)
Science
, vol.332
, pp. 687-696
-
-
Bendall, S.C.1
-
71
-
-
84866096861
-
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
-
Bodenmiller, B. et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nature Biotech. 30, 858-867 (2012).
-
(2012)
Nature Biotech
, vol.30
, pp. 858-867
-
-
Bodenmiller, B.1
-
72
-
-
33845792555
-
CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
-
Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
-
(2006)
Genome Biol
, vol.7
, pp. R100
-
-
Carpenter, A.E.1
-
73
-
-
84863208608
-
Biological imaging software tools
-
Eliceiri, K. W. et al. Biological imaging software tools. Nature Methods 9, 697-710 (2012).
-
(2012)
Nature Methods
, vol.9
, pp. 697-710
-
-
Eliceiri, K.W.1
-
74
-
-
33749867157
-
Analyzing proteome topology and function by automated multidimensional fluorescence microscopy
-
Schubert, W. et al. Analyzing proteome topology and function by automated multidimensional fluorescence microscopy. Nature Biotech. 24, 1270-1278 (2006).
-
(2006)
Nature Biotech
, vol.24
, pp. 1270-1278
-
-
Schubert, W.1
-
75
-
-
84875902633
-
Quantum dot imaging platform for single-cell molecular profiling
-
Zrazhevskiy, P. & Gao, X. Quantum dot imaging platform for single-cell molecular profiling. Nature Commun. 4, 1619 (2013).
-
(2013)
Nature Commun
, vol.4
, pp. 1619
-
-
Zrazhevskiy, P.1
Gao, X.2
-
76
-
-
79952769971
-
Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging
-
Valm, A. M. et al. Systems-level analysis of microbial community organization through combinatorial labeling and spectral imaging. Proc. Natl Acad. Sci. USA 108, 4152-4157 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 4152-4157
-
-
Valm, A.M.1
-
77
-
-
77952917698
-
Spatial organization of intracellular communication: Insights from imaging
-
Dehmelt, L. & Bastiaens, P. I. Spatial organization of intracellular communication: insights from imaging. Nature Rev. Mol. Cell Biol. 11, 440-452 (2010).
-
(2010)
Nature Rev. Mol. Cell Biol
, vol.11
, pp. 440-452
-
-
Dehmelt, L.1
Bastiaens, P.I.2
-
78
-
-
80054930783
-
Imaging the coordination of multiple signalling activities in living cells
-
Welch, C. M., Elliott, H., Danuser, G. & Hahn, K. M. Imaging the coordination of multiple signalling activities in living cells. Nature Rev. Mol. Cell Biol. 12, 749-756 (2011).
-
(2011)
Nature Rev. Mol. Cell Biol
, vol.12
, pp. 749-756
-
-
Welch, C.M.1
Elliott, H.2
Danuser, G.3
Hahn, K.M.4
-
79
-
-
70349466529
-
Population context determines cell-to-cell variability in endocytosis and virus infection
-
Snijder, B. et al. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461, 520-523 (2009).
-
(2009)
Nature
, vol.461
, pp. 520-523
-
-
Snijder, B.1
-
80
-
-
70449419850
-
CellClassifier: Supervised learning of cellular phenotypes
-
Ramo, P., Sacher, R., Snijder, B., Begemann, B. & Pelkmans, L. CellClassifier: supervised learning of cellular phenotypes. Bioinformatics 25, 3028-3030 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 3028-3030
-
-
Ramo, P.1
Sacher, R.2
Snijder, B.3
Begemann, B.4
Pelkmans, L.5
-
81
-
-
58149510531
-
CellProfiler Analyst: Data exploration and analysis software for complex image-based screens
-
Jones, T. R. et al. CellProfiler Analyst: data exploration and analysis software for complex image-based screens. BMC Bioinformatics 9, 482 (2008).
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 482
-
-
Jones, T.R.1
-
82
-
-
84899574465
-
Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development
-
Bendall, S. C. et al. Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157, 714-725 (2014).
-
(2014)
Cell
, vol.157
, pp. 714-725
-
-
Bendall, S.C.1
-
84
-
-
78049434350
-
Dimension reduction for high-dimensional data
-
Li, L. Dimension reduction for high-dimensional data. Methods Mol. Biol. 620, 417-434 (2010).
-
(2010)
Methods Mol. Biol
, vol.620
, pp. 417-434
-
-
Li, L.1
-
86
-
-
60549104030
-
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
-
Jones, T. R. et al. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc. Natl Acad. Sci. USA 106, 1826-1831 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1826-1831
-
-
Jones, T.R.1
-
87
-
-
58049200628
-
Characterizing heterogeneous cellular responses to perturbations
-
Slack, M. D., Martinez, E. D., Wu, L. F. & Altschuler, S. J. Characterizing heterogeneous cellular responses to perturbations. Proc. Natl Acad. Sci. USA 105, 19306-193011 (2008).
-
(2008)
. Proc. Natl Acad. Sci. USA
, vol.105
, pp. 19306-193011
-
-
Slack, M.D.1
Martinez, E.D.2
Wu, L.F.3
Altschuler, S.J.4
-
88
-
-
77952257945
-
Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities
-
Singh, D. K. et al. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol. Syst. Biol. 6, 639 (2010).
-
(2010)
Mol. Syst. Biol
, vol.6
, pp. 639
-
-
Singh, D.K.1
-
89
-
-
84863203974
-
Unsupervised modeling of cell morphology dynamics for time-lapse microscopy
-
Zhong, Q., Busetto, A. G., Fededa, J. P., Buhmann, J. M. & Gerlich, D. W. Unsupervised modeling of cell morphology dynamics for time-lapse microscopy. Nature Methods 9, 711-713 (2012).
-
(2012)
Nature Methods
, vol.9
, pp. 711-713
-
-
Zhong, Q.1
Busetto, A.G.2
Fededa, J.P.3
Buhmann, J.M.4
Gerlich, D.W.5
-
90
-
-
80054768631
-
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE
-
Qiu, P. et al. Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nature Biotech. 29, 886-891 (2011).
-
(2011)
Nature Biotech
, vol.29
, pp. 886-891
-
-
Qiu, P.1
-
91
-
-
84887115231
-
Image-based transcriptomics in thousands of single human cells at single-molecule resolution
-
Battich, N., Stoeger, T. & Pelkmans, L. Image-based transcriptomics in thousands of single human cells at single-molecule resolution. Nature Methods 10, 1127-1133 (2013).
-
(2013)
. Nature Methods
, vol.10
, pp. 1127-1133
-
-
Battich, N.1
Stoeger, T.2
Pelkmans, L.3
-
92
-
-
51149203927
-
Canalization of development and the inheritance of acquired characters
-
Waddington, C. H. Canalization of development and the inheritance of acquired characters. Nature 150, 563-565 (1942).
-
(1942)
Nature
, vol.150
, pp. 563-565
-
-
Waddington, C.H.1
-
93
-
-
84874346987
-
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle
-
Kafri, R. et al. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature 494, 480-483 (2013).
-
(2013)
Nature
, vol.494
, pp. 480-483
-
-
Kafri, R.1
-
94
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
-
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M. & Sorger, P. K. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428-432 (2009).
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
Gaudet, S.2
Albeck, J.G.3
Burke, J.M.4
Sorger, P.K.5
-
95
-
-
77952474987
-
Cellular heterogeneity: Do differences make a difference?
-
Altschuler, S. J. & Wu, L. F. Cellular heterogeneity: do differences make a difference? Cell 141, 559-563 (2010).
-
(2010)
Cell
, vol.141
, pp. 559-563
-
-
Altschuler, S.J.1
Wu, L.F.2
-
96
-
-
78951470515
-
Origins of regulated cell-to-cell variability
-
Snijder, B. & Pelkmans, L. Origins of regulated cell-to-cell variability. Nature Rev. Mol. Cell Biol. 12, 119-125 (2011).
-
(2011)
Nature Rev. Mol. Cell Biol
, vol.12
, pp. 119-125
-
-
Snijder, B.1
Pelkmans, L.2
-
97
-
-
79651474934
-
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations
-
Yuan, T. L., Wulf, G., Burga, L. & Cantley, L. C. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr. Biol. 21, 173-183 (2011).
-
(2011)
Curr. Biol
, vol.21
, pp. 173-183
-
-
Yuan, T.L.1
Wulf, G.2
Burga, L.3
Cantley, L.C.4
-
98
-
-
44349186015
-
Mechanism of shape determination in motile cells
-
Keren, K. et al. Mechanism of shape determination in motile cells. Nature 453, 475-480 (2008).
-
(2008)
Nature
, vol.453
, pp. 475-480
-
-
Keren, K.1
-
99
-
-
26944476331
-
Regulated cell-to-cell variation in a cell-fate decision system
-
Colman-Lerner, A. et al. Regulated cell-to-cell variation in a cell-fate decision system. Nature 437, 699-706 (2005).
-
(2005)
Nature
, vol.437
, pp. 699-706
-
-
Colman-Lerner, A.1
-
100
-
-
0014733956
-
Movement and control of division of epithelial-like cells
-
Castor, L. N. Flattening, movement and control of division of epithelial-like cells. J. Cell. Physiol. 75, 57-64 (1970).
-
(1970)
J. Cell. Physiol
, vol.75
, pp. 57-64
-
-
Castor, L.N.1
-
101
-
-
0014423348
-
Species specificity in growth regulatory effects of cellular interaction
-
Eagle, H., Levine, E. M. & Koprowski, H. Species specificity in growth regulatory effects of cellular interaction. Nature 220, 266-269 (1968).
-
(1968)
Nature
, vol.220
, pp. 266-269
-
-
Eagle, H.1
Levine, E.M.2
Koprowski, H.3
-
102
-
-
0014210015
-
Growth regulatory effects of cellular interaction
-
Eagle, H. & Levine, E. M. Growth regulatory effects of cellular interaction. Nature 213, 1102-1106 (1967).
-
(1967)
Nature
, vol.213
, pp. 1102-1106
-
-
Eagle, H.1
Levine, E.M.2
-
103
-
-
77952536835
-
Decision making at a subcellular level determines the outcome of bacteriophage infection
-
Zeng, L. et al. Decision making at a subcellular level determines the outcome of bacteriophage infection. Cell 141, 682-691 (2010).
-
(2010)
Cell
, vol.141
, pp. 682-691
-
-
Zeng, L.1
-
104
-
-
58549110229
-
Determination of cell fate selection during phage λ infection
-
St-Pierre, F. & Endy, D. Determination of cell fate selection during phage λ infection. Proc. Natl Acad. Sci. USA 105, 20705-20710 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 20705-20710
-
-
St-Pierre, F.1
Endy, D.2
-
105
-
-
77951129749
-
Pre-dispositions and epigenetic inheritance in the Escherichia coli lactose operon bistable switch
-
Robert, L. et al. Pre-dispositions and epigenetic inheritance in the Escherichia coli lactose operon bistable switch. Mol. Syst. Biol. 6, 357 (2010).
-
(2010)
Mol. Syst. Biol
, vol.6
, pp. 357
-
-
Robert, L.1
-
106
-
-
84860171972
-
Cell Biology. Using cell-to-cell variability - A new era in molecular biology
-
Pelkmans, L. Cell Biology. Using cell-to-cell variability - a new era in molecular biology. Science 336, 425-426 (2012).
-
(2012)
Science
, vol.336
, pp. 425-426
-
-
Pelkmans, L.1
-
107
-
-
1642276329
-
Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast
-
Halme, A., Bumgarner, S., Styles, C. & Fink, G. R. Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. Cell 116, 405-415 (2004).
-
(2004)
Cell
, vol.116
, pp. 405-415
-
-
Halme, A.1
Bumgarner, S.2
Styles, C.3
Fink, G.R.4
-
108
-
-
33747174575
-
Microbial cell individuality and the underlying sources of heterogeneity
-
Avery, S. V. Microbial cell individuality and the underlying sources of heterogeneity. Nature Rev. Microbiol. 4, 577-587 (2006).
-
(2006)
Nature Rev. Microbiol
, vol.4
, pp. 577-587
-
-
Avery, S.V.1
-
109
-
-
41649102927
-
Control of cell fate by the formation of an architecturally complex bacterial community
-
Vlamakis, H., Aguilar, C., Losick, R. & Kolter, R. Control of cell fate by the formation of an architecturally complex bacterial community. Genes Dev. 22, 945-953 (2008).
-
(2008)
Genes Dev
, vol.22
, pp. 945-953
-
-
Vlamakis, H.1
Aguilar, C.2
Losick, R.3
Kolter, R.4
-
110
-
-
77954056447
-
Direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay
-
Parsons, B. D., Schindler, A., Evans, D. H. & Foley, E. A. Direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay. PLoS ONE 4, e8471 (2009).
-
(2009)
PLoS ONE
, vol.4
, pp. e8471
-
-
Parsons, B.D.1
Schindler, A.2
Evans, D.H.3
Foley, E.A.4
-
111
-
-
84861455657
-
Cell differentiation within a yeast colony: Metabolic and regulatory parallels with a tumor-affected organism
-
Cap, M., Stepanek, L., Harant, K., Vachova, L. & Palkova, Z. Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism. Mol. Cell 46, 436-448 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 436-448
-
-
Cap, M.1
Stepanek, L.2
Harant, K.3
Vachova, L.4
Palkova, Z.5
-
112
-
-
73349095048
-
Systematic mapping of genetic interaction networks
-
Dixon, S. J., Costanzo, M., Baryshnikova, A., Andrews, B. & Boone, C. Systematic mapping of genetic interaction networks. Annu. Rev. Genet. 43, 601-625 (2009).
-
(2009)
Annu. Rev. Genet
, vol.43
, pp. 601-625
-
-
Dixon, S.J.1
Costanzo, M.2
Baryshnikova, A.3
Andrews, B.4
Boone, C.5
-
114
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong, A. H. Y. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004).
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Tong, A.H.Y.1
-
115
-
-
78650475398
-
Phenotypic landscape of a bacterial cell
-
Nichols, R. J. et al. Phenotypic landscape of a bacterial cell. Cell 144, 143-156 (2011).
-
(2011)
Cell
, vol.144
, pp. 143-156
-
-
Nichols, R.J.1
-
116
-
-
79953289737
-
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
-
Horn, T. et al. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nature Methods 8, 341-U391 (2011).
-
(2011)
Nature Methods
, vol.8
, pp. 341-U391
-
-
Horn, T.1
-
117
-
-
84872821321
-
Dissection of DNA damage responses using multiconditional genetic interaction maps
-
Guinoli, A. et al. Dissection of DNA damage responses using multiconditional genetic interaction maps. Mol. Cell 49, 346-358 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 346-358
-
-
Guinoli, A.1
-
118
-
-
78649703966
-
Rewiring of genetic networks in response to DNA damage
-
Bandyopadhyay, S. et al. Rewiring of genetic networks in response to DNA damage. Science 330, 1385-1389 (2010).
-
(2010)
Science
, vol.330
, pp. 1385-1389
-
-
Bandyopadhyay, S.1
-
120
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
Santos, S. D. M., Verveer, P. J. & Bastiaens, P. I. H. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nature Cell Biol. 9, 324-U139 (2007).
-
(2007)
Nature Cell Biol
, vol.9
, pp. 324-U139
-
-
Santos, S.D.M.1
Verveer, P.J.2
Bastiaens, P.I.H.3
-
121
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protoc. 4, 44-57 (2009).
-
(2009)
Nature Protoc
, vol.4
, pp. 44-57
-
-
Huang, D.W.1
Sherman, B.T.2
Lempicki, R.A.3
-
122
-
-
78651324347
-
The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
-
Szklarczyk, D. et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39, D561-D568 (2011).
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D561-D568
-
-
Szklarczyk, D.1
-
123
-
-
78651332286
-
Pathway Commons, a web resource for biological pathway data
-
Cerami, E. G. et al. Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res. 39, D685-D690 (2011).
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D685-D690
-
-
Cerami, E.G.1
-
124
-
-
78650373804
-
Network medicine: A network-based approach to human disease
-
Barabasi, A. L., Gulbahce, N. & Loscalzo, J. Network medicine: a network-based approach to human disease. Nature Rev. Genet. 12, 56-68 (2011).
-
(2011)
Nature Rev. Genet
, vol.12
, pp. 56-68
-
-
Barabasi, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
125
-
-
77649213364
-
How to understand the cell by breaking it: Network analysis of gene perturbation screens
-
Markowetz, F. How to understand the cell by breaking it: network analysis of gene perturbation screens. PLoS Comput. Biol. 6, e1000655 (2010).
-
(2010)
PLoS Comput. Biol
, vol.6
, pp. e1000655
-
-
Markowetz, F.1
-
126
-
-
33745561205
-
An introduction to variable and feature selection
-
Guyon, I. & Elisseeff, A. An introduction to variable and feature selection. J. Machine Learn. Res. 3, 1157-1182 (2003).
-
(2003)
J. Machine Learn. Res
, vol.3
, pp. 1157-1182
-
-
Guyon, I.1
Elisseeff, A.2
-
127
-
-
84873290420
-
Inference of gene regulatory networks from genome-wide knockout fitness data
-
Wang, L., Wang, X., Arkin, A. P. & Samoilov, M. S. Inference of gene regulatory networks from genome-wide knockout fitness data. Bioinformatics 29, 338-346 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 338-346
-
-
Wang, L.1
Wang, X.2
Arkin, A.P.3
Samoilov, M.S.4
-
128
-
-
34249041230
-
Exploring genetic interactions and networks with yeast
-
Boone, C., Bussey, H. & Andrews, B. J. Exploring genetic interactions and networks with yeast. Nature Rev. Genet. 8, 437-449 (2007).
-
(2007)
Nature Rev. Genet
, vol.8
, pp. 437-449
-
-
Boone, C.1
Bussey, H.2
Andrews, B.J.3
-
129
-
-
77953245945
-
Automated identification of pathways from quantitative genetic interaction data
-
Battle, A., Jonikas, M. C., Walter, P., Weissman, J. S. & Koller, D. Automated identification of pathways from quantitative genetic interaction data. Mol. Syst. Biol. 6, 379 (2010).
-
(2010)
Mol. Syst. Biol
, vol.6
, pp. 379
-
-
Battle, A.1
Jonikas, M.C.2
Walter, P.3
Weissman, J.S.4
Koller, D.5
-
130
-
-
84873290420
-
Inference of gene regulatory networks from genome-wide knockout fitness data
-
Wang, L. M., Wang, X. D., Arkin, A. P. & Samoilov, M. S. Inference of gene regulatory networks from genome-wide knockout fitness data. Bioinformatics 29, 338-346 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 338-346
-
-
Wang, L.M.1
Wang, X.D.2
Arkin, A.P.3
Samoilov, M.S.4
-
131
-
-
0032441150
-
Cluster analysis and display of genome-wide expression patterns
-
Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA 95, 14863-14868 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 14863-14868
-
-
Eisen, M.B.1
Spellman, P.T.2
Brown, P.O.3
Botstein, D.4
-
132
-
-
0034616930
-
Functional discovery via a compendium of expression profiles
-
Hughes, T. R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
-
133
-
-
23844494458
-
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
-
Gunsalus, K. C. et al. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Nature 436, 861-865 (2005).
-
(2005)
Nature
, vol.436
, pp. 861-865
-
-
Gunsalus, K.C.1
-
134
-
-
61349119934
-
Functional organization of the S. Cerevisiae phosphorylation network
-
Fiedler, D. et al. Functional organization of the S. cerevisiae phosphorylation network. Cell 136, 952-963 (2009).
-
(2009)
Cell
, vol.136
, pp. 952-963
-
-
Fiedler, D.1
-
135
-
-
0036848010
-
Sequential activation of signaling pathways during innate immune responses in
-
Boutros, M., Agaisse, H. & Perrimon, N. Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev. Cell 3, 711-722 (2002).
-
(2002)
Drosophila. Dev. Cell
, vol.3
, pp. 711-722
-
-
Boutros, M.1
Agaisse, H.2
Perrimon, N.3
-
136
-
-
27744489138
-
Non-transcriptional pathway features reconstructed from secondary effects of RNA interference
-
Markowetz, F., Bloch, J. & Spang, R. Non-transcriptional pathway features reconstructed from secondary effects of RNA interference. Bioinformatics 21, 4026-4032 (2005).
-
(2005)
Bioinformatics
, vol.21
, pp. 4026-4032
-
-
Markowetz, F.1
Bloch, J.2
Spang, R.3
-
137
-
-
34547840242
-
Nested effects models for high-dimensional phenotyping screens
-
Markowetz, F., Kostka, D., Troyanskaya, O. G. & Spang, R. Nested effects models for high-dimensional phenotyping screens. Bioinformatics 23, i305-i312 (2007).
-
(2007)
Bioinformatics
, vol.23
, pp. i305-i312
-
-
Markowetz, F.1
Kostka, D.2
Troyanskaya, O.G.3
Spang, R.4
-
138
-
-
84887104223
-
Predicting functional gene interactions with the hierarchical interaction score
-
Snijder, B., Liberali, P., Frechin, M., Stoeger, T. & Pelkmans, L. Predicting functional gene interactions with the hierarchical interaction score. Nature Methods 10, 1089-1092 (2013).
-
(2013)
Nature Methods
, vol.10
, pp. 1089-1092
-
-
Snijder, B.1
Liberali, P.2
Frechin, M.3
Stoeger, T.4
Pelkmans, L.5
-
139
-
-
37249026328
-
Integrating high-content screening and ligand-target prediction to identify mechanism of action
-
Young, D. W. et al. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nature Chem. Biol. 4, 59-68 (2007).
-
(2007)
Nature Chem. Biol
, vol.4
, pp. 59-68
-
-
Young, D.W.1
-
140
-
-
3242683662
-
Single cell profiling of potentiated phospho-protein networks in cancer cells
-
Irish, J. M. et al. Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell 118, 217-228 (2004).
-
(2004)
Cell
, vol.118
, pp. 217-228
-
-
Irish, J.M.1
-
141
-
-
0037119587
-
Stochastic gene expression in a single cell
-
Elowitz, M. B. Stochastic gene expression in a single cell. Science 297, 1183-1186 (2002).
-
(2002)
Science
, vol.297
, pp. 1183-1186
-
-
Elowitz, M.B.1
-
142
-
-
77956520011
-
Functional roles for noise in genetic circuits
-
Eldar, A. & Elowitz, M. B. Functional roles for noise in genetic circuits. Nature 467, 167-173 (2010).
-
(2010)
Nature
, vol.467
, pp. 167-173
-
-
Eldar, A.1
Elowitz, M.B.2
-
143
-
-
77249114260
-
Variability in gene expression underlies incomplete penetrance
-
Raj, A., Rifkin, S. A., Andersen, E. & van Oudenaarden, A. Variability in gene expression underlies incomplete penetrance. Nature 463, 913-918 (2010).
-
(2010)
Nature
, vol.463
, pp. 913-918
-
-
Raj, A.1
Rifkin, S.A.2
Andersen, E.3
Van Oudenaarden, A.4
-
144
-
-
84859641038
-
Using gene expression noise to understand gene regulation
-
Munsky, B., Neuert, G. & van Oudenaarden, A. Using gene expression noise to understand gene regulation. Science 336, 183-187 (2012).
-
(2012)
Science
, vol.336
, pp. 183-187
-
-
Munsky, B.1
Neuert, G.2
Van Oudenaarden, A.3
-
145
-
-
4544346660
-
Robustness of cellular functions
-
Stelling, J. et al. Robustness of cellular functions. Cell 118, 675-685 (2004).
-
(2004)
Cell
, vol.118
, pp. 675-685
-
-
Stelling, J.1
-
146
-
-
70349445264
-
Systems biology of stem cell fate and cellular reprogramming
-
Macarthur, B. D., Ma'ayan, A. & Lemischka, I. R. Systems biology of stem cell fate and cellular reprogramming. Nature Rev. Mol. Cell Biol. 10, 672-681 (2009).
-
(2009)
Nature Rev. Mol. Cell Biol
, vol.10
, pp. 672-681
-
-
Macarthur, B.D.1
Ma'ayan, A.2
Lemischka, I.R.3
-
147
-
-
82555169814
-
Robust selection of sensory organ precursors by the Notch-δ pathway
-
Barad, O. et al. Robust selection of sensory organ precursors by the Notch-δ pathway. Curr. Opin. Cell Biol. 23, 663-667 (2011).
-
(2011)
Curr. Opin. Cell Biol
, vol.23
, pp. 663-667
-
-
Barad, O.1
-
148
-
-
79959433547
-
From the stochasticity of molecular processes to the variability of synaptic transmission
-
Ribrault, C., Sekimoto, K. & Triller, A. From the stochasticity of molecular processes to the variability of synaptic transmission. Nature Rev. Neurosci. 12, 375-387 (2011).
-
(2011)
Nature Rev. Neurosci
, vol.12
, pp. 375-387
-
-
Ribrault, C.1
Sekimoto, K.2
Triller, A.3
-
149
-
-
54249137797
-
Feedback loops shape cellular signals in space and time
-
Brandman, O. & Meyer, T. Feedback loops shape cellular signals in space and time. Science 322, 390-395 (2008).
-
(2008)
Science
, vol.322
, pp. 390-395
-
-
Brandman, O.1
Meyer, T.2
-
150
-
-
77954243855
-
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions
-
Connelly, J. T. et al. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biol. 12, 711-718 (2010).
-
(2010)
Nature Cell Biol
, vol.12
, pp. 711-718
-
-
Connelly, J.T.1
-
151
-
-
33747152561
-
Matrix elasticity directs stem cell lineage specification
-
Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677-689 (2006).
-
(2006)
Cell
, vol.126
, pp. 677-689
-
-
Engler, A.J.1
Sen, S.2
Sweeney, H.L.3
Discher, D.E.4
-
152
-
-
84893421205
-
Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates
-
Ullal, A. V. et al. Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci. Transl Med. 6, 219ra9 (2014).
-
(2014)
Sci. Transl Med
, vol.6
, pp. 219-229
-
-
Ullal, A.V.1
-
153
-
-
84895541878
-
Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT
-
Jungmann, R. et al. Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT. Nature Methods 11, 313-318 (2014).
-
(2014)
Nature Methods
, vol.11
, pp. 313-318
-
-
Jungmann, R.1
-
154
-
-
84863202666
-
Single-cell systems biology by super-resolution imaging and combinatorial labeling
-
Lubeck, E. & Cai, L. Single-cell systems biology by super-resolution imaging and combinatorial labeling. Nature Methods 9, 743-748 (2012).
-
(2012)
Nature Methods
, vol.9
, pp. 743-748
-
-
Lubeck, E.1
Cai, L.2
-
155
-
-
84880357794
-
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
-
Gerdes, M. J. et al. Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue. Proc. Natl Acad. Sci. USA 110, 11982-11987 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 11982-11987
-
-
Gerdes, M.J.1
|