Sequential activation of signaling pathways during innate immune responses in Drosophila

Developmental Cell

Volumn 3, Issue 5, 2002, Pages 711-722

  Boutros, Michael ^a   Agaisse, Hervé ^a,b   Perrimon, Norbert ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; METAZOON; NONHUMAN; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ARACHNIDA; BACTERIA (MICROORGANISMS); HEXAPODA; METAZOA;

EID: 0036848010     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00325-8     Document Type: Article

References (52)

1. Aderem, A., and Ulevitch, R. (2000). Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787.
2. Akira, S., Takeda, K., and Kaisho, T. (2001). Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680.
3. Alexopoulou, L., Holt, A.C., Medzhitov, R., and Flavell, R.A. (2001). Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413, 732-738.
4. Anderson, K.V., Bokla, L., and Nusslein-Volhard, C. (1985). Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42, 791-798.
5. Barillas-Mury, C., Han, Y.S., Seeley, D., and Kafatos, F.C. (1999). Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection. EMBO J. 18, 959-967.
6. Boutros, M., Paricio, N., Strutt, D.I., and Mlodzik, M. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94, 109-118.
7. Chu, S., DeRisi, J., Eisen, M., Mulholland, J., Botstein, D., Brown, P.O., and Herskowitz, I. (1998). The transcriptional program of sporulation in budding yeast. Science 282, 699-705.
8. Clemens, J.C., Worby, C.A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B.A., and Dixon, J.E. (2000). Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. USA 97, 6499-6503.
9. De Gregorio, E., Spellman, P.T., Rubin, G.M., and Lemaitre, B. (2001). Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc. Natl. Acad. Sci. USA 98, 12590-12595.
10. Dong, C., Yang, D.D., Tournier, C., Whitmarsh, A.J., Xu, J., Davis, R.J., and Flavell, R.A. (2000). JNK is required for effector T-cell function but not for T-cell activation. Nature 405, 91-94.
11. Eisen, M.B., Spellman, P.T., Brown, P.O., and Botstein, D. (1998). Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14863-14868.
12. Ekengren, S., and Hultmark, D. (2001). A family of Turandot-related genes in the humoral stress response of Drosophila. Biochem. Biophys. Res. Commun. 284, 998-1003.
13. Fearon, D.T., and Locksley, R.M. (1996). The instructive role of innate immunity in the acquired immune response. Science 272, 50-53.
14. Ge, B., Gram, H., Di Padova, F., Huang, B., New, L., Ulevitch, R.J., Luo, Y., and Han, J. (2002). MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295, 1291-1294.
15. Georgel, P., Naitza, S., Kappler, C., Ferrandon, D., Zachary, D., Swimmer, C., Kopczynski, C., Duyk, G., Reichhart, J.M., and Hoffmann, J.A. (2001). Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev. Cell 1, 503-514.
16. Glise, B., Bourbon, H., and Noselli, S. (1995). Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83, 451-461.
17. Hambleton, J., Weinstein, S.L., Lem, L., and DeFranco, A.L. (1996). Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93, 2774-2778.
18. Han, Z.S., and Ip, Y.T. (1999). Interaction and specificity of Relrelated proteins in regulating Drosophila immunity gene expression. J. Biol. Chem. 274, 21355-21361.
19. Hayashi, F., Smith, K.D., Ozinsky, A., Hawn, T.R., Yi, E.C., Goodlett, D.R., Eng, J.K., Akira, S., Underhill, D.M., and Aderem, A. (2001). The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099-1103.
20. Hedengren, M., Asling, B., Dushay, M.S., Ando, I., Ekengren, S., Wihlborg, M., and Hultmark, D. (1999). Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Mol. Cell 4, 827-837.
21. Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., and Ezekowitz, R.A. (1999). Phylogenetic perspectives in innate immunity. Science 284, 1313-1318.
22. Hou, X.S., and Perrimon, N. (1997). The JAK-STAT pathway in Drosophila. Trends Genet. 13, 105-110.
23. Ihle, J.N. (2001). The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13, 211-217.
24. Irving, P., Troxler, L., Heuer, T.S., Belvin, M., Kopczynski, C., Reichhart, J.M., Hoffmann, J.A., and Hetru, C. (2001). A genome-wide analysis of immune responses in Drosophila. Proc. Natl. Acad. Sci. USA 11, 11.
25. Jacinto, A., Martinez-Arias, A., and Martin, P. (2001). Mechanisms of epithelial fusion and repair. Nat. Cell Biol. 3, E117-E123.
26. Janeway, C.A., Jr. (1989). Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1-13.
27. Jasper, H., Benes, V., Schwager, C., Sauer, S., Clauder-Munster, S., Ansorge, W., and Bohmann, D. (2001). The genomic response of the Drosophila embryo to JNK signaling. Dev. Cell 1, 579-586.
28. Kyriakis, J.M., and Avruch, J. (2001). Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869.
29. Kimbrell, D.A., and Beutler, B. (2001). The evolution and genetics of innate immunity. Nat. Rev. Genet. 2, 256-267.
30. Lagueux, M., Perrodou, E., Levashina, E.A., Capovilla, M., and Hoffmann, J.A. (2000). Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc. Natl. Acad. Sci. USA 97, 11427-11432.
31. Lemaitre, B., Kromer-Metzger, E., Michaut, L., Nicolas, E., Meister, M., Georgel, P., Reichhart, J.M., and Hoffmann, J.A. (1995a). A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. USA 92, 9465-9469.
32. Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J.M., and Hoffmann, J.A. (1995b). Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 14, 536-545.
33. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., and Hoffmann, J.A. (1996). The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.
34. Li, C., and Wong, W.H. (2001). Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. USA 98, 31-36.
35. Lu, Y., Wu, L.P., and Anderson, K.V. (2001). The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. Genes Dev. 15, 104-110.
36. Martin-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A.M., and Martinez-Arias, A. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12, 557-570.
37. Michel, T., Reichhart, J.M., Hoffmann, J.A., and Royet, J. (2001). Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414, 756-759.
38. Perrimon, N., and Mahowald, A.P. (1986). I(1)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev. Biol. 118, 28-41.
39. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Huffel, C.V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998). Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088.
40. Ramet, M., Lanot, R., Zachary, D., and Manfruelli, P. (2002). JNK signaling pathway is required for efficient wound healing in Drosophila. Dev. Biol. 241, 145-156.
41. Ravanti, L., and Kahari, V.M. (2000). Matrix metalloproteinases in wound repair. Int. J. Mol. Med. 6, 391-407.
42. Reedy, M.C., Bullard, B., and Vigoreaux, J.O. (2000). Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles. J. Cell Biol. 151, 1483-1500.
43. Samakovlis, C., Asling, B., Boman, H.G., Gateff, E., and Hultmark, D. (1992). In vitro induction of cecropin genes-an immune response in a Drosophila blood cell line. Biochem. Biophys. Res. Commun. 188, 1169-1175.
44. Schnare, M., Barton, G.M., Holt, A.C., Takeda, K., Akira, S., and Medzhitov, R. (2001). Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2, 947-950.
45. Silverman, N., Zhou, R., Stoven, S., Pandey, N., Hultmark, D., and Maniatis, T. (2000). A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14, 2461-2471.
46. Sluss, H.K., Han, Z., Barrett, T., Davis, R.J., and Ip, Y.T. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10, 2745-2758.
47. Stronach, B.E., and Perrimon, N. (1999). Stress signaling in Drosophila. Oncogene 18, 6172-6182.
48. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., and Akira, S. (1999). Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
49. Vidal, S., Khush, R.S., Leulier, F., Tzou, P., Nakamura, M., and Lemaitre, B. (2001). Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev. 15, 1900-1912.
50. Weston, C.R., and Davis, R.J. (2002). The JNK signal transduction pathway. Curr. Opin. Genet. Dev. 12, 14-21.
51. Wodicka, L., Dong, H., Mittmann, M., Ho, M.H., and Lockhart, D.J. (1997). Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat. Biotechnol. 15, 1359-1367.
52. Yamanaka, H., Moriguchi, T., Masuyama, N., Kusakabe, M., Hanafusa, H., Takada, R., Takada, S., and Nishida, E. (2002). JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3, 69-75.