Global Mapping of the Yeast Genetic Interaction Network

Science

Volumn 303, Issue 5659, 2004, Pages 808-813

  Tong, Amy Hin Yan ^a,b   Lesage, Guillaume ^c   Bader, Gary D ^d   Ding, Huiming ^a   Xu, Hong ^a,b   Xin, Xiaofeng ^a,b   Young, James ^e   Berriz, Gabriel F ^f   Brost, Renee L ^a   Chang, Michael ^b   Chen, YiQun ^a   Cheng, Xin ^a   Chua, Gordon ^a   Friesen, Helena ^b   Goldberg, Debra S ^f   Haynes, Jennifer ^b   Humphries, Christine ^b   He, Grace ^a   Hussein, Shamiza ^c   Ke, Lizhu ^a   Krogan, Nevan ^a,b   Li, Zhijian ^a,b   Levinson, Joshua N ^c   Lu, Hong ^a   Ménard, Patrice ^c   Munyana, Christella ^c   Parsons, Ainslie B ^a,b   Ryan, Owen ^a   Tonikian, Raffi ^a,b   Roberts, Tania ^b   Sdicu, Anne Marie ^c   Shapiro, Jesse ^c   Sheikh, Bilal ^a   Suter, Bernhard ^g   Wong, Sharyl L ^f   Zhang, Lan V ^f   Zhu, Hongwei ^a   Burd, Christopher G ^h   Munro, Sean ⁱ   Sander, Chris ^d   Rine, Jasper ^g   Greenblatt, Jack ^a,b   Peter, Matthias ^j   Bretscher, Anthony ^e   Bell, Graham ^c   Roth, Frederick P ^f   Brown, Grant W ^b   Andrews, Brenda ^b   Bussey, Howard ^c   Boone, Charles ^a,b   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^j ETH ZURICH   (Switzerland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DEFECTS; MUTAGENESIS; YEAST;

GENETIC INTERACTION NETWORK; MUTANTS;

GENES;

YEAST;

ARTICLE; FUNGAL GENE; GENE CLUSTER; GENE FUNCTION; GENE MAPPING; MOLECULAR INTERACTION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; CYSTIC FIBROSIS; GENE DELETION; GENES, ESSENTIAL; GENES, FUNGAL; GENETIC DISEASES, INBORN; GENOTYPE; HUMANS; MOLECULAR SEQUENCE DATA; MULTIFACTORIAL INHERITANCE; MUTATION; PHENOTYPE; POLYMORPHISM, GENETIC; RETINITIS PIGMENTOSA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 10744230485     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1091317     Document Type: Article

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30. We thank S. Barker, M. McCabe, K. Lau, E. Lee, M. Ray, F. Tremblay, T. Weerasooriya, and J. Ylanko for help in evaluation of the putative genetic interactions by random spore and tetrad analysis; W. L. Lee and J. Cooper for sharing plasmids; T. Huffaker and B. Brown for sharing antibodies and the use of their microscopes; L. Hartwell for suggesting that we consider both the population genetics of synthetic lethality and the relationship between the topology of genetic networks and human disease complexity; C. Scriver and M. Tyers for comments on the manuscript. Supported by grants from the Canadian Institute of Health Research (B.A., C.B., G.W.B.), Genome Canada (B.A., C.B., H.B.), Genome Ontario (B.A. and C.B), Genome Quebec (H.B.), NIH (grants GM61221, C.G.B.; GM39066, A.B.), Fu (L.V.Z.) and N5F Fellowships (D.S.G), the Milton Fund (S.L.W.), and a Howard Hughes Medical Institute institutional grant (G.F.B., F.P.R.).