Phosphorylation networks regulating JNK activity in diverse genetic backgrounds

Science

Volumn 322, Issue 5900, 2008, Pages 453-456

  Bakal, Chris ^a,b   Linding, Rune ^c   Llense, Flora ^d   Heffern, Elleard ^b   Martin Blanco, Enrique ^d   Pawson, Tony ^e   Perrimon, Norbert ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^e MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE;

BIOLOGICAL METHOD; ENZYME; GENE; GENETIC ALGORITHM; GENETIC ANALYSIS; PERTURBATION; SIGNALING;

ALGORITHM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME PHOSPHORYLATION; GENE CONTROL; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 54249117296     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1158739     Document Type: Article

References (27)

1. M. A. Felix, A. Wagner, Heredity 100, 132 (2008).
2. C. R. Weston, R. J. Davis, Curr. Opin. Cell Biol. 19, 142 (2007).
3. Y. Xia, M. Karin, Trends Cell Biol. 14, 94 (2004).
4. Materials and methods are available as supporting material on Science Online.
5. Supplemental tables and files are available at http://genepath.med. harvard.edu/~cbakal/Supplemental.
6. E. Martin-Blanco et al., Genes Dev. 12, 557 (1998).
7. B. Glise, H. Bourbon, S. Noselli, Cell 83, 451 (1995).
8. M. Uhlirova, D. Bohmann, EMBO J. 25, 5294 (2006).
9. A. Srivastava, J. C. Pastor-Pareja, T. Igaki, R. Pagliarini, T. Xu, Proc. Natl. Acad. Sci. U.S.A. 104, 2721 (2007).
10. R. Linding et al., Cell 129, 1415 (2007).
11. B. Bodenmiller et al., Mol. Biosyst. 3, 275 (2007).
12. M. J. Murray, C. M. Davidson, N. M. Hayward, A. H. Brand, Development 133, 3063 (2006).
13. C. J. Desai, J. G. Gindhart Jr., L. S. Goldstein, K. Zinn, Cell 84, 599 (1996).
14. M. L. Winberg et al., Neuron 32, 53 (2001).
15. X. Lu et al., Nature 430, 93 (2004).
16. M. Affolter, D. Nellen, U. Nussbaumer, K. Basler, Development 120, 3105 (1994).
17. M. Chiariello et al., Oncogene 16, 2435 (1998).
18. M. Starz-Gaiano, N. K. Cho, A. Forbes, R. Lehmann, Development 128, 983 (2001).
19. S. Etienne-Manneville, A. Hall, Nature 421, 753 (2003).
20. L. Primo et al., J. Cell Biol. 176, 1035 (2007).
21. S. X. Hou, Z. Zheng, X. Chen, N. Perrimon, Dev. Cell 3, 765 (2002).
22. L. Funke, S. Dakoji, D. S. Bredt, Annu. Rev. Biochem. 74, 219 (2005).
23. T. Igaki, R. A. Pagliarini, T. Xu, Curr. Biol. 16, 1139 (2006).
24. L. J. Saucedo, B. A. Edgar, Nat. Rev. Mol. Cell Biol. 8, 613 (2007).
25. P. Massimi, D. Gardiol, S. Roberts, L. Banks, Exp. Cell Res. 290, 265 (2003).
26. A. Friedman, N. Perrimon, Nature 444, 230 (2006).
27. We are deeply indebted to the Drosophila RNAi Screening Center and to J. Aach, S. Lee, C. Jørgensen, B. Mathey-Prevot, and B. Bodenmiller. The NetworKIN and NetPhorest algorithms are available at http:// networkin.info and http://NetPhorest.info, respectively. This work is supported by Genome Canada through the Ontario Genomics Institute, the Spanish Ministerio de Ciencía e Innovación (BFU/Consolider 2007), and the European Union (FP6). C.B. is a Fellow of the Leukemia and Lymphoma Society. N.P. is an Investigator of the Howard Hughes Medical Institute.