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Volumn 10, Issue 1, 2015, Pages 14-29

Potential Neuroprotective Activity of Ginseng in Parkinson’s Disease: A Review

Author keywords

Ginseng; Ginsenosides; Neuroprotection; Parkinson s disease

Indexed keywords

ANTIPARKINSON AGENT; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 3; HERBACEOUS AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PANAXATRIOL; PSEUDOGINSENOSIDE F11; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; PLANT MEDICINAL PRODUCT;

EID: 84925506186     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9569-6     Document Type: Review
Times cited : (87)

References (168)
  • 1
    • 5444221722 scopus 로고    scopus 로고
    • Biology of Parkinson’s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder
    • PID: 22033559
    • Alexander GE (2004) Biology of Parkinson’s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialogues Clin Neurosci 6:259–280
    • (2004) Dialogues Clin Neurosci , vol.6 , pp. 259-280
    • Alexander, G.E.1
  • 3
    • 0036370799 scopus 로고    scopus 로고
    • Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    • COI: 1:CAS:528:DC%2BD38XhvVehtw%3D%3D, PID: 11824558
    • Bae E, Han MJ, Choo M, Park S, Kim D (2002) Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 25:58–63
    • (2002) Biol Pharm Bull , vol.25 , pp. 58-63
    • Bae, E.1    Han, M.J.2    Choo, M.3    Park, S.4    Kim, D.5
  • 4
    • 84872231378 scopus 로고    scopus 로고
    • The world ginseng market and the ginseng (Korea)
    • PID: 23717152
    • Baeg IH, So SH (2013) The world ginseng market and the ginseng (Korea). J Ginseng Res 37:1–7
    • (2013) J Ginseng Res , vol.37 , pp. 1-7
    • Baeg, I.H.1    So, S.H.2
  • 5
    • 84866514986 scopus 로고    scopus 로고
    • Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng
    • PID: 22183805
    • Beamer CA, Shepherd DM (2012) Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng. J Neuroimmune Pharmacol 7:465–476
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 465-476
    • Beamer, C.A.1    Shepherd, D.M.2
  • 6
    • 84858652204 scopus 로고    scopus 로고
    • Misfolded α-synuclein and Toll-like receptors: therapeutic targets for Parkinson’s disease
    • PID: 22166424
    • Béraud D, Maguire-Zeiss KA (2012) Misfolded α-synuclein and Toll-like receptors: therapeutic targets for Parkinson’s disease. Parkinsonism Relat Disord 18(Suppl1):S17–S20
    • (2012) Parkinsonism Relat Disord , vol.18 , pp. 17-20
    • Béraud, D.1    Maguire-Zeiss, K.A.2
  • 8
    • 85018154198 scopus 로고    scopus 로고
    • American ginseng production in woodlots
    • Beyfuss RL (1999) American ginseng production in woodlots. Agroforestry Notes (USDA-NAC) 3:1–4
    • (1999) Agroforestry Notes (USDA-NAC) , vol.3 , pp. 1-4
    • Beyfuss, R.L.1
  • 10
    • 78649321978 scopus 로고    scopus 로고
    • Therapeutic efficacy of the neuroprotective plant adaptogen in neurodegenerative disease (Parkinson’s disease as an example)
    • COI: 1:STN:280:DC%2BC3M%2FkvV2isw%3D%3D, PID: 21165417
    • Bocharov EV, Ivanova-Smolenskaya IA, Poleshchuk VV, Kucheryanu VG, Il’enko VA, Bocharova OA (2010) Therapeutic efficacy of the neuroprotective plant adaptogen in neurodegenerative disease (Parkinson’s disease as an example). Bull Exp Biol Med 149:682–684
    • (2010) Bull Exp Biol Med , vol.149 , pp. 682-684
    • Bocharov, E.V.1    Ivanova-Smolenskaya, I.A.2    Poleshchuk, V.V.3    Kucheryanu, V.G.4    Il’enko, V.A.5    Bocharova, O.A.6
  • 11
    • 37848999407 scopus 로고    scopus 로고
    • Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: a stereological study
    • COI: 1:CAS:528:DC%2BD1cXlvVKruw%3D%3D, PID: 18023481
    • Bostanci MO, Bagirici F (2008) Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity: a stereological study. Neurotoxicology 29:130–135
    • (2008) Neurotoxicology , vol.29 , pp. 130-135
    • Bostanci, M.O.1    Bagirici, F.2
  • 12
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson’s disease: diagnosis and management
    • PID: 16488379
    • Chaudhuri KR, Healy DG, Schapira AH (2006) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5:235–245
    • (2006) Lancet Neurol , vol.5 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.3
  • 13
    • 0036712333 scopus 로고    scopus 로고
    • Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons
    • COI: 1:CAS:528:DC%2BD38XntVSitro%3D, PID: 12230953
    • Chen XC, Chen Y, Zhu YG, Fang F, Chen LM (2002) Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 23:829–834
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 829-834
    • Chen, X.C.1    Chen, Y.2    Zhu, Y.G.3    Fang, F.4    Chen, L.M.5
  • 14
    • 0038825258 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress
    • COI: 1:CAS:528:DC%2BD3sXls1Omurg%3D, PID: 12877931
    • Chen XC, Zhu YG, Zhu LA, Huang C, Chen Y, Chen LM, Fang F, Zhou YC, Zhao CH (2003) Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol 473:1–7
    • (2003) Eur J Pharmacol , vol.473 , pp. 1-7
    • Chen, X.C.1    Zhu, Y.G.2    Zhu, L.A.3    Huang, C.4    Chen, Y.5    Chen, L.M.6    Fang, F.7    Zhou, Y.C.8    Zhao, C.H.9
  • 15
    • 11844268081 scopus 로고    scopus 로고
    • Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress
    • PID: 15659115
    • Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM (2005) Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol Sin 26:56–62
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 56-62
    • Chen, X.C.1    Zhou, Y.C.2    Chen, Y.3    Zhu, Y.G.4    Fang, F.5    Chen, L.M.6
  • 16
    • 84877684224 scopus 로고    scopus 로고
    • Determination of 10 ginsenosides in Panax ginseng of different harvest times based on HPLC fingerprints and principal component analysis
    • COI: 1:CAS:528:DC%2BC38XhtFKiur3P, PID: 22871218
    • Chen F, Luo J, Kong L (2013) Determination of 10 ginsenosides in Panax ginseng of different harvest times based on HPLC fingerprints and principal component analysis. Nat Prod Res 27:851–854
    • (2013) Nat Prod Res , vol.27 , pp. 851-854
    • Chen, F.1    Luo, J.2    Kong, L.3
  • 17
    • 51349106992 scopus 로고    scopus 로고
    • Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
    • COI: 1:CAS:528:DC%2BD1cXhtV2rurbI, PID: 18718180
    • Choi KT (2008) Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 29:1109–1118
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1109-1118
    • Choi, K.T.1
  • 18
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • COI: 1:CAS:528:DC%2BD1cXhsVOqsLzJ, PID: 18772102
    • Christensen LP (2009) Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 55:1–99
    • (2009) Adv Food Nutr Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 19
    • 0030470864 scopus 로고    scopus 로고
    • Influence of root age on the concentration of ginsenosides of American ginseng (Panax quinquefolium)
    • COI: 1:CAS:528:DyaK2sXosVahug%3D%3D
    • Court WA, Reynolds LB, Hendel JG (1996) Influence of root age on the concentration of ginsenosides of American ginseng (Panax quinquefolium). Can J Plant Sci 76:853–855
    • (1996) Can J Plant Sci , vol.76 , pp. 853-855
    • Court, W.A.1    Reynolds, L.B.2    Hendel, J.G.3
  • 20
    • 0015359140 scopus 로고
    • Clinical manifestations of essential tremor
    • COI: 1:STN:280:DyaE383htVCisg%3D%3D, PID: 5035310
    • Critchley E (1972) Clinical manifestations of essential tremor. J Neurol Neurosurg Psychiatry 35:365–372
    • (1972) J Neurol Neurosurg Psychiatry , vol.35 , pp. 365-372
    • Critchley, E.1
  • 21
    • 3242729103 scopus 로고    scopus 로고
    • Genetic diversity in harvested and protected populations of wild American ginseng, Panax quinquefolius L. (Araliaceae)
    • PID: 21653409
    • Cruse-Sanders JM, Hamrick JL (2004) Genetic diversity in harvested and protected populations of wild American ginseng, Panax quinquefolius L. (Araliaceae). Am J Bot 91:540–548
    • (2004) Am J Bot , vol.91 , pp. 540-548
    • Cruse-Sanders, J.M.1    Hamrick, J.L.2
  • 22
    • 84881427177 scopus 로고    scopus 로고
    • Parkinson disease: from pathology to molecular disease mechanisms
    • COI: 1:CAS:528:DC%2BC3sXjtlykt7c%3D, PID: 23380027
    • Dexter DT, Jenner P (2013) Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med 62:132–144
    • (2013) Free Radic Biol Med , vol.62 , pp. 132-144
    • Dexter, D.T.1    Jenner, P.2
  • 25
    • 84894544413 scopus 로고    scopus 로고
    • Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2cXivFyhsLc%3D, PID: 23399912
    • Drui G, Carnicella S, Carcenac C, Favier M, Bertrand A, Boulet S, Savasta M (2014) Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease. Mol Psychiatry 19:358–367
    • (2014) Mol Psychiatry , vol.19 , pp. 358-367
    • Drui, G.1    Carnicella, S.2    Carcenac, C.3    Favier, M.4    Bertrand, A.5    Boulet, S.6    Savasta, M.7
  • 26
    • 0023213191 scopus 로고
    • Genetics of Parkinson’s disease
    • COI: 1:STN:280:DyaL2s7lt1KmsQ%3D%3D, PID: 3825703
    • Duvoisin RC (1987) Genetics of Parkinson’s disease. Adv Neurol 45:307–312
    • (1987) Adv Neurol , vol.45 , pp. 307-312
    • Duvoisin, R.C.1
  • 28
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson’s disease
    • COI: 1:STN:280:DyaK283gslyhsw%3D%3D, PID: 8786384
    • Forno LS (1996) Neuropathology of Parkinson’s disease. J Neuropathol Exp Neurol 55:259–272
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 30
    • 65549127731 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways
    • COI: 1:CAS:528:DC%2BD1MXntVCisro%3D, PID: 19476546
    • Gao QG, Chen WF, Xie JX, Wong MS (2009) Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. J Neurochem 109:1338–1347
    • (2009) J Neurochem , vol.109 , pp. 1338-1347
    • Gao, Q.G.1    Chen, W.F.2    Xie, J.X.3    Wong, M.S.4
  • 31
    • 72149127646 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways
    • Ge KL, Chen WF, Xie JX, Wong MS (2010) Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways. J Ethnopharmacol 127:118–123
    • (2010) J Ethnopharmacol , vol.127 , pp. 118-123
    • Ge, K.L.1    Chen, W.F.2    Xie, J.X.3    Wong, M.S.4
  • 32
    • 0038784529 scopus 로고    scopus 로고
    • Are ubiquitination pathways central to Parkinson’s disease?
    • COI: 1:CAS:528:DC%2BD3sXlslWqsb4%3D, PID: 12859888
    • Giasson BI, Lee VM (2003) Are ubiquitination pathways central to Parkinson’s disease? Cell 114:1–8
    • (2003) Cell , vol.114 , pp. 1-8
    • Giasson, B.I.1    Lee, V.M.2
  • 34
    • 84869457747 scopus 로고    scopus 로고
    • Effects of extrusion conditions on the physicochemical properties of extruded red ginseng
    • PID: 24471085
    • Gui Y, Gil SK, Ryu GH (2012) Effects of extrusion conditions on the physicochemical properties of extruded red ginseng. Prev Nutr Food Sci 17:203–209
    • (2012) Prev Nutr Food Sci , vol.17 , pp. 203-209
    • Gui, Y.1    Gil, S.K.2    Ryu, G.H.3
  • 35
    • 84880157962 scopus 로고    scopus 로고
    • Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol
    • COI: 1:CAS:528:DC%2BC3sXhtlalsLrO, PID: 23750847
    • Gum SI, Cho MK (2013) Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol. Liver Int 33:1071–1084
    • (2013) Liver Int , vol.33 , pp. 1071-1084
    • Gum, S.I.1    Cho, M.K.2
  • 36
    • 2542431131 scopus 로고    scopus 로고
    • Rationale for and use of NMDA receptor antagonists in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2cXksVCiur4%3D, PID: 15163596
    • Hallett PJ, Standaert DG (2004) Rationale for and use of NMDA receptor antagonists in Parkinson’s disease. Pharmacol Ther 102:155–174
    • (2004) Pharmacol Ther , vol.102 , pp. 155-174
    • Hallett, P.J.1    Standaert, D.G.2
  • 37
    • 84865967382 scopus 로고    scopus 로고
    • Neuroprotective effect of 20(R)-ginsenoside Rg(3) against transient focal cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BC38Xht12jt7vK, PID: 22925661
    • He B, Chen P, Yang J, Yun Y, Zhang X, Yang R, Shen Z (2012) Neuroprotective effect of 20(R)-ginsenoside Rg(3) against transient focal cerebral ischemia in rats. Neurosci Lett 526:106–111
    • (2012) Neurosci Lett , vol.526 , pp. 106-111
    • He, B.1    Chen, P.2    Yang, J.3    Yun, Y.4    Zhang, X.5    Yang, R.6    Shen, Z.7
  • 38
    • 0038051266 scopus 로고    scopus 로고
    • The role of glial reaction and inflammation in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3sXmtVCku7c%3D, PID: 12846989
    • Hirsch EC, Breidert T, Rousselet E, Hunot S, Hartmann A, Michel PP (2003) The role of glial reaction and inflammation in Parkinson’s disease. Ann NY Acad Sci 991:214–228
    • (2003) Ann NY Acad Sci , vol.991 , pp. 214-228
    • Hirsch, E.C.1    Breidert, T.2    Rousselet, E.3    Hunot, S.4    Hartmann, A.5    Michel, P.P.6
  • 39
    • 84891478127 scopus 로고    scopus 로고
    • Time trends in incidence of Parkinson’s disease diagnosis in UK primary care
    • PID: 23263597
    • Horsfall L, Petersen I, Walters K, Schrag A (2013) Time trends in incidence of Parkinson’s disease diagnosis in UK primary care. J Neurol 260:1351–1357
    • (2013) J Neurol , vol.260 , pp. 1351-1357
    • Horsfall, L.1    Petersen, I.2    Walters, K.3    Schrag, A.4
  • 40
    • 0017596870 scopus 로고
    • The chemical constituents of ginseng plants
    • COI: 1:CAS:528:DyaE1cXhslOjtr8%3D, PID: 608333
    • Hou JP (1977) The chemical constituents of ginseng plants. Comp Med East West 5:123–145
    • (1977) Comp Med East West , vol.5 , pp. 123-145
    • Hou, J.P.1
  • 41
    • 79955473944 scopus 로고    scopus 로고
    • Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells
    • COI: 1:CAS:528:DC%2BC3MXlt1Sls70%3D, PID: 21349320
    • Hu S, Han R, Mak S, Han Y (2011) Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol 135:34–42
    • (2011) J Ethnopharmacol , vol.135 , pp. 34-42
    • Hu, S.1    Han, R.2    Mak, S.3    Han, Y.4
  • 42
    • 70449535513 scopus 로고    scopus 로고
    • Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells
    • COI: 1:CAS:528:DC%2BD1MXhsVGmsr7F, PID: 19781563
    • Hwang YP, Jeong HG (2010) Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. Toxicol Appl Pharmacol 242:18–28
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 18-28
    • Hwang, Y.P.1    Jeong, H.G.2
  • 43
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3sXjtFGitLs%3D, PID: 12666096
    • Jenner P (2003) Oxidative stress in Parkinson’s disease. Ann Neurol 53:S26–S36
    • (2003) Ann Neurol , vol.53 , pp. 26-36
    • Jenner, P.1
  • 44
    • 70349397280 scopus 로고    scopus 로고
    • Current evaluation of the millennium phytomedicine—ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations
    • COI: 1:CAS:528:DC%2BD1MXptVahs7Y%3D, PID: 19601793
    • Jia L, Zhao Y (2009) Current evaluation of the millennium phytomedicine—ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem 16:2475–2484
    • (2009) Curr Med Chem , vol.16 , pp. 2475-2484
    • Jia, L.1    Zhao, Y.2
  • 45
    • 70349408655 scopus 로고    scopus 로고
    • Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine
    • COI: 1:CAS:528:DC%2BD1MXpvVyntLs%3D, PID: 19689273
    • Jia L, Zhao Y, Liang XJ (2009) Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem 16:2924–2942
    • (2009) Curr Med Chem , vol.16 , pp. 2924-2942
    • Jia, L.1    Zhao, Y.2    Liang, X.J.3
  • 46
    • 0034327293 scopus 로고    scopus 로고
    • Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice
    • COI: 1:STN:280:DC%2BD3M%2Fpt1Shuw%3D%3D, PID: 11090864
    • Jiang F, DeSilva S, Turnbull J (2000) Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice. J Neurol Sci 180:52–54
    • (2000) J Neurol Sci , vol.180 , pp. 52-54
    • Jiang, F.1    DeSilva, S.2    Turnbull, J.3
  • 47
    • 0021684153 scopus 로고
    • Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse
    • COI: 1:CAS:528:DyaL2cXmtVCjsb0%3D, PID: 6084415
    • Jie YH, Cammisuli S, Baggiolini M (1984) Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Agents Actions 15:386–391
    • (1984) Agents Actions , vol.15 , pp. 386-391
    • Jie, Y.H.1    Cammisuli, S.2    Baggiolini, M.3
  • 48
    • 0034199462 scopus 로고    scopus 로고
    • Asian studies of cancer chemoprevention: latest clinical results
    • COI: 1:CAS:528:DC%2BD3cXksFCrs7g%3D, PID: 10882871
    • Kakizoe T (2000) Asian studies of cancer chemoprevention: latest clinical results. Eur J Cancer 36:1303–1309
    • (2000) Eur J Cancer , vol.36 , pp. 1303-1309
    • Kakizoe, T.1
  • 49
    • 84875415994 scopus 로고    scopus 로고
    • α-Synuclein oligomers and clinical implications for Parkinson disease
    • COI: 1:CAS:528:DC%2BC3sXks1Cqs70%3D, PID: 23225525
    • Kalia LV, Kalia SK, McLean PJ, Lozano AM, Lang AE (2013) α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol 73:155–169
    • (2013) Ann Neurol , vol.73 , pp. 155-169
    • Kalia, L.V.1    Kalia, S.K.2    McLean, P.J.3    Lozano, A.M.4    Lang, A.E.5
  • 50
    • 0025681804 scopus 로고
    • Immunomodulating activity of ginsenoside Rg1 from Panax ginseng
    • COI: 1:CAS:528:DyaK3MXlsFCmug%3D%3D, PID: 2087006
    • Kenarova B, Neychev H, Hadjiivanova C, Petkov VD (1990) Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 54:447–454
    • (1990) Jpn J Pharmacol , vol.54 , pp. 447-454
    • Kenarova, B.1    Neychev, H.2    Hadjiivanova, C.3    Petkov, V.D.4
  • 51
    • 84862925405 scopus 로고    scopus 로고
    • Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng
    • COI: 1:CAS:528:DC%2BC38XjvFOmtL0%3D, PID: 23717099
    • Kim DH (2012) Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. J Ginseng Res 36:1–15
    • (2012) J Ginseng Res , vol.36 , pp. 1-15
    • Kim, D.H.1
  • 52
    • 0025173264 scopus 로고
    • Panax ginseng as a potential immunomodulator: studies in mice
    • COI: 1:STN:280:DyaK3M%2Fjs1Kqtw%3D%3D, PID: 2229924
    • Kim JY, Germolec DR, Luster MI (1990) Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol 12:257–276
    • (1990) Immunopharmacol Immunotoxicol , vol.12 , pp. 257-276
    • Kim, J.Y.1    Germolec, D.R.2    Luster, M.I.3
  • 53
    • 0030767339 scopus 로고    scopus 로고
    • Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by redginseng saponin through cytochrome P450 inhibition
    • COI: 1:CAS:528:DyaK2sXmt12gsL0%3D, PID: 9342944
    • Kim HJ, Chun YJ, Park JD, Kim SI, Roh JK, Jeong TC (1997) Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by redginseng saponin through cytochrome P450 inhibition. Planta Med 63:415–418
    • (1997) Planta Med , vol.63 , pp. 415-418
    • Kim, H.J.1    Chun, Y.J.2    Park, J.D.3    Kim, S.I.4    Roh, J.K.5    Jeong, T.C.6
  • 54
    • 0037137224 scopus 로고    scopus 로고
    • Structural and functional implications of C-terminal regions of alpha-synuclein
    • COI: 1:CAS:528:DC%2BD38XotVWqsL8%3D, PID: 12427041
    • Kim TD, Paik SR, Yang CH (2002) Structural and functional implications of C-terminal regions of alpha-synuclein. Biochemistry 41:13782–13790
    • (2002) Biochemistry , vol.41 , pp. 13782-13790
    • Kim, T.D.1    Paik, S.R.2    Yang, C.H.3
  • 55
    • 4644325964 scopus 로고    scopus 로고
    • Protective effect of aqueous extract of ginseng radix against 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells
    • COI: 1:CAS:528:DC%2BD3sXpvFalu7g%3D, PID: 14646168
    • Kim EH, Jang MH, Shin MC, Shin MS, Kim CJ (2003) Protective effect of aqueous extract of ginseng radix against 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells. Biol Pharm Bull 26:1668–1673
    • (2003) Biol Pharm Bull , vol.26 , pp. 1668-1673
    • Kim, E.H.1    Jang, M.H.2    Shin, M.C.3    Shin, M.S.4    Kim, C.J.5
  • 56
    • 67651036901 scopus 로고    scopus 로고
    • Immunomodulatory activity of ginsan, a polysaccharide of Panax ginseng, on dendritic cells
    • COI: 1:CAS:528:DC%2BD1MXpt1ehs7w%3D, PID: 19885033
    • Kim MH, Byon YY, Ko EJ, Song JY, Yun YS, Shin T, Joo HG (2009) Immunomodulatory activity of ginsan, a polysaccharide of Panax ginseng, on dendritic cells. Korean J Physiol Pharmacol 13:169–173
    • (2009) Korean J Physiol Pharmacol , vol.13 , pp. 169-173
    • Kim, M.H.1    Byon, Y.Y.2    Ko, E.J.3    Song, J.Y.4    Yun, Y.S.5    Shin, T.6    Joo, H.G.7
  • 57
    • 84155160600 scopus 로고    scopus 로고
    • Modulation of LPS-stimulated astroglial activation by ginseng total saponins
    • COI: 1:CAS:528:DC%2BC3MXmtVyks7g%3D
    • Kim S, Shim S, Choi DS, Kim JH, Kwon YB, Kwon J (2011) Modulation of LPS-stimulated astroglial activation by ginseng total saponins. J Ginseng Res 35:80–85
    • (2011) J Ginseng Res , vol.35 , pp. 80-85
    • Kim, S.1    Shim, S.2    Choi, D.S.3    Kim, J.H.4    Kwon, Y.B.5    Kwon, J.6
  • 58
    • 84871748170 scopus 로고    scopus 로고
    • Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signaling
    • COI: 1:CAS:528:DC%2BC3sXjslWi, PID: 23144451
    • Kim KH, Song K, Yoon SH, Shehzad O, Kim YS, Son JH (2012) Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signaling. J Biol Chem 287:44109–44120
    • (2012) J Biol Chem , vol.287 , pp. 44109-44120
    • Kim, K.H.1    Song, K.2    Yoon, S.H.3    Shehzad, O.4    Kim, Y.S.5    Son, J.H.6
  • 59
    • 0034508151 scopus 로고    scopus 로고
    • Efficacy and safety of ginseng
    • COI: 1:STN:280:DC%2BD3M7otVelsA%3D%3D, PID: 11276295
    • Kitts D, Hu C (2000) Efficacy and safety of ginseng. Public Health Nutr 3:473–485
    • (2000) Public Health Nutr , vol.3 , pp. 473-485
    • Kitts, D.1    Hu, C.2
  • 60
    • 0022377798 scopus 로고
    • Isolation and hypoglycemic activity of panaxans Q, R, S, T and U, glycans of Panax ginseng roots
    • COI: 1:CAS:528:DyaL28XksFGrtw%3D%3D, PID: 4087924
    • Konno C, Murakami M, Oshima Y, Hikino H (1985) Isolation and hypoglycemic activity of panaxans Q, R, S, T and U, glycans of Panax ginseng roots. J Ethnopharmacol 14:69–74
    • (1985) J Ethnopharmacol , vol.14 , pp. 69-74
    • Konno, C.1    Murakami, M.2    Oshima, Y.3    Hikino, H.4
  • 61
    • 0026484964 scopus 로고
    • Platelet mitochondrial function in Parkinson’s disease
    • COI: 1:STN:280:DyaK3s7htFOjsQ%3D%3D, PID: 1471869
    • Krige D, Carroll MT, Cooper JM, Marsden CD, Schapira AH (1992) Platelet mitochondrial function in Parkinson’s disease. Ann Neurol 32:782–788
    • (1992) Ann Neurol , vol.32 , pp. 782-788
    • Krige, D.1    Carroll, M.T.2    Cooper, J.M.3    Marsden, C.D.4    Schapira, A.H.5
  • 62
    • 84863643572 scopus 로고    scopus 로고
    • Genetics of Parkinson disease and other movement disorders
    • COI: 1:CAS:528:DC%2BC38XhtVWjs7zK, PID: 22772876
    • Kumar KR, Lohmann K, Klein C (2012) Genetics of Parkinson disease and other movement disorders. Curr Opin Neurol 25:466–474
    • (2012) Curr Opin Neurol , vol.25 , pp. 466-474
    • Kumar, K.R.1    Lohmann, K.2    Klein, C.3
  • 63
    • 0032531924 scopus 로고    scopus 로고
    • Parkinson´s disease
    • Lang AE, Lozano AM (1998) Parkinson´s disease. N Eng J Med 339: 1044–1053
    • (1998) N Eng J Med , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 64
    • 33749240943 scopus 로고    scopus 로고
    • Mechanisms of Parkinson’s disease linked to pathological alpha-synuclein: new targets for drug discovery
    • COI: 1:CAS:528:DC%2BD28XhtFensbfO, PID: 17015225
    • Lee VM, Trojanowski JQ (2006) Mechanisms of Parkinson’s disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron 52:33–38
    • (2006) Neuron , vol.52 , pp. 33-38
    • Lee, V.M.1    Trojanowski, J.Q.2
  • 65
    • 70350490843 scopus 로고    scopus 로고
    • Ginseng for cognitive function in Alzheimer’s disease: a systematic review
    • PID: 19584437
    • Lee MS, Yang EJ, Kim JI, Ernst E (2009) Ginseng for cognitive function in Alzheimer’s disease: a systematic review. J Alzheimers Dis 18:339–344
    • (2009) J Alzheimers Dis , vol.18 , pp. 339-344
    • Lee, M.S.1    Yang, E.J.2    Kim, J.I.3    Ernst, E.4
  • 66
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: a literature review
    • PID: 20537195
    • Leung KW, Wong AS (2010) Pharmacology of ginsenosides: a literature review. Chin Med 5:20
    • (2010) Chin Med , vol.5 , pp. 20
    • Leung, K.W.1    Wong, A.S.2
  • 67
    • 33846890205 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    • COI: 1:CAS:528:DC%2BD2sXhvVyqt7s%3D, PID: 17123556
    • Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN (2007) Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 52:827–835
    • (2007) Neuropharmacology , vol.52 , pp. 827-835
    • Leung, K.W.1    Yung, K.K.2    Mak, N.K.3    Chan, Y.S.4    Fan, T.P.5    Wong, R.N.6
  • 68
    • 85018148464 scopus 로고    scopus 로고
    • Medical botany: plants affecting human health
    • Lewis WH (2003) Medical botany: plants affecting human health. USA
    • (2003) USA
    • Lewis, W.H.1
  • 69
    • 84866781156 scopus 로고    scopus 로고
    • The effect of TSPG in vivo on transplantation of neural stem cells in treatment of Parkinson’s disease mouse
    • COI: 1:CAS:528:DC%2BD1MXhsVCmsrjP, PID: 21186637
    • Li YB, Wang SL (2009) The effect of TSPG in vivo on transplantation of neural stem cells in treatment of Parkinson’s disease mouse. Zhongguo Ying Yong Sheng Li Xue Za Zhi 25:133–137
    • (2009) Zhongguo Ying Yong Sheng Li Xue Za Zhi , vol.25 , pp. 133-137
    • Li, Y.B.1    Wang, S.L.2
  • 70
    • 0034329658 scopus 로고    scopus 로고
    • Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C.A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng)
    • COI: 1:CAS:528:DC%2BD3cXntVegurY%3D, PID: 11080895
    • Li W, Gu C, Zhang H, Awang DVC, Fitzloff JF, Fong HHS, van Breemen RB (2000) Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C.A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal Chem 72:5417–5422
    • (2000) Anal Chem , vol.72 , pp. 5417-5422
    • Li, W.1    Gu, C.2    Zhang, H.3    Awang, D.V.C.4    Fitzloff, J.F.5    Fong, H.H.S.6    van Breemen, R.B.7
  • 73
    • 84899790223 scopus 로고    scopus 로고
    • Ginsenoside Rg1 induces apoptosis through inhibition of the EpoR-Mediated JAK2/STAT5 signalling pathway in the TF-1/ Epo human leukemia cell line
    • PID: 24761846
    • Li J, Wei Q, Zuo GW, Xia J, You ZM, Li CL, Chen DL (2014) Ginsenoside Rg1 induces apoptosis through inhibition of the EpoR-Mediated JAK2/STAT5 signalling pathway in the TF-1/ Epo human leukemia cell line. Asian Pac J Cancer Prev 15:2453–2459
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 2453-2459
    • Li, J.1    Wei, Q.2    Zuo, G.W.3    Xia, J.4    You, Z.M.5    Li, C.L.6    Chen, D.L.7
  • 74
    • 1842476299 scopus 로고    scopus 로고
    • Immunomodulating activities of polysaccharides isolated from Panax ginseng
    • COI: 1:CAS:528:DC%2BD2cXjtV2mu7w%3D, PID: 15117545
    • Lim TS, Na K, Choi EM, Chung JY, Hwang JK (2004) Immunomodulating activities of polysaccharides isolated from Panax ginseng. J Med Food 7:1–6
    • (2004) J Med Food , vol.7 , pp. 1-6
    • Lim, T.S.1    Na, K.2    Choi, E.M.3    Chung, J.Y.4    Hwang, J.K.5
  • 75
    • 27744539639 scopus 로고    scopus 로고
    • Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium)
    • COI: 1:CAS:528:DC%2BD2MXhtVeqtLjE, PID: 16248544
    • Lim W, Mudge KW, Vermeylen F (2005) Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). J Agric Food Chem 53:8498–8505
    • (2005) J Agric Food Chem , vol.53 , pp. 8498-8505
    • Lim, W.1    Mudge, K.W.2    Vermeylen, F.3
  • 76
    • 84883868799 scopus 로고    scopus 로고
    • Korean red ginseng induced cardioprotection against myocardial ischemia in Guinea Pig
    • PID: 23946687
    • Lim KH, Kang CW, Choi JY, Kim JH (2013) Korean red ginseng induced cardioprotection against myocardial ischemia in Guinea Pig. Korean J Physiol Pharmacol 17:283–289
    • (2013) Korean J Physiol Pharmacol , vol.17 , pp. 283-289
    • Lim, K.H.1    Kang, C.W.2    Choi, J.Y.3    Kim, J.H.4
  • 77
    • 38449083961 scopus 로고    scopus 로고
    • Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture
    • COI: 1:CAS:528:DC%2BD2sXhsVKns7jE, PID: 17982883
    • Lin WM, Zhang YM, Moldzio R, Rausch WD (2007) Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture. J Neural Transm Suppl 72:105–112
    • (2007) J Neural Transm Suppl , vol.72 , pp. 105-112
    • Lin, W.M.1    Zhang, Y.M.2    Moldzio, R.3    Rausch, W.D.4
  • 78
    • 78650415275 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation
    • COI: 1:CAS:528:DC%2BC3cXhsF2jt73O, PID: 21078355
    • Liu Q, Kou JP, Yu BY (2011) Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation. Neurochem Int 58:119–125
    • (2011) Neurochem Int , vol.58 , pp. 119-125
    • Liu, Q.1    Kou, J.P.2    Yu, B.Y.3
  • 79
    • 84863680351 scopus 로고    scopus 로고
    • A new ocotillol-type triterpenoid saponin from red American ginseng
    • COI: 1:CAS:528:DC%2BC38XmtlKisL0%3D, PID: 22010954
    • Liu JP, Wang F, Li PY, Lu D (2012) A new ocotillol-type triterpenoid saponin from red American ginseng. Nat Prod Res 26:731–735
    • (2012) Nat Prod Res , vol.26 , pp. 731-735
    • Liu, J.P.1    Wang, F.2    Li, P.Y.3    Lu, D.4
  • 80
    • 69149110615 scopus 로고    scopus 로고
    • Ginseng compounds: an update on their molecular mechanisms and medical applications
    • PID: 19601854
    • Lü JM, Yao Q, Chen C (2009) Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 7:293–302
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 293-302
    • Lü, J.M.1    Yao, Q.2    Chen, C.3
  • 81
    • 72149119358 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    • COI: 1:CAS:528:DC%2BD1MXhsFGjtLvL, PID: 19892735
    • Luk KC, Song C, O’Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM (2009) Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A 106:20051–20056
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20051-20056
    • Luk, K.C.1    Song, C.2    O’Brien, P.3    Stieber, A.4    Branch, J.R.5    Brunden, K.R.6    Trojanowski, J.Q.7    Lee, V.M.8
  • 82
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM (2012a) Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 16:949–953
    • (2012) Science , vol.16 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 83
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    • COI: 1:CAS:528:DC%2BC38Xmsl2itb8%3D, PID: 22508839
    • Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM (2012b) Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 209:975–986
    • (2012) J Exp Med , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O'Brien, P.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 84
    • 73749086765 scopus 로고    scopus 로고
    • Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
    • COI: 1:CAS:528:DC%2BC3cXot12msw%3D%3D, PID: 19857566
    • Luo FC, Wang SD, Li K, Nakamura H, Yodoi J, Bai J (2010) Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. J Ethnopharmacol 127:419–423
    • (2010) J Ethnopharmacol , vol.127 , pp. 419-423
    • Luo, F.C.1    Wang, S.D.2    Li, K.3    Nakamura, H.4    Yodoi, J.5    Bai, J.6
  • 85
    • 78651402013 scopus 로고    scopus 로고
    • Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo
    • COI: 1:CAS:528:DC%2BC3MXmvFykug%3D%3D, PID: 20951784
    • Luo FC, Wang SD, Qi L, Song JY, Lv T, Bai J (2011) Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo. J Ethnopharmacol 133:448–453
    • (2011) J Ethnopharmacol , vol.133 , pp. 448-453
    • Luo, F.C.1    Wang, S.D.2    Qi, L.3    Song, J.Y.4    Lv, T.5    Bai, J.6
  • 86
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains
    • COI: 1:STN:280:DyaL1c3ovVKkuw%3D%3D, PID: 3399080
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains. Neurology 38:1285–1291
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 87
    • 0037025111 scopus 로고    scopus 로고
    • Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD38XkvFyktbs%3D, PID: 12095645
    • McNaught KS, Belizaire R, Jenner P, Olanow CW, Isacson O (2002) Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson’s disease. Neurosci Lett 326:155–158
    • (2002) Neurosci Lett , vol.326 , pp. 155-158
    • McNaught, K.S.1    Belizaire, R.2    Jenner, P.3    Olanow, C.W.4    Isacson, O.5
  • 88
    • 0037227397 scopus 로고    scopus 로고
    • Altered proteasomal function in sporadic Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD38Xps12ku70%3D, PID: 12504866
    • McNaught KS, Belizaire R, Isacson O, Jenner P, Olanow CW (2003) Altered proteasomal function in sporadic Parkinson’s disease. Exp Neurol 179:38–46
    • (2003) Exp Neurol , vol.179 , pp. 38-46
    • McNaught, K.S.1    Belizaire, R.2    Isacson, O.3    Jenner, P.4    Olanow, C.W.5
  • 89
    • 3042794162 scopus 로고    scopus 로고
    • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2cXmsVSns7c%3D, PID: 15236415
    • McNaught KS, Perl DP, Brownell AL, Olanow CW (2004) Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson’s disease. Ann Neurol 56:149–162
    • (2004) Ann Neurol , vol.56 , pp. 149-162
    • McNaught, K.S.1    Perl, D.P.2    Brownell, A.L.3    Olanow, C.W.4
  • 90
    • 84885598853 scopus 로고    scopus 로고
    • P90RSK and Nrf2 activation via MEK1/2-ERK1/2 pathways mediated by notoginsenoside R2 to prevent 6-hydroxydopamine-induced apoptotic death in SH-SY5Y cells
    • Meng XB, Sun GB, Wang M, Sun J, Qin M, Sun XB (2013) P90RSK and Nrf2 activation via MEK1/2-ERK1/2 pathways mediated by notoginsenoside R2 to prevent 6-hydroxydopamine-induced apoptotic death in SH-SY5Y cells. Evid Based Complement Alternat Med. doi:10.1155/2013/971712
    • (2013) Evid Based Complement Alternat Med
    • Meng, X.B.1    Sun, G.B.2    Wang, M.3    Sun, J.4    Qin, M.5    Sun, X.B.6
  • 92
    • 0346434141 scopus 로고    scopus 로고
    • A missense mutation (L166P) in DJ-1, linked to familial Parkinson’s disease, confers reduced protein stability and impairs homo-oligomerization
    • COI: 1:CAS:528:DC%2BD2cXit12j, PID: 14713311
    • Moore DJ, Zhang L, Dawson TM, Dawson VL (2003) A missense mutation (L166P) in DJ-1, linked to familial Parkinson’s disease, confers reduced protein stability and impairs homo-oligomerization. J Neurochem 87:1558–1567
    • (2003) J Neurochem , vol.87 , pp. 1558-1567
    • Moore, D.J.1    Zhang, L.2    Dawson, T.M.3    Dawson, V.L.4
  • 93
    • 20744435383 scopus 로고    scopus 로고
    • Molecular pathophysiology of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2MXosVegt7c%3D, PID: 16022590
    • Moore DJ, West AB, Dawson VL, Dawson TM (2005) Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci 28:57–87
    • (2005) Annu Rev Neurosci , vol.28 , pp. 57-87
    • Moore, D.J.1    West, A.B.2    Dawson, V.L.3    Dawson, T.M.4
  • 95
    • 84859633021 scopus 로고    scopus 로고
    • A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer
    • COI: 1:CAS:528:DC%2BC38XkvVKksrY%3D, PID: 22481061
    • Musende AG, Eberding A, Wood CA, Adomat H, Fazli L, Hurtado-Coll A, Jia W, Bally MB, Tomlinson Guns ES (2012) A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer. Anticancer Drugs 23:543–552
    • (2012) Anticancer Drugs , vol.23 , pp. 543-552
    • Musende, A.G.1    Eberding, A.2    Wood, C.A.3    Adomat, H.4    Fazli, L.5    Hurtado-Coll, A.6    Jia, W.7    Bally, M.B.8    Tomlinson Guns, E.S.9
  • 96
    • 84897939867 scopus 로고    scopus 로고
    • Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors
    • Nah SY (2014) Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors. Front Physiol 19:98
    • (2014) Front Physiol , vol.19 , pp. 98
    • Nah, S.Y.1
  • 97
    • 0022379080 scopus 로고
    • Hypoglycemic constituents of Panax ginseng
    • COI: 1:CAS:528:DyaL28XivVantg%3D%3D, PID: 3910515
    • Ng TB, Yeung HW (1985) Hypoglycemic constituents of Panax ginseng. Gen Pharmacol 16:549–552
    • (1985) Gen Pharmacol , vol.16 , pp. 549-552
    • Ng, T.B.1    Yeung, H.W.2
  • 98
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson´s disease
    • Olanow CV, Tatton WG (1999) Etiology and pathogenesis of Parkinson´s disease. Annu Rev Neurosci 22:123–144
    • (1999) Annu Rev Neurosci , vol.22 , pp. 123-144
    • Olanow, C.V.1    Tatton, W.G.2
  • 99
    • 0022347333 scopus 로고
    • Isolation and hypoglycemic activity of panaxans I, J, K and L, glycans of Panax ginseng roots
    • COI: 1:CAS:528:DyaL28XhsFGkurw%3D, PID: 4094469
    • Oshima Y, Konno C, Hikino H (1985) Isolation and hypoglycemic activity of panaxans I, J, K and L, glycans of Panax ginseng roots. J Ethnopharmacol 14:255–259
    • (1985) J Ethnopharmacol , vol.14 , pp. 255-259
    • Oshima, Y.1    Konno, C.2    Hikino, H.3
  • 100
    • 0023176235 scopus 로고
    • Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots
    • COI: 1:CAS:528:DyaL2sXkslSktbs%3D, PID: 3655794
    • Oshima Y, Sato K, Hikino H (1987) Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 50:188–190
    • (1987) J Nat Prod , vol.50 , pp. 188-190
    • Oshima, Y.1    Sato, K.2    Hikino, H.3
  • 101
    • 70349182370 scopus 로고    scopus 로고
    • Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs
    • COI: 1:CAS:528:DC%2BD1MXhtVynsrbE
    • Park J, Cho J (2009) Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs. Afr J Biotechnol 8:3682–3690
    • (2009) Afr J Biotechnol , vol.8 , pp. 3682-3690
    • Park, J.1    Cho, J.2
  • 102
    • 84872222109 scopus 로고    scopus 로고
    • Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats
    • PID: 23717155
    • Park SJ, Lee JR, Jo MJ, Park SM, Ku SK, Kim SC (2013) Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats. J Ginseng Res 37:37–44
    • (2013) J Ginseng Res , vol.37 , pp. 37-44
    • Park, S.J.1    Lee, J.R.2    Jo, M.J.3    Park, S.M.4    Ku, S.K.5    Kim, S.C.6
  • 103
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson’s disease
    • PID: 2557792
    • Parker WD Jr, Boyson SJ, Parks JK (1989) Abnormalities of the electron transport chain in idiopathic Parkinson’s disease. Ann Neurol 26:719–723
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 104
    • 30044442094 scopus 로고    scopus 로고
    • Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
    • COI: 1:CAS:528:DC%2BD28XivV2gtw%3D%3D, PID: 16365298
    • Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V (2005) Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A 102:19126–19131
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19126-19131
    • Perier, C.1    Tieu, K.2    Guegan, C.3    Caspersen, C.4    Jackson-Lewis, V.5    Carelli, V.6
  • 106
    • 84857968555 scopus 로고    scopus 로고
    • Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond
    • COI: 1:CAS:528:DC%2BC38Xjt1Wisbk%3D, PID: 21619488
    • Perier C, Bové J, Vila M (2012) Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond. Antioxid Redox Signal 16:883–895
    • (2012) Antioxid Redox Signal , vol.16 , pp. 883-895
    • Perier, C.1    Bové, J.2    Vila, M.3
  • 107
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    • COI: 1:CAS:528:DC%2BD3sXhtVOhug%3D%3D, PID: 12495618
    • Petrucelli L, O’Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR (2002) Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36:1007–1019
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O’Farrell, C.2    Lockhart, P.J.3    Baptista, M.4    Kehoe, K.5    Vink, L.6    Choi, P.7    Wolozin, B.8    Farrer, M.9    Hardy, J.10    Cookson, M.R.11
  • 109
    • 79954627696 scopus 로고    scopus 로고
    • Ginsenosides from American ginseng: chemical and pharmacological diversity
    • COI: 1:CAS:528:DC%2BC3MXkvFWrurw%3D, PID: 21396670
    • Qi LW, Wang CZ, Yuan CS (2011) Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 72:689–699
    • (2011) Phytochemistry , vol.72 , pp. 689-699
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 110
    • 84893423950 scopus 로고    scopus 로고
    • Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng
    • PID: 24484594
    • Qian M, Yi L, Song-Lin L, Jie Y, Ping-Hu Z, Qiang W (2014) Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng. Chin J Nat Med 12:30–37
    • (2014) Chin J Nat Med , vol.12 , pp. 30-37
    • Qian, M.1    Yi, L.2    Song-Lin, L.3    Jie, Y.4    Ping-Hu, Z.5    Qiang, W.6
  • 111
    • 0842265668 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP + -affected mesencephalic dopaminergic cells
    • COI: 1:CAS:528:DC%2BD2cXhtlGktQ%3D%3D, PID: 14714214
    • Radad K, Gille G, Moldzio R, Saito H, Ishige K, Rausch WD (2004a) Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP + -affected mesencephalic dopaminergic cells. J Neural Transm 111:37–45
    • (2004) J Neural Transm , vol.111 , pp. 37-45
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Ishige, K.5    Rausch, W.D.6
  • 112
    • 4344622460 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate
    • COI: 1:CAS:528:DC%2BD2cXmvFWkur4%3D, PID: 15328030
    • Radad K, Gille G, Moldzio R, Saito H, Rausch WD (2004b) Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 1021:41–53
    • (2004) Brain Res , vol.1021 , pp. 41-53
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Rausch, W.D.5
  • 113
    • 82355191863 scopus 로고    scopus 로고
    • Ginsenosides and their CNS targets
    • COI: 1:CAS:528:DC%2BC38XnsVGhsw%3D%3D, PID: 21143430
    • Radad K, Moldzio R, Rausch WD (2011) Ginsenosides and their CNS targets. CNS Neurosci Ther 17:761–768
    • (2011) CNS Neurosci Ther , vol.17 , pp. 761-768
    • Radad, K.1    Moldzio, R.2    Rausch, W.D.3
  • 114
    • 33646534388 scopus 로고    scopus 로고
    • Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells
    • PID: 16427227
    • Rhule A, Navarro S, Smith JR, Shepherd DM (2006) Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. J Ethnopharmacol 106:121–128
    • (2006) J Ethnopharmacol , vol.106 , pp. 121-128
    • Rhule, A.1    Navarro, S.2    Smith, J.R.3    Shepherd, D.M.4
  • 115
    • 84893512864 scopus 로고    scopus 로고
    • Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations
    • COI: 1:CAS:528:DC%2BC3sXhs1eqtb7P, PID: 24132508
    • Rinwa P, Kumar A (2014) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations. Naunyn Schmiedebergs Arch Pharmacol 387:129–141
    • (2014) Naunyn Schmiedebergs Arch Pharmacol , vol.387 , pp. 129-141
    • Rinwa, P.1    Kumar, A.2
  • 118
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD1cXhtlaqtbg%3D, PID: 18093566
    • Schapira AH (2008) Mitochondria in the aetiology and pathogenesis of Parkinson’s disease. Lancet Neurol 7:97–109
    • (2008) Lancet Neurol , vol.7 , pp. 97-109
    • Schapira, A.H.1
  • 119
    • 80855139395 scopus 로고    scopus 로고
    • Mitochondrial pathology in Parkinson’s disease
    • PID: 22069211
    • Schapira AH (2011) Mitochondrial pathology in Parkinson’s disease. Mt Sinai J Med 78:872–881
    • (2011) Mt Sinai J Med , vol.78 , pp. 872-881
    • Schapira, A.H.1
  • 121
    • 33746253768 scopus 로고    scopus 로고
    • Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations
    • COI: 1:CAS:528:DC%2BD28Xnt1ylsbc%3D, PID: 16839573
    • Schlag EM, McIntosh MS (2006) Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations. Phytochemistry 67:1510–1519
    • (2006) Phytochemistry , vol.67 , pp. 1510-1519
    • Schlag, E.M.1    McIntosh, M.S.2
  • 123
    • 0034703336 scopus 로고    scopus 로고
    • TorsinA accumulation in Lewy bodies in sporadic Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3cXmtlGrsLc%3D, PID: 10986355
    • Shashidharan P, Good PF, Hsu A, Perl DP, Brin MF, Olanow CW (2000) TorsinA accumulation in Lewy bodies in sporadic Parkinson’s disease. Brain Res 877:379–381
    • (2000) Brain Res , vol.877 , pp. 379-381
    • Shashidharan, P.1    Good, P.F.2    Hsu, A.3    Perl, D.P.4    Brin, M.F.5    Olanow, C.W.6
  • 124
    • 0036100742 scopus 로고    scopus 로고
    • Environment, mitochondria, and Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD38XkvF2ntLw%3D, PID: 12061498
    • Sherer TB, Betarbet R, Greenamyre JT (2002) Environment, mitochondria, and Parkinson’s disease. Neuroscientist 8:192–197
    • (2002) Neuroscientist , vol.8 , pp. 192-197
    • Sherer, T.B.1    Betarbet, R.2    Greenamyre, J.T.3
  • 125
    • 77951641169 scopus 로고    scopus 로고
    • Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease
    • Shi C, Zhang Y, Zhang Z (2009) Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease. J South Med Univ 29:60–63
    • (2009) J South Med Univ , vol.29 , pp. 60-63
    • Shi, C.1    Zhang, Y.2    Zhang, Z.3
  • 126
    • 84873549615 scopus 로고    scopus 로고
    • Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats
    • PID: 23202798
    • Shi J, Xue W, Zhao WJ, Li KX (2013) Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats. Acta Pharmacol Sin 34:214–220
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 214-220
    • Shi, J.1    Xue, W.2    Zhao, W.J.3    Li, K.X.4
  • 127
    • 8044261389 scopus 로고
    • Studies on the constituents of Japanese and Chinese crude drugs. XII. panaxadiol, a sapogenin of ginseng roots
    • COI: 1:CAS:528:DyaF3sXksFGgtrY%3D
    • Shibata S, Tanaka O, NagaI M, Ishit T (1963) Studies on the constituents of Japanese and Chinese crude drugs. XII. panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull (Tokyo) 11:762–765
    • (1963) Chem Pharm Bull (Tokyo) , vol.11 , pp. 762-765
    • Shibata, S.1    Tanaka, O.2    NagaI, M.3    Ishit, T.4
  • 128
    • 76549190817 scopus 로고
    • Saponins and sapogenins of Panax ginseng C.A. Meyer and some other Panax spp
    • COI: 1:STN:280:DyaF28%2FgslKltQ%3D%3D, PID: 5890334
    • Shibata S, Ando T, Tanaka O, Meguro Y, Sôma K, Iida Y (1965a) Saponins and sapogenins of Panax ginseng C.A. Meyer and some other Panax spp. Yakugaku Zasshi 85:753–755
    • (1965) Yakugaku Zasshi , vol.85 , pp. 753-755
    • Shibata, S.1    Ando, T.2    Tanaka, O.3    Meguro, Y.4    Sôma, K.5    Iida, Y.6
  • 129
    • 0001795978 scopus 로고
    • Studies on saponins and sapogenins of ginseng. the structure of panaxatriol
    • COI: 1:STN:280:DyaF2M%2Fls12ruw%3D%3D, PID: 14252492
    • Shibata S, Tanaka O, Soma K, Aando T, Iida Y, Nakamura H (1965b) Studies on saponins and sapogenins of ginseng. the structure of panaxatriol. Tetrahedron Lett 42:207–213
    • (1965) Tetrahedron Lett , vol.42 , pp. 207-213
    • Shibata, S.1    Tanaka, O.2    Soma, K.3    Aando, T.4    Iida, Y.5    Nakamura, H.6
  • 130
    • 0034075605 scopus 로고    scopus 로고
    • The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence
    • COI: 1:STN:280:DC%2BD3cvotVyqug%3D%3D
    • Shin HR, Kim JY, Yun TK, Morgan G, Vainio H (2000) The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Canc Causes Contr 11:565–576
    • (2000) Canc Causes Contr , vol.11 , pp. 565-576
    • Shin, H.R.1    Kim, J.Y.2    Yun, T.K.3    Morgan, G.4    Vainio, H.5
  • 131
    • 84861050601 scopus 로고    scopus 로고
    • Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic acid receptor-mediated ion currents
    • COI: 1:CAS:528:DC%2BC38Xpt1yqsbY%3D, PID: 22563256
    • Shin TJ, Hwang SH, Choi SH, Lee BH, Kang J, Kim HJ, Zukin RS, Rhim H, Nah SY (2012) Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic acid receptor-mediated ion currents. Korean J Physiol Pharmacol 16:113–118
    • (2012) Korean J Physiol Pharmacol , vol.16 , pp. 113-118
    • Shin, T.J.1    Hwang, S.H.2    Choi, S.H.3    Lee, B.H.4    Kang, J.5    Kim, H.J.6    Zukin, R.S.7    Rhim, H.8    Nah, S.Y.9
  • 135
    • 85018148907 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson’s disease
    • Summers AP, Koob TJ, Brainerd EL (1998) The ubiquitin pathway in Parkinson’s disease. Nature 395:451–452
    • (1998) Nature , vol.395 , pp. 451-452
    • Summers, A.P.1    Koob, T.J.2    Brainerd, E.L.3
  • 136
    • 0035651290 scopus 로고    scopus 로고
    • Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer
    • COI: 1:CAS:528:DC%2BD38XlvFCqsg%3D%3D, PID: 11748375
    • Surh YJ, Na HK, Lee JY, Keum YS (2001) Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 16:S38–S41
    • (2001) J Korean Med Sci , vol.16 , pp. 38-41
    • Surh, Y.J.1    Na, H.K.2    Lee, J.Y.3    Keum, Y.S.4
  • 137
    • 84875703698 scopus 로고    scopus 로고
    • Neuroinflammation and oxidative stress: coconspirators in the pathology of Parkinson´s disease
    • Taylor JM, Main BS, Crack PJ (2013) Neuroinflammation and oxidative stress: coconspirators in the pathology of Parkinson´s disease. Neurochem Int 62:803–819
    • (2013) Neurochem Int , vol.62 , pp. 803-819
    • Taylor, J.M.1    Main, B.S.2    Crack, P.J.3
  • 138
    • 0345257309 scopus 로고    scopus 로고
    • Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease
    • PID: 14637121
    • Van Kampen J, Robertson H, Hagg T, Drobitch R (2003) Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease. Exp Neurol 184:521–529
    • (2003) Exp Neurol , vol.184 , pp. 521-529
    • Van Kampen, J.1    Robertson, H.2    Hagg, T.3    Drobitch, R.4
  • 139
    • 84890578671 scopus 로고    scopus 로고
    • Panax ginseng is neuroprotective in a novel progressive model of Parkinson’s disease
    • PID: 24316034
    • Van Kampen JM, Baranowski DB, Shaw CA, Kay DG (2014) Panax ginseng is neuroprotective in a novel progressive model of Parkinson’s disease. Exp Gerontol 50:95–105
    • (2014) Exp Gerontol , vol.50 , pp. 95-105
    • Van Kampen, J.M.1    Baranowski, D.B.2    Shaw, C.A.3    Kay, D.G.4
  • 140
    • 84875713441 scopus 로고    scopus 로고
    • Programmed cell death in Parkinson’s disease
    • Venderova K, Park DS (2012) Programmed cell death in Parkinson’s disease. Cold Spring Harb Perspect Med 2(8) doi: 10.1101/cshperspect.a009365
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.8
    • Venderova, K.1    Park, D.S.2
  • 141
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3MXhslKmtLc%3D, PID: 11226327
    • Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. Proc Natl Acad Sci U S A 98:2837–2842
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2837-2842
    • Vila, M.1    Jackson-Lewis, V.2    Vukosavic, S.3    Djaldetti, R.4    Liberatore, G.5    Offen, D.6    Korsmeyer, S.J.7    Przedborski, S.8
  • 142
    • 5444236802 scopus 로고    scopus 로고
    • Parkin-associated Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2cXos1aqsLc%3D
    • Von Coelln R, Dawson VL, Dawson TM (2004) Parkin-associated Parkinson’s disease. Cell Tissue Res 318:175–184
    • (2004) Cell Tissue Res , vol.318 , pp. 175-184
    • Von Coelln, R.1    Dawson, V.L.2    Dawson, T.M.3
  • 143
    • 0033561519 scopus 로고    scopus 로고
    • Determination of ginsenosides in plant extracts from Panax ginseng and Panax quinquefolius L. by LC/MS/MS
    • COI: 1:CAS:528:DyaK1MXhslektL0%3D, PID: 10221076
    • Wang X, Sakuma T, Asafu-Adjaye E, Shiu GK (1999) Determination of ginsenosides in plant extracts from Panax ginseng and Panax quinquefolius L. by LC/MS/MS. Anal Chem 71:1579–1584
    • (1999) Anal Chem , vol.71 , pp. 1579-1584
    • Wang, X.1    Sakuma, T.2    Asafu-Adjaye, E.3    Shiu, G.K.4
  • 144
    • 22144449967 scopus 로고    scopus 로고
    • Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography
    • COI: 1:CAS:528:DC%2BD2MXmsVGqs7w%3D, PID: 16042154
    • Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS (2005) Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal 16:272–277
    • (2005) Phytochem Anal , vol.16 , pp. 272-277
    • Wang, A.1    Wang, C.Z.2    Wu, J.A.3    Osinski, J.4    Yuan, C.S.5
  • 145
    • 33750717191 scopus 로고    scopus 로고
    • Simultaneous determination of ginsenosides in Panax ginseng with different growth ages using high-performance liquid chromatography-mass spectrometry
    • COI: 1:CAS:528:DC%2BD28XhtlCjsb3N, PID: 17144251
    • Wang Y, Pan JY, Xiao XY, Lin RC, Cheng YY (2006) Simultaneous determination of ginsenosides in Panax ginseng with different growth ages using high-performance liquid chromatography-mass spectrometry. Phytochem Anal 17:424–430
    • (2006) Phytochem Anal , vol.17 , pp. 424-430
    • Wang, Y.1    Pan, J.Y.2    Xiao, X.Y.3    Lin, R.C.4    Cheng, Y.Y.5
  • 146
    • 34250014148 scopus 로고    scopus 로고
    • Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats
    • PID: 17561842
    • Wang J, Jiang H, Xie JX (2007) Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Eur J Neurosci 25:2766–2772
    • (2007) Eur J Neurosci , vol.25 , pp. 2766-2772
    • Wang, J.1    Jiang, H.2    Xie, J.X.3
  • 147
    • 59049094805 scopus 로고    scopus 로고
    • Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins
    • Wang J, Xu HM, Yang HD, Du XX, Jiang H, Xie JX (2009) Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochem Int 4:43–48
    • (2009) Neurochem Int , vol.4 , pp. 43-48
    • Wang, J.1    Xu, H.M.2    Yang, H.D.3    Du, X.X.4    Jiang, H.5    Xie, J.X.6
  • 148
    • 63649140149 scopus 로고    scopus 로고
    • Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway
    • COI: 1:CAS:528:DC%2BD1cXht1GisrfE, PID: 18819875
    • Wang Q, Zheng H, Zhang ZF, Zhang YX (2008) Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway. Nan Fang Yi Ke Da Xue Xue Bao 28:1594–1598
    • (2008) Nan Fang Yi Ke Da Xue Xue Bao , vol.28 , pp. 1594-1598
    • Wang, Q.1    Zheng, H.2    Zhang, Z.F.3    Zhang, Y.X.4
  • 149
    • 84862908915 scopus 로고    scopus 로고
    • Panax quinquefolium saponins reduce myocardial hypoxia-reoxygenation injury by inhibiting excessive endoplasmic reticulum stress
    • COI: 1:CAS:528:DC%2BC38XpsVynuw%3D%3D, PID: 22089206
    • Wang C, Li YZ, Wang XR, Lu ZR, Shi DZ, Liu XH (2012) Panax quinquefolium saponins reduce myocardial hypoxia-reoxygenation injury by inhibiting excessive endoplasmic reticulum stress. Shock 37:228–233
    • (2012) Shock , vol.37 , pp. 228-233
    • Wang, C.1    Li, Y.Z.2    Wang, X.R.3    Lu, Z.R.4    Shi, D.Z.5    Liu, X.H.6
  • 151
    • 0037379324 scopus 로고    scopus 로고
    • Genetic and environmental factors in the cause of Parkinson’s disease
    • Warner TT, Schapira AH (2003) Genetic and environmental factors in the cause of Parkinson’s disease. Ann Neurol 53:16–23
    • (2003) Ann Neurol , vol.53 , pp. 16-23
    • Warner, T.T.1    Schapira, A.H.2
  • 152
    • 0033301347 scopus 로고    scopus 로고
    • Pollen ultrastructure of Panax (the ginseng genus, Araliaceae), an eastern Asian and eastern North American disjunct genus
    • COI: 1:STN:280:DC%2BC3Mngs1Gksg%3D%3D, PID: 10562253
    • Wen J, Nowicke JW (1999) Pollen ultrastructure of Panax (the ginseng genus, Araliaceae), an eastern Asian and eastern North American disjunct genus. Am J Bot 86:1624–1636
    • (1999) Am J Bot , vol.86 , pp. 1624-1636
    • Wen, J.1    Nowicke, J.W.2
  • 153
    • 84891642022 scopus 로고    scopus 로고
    • Parkinson disease in the elderly adult
    • PID: 24279192
    • Willis AW (2013) Parkinson disease in the elderly adult. Mo Med 110:406–410
    • (2013) Mo Med , vol.110 , pp. 406-410
    • Willis, A.W.1
  • 154
    • 74249120382 scopus 로고    scopus 로고
    • Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries
    • Willis AW, Evanoff BA, Lian M, Criswell SR, Racette BA (2010) Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries. Neuroepidemiology 34:143–151
    • (2010) Neuroepidemiology , vol.34 , pp. 143-151
    • Willis, A.W.1    Evanoff, B.A.2    Lian, M.3    Criswell, S.R.4    Racette, B.A.5
  • 156
    • 84860578177 scopus 로고    scopus 로고
    • Progression of motor symptoms in Parkinson’s disease
    • PID: 22233888
    • Xia R, Mao ZH (2012) Progression of motor symptoms in Parkinson’s disease. Neurosci Bull 28:39–48
    • (2012) Neurosci Bull , vol.28 , pp. 39-48
    • Xia, R.1    Mao, Z.H.2
  • 158
    • 12344336324 scopus 로고    scopus 로고
    • Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson’s disease mouse model
    • COI: 1:CAS:528:DC%2BD2cXhtFCqtbjL, PID: 15621629
    • Xu BB, Liu CQ, Gao X, Zhang WQ, Wang SW, Cao YL (2005) Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson’s disease mouse model. J Asian Nat Prod Res 7:215–224
    • (2005) J Asian Nat Prod Res , vol.7 , pp. 215-224
    • Xu, B.B.1    Liu, C.Q.2    Gao, X.3    Zhang, W.Q.4    Wang, S.W.5    Cao, Y.L.6
  • 159
    • 70350062072 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson’s disease through the IGF-I receptor signalling pathway
    • COI: 1:CAS:528:DC%2BD1MXhsVSks7vO, PID: 19703168
    • Xu L, Chen WF, Wong MS (2009) Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson’s disease through the IGF-I receptor signalling pathway. Br J Pharmacol 158:738–748
    • (2009) Br J Pharmacol , vol.158 , pp. 738-748
    • Xu, L.1    Chen, W.F.2    Wong, M.S.3
  • 160
    • 72049117894 scopus 로고    scopus 로고
    • Rg1 protects the MPP + -treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake
    • COI: 1:CAS:528:DC%2BD1MXhsFymsb%2FL, PID: 19744503
    • Xu H, Jiang H, Wang J, Xie J (2010a) Rg1 protects the MPP + -treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology 58:488–494
    • (2010) Neuropharmacology , vol.58 , pp. 488-494
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 161
    • 78649782421 scopus 로고    scopus 로고
    • Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells
    • COI: 1:CAS:528:DC%2BC3cXhsVyhsrbF, PID: 20872781
    • Xu H, Jiang H, Wang J, Xie J (2010b) Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells. J Cell Biochem 111:1537–1545
    • (2010) J Cell Biochem , vol.111 , pp. 1537-1545
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 162
    • 84896779646 scopus 로고    scopus 로고
    • Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6 J mice
    • COI: 1:CAS:528:DC%2BC2cXls12hsbo%3D, PID: 23833204
    • Yang L, Zhang J, Zheng K, Shen H, Chen X (2014) Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6 J mice. J Gerontol A Biol Sci Med Sci 69:282–294
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 282-294
    • Yang, L.1    Zhang, J.2    Zheng, K.3    Shen, H.4    Chen, X.5
  • 163
    • 32944477587 scopus 로고    scopus 로고
    • Overview on the analytical tools for quality control of natural product-based supplements: a case study of ginseng
    • PID: 16438663
    • Yap KY, Chan SY, Weng Chan Y, Sing Lim C (2005) Overview on the analytical tools for quality control of natural product-based supplements: a case study of ginseng. Assay Drug Dev Technol 3:683–699
    • (2005) Assay Drug Dev Technol , vol.3 , pp. 683-699
    • Yap, K.Y.1    Chan, S.Y.2    Weng Chan, Y.3    Sing Lim, C.4
  • 164
    • 79960821247 scopus 로고    scopus 로고
    • Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window
    • COI: 1:CAS:528:DC%2BC3MXpsFKhu7o%3D, PID: 21647765
    • Ye R, Kong X, Yang Q, Zhang Y, Han J, Li P, Xiong L, Zhao G (2011a) Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics 8:515–525
    • (2011) Neurotherapeutics , vol.8 , pp. 515-525
    • Ye, R.1    Kong, X.2    Yang, Q.3    Zhang, Y.4    Han, J.5    Li, P.6    Xiong, L.7    Zhao, G.8
  • 165
    • 79960025353 scopus 로고    scopus 로고
    • Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice
    • COI: 1:CAS:528:DC%2BC3MXosFaqs70%3D, PID: 21664366
    • Ye R, Kong X, Yang Q, Zhang Y, Han J, Zhao G (2011b) Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology 61:815–824
    • (2011) Neuropharmacology , vol.61 , pp. 815-824
    • Ye, R.1    Kong, X.2    Yang, Q.3    Zhang, Y.4    Han, J.5    Zhao, G.6
  • 166
    • 84879098852 scopus 로고    scopus 로고
    • Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside
    • COI: 1:CAS:528:DC%2BC3sXosl2rs7k%3D, PID: 23738998
    • Ye R, Zhao G, Liu X (2013) Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside. Expert Rev Neurother 13:603–613
    • (2013) Expert Rev Neurother , vol.13 , pp. 603-613
    • Ye, R.1    Zhao, G.2    Liu, X.3
  • 167
    • 0035650950 scopus 로고    scopus 로고
    • Brief introduction of Panax ginseng C.A. Meyer
    • PID: 11748372
    • Yun TK (2001) Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 16:S3–S5
    • (2001) J Korean Med Sci , vol.16 , pp. 3-5
    • Yun, T.K.1
  • 168
    • 4444239425 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease
    • PID: 15278009
    • Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ (2004) Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit 10:RA187–RA192
    • (2004) Med Sci Monit , vol.10 , pp. 187-192
    • Zhou, W.1    Chai, H.2    Lin, P.H.3    Lumsden, A.B.4    Yao, Q.5    Chen, C.J.6


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