Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation

Neurochemistry International

Volumn 58, Issue 1, 2011, Pages 119-125

  Liu, Qian ^a,b   Kou, Jun Ping ^a   Yu, Bo Yang ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Ginsenoside Rg1; H2O2; NF B pathway; Oxidative stress; PC12 cells

Indexed keywords

GINSENOSIDE RG 1; HYDROGEN PEROXIDE; I KAPPA B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SYNAPTOTAGMIN I;

ARTICLE; CELL DEATH; CELL STRAIN; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTIOXIDANTS; BENZIMIDAZOLES; BLOTTING, WESTERN; CELL SURVIVAL; COLORING AGENTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENT DYES; GINSENOSIDES; HYDROGEN PEROXIDE; I-KAPPA B PROTEINS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

PANAX GINSENG;

EID: 78650415275     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.11.004     Document Type: Article

References (41)

1. K.J. Barnham, C.L. Masters, and A.I. Bush Neurodegenerative diseases and oxidative stress Nat. Rev. Drug Discov. 3 2004 205 214
2. M. Bisaglia, V. Venezia, P. Piccioli, S. Stanzione, C. Porcile, C. Russo, F. Mancini, C. Milanese, and G. Schettini Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappa B activation Neurochem. Int. 41 2002 43 54
3. T.G. Canty Jr., E.M. Boyle Jr., A. Farr, E.N. Morgan, E.D. Verrier, and T.H. Pohlman Oxidative stress induces NF-kappa B nuclear translocation without degradation of IkappaBalpha Circulation 100 1999 II361 II364
4. R.J. Castellani, P.I. Moreira, G. Liu, J. Dobson, G. Perry, M.A. Smith, and X. Zhu Iron: the redox-active center of oxidative stress in Alzheimer disease Neurochem. Res. 32 2007 1640 1645
5. P.H. Chan Reactive oxygen radicals in signaling and damage in the ischemic brain J. Cereb. Blood Flow Metab. 21 2001 2 14
6. X.C. Chen, Y.C. Zhou, Y. Chen, Y.G. Zhu, F. Fang, and L.M. Chen Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress Acta Pharmacol. Sin. 26 2005 56 62
7. X.C. Chen, Y.G. Zhu, L.A. Zhu, C. Huang, Y. Chen, L.M. Chen, F. Fang, Y.C. Zhou, and C.H. Zhao Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress Eur. J. Pharmacol. 473 2003 1 7
8. A.J. Chia, C.E. Goldring, N.R. Kitteringham, S.Q. Wong, P. Morgan, and B.K. Park Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappa B Biochem. Pharmacol. 80 2010 410 421
9. J.J. Choi, J. Choi, C.D. Kang, X. Chen, C.F. Wu, K.H. Ko, and W.K. Kim Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappa B activity Free Radic. Res. 41 2007 555 562
10. R. Colognato, I. Laurenza, I. Fontana, F. Coppede, G. Siciliano, S. Coecke, O.I. Aruoma, L. Benzi, and L. Migliore Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine Clin. Nutr. 25 2006 135 145
11. T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of aging Nature 408 2000 239 247
12. Q.G. Gao, W.F. Chen, J.X. Xie, and M.S. Wong Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways J. Neurochem. 109 2009 1338 1347
13. K.L. Ge, W.F. Chen, J.X. Xie, and M.S. Wong Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways J. Ethnopharmacol. 127 2010 118 123
14. S.H. Green The use of PC12 cells for the study of the mechanism of action of neurotrophic factors: signal transduction and programmed cell death Methods 7 1995 222 237
15. G. Groeger, C. Quiney, and T.G. Cotter Hydrogen peroxide as a cell-survival signaling molecule Antioxid. Redox Signal. 11 2009 2655 2671
16. W. Jiang, J. Kou, Z. Zhang, and B. Yu The effects of twelve representative flavonoids on tissue factor expression in human monocytes: structure-activity relationships Thromb. Res. 124 2009 714 720
17. B. Kaltschmidt, D. Widera, and C. Kaltschmidt Signaling via NF-kappaB in the nervous system Biochim. Biophys. Acta 1745 2005 287 299
18. B.H. Kim, E. Roh, H.Y. Lee, I.J. Lee, B. Ahn, S.H. Jung, H. Lee, S.B. Han, and Y. Kim Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappa B-regulated gene transcription through inactivating inhibitory kappaB kinase beta Mol. Pharmacol. 73 2008 1309 1318
19. D. Krappmann, E.N. Hatada, S. Tegethoff, J. Li, A. Klippel, K. Giese, P.A. Baeuerle, and C. Scheidereit The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component J. Biol. Chem. 275 2000 29779 29787
20. 2-induced PC12 cell injury Nat. Prod. Commun. 5 2010 571 574
21. A. Lewen, P. Matz, and P.H. Chan Free radical pathways in CNS injury J. Neurotrauma 17 2000 871 890
22. W.B. Liu, J. Zhou, Y. Qu, X. Li, C.T. Lu, K.L. Xie, X.L. Sun, and Z. Fei Neuroprotective effect of osthole on MPP(+)-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production Neurochem. Int. 57 2010 206 215
23. K.P. Loh, S.H. Huang, R. De Silva, B.K. Tan, and Y.Z. Zhu Oxidative stress: apoptosis in neuronal injury Curr. Alzheimer Res. 3 2006 327 337
24. M.V. Lopez, M.P. Cuadrado, O.M. Ruiz-Poveda, A.M. Del Fresno, and M.E. Accame Neuroprotective effect of individual ginsenosides on astrocytes primary culture Biochim. Biophys. Acta 1770 2007 1308 1316
25. P. Maroni, P. Bendinelli, L. Tiberio, F. Rovetta, R. Piccoletti, and L. Schiaffonati In vivo heat-shock response in the brain: signalling pathway and transcription factor activation Brain Res. Mol. Brain Res. 119 2003 90 99
26. M.P. Mattson NF-kappa B in the survival and plasticity of neurons Neurochem. Res. 30 2005 883 893
27. M.V. Naval, M.P. Gómez-Serranillos, M.E. Carretero, and A.M. Villar Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocyts primary culture J. Ethnopharmacol. 112 2007 262 270
28. 2: a major role for a simple chemical process in a complex biological response Antioxid. Redox Signal. 11 2009 2043 2053
29. V. Oliveira-Marques, H.S. Marinho, L. Cyrne, and F. Antunes Role of hydrogen peroxide in NF-kappa B activation: from inducer to modulator Antioxid. Redox Signal. 11 2009 2223 2243
30. Z.H. Qin, L.Y. Tao, and X. Chen Dual roles of NF-kappa B in cell survival and implications of NF-kappa B inhibitors in neuroprotective therapy Acta Pharmacol. Sin. 28 2007 1859 1872
31. A. Reynolds, C. Laurie, R.L. Mosley, and H.E. Gendelman Oxidative stress and the pathogenesis of neurodegenerative disorders Int. Rev. Neurobiol. 82 2007 297 325
32. R. Schreck, P. Rieber, and P.A. Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 Embo. J. 10 1991 2247 2258
33. 2+ dyshomeostasis that is blocked by EGb761 Neurochem. Int. 56 2010 893 905
34. H.M. Shin, M.H. Kim, B.H. Kim, S.H. Jung, Y.S. Kim, H.J. Park, J.T. Hong, K.R. Min, and Y. Kim Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappa B without affecting I kappa B degradation FEBS Lett. 571 2004 50 54
35. Y. Takada, A. Mukhopadhyay, G.C. Kundu, G.H. Mahabeleshwar, S. Singh, and B.B. Aggarwal Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase J. Biol. Chem. 278 2003 24233 24241
36. 2 enhances cell damage in rat PC12 cells Neurosci. Lett. 353 2003 115 118
37. L. Wang, M.X. Gong, X. Chen, and K. Tetsuya The protective efects of ginsenoside Rgl on hydrogen peroxide-induced oxidative damage in PC12 cells J. Shanghai Trad. Chin. Med. 39 2005 56 58
38. C. Wei, J. Jia, P. Liang, and Y. Guan Ginsenoside Rg1 attenuates beta-amyloid-induced apoptosis in mutant PS1 M146L cells Neurosci. Lett. 443 2008 145 149
39. +-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake Neuropharmacology 58 2010 488 494
40. R. Ye, J. Han, X. Kong, L. Zhao, R. Cao, Z. Rao, and G. Zhao Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide Biol. Pharm. Bull. 31 2008 1923 1927
41. X. Zhu, M.A. Smith, K. Honda, G. Aliev, P.I. Moreira, A. Nunomura, G. Casadesus, P.L. Harris, S.L. Siedlak, and G. Perry Vascular oxidative stress in Alzheimer disease J. Neurol. Sci. 257 2007 240 246 (Pubitemid 46856513)