Neuroprotective effect of 20(R)-ginsenoside Rg3 against transient focal cerebral ischemia in rats

Neuroscience Letters

Volumn 526, Issue 2, 2012, Pages

  He, Bo ^a   Chen, Peng ^a   Yang, Jianyu ^a   Yun, Yu ^a   Zhang, Xiaochao ^a   Yang, Renhua ^a   Shen, Zhiqiang ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

20(R) ginsenoside Rg3; Apoptosis; Calpain; Caspase 3; Cerebral ischemia reperfusion injury

Indexed keywords

CALPAIN 1; CASPASE 3; GINSENOSIDE RG 3; MESSENGER RNA; NIMODIPINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BEHAVIOR DISORDER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENZYME REGULATION; IN SITU HYBRIDIZATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; BRAIN; BRAIN INFARCTION; CA1 REGION, HIPPOCAMPAL; CALPAIN; CASPASE 3; GINSENOSIDES; ISCHEMIC ATTACK, TRANSIENT; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER;

EID: 84865967382     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.022     Document Type: Article

References (22)

1. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
2. Benedek A., Moricz K., Juranyi Z., Gigler G., Levay G., Harsing L.G., Matyus P., Szenasi G., Albert M. Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats. Brain Research 2006, 1116:159-165.
3. Boatright K.M., Salvesen G.S. Mechanisms of caspase activation. Current Opinion in Cell Biology 2003, 15:725-731.
4. Dong H., Bai L.-P., Wong V.K.W., Zhou H., Wang J.-R., Liu Y., Jiang Z.-H., Liu L. The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. Molecules 2011, 16:10619-10630.
5. Durukan A., Tatlisumak T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacology Biochemistry and Behavior 2007, 87:179-197.
6. 3 on human umbilical vein endothelial cell injury induced by LPS. Chinese Pharmaceutical Journal 2009, 44:1703-1707.
7. 3 action on ion channels. Molecules and Cells 2004, 18:383-389.
8. Joshi C.N., Jain S.K., Murthy P.S. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Research. Brain Research Protocols 2004, 13:11-17.
9. 3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Research 2007, 1136:190-199.
10. 3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochemical and Biophysical Research Communications 2004, 323:416-424.
11. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
12. Lu J.M., Yao Q., Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Current Vascular Pharmacology 2009, 7:293-302.
13. Martinez M.M., Reif R.D., Pappas D. Detection of apoptosis: a review of conventional and novel techniques. Analytical Methods 2010, 2:996-1004.
14. Nicotera P., Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 2004, 23:2757-2765.
15. Ono Y., Sorimachi H. Calpains - an elaborate proteolytic system. Biochimica et Biophysica Acta 2012, 1824:224-236.
16. Rami A. Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis. Neurobiology of Disease 2003, 13:75-88.
17. Rami A., Agarwal R., Botez G., Winckler J. mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage. Brain Research 2000, 866:299-312.
18. Segura T., Calleja S., Jordan J. Recommendations and treatment strategies for the management of acute ischemic stroke. Expert Opinion on Pharmacotherapy 2008, 9:1071-1085.
19. 3 in mice by intranasally administration. Biological and Pharmaceutical Bulletin 2008, 31:2024-2027.
20. 3 on cerebral ischemia in rats. Neuroscience Letters 2005, 374:92-97.
21. 3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain. Phytotherapy Research 2009, 23:486-491.
22. Vanlangenakker N., Vanden Berghe T., Krysko D.V., Festjens N., Vandenabeele P. Molecular mechanisms and pathophysiology of necrotic cell death. Current Molecular Medicine 2008, 8:207-220.