Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells

Toxicology and Applied Pharmacology

Volumn 242, Issue 1, 2010, Pages 18-28

  Hwang, Yong Pil ^a,b   Jeong, Hye Gwang ^a,b  

^a Chungnam National University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Cytoprotection; Estrogen receptor; Ginsenoside Rb1; Heme oxygenase 1; NF E2 related factor 2; Phosphatidylinositol 3 kinase

Indexed keywords

CASPASE 3; ESTROGEN RECEPTOR; FULVESTRANT; GINSENOSIDE RB 1; HEME OXYGENASE 1; OXIDOPAMINE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROPROTECTION; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; DOPAMINE; GINSENOSIDES; HEME OXYGENASE-1; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; NF-E2-RELATED FACTOR 2; ONCOGENE PROTEIN V-AKT; OXIDATIVE STRESS; OXIDOPAMINE; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSFECTION;

ARALIACEAE; PANAX GINSENG;

EID: 70449535513     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.09.009     Document Type: Article

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