Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 19126-19131

  Perier, Celine ^a   Tieu, Kim ^a,d   Guégan, Christelle ^a,e   Caspersen, Casper ^a   Jackson Lewis, Vernice ^a   Carelli, Valerio ^b   Martinuzzi, Andréa ^c   Hirano, Michio ^a   Przedborski, Serge ^a   Vila, Miquel ^a,f  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SCIENTIFIC INSTITUTE   (Italy)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e INSERM   (France)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Mitochondria; Neurodegeneration; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CYTOCHROME C; CYTOCHROME C OXIDASE; HYDROGEN PEROXIDE; PROTEIN; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LEBER HEREDITARY OPTIC NEUROPATHY; MALE; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; POLAROGRAPHY; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ASCORBIC ACID; BCL-2-ASSOCIATED X PROTEIN; BRAIN; CARDIOLIPINS; CELL DEATH; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX I; GENETIC TECHNIQUES; HYDROGEN PEROXIDE; MALE; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; NEURONS; OXIDATIVE STRESS; OXYGEN; PARKINSON DISEASE; REACTIVE OXYGEN SPECIES; SUBCELLULAR FRACTIONS; SUBMITOCHONDRIAL PARTICLES; TIME FACTORS;

ANIMALIA;

EID: 30044442094     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508215102     Document Type: Article

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