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Volumn 72, Issue 8, 2011, Pages 689-699

Ginsenosides from American ginseng: Chemical and pharmacological diversity

Author keywords

American ginseng; Araliaceae; Asian ginseng; Diversity; Ginsenosides; Panax quinquefolius; Structural activity relationship

Indexed keywords

BIOLOGICAL PRODUCT; GINSENOSIDE;

EID: 79954627696     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2011.02.012     Document Type: Review
Times cited : (382)

References (152)
  • 1
    • 68149145788 scopus 로고    scopus 로고
    • Molecular targets of nutraceuticals derived from dietary spices: Potential role in suppression of inflammation and tumorigenesis
    • B.B. Aggarwal, M.E. Van Kuiken, L.H. Iyer, K.B. Harikumar, and B. Sung Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis Exp. Biol. Med. 234 2009 825 849
    • (2009) Exp. Biol. Med. , vol.234 , pp. 825-849
    • Aggarwal, B.B.1    Van Kuiken, M.E.2    Iyer, L.H.3    Harikumar, K.B.4    Sung, B.5
  • 3
    • 0042303946 scopus 로고    scopus 로고
    • Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng)
    • V.A. Assinewe, B.R. Baum, D. Gagnon, and J.T. Arnason Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng) J. Agric. Food Chem. 51 2003 4549 4553
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 4549-4553
    • Assinewe, V.A.1    Baum, B.R.2    Gagnon, D.3    Arnason, J.T.4
  • 4
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • DOI 10.1016/S0006-2952(99)00212-9, PII S0006295299002129
    • A.S. Attele, J.A. Wu, and C.S. Yuan Ginseng pharmacology: multiple constituents and multiple actions Biochem. Pharmacol. 58 1999 1685 1693 (Pubitemid 29505408)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.11 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.-S.3
  • 8
    • 77952557635 scopus 로고    scopus 로고
    • A comparative study of the potential antioxidant activities of ginsenosides
    • S. Chae, K.A. Kang, U. Youn, J.S. Park, and J.W. Hyun A comparative study of the potential antioxidant activities of ginsenosides J. Food Biochem. 34 2010 31 43
    • (2010) J. Food Biochem. , vol.34 , pp. 31-43
    • Chae, S.1    Kang, K.A.2    Youn, U.3    Park, J.S.4    Hyun, J.W.5
  • 9
    • 64549121101 scopus 로고    scopus 로고
    • Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates
    • Y.H. Chang, and P.K.W. Ng Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates J. Agric. Food Chem. 57 2009 2356 2362
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 2356-2362
    • Chang, Y.H.1    Ng, P.K.W.2
  • 12
    • 51349086818 scopus 로고    scopus 로고
    • Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium
    • C.F. Chen, W.F. Chiou, and J.T. Zhang Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium Acta Pharmacol. Sin. 29 2008 1103 1108
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 1103-1108
    • Chen, C.F.1    Chiou, W.F.2    Zhang, J.T.3
  • 13
    • 53549093298 scopus 로고    scopus 로고
    • Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells
    • J.X. Chen, H.M. Peng, O.Y. Xi, and X.Y. He Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells Melanoma Res. 18 2008 322 329
    • (2008) Melanoma Res. , vol.18 , pp. 322-329
    • Chen, J.X.1    Peng, H.M.2    Xi, O.Y.3    He, X.Y.4
  • 14
    • 45849093732 scopus 로고    scopus 로고
    • Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats
    • L.M. Chen, X.M. Zhou, Y.L. Cao, and W.X. Hu Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats J. Asian Nat. Prod. Res. 10 2008 439 445
    • (2008) J. Asian Nat. Prod. Res. , vol.10 , pp. 439-445
    • Chen, L.M.1    Zhou, X.M.2    Cao, Y.L.3    Hu, W.X.4
  • 15
    • 40849125462 scopus 로고    scopus 로고
    • Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide(25-35)-induced tau hyperphosphorylation in cortical neurons
    • X.C. Chen, T.W. Huang, J. Zhang, J.Q. Song, L.M. Chen, and Y.G. Zhu Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide(25-35)-induced tau hyperphosphorylation in cortical neurons Brain Res. 1200 2008 99 106
    • (2008) Brain Res. , vol.1200 , pp. 99-106
    • Chen, X.C.1    Huang, T.W.2    Zhang, J.3    Song, J.Q.4    Chen, L.M.5    Zhu, Y.G.6
  • 17
    • 64849089057 scopus 로고    scopus 로고
    • Effect of sugar positions in ginsenosides and their inhibitory potency on Na+/K+-ATPase activity
    • R.J.Y. Chen, T.Y. Chung, F.Y. Li, N.H. Lin, and J.T.C. Tzen Effect of sugar positions in ginsenosides and their inhibitory potency on Na+/K+-ATPase activity Acta Pharmacol. Sin. 30 2009 61 69
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 61-69
    • Chen, R.J.Y.1    Chung, T.Y.2    Li, F.Y.3    Lin, N.H.4    Tzen, J.T.C.5
  • 18
    • 77955924177 scopus 로고    scopus 로고
    • Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: With emphasis on autophagy
    • Z.Y. Chen, T.T. Lu, X.Y. Yue, N. Wei, Y.J. Jiang, M.G. Chen, G.Z. Ni, X.F. Liu, and G.L. Xu Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy Neurosci. Lett. 482 2010 264 268
    • (2010) Neurosci. Lett. , vol.482 , pp. 264-268
    • Chen, Z.Y.1    Lu, T.T.2    Yue, X.Y.3    Wei, N.4    Jiang, Y.J.5    Chen, M.G.6    Ni, G.Z.7    Liu, X.F.8    Xu, G.L.9
  • 19
    • 18744403057 scopus 로고    scopus 로고
    • Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
    • C.C. Cheng, S.M. Yang, C.Y. Huang, J.C. Chen, W.M. Chang, and S.L. Hsu Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells Cancer Chemother. Pharmacol. 55 2005 531 540
    • (2005) Cancer Chemother. Pharmacol. , vol.55 , pp. 531-540
    • Cheng, C.C.1    Yang, S.M.2    Huang, C.Y.3    Chen, J.C.4    Chang, W.M.5    Hsu, S.L.6
  • 20
    • 13444293396 scopus 로고    scopus 로고
    • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
    • DOI 10.1111/j.1745-7254.2005.00034.x
    • Y. Cheng, L.H. Shen, and J.T. Zhang Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action Acta Pharmacol. Sin. 26 2005 143 149 (Pubitemid 40203956)
    • (2005) Acta Pharmacologica Sinica , vol.26 , Issue.2 , pp. 143-149
    • Cheng, Y.1    Shen, L.-H.2    Zhang, J.-T.3
  • 21
    • 74549165964 scopus 로고    scopus 로고
    • Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells
    • S.H. Cho, K.S. Chung, J.H. Choi, D.H. Kim, and K.T. Lee Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells BMC Cancer 9 2009 449
    • (2009) BMC Cancer , vol.9 , pp. 449
    • Cho, S.H.1    Chung, K.S.2    Choi, J.H.3    Kim, D.H.4    Lee, K.T.5
  • 22
    • 69949130845 scopus 로고    scopus 로고
    • Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent Inhibition of cyclin-dependent kinases
    • S. Choi, T.W. Kim, and S.V. Singh Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent Inhibition of cyclin-dependent kinases Pharm. Res. 26 2009 2280 2288
    • (2009) Pharm. Res. , vol.26 , pp. 2280-2288
    • Choi, S.1    Kim, T.W.2    Singh, S.V.3
  • 23
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • L.P. Christensen Ginsenosides chemistry, biosynthesis, analysis, and potential health effects Adv. Food Nutr. Res. 55 2009 1 99
    • (2009) Adv. Food Nutr. Res. , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 24
    • 0034267967 scopus 로고    scopus 로고
    • Ginseng: The history of an insignificant plant
    • W.E. Court Ginseng: the history of an insignificant plant Pharm. Hist. (London) 30 2000 38 44
    • (2000) Pharm. Hist. (London) , vol.30 , pp. 38-44
    • Court, W.E.1
  • 25
    • 0031581905 scopus 로고    scopus 로고
    • Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxiatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations
    • DOI 10.1016/S0378-4347(96)00304-0, PII S0378434796003040
    • J.F. Cui, I. Bjorkhem, and P. Eneroth Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations J. Chromatogr. B 689 1997 349 355 (Pubitemid 27091361)
    • (1997) Journal of Chromatography B: Biomedical Applications , vol.689 , Issue.2 , pp. 349-355
    • Cui, J.-F.1    Bjorkhem, I.2    Eneroth, P.3
  • 27
    • 0041336976 scopus 로고    scopus 로고
    • Anti-hyperglycemic effects of ginseng: Comparison between root and berry
    • DOI 10.1078/094471103322331908
    • L. Dey, J.T. Xie, A. Wang, J. Wu, S.A. Maleckar, and C.S. Yuan Anti-hyperglycemic effects of ginseng: comparison between root and berry Phytomedicine 10 2003 600 605 (Pubitemid 37092688)
    • (2003) Phytomedicine , vol.10 , Issue.6-7 , pp. 600-605
    • Dey, L.1    Xie, J.T.2    Wang, A.3    Wu, J.4    Maleckar, S.A.5    Yuan, C.-S.6
  • 28
    • 1442360991 scopus 로고    scopus 로고
    • Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction
    • DOI 10.1016/j.foodchem.2003.11.003
    • X.W. Du, R.B.H. Wills, and D.L. Stuart Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction Food Chem. 86 2004 155 159 (Pubitemid 38283566)
    • (2004) Food Chemistry , vol.86 , Issue.2 , pp. 155-159
    • Du, X.W.1    Wills, R.B.H.2    Stuart, D.L.3
  • 30
    • 71849114694 scopus 로고    scopus 로고
    • Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers
    • D. Giustarini, I. Dalle-Donne, D. Tsikas, and R. Rossi Oxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkers Crit. Rev. Clin. Lab. Sci. 46 2009 241 281
    • (2009) Crit. Rev. Clin. Lab. Sci. , vol.46 , pp. 241-281
    • Giustarini, D.1    Dalle-Donne, I.2    Tsikas, D.3    Rossi, R.4
  • 31
    • 77951222633 scopus 로고    scopus 로고
    • Validated quantification for selective cellular uptake of ginsenosides on MCF-7 human breast cancer cells by liquid chromatography-mass spectrometry
    • Y.W. Ha, K.S. Ahn, J.C. Lee, S.H. Kim, B.C. Chung, and M.H. Choi Validated quantification for selective cellular uptake of ginsenosides on MCF-7 human breast cancer cells by liquid chromatography-mass spectrometry Anal. Bioanal. Chem. 396 2010 3017 3025
    • (2010) Anal. Bioanal. Chem. , vol.396 , pp. 3017-3025
    • Ha, Y.W.1    Ahn, K.S.2    Lee, J.C.3    Kim, S.H.4    Chung, B.C.5    Choi, M.H.6
  • 32
    • 29844443744 scopus 로고    scopus 로고
    • Ginsenoside 20(S)-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor γ (PPARγ) in 3T3-L1 adipocytes
    • DOI 10.1248/bpb.29.110
    • K.L. Han, M.H. Jung, J.H. Sohn, and J.K. Hwang Ginsenoside 20(S)-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPAR gamma) in 3T3-L1 adipocytes Biol. Pharm. Bull. 29 2006 110 113 (Pubitemid 43036705)
    • (2006) Biological and Pharmaceutical Bulletin , vol.29 , Issue.1 , pp. 110-113
    • Han, K.L.1    Jung, M.H.2    Sohn, J.H.3    Hwang, J.-K.4
  • 33
    • 3142621044 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: Basic and clinical trials: Metabolic activation of ginsenoside: Deglycosylation by intestinal bacteria and esterification with fatty acid
    • DOI 10.1254/jphs.FMJ04001X4
    • H. Hasegawa Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid J. Pharmacol. Sci. 95 2004 153 157 (Pubitemid 38899683)
    • (2004) Journal of Pharmacological Sciences , vol.95 , Issue.2 , pp. 153-157
    • Hasegawa, H.1
  • 34
    • 0036774226 scopus 로고    scopus 로고
    • Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships
    • DOI 10.1016/S0955-2863(02)00208-5, PII S0955286302002085
    • K.E. Heim, A.R. Tagliaferro, and D.J. Bobilya Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships J. Nutr. Biochem. 13 2002 572 584 (Pubitemid 35246546)
    • (2002) Journal of Nutritional Biochemistry , vol.13 , Issue.10 , pp. 572-584
    • Heim, K.E.1    Tagliaferro, A.R.2    Bobilya, D.J.3
  • 35
    • 59449096216 scopus 로고    scopus 로고
    • Novel aspects of oxidative stress in cardiovascular diseases
    • D.D. Heistad, Y. Wakisaka, J. Miller, Y. Chu, and R. Pena-Silva Novel aspects of oxidative stress in cardiovascular diseases Circ. J. 73 2009 201 207
    • (2009) Circ. J. , vol.73 , pp. 201-207
    • Heistad, D.D.1    Wakisaka, Y.2    Miller, J.3    Chu, Y.4    Pena-Silva, R.5
  • 36
    • 26244456602 scopus 로고    scopus 로고
    • American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings
    • C.C. Hsu, M.C. Ho, L.C. Lin, B. Su, and M.C. Hsu American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings World J. Gastroenterol. 11 2005 5327 5331 (Pubitemid 41410300)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.34 , pp. 5327-5331
    • Hsu, C.-C.1    Ho, M.-C.2    Lin, L.-C.3    Su, B.4    Hsu, M.-C.5
  • 37
    • 77649224706 scopus 로고    scopus 로고
    • Isolation and identification of two new polyynes from a North American ethnic medicinal plant-Oplopanax horridus (Smith) Miq
    • W.H. Huang, Q.W. Zhang, C.Z. Wang, C.S. Yuan, and S.P. Li Isolation and identification of two new polyynes from a North American ethnic medicinal plant-Oplopanax horridus (Smith) Miq Molecules 15 2010 1089 1096
    • (2010) Molecules , vol.15 , pp. 1089-1096
    • Huang, W.H.1    Zhang, Q.W.2    Wang, C.Z.3    Yuan, C.S.4    Li, S.P.5
  • 40
    • 70349397280 scopus 로고    scopus 로고
    • Current evaluation of the millennium phytomedicine-ginseng (I): Etymology, pharmacognosy, phytochemistry, market and regulations
    • L. Jia, and Y.Q. Zhao Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations Curr. Med. Chem. 16 2009 2475 2484
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2475-2484
    • Jia, L.1    Zhao, Y.Q.2
  • 41
    • 47049126102 scopus 로고    scopus 로고
    • Two new acetylated ginsenosides from the roots of Panax quinquefolium
    • J.M. Jia, Z.Q. Wang, and L.J. Wu Two new acetylated ginsenosides from the roots of Panax quinquefolium Chin. Chem. Lett. 19 2008 1099 1102
    • (2008) Chin. Chem. Lett. , vol.19 , pp. 1099-1102
    • Jia, J.M.1    Wang, Z.Q.2    Wu, L.J.3
  • 42
    • 48549086545 scopus 로고    scopus 로고
    • Structure elucidation and complete NMR spectral assignments of two new dammarane-type tetraglycosides from Panax quinquefolium
    • H.P. Jiang, Y.K. Qiu, D.R. Cheng, T.G. Kang, and D.Q. Dou Structure elucidation and complete NMR spectral assignments of two new dammarane-type tetraglycosides from Panax quinquefolium Magn. Reson. Chem. 46 2008 786 790
    • (2008) Magn. Reson. Chem. , vol.46 , pp. 786-790
    • Jiang, H.P.1    Qiu, Y.K.2    Cheng, D.R.3    Kang, T.G.4    Dou, D.Q.5
  • 45
    • 20544477459 scopus 로고    scopus 로고
    • Reciprocal activity of ginsenosides in the production of proinflammatory repertoire, and their potential roles in neuroprotection in vitro
    • DOI 10.1055/s-2005-864145
    • S.S. Joo, T.J. Won, and D.I. Lee Reciprocal activity of ginsenosides in the production of proinflarnmatory repertoire, and their potential roles in neuroprotection in vitro Planta Med. 71 2005 476 481 (Pubitemid 40839784)
    • (2005) Planta Medica , vol.71 , Issue.5 , pp. 476-481
    • Joo, S.S.1    Won, T.J.2    Lee, D.I.3
  • 47
    • 33747338973 scopus 로고    scopus 로고
    • Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing
    • DOI 10.1016/j.bmcl.2006.07.071, PII S0960894X06008560
    • K.S. Kang, H.Y. Kim, N. Yamabe, and T. Yokozawa Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing Bioorg. Med. Chem. Lett. 16 2006 5028 5031 (Pubitemid 44247717)
    • (2006) Bioorganic and Medicinal Chemistry Letters , vol.16 , Issue.19 , pp. 5028-5031
    • Kang, K.S.1    Kim, H.Y.2    Yamabe, N.3    Yokozawa, T.4
  • 48
    • 34248221485 scopus 로고    scopus 로고
    • ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C. A. MEYER
    • DOI 10.1248/bpb.30.917
    • K.S. Kang, T. Yokozawa, N. Yamabe, H.Y. Kim, and J.H. Park ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C. A. MEYER Biol. Pharm. Bull. 30 2007 917 921 (Pubitemid 46708640)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.5 , pp. 917-921
    • Kang, K.S.1    Yokozawa, T.2    Yamabe, N.3    Kim, H.Y.4    Park, J.H.5
  • 51
    • 35548991447 scopus 로고    scopus 로고
    • Protective effect of heat-processed American ginseng against diabetic renal damage in rats
    • DOI 10.1021/jf071770y
    • H.Y. Kim, K.S. Kang, N. Yamabe, R. Nagai, and T. Yokozawa Protective effect of heat-processed American ginseng against diabetic renal damage in rats J. Agric. Food Chem. 55 2007 8491 8497 (Pubitemid 350013093)
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , Issue.21 , pp. 8491-8497
    • Hyun, Y.K.1    Ki, S.K.2    Yamabe, N.3    Nagai, R.4    Yokozawa, T.5
  • 52
    • 35348993755 scopus 로고    scopus 로고
    • Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells
    • S.Y. Kim, D.H. Kim, S.J. Han, J.W. Hyun, and H.S. Kim Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells Biochem. Pharmacol. 74 2007 1642 1651
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 1642-1651
    • Kim, S.Y.1    Kim, D.H.2    Han, S.J.3    Hyun, J.W.4    Kim, H.S.5
  • 53
    • 75249083418 scopus 로고    scopus 로고
    • Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell proliferation by American ginseng (Panax quinquefolius) and its constituents
    • M.L. King, and L.L. Murphy Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell proliferation by American ginseng (Panax quinquefolius) and its constituents Phytomedicine 17 2010 261 268
    • (2010) Phytomedicine , vol.17 , pp. 261-268
    • King, M.L.1    Murphy, L.L.2
  • 55
    • 7744240334 scopus 로고    scopus 로고
    • High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng
    • A.J. Lau, B.H. Seo, S.O. Woo, and H.L. Koh High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng J. Chromatogr. A 1057 2004 141 149
    • (2004) J. Chromatogr. A , vol.1057 , pp. 141-149
    • Lau, A.J.1    Seo, B.H.2    Woo, S.O.3    Koh, H.L.4
  • 56
    • 0034284840 scopus 로고    scopus 로고
    • Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
    • S.J. Lee, W.G. Ko, J.H. Kim, J.H. Sung, S.J. Lee, C.K. Moon, and B.H. Lee Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease Biochem. Pharmacol. 60 2000 677 685
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 677-685
    • Lee, S.J.1    Ko, W.G.2    Kim, J.H.3    Sung, J.H.4    Lee, S.J.5    Moon, C.K.6    Lee, B.H.7
  • 57
    • 33645083467 scopus 로고    scopus 로고
    • Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats
    • W.K. Lee, S.T. Kao, I.M. Liu, and J.T. Cheng Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats Clin. Exp. Pharmacol. Physiol. 33 2006 27 32
    • (2006) Clin. Exp. Pharmacol. Physiol. , vol.33 , pp. 27-32
    • Lee, W.K.1    Kao, S.T.2    Liu, I.M.3    Cheng, J.T.4
  • 58
    • 41849106806 scopus 로고    scopus 로고
    • Possible differential induction of phase 2 enzyme and antioxidant pathways by American ginseng, Panax quinquefolius
    • DOI 10.1177/0091270008314252
    • L.S. Lee, S.D. Wise, C. Chan, T.L. Parsons, C. Flexner, and P.S. Lietman Possible differential induction of phase 2 enzyme and antioxidant pathways by American ginseng, Panax quinquefolius J. Clin. Pharmacol. 48 2008 599 609 (Pubitemid 351503513)
    • (2008) Journal of Clinical Pharmacology , vol.48 , Issue.5 , pp. 599-609
    • Lee, L.S.1    Wise, S.D.2    Chan, C.3    Parsons, T.L.4    Flexner, C.5    Lietman, P.S.6
  • 59
    • 57549109681 scopus 로고    scopus 로고
    • Effect of North American ginseng on cs-137-induced micronuclei in human lymphocytes: A comparison with WR-1065
    • T.K. Lee, W.D. Wang, K.F. O'Brien, R.M. Johnke, T. Wang, R.R. Allison, and A.L. Diaz Effect of North American ginseng on cs-137-induced micronuclei in human lymphocytes: a comparison with WR-1065 Phytother. Res. 22 2008 1614 1622
    • (2008) Phytother. Res. , vol.22 , pp. 1614-1622
    • Lee, T.K.1    Wang, W.D.2    O'Brien, K.F.3    Johnke, R.M.4    Wang, T.5    Allison, R.R.6    Diaz, A.L.7
  • 60
    • 48649105424 scopus 로고    scopus 로고
    • The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb-1 by heat processing
    • Y.J. Lee, H.Y. Kim, K.S. Kang, J.G. Lee, T. Yokozawa, and J.H. Park The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb-1 by heat processing Bioorg. Med. Chem. Lett. 18 2008 4515 4520
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4515-4520
    • Lee, Y.J.1    Kim, H.Y.2    Kang, K.S.3    Lee, J.G.4    Yokozawa, T.5    Park, J.H.6
  • 62
    • 38649129752 scopus 로고    scopus 로고
    • The protective effects of ginsenosides on human erythrocytes against hemin-induced hemolysis
    • G.X. Li, and Z.Q. Liu The protective effects of ginsenosides on human erythrocytes against hemin-induced hemolysis Food Chem. Toxicol. 46 2008 886 892
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 886-892
    • Li, G.X.1    Liu, Z.Q.2
  • 63
    • 68749101880 scopus 로고    scopus 로고
    • A new triterpenoid saponin from the leaves and stems of Panax quinquefolium L
    • G.Y. Li, Y.M. Zeng, H. Meng, X. Li, and J.H. Wang A new triterpenoid saponin from the leaves and stems of Panax quinquefolium L Chinese Chem. Lett. 20 2009 1207 1210
    • (2009) Chinese Chem. Lett. , vol.20 , pp. 1207-1210
    • Li, G.Y.1    Zeng, Y.M.2    Meng, H.3    Li, X.4    Wang, J.H.5
  • 65
    • 59449090739 scopus 로고    scopus 로고
    • Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: Mechanism and possible structure-activity relationship investigation
    • W. Li, Y. Liu, J.W. Zhang, C.Z. Ai, N. Xiang, H.X. Liu, and L. Yang Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation Arch. Pharm. Res. 32 2009 49 57
    • (2009) Arch. Pharm. Res. , vol.32 , pp. 49-57
    • Li, W.1    Liu, Y.2    Zhang, J.W.3    Ai, C.Z.4    Xiang, N.5    Liu, H.X.6    Yang, L.7
  • 66
    • 70350370012 scopus 로고    scopus 로고
    • American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells
    • X.L. Li, C.Z. Wang, S. Sun, S.R. Mehendale, W. Du, T.C. He, and C.S. Yuan American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells Oncol. Rep. 22 2009 943 952
    • (2009) Oncol. Rep. , vol.22 , pp. 943-952
    • Li, X.L.1    Wang, C.Z.2    Sun, S.3    Mehendale, S.R.4    Du, W.5    He, T.C.6    Yuan, C.S.7
  • 67
    • 75949127378 scopus 로고    scopus 로고
    • Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
    • B.H. Li, C.Z. Wang, T.C. He, C.S. Yuan, and W. Du Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells Cancer Lett. 289 2010 62 70
    • (2010) Cancer Lett. , vol.289 , pp. 62-70
    • Li, B.H.1    Wang, C.Z.2    He, T.C.3    Yuan, C.S.4    Du, W.5
  • 70
    • 0036180097 scopus 로고    scopus 로고
    • Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in Vitro
    • DOI 10.1006/exnr.2001.7841
    • B. Liao, H. Newmark, and R. Zhou Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro Exp. Neurol. 173 2002 224 234 (Pubitemid 34151374)
    • (2002) Experimental Neurology , vol.173 , Issue.2 , pp. 224-234
    • Liao, B.1    Newmark, H.2    Zhou, R.3
  • 72
    • 0037462036 scopus 로고    scopus 로고
    • In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes
    • Z.Q. Liu, X.Y. Luo, G.Z. Liu, Y.P. Chen, Z.C. Wang, and Y.X. Sun In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes J. Agric. Food Chem. 51 2003 2555 2558
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 2555-2558
    • Liu, Z.Q.1    Luo, X.Y.2    Liu, G.Z.3    Chen, Y.P.4    Wang, Z.C.5    Sun, Y.X.6
  • 73
    • 65749114119 scopus 로고    scopus 로고
    • 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity
    • J. Liu, J. Shiono, K. Shimizu, H.S. Yu, C.Z. Zhang, F.X. Jin, and R. Kondo 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity Bioorg. Med. Chem. Lett. 19 2009 3320 3323
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 3320-3323
    • Liu, J.1    Shiono, J.2    Shimizu, K.3    Yu, H.S.4    Zhang, C.Z.5    Jin, F.X.6    Kondo, R.7
  • 74
    • 77952102126 scopus 로고    scopus 로고
    • Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin- dependent protein kinase II-dependent signaling pathway
    • Z.J. Liu, M. Zhao, Y. Zhang, J.F. Xue, and N.H. Chen Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway Brain Res. 1333 2010 1 8
    • (2010) Brain Res. , vol.1333 , pp. 1-8
    • Liu, Z.J.1    Zhao, M.2    Zhang, Y.3    Xue, J.F.4    Chen, N.H.5
  • 75
    • 0345868416 scopus 로고    scopus 로고
    • A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults
    • DOI 10.1111/j.1532-5415.2004.52004.x
    • J.E. McElhaney, S. Gravenstein, S.K. Cole, E. Davidson, D. O'Neill, S. Petitjean, B. Rumble, and J.J. Shan A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults J. Am. Geriatr. Soc. 52 2004 13 19 (Pubitemid 38090384)
    • (2004) Journal of the American Geriatrics Society , vol.52 , Issue.1 , pp. 13-19
    • McElhaney, J.E.1    Gravenstein, S.2    Cole, S.K.3    Davidson, E.4    O'Neill, D.5    Petitjean, S.6    Rumble, B.7    Shan, J.J.8
  • 76
    • 33751188067 scopus 로고    scopus 로고
    • Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes
    • DOI 10.1016/j.ejphar.2006.09.051, PII S0014299906010429
    • S.R. Mehendale, C.Z. Wang, Z.H. Shao, C.Q. Li, J.T. Xie, H.H. Aung, and C.S. Yuan Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes Eur. J. Pharmacol. 553 2006 209 214 (Pubitemid 44779590)
    • (2006) European Journal of Pharmacology , vol.553 , Issue.1-3 , pp. 209-214
    • Mehendale, S.R.1    Wang, C.-Z.2    Shao, Z.-H.3    Li, C.-Q.4    Xie, J.-T.5    Aung, H.H.6    Yuan, C.-S.7
  • 77
    • 69049109763 scopus 로고    scopus 로고
    • Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: Formulation, pharmacokinetics, biodistribution and efficacy
    • A.G. Musende, A. Eberding, C. Wood, H. Adomat, L. Fazli, A. Hurtado-Coll, W. Jia, M.B. Bally, and E.T. Guns Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy Cancer Chemother. Pharmacol. 64 2009 1085 1095
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 1085-1095
    • Musende, A.G.1    Eberding, A.2    Wood, C.3    Adomat, H.4    Fazli, L.5    Hurtado-Coll, A.6    Jia, W.7    Bally, M.B.8    Guns, E.T.9
  • 78
    • 36849043044 scopus 로고    scopus 로고
    • Ginsenosides: Are any of them candidates for drugs acting on the central nervous system?
    • DOI 10.1111/j.1527-3458.2007.00023.x
    • S.Y. Nah, D.H. Kim, and H. Rhim Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev. 13 2007 381 404 (Pubitemid 350233470)
    • (2007) CNS Drug Reviews , vol.13 , Issue.4 , pp. 381-404
    • Nah, S.-Y.1    Kim, D.-H.2    Rhim, H.3
  • 79
    • 34548681408 scopus 로고    scopus 로고
    • Medicinal flowers. XVII. New dammarane-type triterpene glycosides from flower buds of American ginseng, Panax quinquefolium L.
    • DOI 10.1248/cpb.55.1342
    • S. Nakamura, S. Sugimoto, H. Matsuda, and M. Yoshikawa Medicinal flowers. XVII. New dammarane-type triterpene glycosides from flower buds of American ginseng, Panax quinquefolium L Chem. Pharm. Bull. 55 2007 1342 1348 (Pubitemid 47414575)
    • (2007) Chemical and Pharmaceutical Bulletin , vol.55 , Issue.9 , pp. 1342-1348
    • Nakamura, S.1    Sugimoto, S.2    Matsuda, H.3    Yoshikawa, M.4
  • 80
    • 56749161352 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways
    • S. Park, I.S. Ahn, D.Y. Kwon, B.S. Ko, and W.K. Jun Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways Biosci. Biotechnol. Biochem. 72 2008 2815 2823
    • (2008) Biosci. Biotechnol. Biochem. , vol.72 , pp. 2815-2823
    • Park, S.1    Ahn, I.S.2    Kwon, D.Y.3    Ko, B.S.4    Jun, W.K.5
  • 81
    • 37849039770 scopus 로고    scopus 로고
    • Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice
    • A.A. Pawar, D.N. Tripathi, P. Ramarao, and G. Jena Protective effects of American ginseng (Panax quinquefolium) against mitomycin C induced micronuclei in mice Phytother. Res. 21 2007 1221 1227
    • (2007) Phytother. Res. , vol.21 , pp. 1221-1227
    • Pawar, A.A.1    Tripathi, D.N.2    Ramarao, P.3    Jena, G.4
  • 82
    • 70450228666 scopus 로고    scopus 로고
    • American ginseng inhibits induced COX-2 and NFKB activation in breast cancer cells
    • E.A. Peralta, L.L. Murphy, J. Minnis, S. Louis, and G.L. Dunnington American ginseng inhibits induced COX-2 and NFKB activation in breast cancer cells J. Surg. Res. 157 2009 261 267
    • (2009) J. Surg. Res. , vol.157 , pp. 261-267
    • Peralta, E.A.1    Murphy, L.L.2    Minnis, J.3    Louis, S.4    Dunnington, G.L.5
  • 83
    • 0036403187 scopus 로고    scopus 로고
    • Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
    • DOI 10.1016/S0003-9861(02)00398-3, PII S0003986102003983
    • D.G. Popovich, and D.D. Kitts Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line Arch. Biochem. Biophys. 406 2002 1 8 (Pubitemid 35191710)
    • (2002) Archives of Biochemistry and Biophysics , vol.406 , Issue.1 , pp. 1-8
    • Popovich, D.G.1    Kitts, D.D.2
  • 84
    • 34248669836 scopus 로고    scopus 로고
    • Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults
    • G.N. Predy, V. Goel, R.E. Lovlin, and T.K. Basu Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults J. Clin. Biochem. Nutr. 39 2006 160 165
    • (2006) J. Clin. Biochem. Nutr. , vol.39 , pp. 160-165
    • Predy, G.N.1    Goel, V.2    Lovlin, R.E.3    Basu, T.K.4
  • 85
    • 0034219727 scopus 로고    scopus 로고
    • Analysis of botanicals and dietary supplements for antioxidant capacity: A review
    • R.L. Prior, and G. Cao Analysis of botanicals and dietary supplements for antioxidant capacity: a review J. AOAC Int. 83 2000 950 956
    • (2000) J. AOAC Int. , vol.83 , pp. 950-956
    • Prior, R.L.1    Cao, G.2
  • 86
    • 77949452664 scopus 로고    scopus 로고
    • Anti-diabetic agents from natural products - An update from 2004 to 2009
    • L.W. Qi, E.H. Liu, C. Chu, Y.B. Peng, H.X. Cai, and P. Li Anti-diabetic agents from natural products - an update from 2004 to 2009 Curr. Top. Med. Chem. 10 2010 434 457
    • (2010) Curr. Top. Med. Chem. , vol.10 , pp. 434-457
    • Qi, L.W.1    Liu, E.H.2    Chu, C.3    Peng, Y.B.4    Cai, H.X.5    Li, P.6
  • 87
    • 77955663174 scopus 로고    scopus 로고
    • American ginseng: Potential structure-function relationship in cancer chemoprevention
    • L.W. Qi, C.Z. Wang, and C.S. Yuan American ginseng: potential structure-function relationship in cancer chemoprevention Biochem. Pharmacol. 80 2010 947 954
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 947-954
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 88
    • 67349150128 scopus 로고    scopus 로고
    • Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells
    • Y.K. Qiu, D.Q. Dou, L.P. Cai, H.P. Jiang, T.G. Kang, B.Y. Yang, H.X. Kuang, and M.Z.C. Li Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells Fitoterapia 80 2009 219 222
    • (2009) Fitoterapia , vol.80 , pp. 219-222
    • Qiu, Y.K.1    Dou, D.Q.2    Cai, L.P.3    Jiang, H.P.4    Kang, T.G.5    Yang, B.Y.6    Kuang, H.X.7    Li, M.Z.C.8
  • 89
    • 60749114139 scopus 로고    scopus 로고
    • Study on ginsenosides in different parts and ages of Panax quinquefolius L
    • C.L. Qu, Y.P. Bai, X.Q. Jin, Y.T. Wang, K. Zhang, J.Y. You, and H.Q. Zhang Study on ginsenosides in different parts and ages of Panax quinquefolius L Food Chem. 115 2009 340 346
    • (2009) Food Chem. , vol.115 , pp. 340-346
    • Qu, C.L.1    Bai, Y.P.2    Jin, X.Q.3    Wang, Y.T.4    Zhang, K.5    You, J.Y.6    Zhang, H.Q.7
  • 90
    • 0842265668 scopus 로고    scopus 로고
    • +-affected mesencephalic dopaminergic cells
    • DOI 10.1007/s00702-003-0063-1
    • K. Radad, G. Gille, R. Moldzio, H. Saito, K. Ishige, and W.D. Rausch Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP+-affected mesencephalic dopaminergic cells J. Neural Transm. 111 2004 37 45 (Pubitemid 38177816)
    • (2004) Journal of Neural Transmission , vol.111 , Issue.1 , pp. 37-45
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Ishige, K.5    Rausch, W.-D.6
  • 91
    • 4344622460 scopus 로고    scopus 로고
    • 1 effects on mesencephalic dopaminergic cells stressed with glutamate
    • DOI 10.1016/j.brainres.2004.06.030, PII S000689930400962X
    • K. Radad, G. Gille, R. Moldzio, H. Saito, and W.D. Rausch Ginsenosides Rb-1 and Rg(1) effects on mesencephalic dopaminergic cells stressed with glutamate Brain Res. 1021 2004 41 53 (Pubitemid 39158655)
    • (2004) Brain Research , vol.1021 , Issue.1 , pp. 41-53
    • Radad, K.1    Gille, G.2    Moldzio, R.3    Saito, H.4    Rausch, W.-D.5
  • 92
    • 33645058893 scopus 로고    scopus 로고
    • Use of ginseng in medicine with emphasis on neurodegenerative disorders
    • K. Radad, G. Gille, L.L. Liu, and W.D. Rausch Use of ginseng in medicine with emphasis on neurodegenerative disorders J. Pharmacol. Sci. 100 2006 175 186
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 175-186
    • Radad, K.1    Gille, G.2    Liu, L.L.3    Rausch, W.D.4
  • 94
    • 0032913555 scopus 로고    scopus 로고
    • Degradation of ginsenosides in American ginseng (Panax quinquefolium) extracts during microwave and conventional heating
    • DOI 10.1021/jf980678m
    • G.X. Ren, and F. Chen Degradation of ginsenosides in American ginseng (Panax quinquefolium) extracts during microwave and conventional heating J. Agric. Food Chem. 47 1999 1501 1505 (Pubitemid 29217146)
    • (1999) Journal of Agricultural and Food Chemistry , vol.47 , Issue.4 , pp. 1501-1505
    • Ren, G.1    Chen, F.2
  • 95
    • 33746253768 scopus 로고    scopus 로고
    • Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations
    • DOI 10.1016/j.phytochem.2006.05.028, PII S0031942206002974
    • E.M. Schlag, and M.S. McIntosh Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations Phytochemistry 67 2006 1510 1519 (Pubitemid 44092919)
    • (2006) Phytochemistry , vol.67 , Issue.14 , pp. 1510-1519
    • Schlag, E.M.1    McIntosh, M.S.2
  • 96
    • 78649290644 scopus 로고    scopus 로고
    • Effects of American ginseng (Panax quinquefolius) on neurocognitive function: An acute, randomised, double-blind, placebo-controlled, crossover study
    • A. Scholey, A. Ossoukhova, L. Owen, A. Ibarra, A. Pipingas, K. He, M. Roller, and C. Stough Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study Psychopharmacology 212 2010 345 356
    • (2010) Psychopharmacology , vol.212 , pp. 345-356
    • Scholey, A.1    Ossoukhova, A.2    Owen, L.3    Ibarra, A.4    Pipingas, A.5    He, K.6    Roller, M.7    Stough, C.8
  • 98
    • 33846064201 scopus 로고    scopus 로고
    • 2 and C/EBPα gene expression
    • DOI 10.1016/j.lfs.2006.10.021, PII S0024320506008046
    • W. Shang, Y. Yang, B. Jiang, H. Jin, L. Zhou, S. Liu, and M. Chen Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression Life Sci. 80 2007 618 625 (Pubitemid 46074052)
    • (2007) Life Sciences , vol.80 , Issue.7 , pp. 618-625
    • Shang, W.1    Yang, Y.2    Jiang, B.3    Jin, H.4    Zhou, L.5    Liu, S.6    Chen, M.7
  • 99
    • 53349141483 scopus 로고    scopus 로고
    • Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes
    • W. Shang, Y. Yang, L. Zhou, B. Jiang, H. Jin, and M. Chen Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes J. Endocrinol. 198 2008 561 569
    • (2008) J. Endocrinol. , vol.198 , pp. 561-569
    • Shang, W.1    Yang, Y.2    Zhou, L.3    Jiang, B.4    Jin, H.5    Chen, M.6
  • 101
    • 33845593946 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Rg5, a main constituent isolated from red ginseng, by human intestinal microflora and their antiallergic effect
    • Y.W. Shin, E.A. Bae, M.J. Han, and D.H. Kim Metabolism of ginsenoside Rg5, a main constituent isolated from red ginseng, by human intestinal microflora and their antiallergic effect J. Microbiol. Biotechnol. 16 2006 1791 1798 (Pubitemid 44932357)
    • (2006) Journal of Microbiology and Biotechnology , vol.16 , Issue.11 , pp. 1791-1798
    • Shin, Y.-W.1    Bae, E.-A.2    Han, M.J.3    Kim, D.-H.4
  • 102
    • 33748363531 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model
    • Y.W. Shin, E.A. Bae, and D.H. Kim Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model Arch. Pharm. Res. 29 2006 685 690
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 685-690
    • Shin, Y.W.1    Bae, E.A.2    Kim, D.H.3
  • 103
    • 2942575883 scopus 로고    scopus 로고
    • Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: The role of ginsenosides
    • J.L. Sievenpiper, J.T. Arnason, L.A. Leiter, and V. Vuksan Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides J. Am. Coll. Nutr. 23 2004 248 258 (Pubitemid 38746114)
    • (2004) Journal of the American College of Nutrition , vol.23 , Issue.3 , pp. 248-258
    • Sievenpiper, J.L.1    Arnason, J.T.2    Leiter, L.A.3    Vuksan, V.4
  • 104
    • 1442275290 scopus 로고    scopus 로고
    • A Systematic Quantitative Analysis of the Literature of the High Variability in Ginseng (Panax spp.) [2]
    • DOI 10.2337/diacare.27.3.839
    • J.L. Sievenpiper, J.T. Arnason, E. Vidgen, L.A. Leiter, and V. Vuksan A systematic quantitative analysis of the literature of the high variability in ginseng (Panax spp.) Diabetes Care 27 2004 839 840 (Pubitemid 38280564)
    • (2004) Diabetes Care , vol.27 , Issue.3 , pp. 839-840
    • Sievenpiper, J.L.1    Arnason, J.T.2    Vidgen, E.3    Leiter, L.A.4    Vuksan, V.5
  • 105
    • 23244447852 scopus 로고    scopus 로고
    • North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension
    • DOI 10.1161/01.HYP.0000173424.77483.1e
    • P.M. Stavro, M. Woo, T.F. Heim, L.A. Leiter, and V. Vuksan North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension Hypertension 46 2005 406 411 (Pubitemid 41099177)
    • (2005) Hypertension , vol.46 , Issue.2 , pp. 406-411
    • Stavro, P.M.1    Woo, M.2    Heim, T.F.3    Leiter, L.A.4    Vuksan, V.5
  • 106
    • 33645831759 scopus 로고    scopus 로고
    • Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function
    • DOI 10.1161/01.HYP.0000205150.43169.2c, PII 0000426820060400000030
    • P.M. Stavro, M. Woo, L.A. Leiter, T.F. Heim, J.L. Sievenpiper, and V. Vuksan Long-term intake of North American ginseng has no effect on 24-h blood pressure and renal function Hypertension 47 2006 791 796 (Pubitemid 43740253)
    • (2006) Hypertension , vol.47 , Issue.4 , pp. 791-796
    • Stavro, P.M.1    Woo, M.2    Leiter, L.A.3    Heim, T.F.4    Sievenpiper, J.L.5    Vuksan, V.6
  • 107
    • 78649327499 scopus 로고    scopus 로고
    • Red notoginseng: Higher ginsenoside content and stronger anticancer potential than Asian and American ginseng
    • S. Sun, L.W. Qi, G.J. Du, S.R. Mehendale, C.Z. Wang, and C.S. Yuan Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng Food Chem. 125 2011 1299 1305
    • (2011) Food Chem. , vol.125 , pp. 1299-1305
    • Sun, S.1    Qi, L.W.2    Du, G.J.3    Mehendale, S.R.4    Wang, C.Z.5    Yuan, C.S.6
  • 109
    • 11844298464 scopus 로고    scopus 로고
    • 3 on cerebral ischemia in rats
    • DOI 10.1016/j.neulet.2004.10.030, PII S0304394004012935
    • J. Tian, F. Fu, M. Geng, M. Jiang, J. Yang, W. Jiang, C. Wang, and K. Liu Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats Neurosci. Lett. 374 2005 92 97 (Pubitemid 40092203)
    • (2005) Neuroscience Letters , vol.374 , Issue.2 , pp. 92-97
    • Tian, J.1    Fu, F.2    Geng, M.3    Jiang, Y.4    Yang, J.5    Jiang, W.6    Wang, C.7    Liu, K.8
  • 110
    • 20444438824 scopus 로고    scopus 로고
    • Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus
    • DOI 10.1021/np049688+
    • Y. Tian, H. Guo, J. Han, and D. Guo Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus J. Nat. Prod. 68 2005 678 680 (Pubitemid 40825274)
    • (2005) Journal of Natural Products , vol.68 , Issue.5 , pp. 678-680
    • Tian, Y.1    Guo, H.2    Han, J.3    Guo, D.4
  • 111
    • 0345257309 scopus 로고    scopus 로고
    • Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease
    • DOI 10.1016/j.expneurol.2003.08.002
    • J. Van Kampen, H. Robertson, T. Hagg, and R. Drobitch Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease Exp. Neurol. 184 2003 521 529 (Pubitemid 37444059)
    • (2003) Experimental Neurology , vol.184 , Issue.1 , pp. 521-529
    • Van Kampen, J.1    Robertson, H.2    Hagg, T.3    Drobitch, R.4
  • 112
    • 49849092416 scopus 로고    scopus 로고
    • Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: A phase II randomized, controlled trial of 2 dosing schedules
    • S. Vohra, B.C. Johnston, K.L. Laycock, W.K. Midodzi, I. Dhunnoo, E. Harris, and L. Baydala Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized, controlled trial of 2 dosing schedules Pediatrics 122 2008 E402 E410
    • (2008) Pediatrics , vol.122
    • Vohra, S.1    Johnston, B.C.2    Laycock, K.L.3    Midodzi, W.K.4    Dhunnoo, I.5    Harris, E.6    Baydala, L.7
  • 113
    • 21644470416 scopus 로고    scopus 로고
    • Herbal remedies in the management of diabetes: Lessons learned from the study of ginseng
    • DOI 10.1016/j.numecd.2005.05.001
    • V. Vuksan, and J.L. Sievenpiper Herbal remedies in the management of diabetes: lessons learned from the study of ginseng Nutr. Metab. Cardiovasc. Dis. 15 2005 149 160 (Pubitemid 40934158)
    • (2005) Nutrition, Metabolism and Cardiovascular Diseases , vol.15 , Issue.3 , pp. 149-160
    • Vuksan, V.1    Sievenpiper, J.L.2
  • 114
    • 0034630423 scopus 로고    scopus 로고
    • American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus
    • V. Vuksan, J.L. Sievenpiper, V.Y. Koo, T. Francis, U. Beljan-Zdravkovic, Z. Xu, and E. Vidgen American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus Arch. Intern. Med. 160 2000 1009 1013 (Pubitemid 30191931)
    • (2000) Archives of Internal Medicine , vol.160 , Issue.7 , pp. 1009-1013
    • Vuksan, V.1    Sievenpiper, J.L.2    Koo, V.Y.Y.3    Francis, T.4    Beljan-Zdravkovic, U.5    Xu, Z.6    Vidgen, E.7
  • 115
    • 0033858725 scopus 로고    scopus 로고
    • Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes
    • V. Vuksan, M.P. Stavro, J.L. Sievenpiper, U. Beljan-Zdravkovic, L.A. Leiter, R.G. Josse, and Z. Xu Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes Diabetes Care 23 2000 1221 1226
    • (2000) Diabetes Care , vol.23 , pp. 1221-1226
    • Vuksan, V.1    Stavro, M.P.2    Sievenpiper, J.L.3    Beljan-Zdravkovic, U.4    Leiter, L.A.5    Josse, R.G.6    Xu, Z.7
  • 119
    • 57349164037 scopus 로고    scopus 로고
    • Potential role of ginseng in the treatment of colorectal cancer
    • C.Z. Wang, and C.S. Yuan Potential role of ginseng in the treatment of colorectal cancer Am. J. Chin. Med. 36 2008 1019 1028
    • (2008) Am. J. Chin. Med. , vol.36 , pp. 1019-1028
    • Wang, C.Z.1    Yuan, C.S.2
  • 120
    • 0031446856 scopus 로고    scopus 로고
    • Microbial transformation of protopanaxadiol and protopanaxatriol derivatives with Mycobacterium sp. (NRRL B-3805)
    • DOI 10.1021/np970331y
    • K.C. Wang, P.H. Wang, and S.S. Lee Microbial transformation of protopanaxadiol and protopanaxatriol derivatives with Mycobacterium sp. (NRRL B-3805) J. Nat. Prod. 60 1997 1236 1241 (Pubitemid 28030243)
    • (1997) Journal of Natural Products , vol.60 , Issue.12 , pp. 1236-1241
    • Wang, K.C.1    Wang, P.-H.2    Lee, S.-S.3
  • 122
    • 22144449967 scopus 로고    scopus 로고
    • Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography
    • DOI 10.1002/pca.838
    • A.B. Wang, C.Z. Wang, J.A. Wu, J. Osinski, and C.S. Yuan Determination of major ginsenosides in Panax quinquefolius (American ginseng) using, high-performance liquid chromatography Phytochem. Anal. 16 2005 272 277 (Pubitemid 40975415)
    • (2005) Phytochemical Analysis , vol.16 , Issue.4 , pp. 272-277
    • Wang, A.1    Wang, C.-Z.2    Wu, J.-A.3    Osinski, J.4    Yuan, C.-S.5
  • 124
    • 34447511713 scopus 로고    scopus 로고
    • Red American ginseng: Ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
    • DOI 10.1055/s-2007-981524
    • C.Z. Wang, H.H. Aung, M. Ni, J.A. Wu, R.B. Tong, S. Wicks, T.C. He, and C.S. Yuan Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots Planta Med. 73 2007 669 674 (Pubitemid 47066161)
    • (2007) Planta Medica , vol.73 , Issue.7 , pp. 669-674
    • Wang, C.-Z.1    Aung, H.H.2    Ni, M.3    Wu, J.-A.4    Tong, R.5    Wicks, S.6    He, T.-C.7    Yuan, C.-S.8
  • 125
    • 34548169064 scopus 로고    scopus 로고
    • Commonly used antioxidant botanicals: Active constituents and their potential role in cardiovascular illness
    • DOI 10.1142/S0192415X07005053, PII S0192415X07005053
    • C.Z. Wang, S.R. Mehendale, and C.S. Yuan Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness Am. J. Chin. Med. 35 2007 543 558 (Pubitemid 47307694)
    • (2007) American Journal of Chinese Medicine , vol.35 , Issue.4 , pp. 543-558
    • Wang, C.-Z.1    Mehendale, S.R.2    Yuan, C.-S.3
  • 126
    • 33847104559 scopus 로고    scopus 로고
    • In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng
    • DOI 10.1007/s00280-006-0300-z
    • W. Wang, Y.Q. Zhao, E.R. Rayburn, D.L. Hill, H. Wang, and R.W. Zhang In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng Cancer Chemother. Pharm. 59 2007 589 601 (Pubitemid 46295123)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.59 , Issue.5 , pp. 589-601
    • Wang, W.1    Zhao, Y.2    Rayburn, E.R.3    Hill, D.L.4    Wang, H.5    Zhang, R.6
  • 127
    • 64849116797 scopus 로고    scopus 로고
    • The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells
    • C.Z. Wang, X.L. Li, Q.F. Wang, S.R. Mehendale, A.B. Fishbein, A.H. Han, S. Sun, and C.S. Yuan The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells Oncol. Rep. 21 2009 577 584
    • (2009) Oncol. Rep. , vol.21 , pp. 577-584
    • Wang, C.Z.1    Li, X.L.2    Wang, Q.F.3    Mehendale, S.R.4    Fishbein, A.B.5    Han, A.H.6    Sun, S.7    Yuan, C.S.8
  • 128
    • 66249141276 scopus 로고    scopus 로고
    • Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol
    • Y.Z. Wang, J. Chen, S.F. Chu, Y.S. Wang, X.Y. Wang, N.H. Chen, and J.T. Zhang Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol J. Pharmacol. Sci. 109 2009 504 510
    • (2009) J. Pharmacol. Sci. , vol.109 , pp. 504-510
    • Wang, Y.Z.1    Chen, J.2    Chu, S.F.3    Wang, Y.S.4    Wang, X.Y.5    Chen, N.H.6    Zhang, J.T.7
  • 131
    • 1542288352 scopus 로고    scopus 로고
    • Anti-hyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob mice
    • DOI 10.1078/0944-7113-00325
    • J.T. Xie, J.A. Wu, S. Mehendale, H.H. Aung, and C.S. Yuan Anti-hyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob mice Phytomedicine 11 2004 182 187 (Pubitemid 38314060)
    • (2004) Phytomedicine , vol.11 , Issue.2-3 , pp. 182-187
    • Xie, J.T.1    Wu, J.A.2    Mehendale, S.3    Aung, H.H.4    Yuan, C.-S.5
  • 136
    • 12344336324 scopus 로고    scopus 로고
    • Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model
    • DOI 10.1080/10286020410001690172
    • B.B. Xu, C.Q. Liu, X. Gao, W.Q. Zhang, S.W. Wang, and Y.L. Cao Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model J. Asian Nat. Prod. Res. 7 2005 215 224 (Pubitemid 40139353)
    • (2005) Journal of Asian Natural Products Research , vol.7 , Issue.3 , pp. 215-224
    • Xu, B.-B.1    Liu, C.-Q.2    Gao, X.3    Zhang, W.-Q.4    Wang, S.-W.5    Cao, Y.-L.6
  • 137
    • 70350062072 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway
    • L. Xu, W.F. Chen, and M.S. Wong Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway Br. J. Pharmacol. 158 2009 738 748
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 738-748
    • Xu, L.1    Chen, W.F.2    Wong, M.S.3
  • 138
    • 33746701913 scopus 로고    scopus 로고
    • Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway
    • DOI 10.1016/j.brainres.2006.05.106, PII S0006899306016556
    • J.F. Xue, Z.J. Liu, J.F. Hu, H. Chen, J.T. Zhang, and N.H. Chen Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway Brain Res. 1106 2006 91 98 (Pubitemid 44163324)
    • (2006) Brain Research , vol.1106 , Issue.1 , pp. 91-98
    • Xue, J.-F.1    Liu, Z.-J.2    Hu, J.-F.3    Chen, H.4    Zhang, J.-T.5    Chen, N.-H.6
  • 139
    • 65549142297 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons
    • R.D. Ye, N.L. Li, J.L. Han, X.W. Kong, R. Cao, Z.R. Rao, and G. Zhao Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons Neurosci. Res. 64 2009 306 310
    • (2009) Neurosci. Res. , vol.64 , pp. 306-310
    • Ye, R.D.1    Li, N.L.2    Han, J.L.3    Kong, X.W.4    Cao, R.5    Rao, Z.R.6    Zhao, G.7
  • 140
    • 0027289223 scopus 로고
    • 2 in diabetic rats
    • DOI 10.1002/ptr.2650070306
    • T. Yokozawa, T. Yasui, and H. Oura Stimulation of RNA-polymerase activity by ginsenoside-Rb2 in diabetic rats Phytother. Res. 7 1993 240 243 (Pubitemid 23160287)
    • (1993) Phytotherapy Research , vol.7 , Issue.3 , pp. 240-243
    • Yokozawa, T.1    Yasui, T.2    Oura, H.3
  • 141
    • 36048962905 scopus 로고    scopus 로고
    • Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice
    • DOI 10.1248/bpb.30.2196
    • S.H. Yoon, E.J. Han, J.H. Sung, and S.H. Chung Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice Biol. Pharm. Bull. 30 2007 2196 2200 (Pubitemid 350097050)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.11 , pp. 2196-2200
    • Yoon, S.H.1    Han, E.J.2    Sung, J.H.3    Chung, S.H.4
  • 142
    • 0031954961 scopus 로고    scopus 로고
    • Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, IV, and V, from American ginseng, the roots of Panax quinquefolium L
    • M. Yoshikawa, T. Murakami, K. Yashiro, J. Yamahara, H. Matsuda, R. Saijoh, and O. Tanaka Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, IV, and V, from American ginseng, the roots of Panax quinquefolium L Chem. Pharm. Bull. 46 1998 647 654 (Pubitemid 28216940)
    • (1998) Chemical and Pharmaceutical Bulletin , vol.46 , Issue.4 , pp. 647-654
    • Yoshikawa, M.1    Murakami, T.2    Yashiro, K.3    Yamahara, J.4    Matsuda, H.5    Saijoh, R.6    Tanaka, O.7
  • 143
    • 34249008148 scopus 로고    scopus 로고
    • Antiestrogenic effect of 20S-protopanaxadiol and its synergy with tamoxifen on breast cancer cells
    • DOI 10.1002/cncr.22659
    • Y. Yu, O. Zhou, Y. Hang, X.X. Bu, and W. Jia Antiestrogenic effect of 20S-protopanaxadiol and its synergy with tamoxifen on breast cancer cells Cancer 109 2007 2374 2382 (Pubitemid 46801570)
    • (2007) Cancer , vol.109 , Issue.11 , pp. 2374-2382
    • Yu, Y.1    Zhou, Q.2    Hang, Y.3    Bu, X.4    Jia, W.5
  • 144
    • 0035755544 scopus 로고    scopus 로고
    • Multiple effects of American ginseng in clinical medicine
    • C.S. Yuan, and L. Dey Multiple effects of American ginseng in clinical medicine Am. J. Chin. Med. 29 2001 567 569
    • (2001) Am. J. Chin. Med. , vol.29 , pp. 567-569
    • Yuan, C.S.1    Dey, L.2
  • 146
    • 34548130846 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats
    • DOI 10.1016/j.brainres.2007.06.024, PII S0006899307013509
    • Q.L. Yuan, C.X. Yang, P. Xu, X.Q. Gao, L. Deng, P. Chen, Z.L. Sun, and Q.Y. Chen Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats Brain Res. 1167 2007 1 12 (Pubitemid 47302431)
    • (2007) Brain Research , vol.1167 , Issue.1 , pp. 1-12
    • Yuan, Q.-L.1    Yang, C.-X.2    Xu, P.3    Gao, X.-Q.4    Deng, L.5    Chen, P.6    Sun, Z.-L.7    Chen, Q.-Y.8
  • 148
    • 0035240033 scopus 로고    scopus 로고
    • Panax ginseng - A non-organ-specific cancer preventive?
    • T.K. Yun Panax ginseng - a non-organ-specific cancer preventive? Lancet Oncol. 2 2001 49 55
    • (2001) Lancet Oncol. , vol.2 , pp. 49-55
    • Yun, T.K.1
  • 149
    • 37549015237 scopus 로고    scopus 로고
    • 2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    • DOI 10.1016/j.jep.2007.10.026, PII S0378874107005454
    • G.Z. Zhang, A.L. Liu, Y.B. Zhou, X. San, T.W. Jin, and Y. Jin Panax ginseng ginsenoside-Rg(2) protects memory impairment via anti-apoptosis in a rat model with vascular dementia J. Ethnopharmacol. 115 2008 441 448 (Pubitemid 50017508)
    • (2007) Journal of Ethnopharmacology , vol.115 , Issue.3 , pp. 441-448
    • Zhang, G.1    Liu, A.2    Zhou, Y.3    San, X.4    Jin, T.5    Jin, Y.6
  • 150
    • 79954586475 scopus 로고    scopus 로고
    • Ginsenoside Re improved memory impairment in aged rats and mice
    • W.J. Zhao, and P.Y. Li Ginsenoside Re improved memory impairment in aged rats and mice Neurobiol. Aging 25 2004 S582 S583
    • (2004) Neurobiol. Aging , vol.25
    • Zhao, W.J.1    Li, P.Y.2
  • 151
    • 67349199183 scopus 로고    scopus 로고
    • Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus
    • H.F. Zhao, Q. Li, X.R. Pei, Z.F. Zhang, R.Y. Yang, J.B. Wang, and Y. Li Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus Behav. Brain Res. 201 2009 311 317
    • (2009) Behav. Brain Res. , vol.201 , pp. 311-317
    • Zhao, H.F.1    Li, Q.2    Pei, X.R.3    Zhang, Z.F.4    Yang, R.Y.5    Wang, J.B.6    Li, Y.7
  • 152
    • 59649100816 scopus 로고    scopus 로고
    • Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus
    • H.F. Zhao, Q. Li, Z.F. Zhang, X.R. Pei, J.B. Wang, and Y. Li Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus Brain Res. 1256 2009 111 122
    • (2009) Brain Res. , vol.1256 , pp. 111-122
    • Zhao, H.F.1    Li, Q.2    Zhang, Z.F.3    Pei, X.R.4    Wang, J.B.5    Li, Y.6


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