Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 19, 2007, Pages 8161-8166

  Perier, Celine ^a,b   Bové, Jordi ^a   Wu, Du Chu ^b   Dehay, Benjamin ^a   Choi, Dong Kug ^b   Jackson Lewis, Vernice ^b   Rathke Hartlieb, Silvia ^c   Bouillet, Philippe ^d   Strasser, Andreas ^d   Schulz, Jörg B ^c   Przedborski, Serge ^b   Vila, Miquel ^a,b,e  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

1 methyl 4 pheny 1,2,3,6 tetrahydropyridine; Apoptosis; Bax; Bim; Complex I

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BH3 PROTEIN; BIM PROTEIN; CYCLOPHILIN D; CYTOCHROME C; DOPAMINE TRANSPORTER; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHORUS 32; PROTEIN BAX; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; RNA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; MEMBRANE PROTEIN; ONCOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL FRACTIONATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; METABOLISM; MITOCHONDRION; PARKINSONISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; SUBSTANTIA NIGRA;

MUS; RODENTIA;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; DNA DAMAGE; ELECTRON TRANSPORT COMPLEX I; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; PARKINSONIAN DISORDERS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; SUBSTANTIA NIGRA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34249947154     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609874104     Document Type: Article

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