-
1
-
-
84875890982
-
The immunobiology and pathophysiology of primary biliary cirrhosis
-
Hirschfield, G. M. & Gershwin, M. E. The immunobiology and pathophysiology of primary biliary cirrhosis. Annu. Rev. Pathol. 8, 303-330 (2013).
-
(2013)
Annu. Rev. Pathol.
, vol.8
, pp. 303-330
-
-
Hirschfield, G.M.1
Gershwin, M.E.2
-
2
-
-
84905036282
-
The new epidemiology of primary biliary cirrhosis
-
Griffiths, L., Dyson, J. K. & Jones, D. E. The new epidemiology of primary biliary cirrhosis. Semin. Liver Dis. 34, 318-328 (2014).
-
(2014)
Semin. Liver Dis.
, vol.34
, pp. 318-328
-
-
Griffiths, L.1
Dyson, J.K.2
Jones, D.E.3
-
3
-
-
84879570951
-
The impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC National Study
-
Mells, G. et al. The impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC National Study. Hepatology 58, 273-283 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 273-283
-
-
Mells, G.1
-
4
-
-
84874043156
-
Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid
-
Carbone, M. et al. Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. Gastorenterology 144, 560-569 (2013).
-
(2013)
Gastorenterology
, vol.144
, pp. 560-569
-
-
Carbone, M.1
-
5
-
-
84918787307
-
Unmet clinical need in autoimmune liver diseases
-
Dyson, J. K. et al. Unmet clinical need in autoimmune liver diseases. J. Hepatol. 62, 208-218 (2014).
-
(2014)
J. Hepatol.
, vol.62
, pp. 208-218
-
-
Dyson, J.K.1
-
6
-
-
51349157245
-
Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
-
Corpechot, C. et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 48, 871-877 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 871-877
-
-
Corpechot, C.1
-
7
-
-
33644854254
-
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
-
Pares, A., Caballeria, L. & Rodes, J. Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology 130, 715-720 (2006).
-
(2006)
Gastroenterology
, vol.130
, pp. 715-720
-
-
Pares, A.1
Caballeria, L.2
Rodes, J.3
-
8
-
-
84873279968
-
Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis
-
Dhirapong, A. et al. Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis. Hepatology 57, 708-715 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 708-715
-
-
Dhirapong, A.1
-
9
-
-
84908202760
-
Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3+ regulatory T cells
-
Tanaka, H. et al. Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3+ regulatory T cells. Clin. Exp. Immunol. 178, 253-261 (2014).
-
(2014)
Clin. Exp. Immunol.
, vol.178
, pp. 253-261
-
-
Tanaka, H.1
-
10
-
-
84911199789
-
Levels of alkaline phosphatase and bilirubin are surrogate endpoints of outcomes of patients with primary biliary cirrhosis: An international follow-up study
-
Lammers, W. J. et al. Levels of alkaline phosphatase and bilirubin are surrogate endpoints of outcomes of patients with primary biliary cirrhosis: an international follow-up study. Gastroenterology 147, 1338-1349 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 1338-1349
-
-
Lammers, W.J.1
-
11
-
-
84924227741
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01389973 (2014).
-
(2014)
-
-
-
12
-
-
67149095289
-
Primary biliary cirrhosis associated with HLA, IL12A and IL12RB2 variants
-
Hirschfield, G. M. et al. Primary biliary cirrhosis associated with HLA, IL12A and IL12RB2 variants. N. Engl. J. Med. 360, 2544-2555 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2544-2555
-
-
Hirschfield, G.M.1
-
13
-
-
79953208931
-
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
-
Mells, G. F. et al. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat. Genet. 43, 329-332 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 329-332
-
-
Mells, G.F.1
-
14
-
-
84899480316
-
IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy
-
Yang, C. Y. et al. IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy. Hepatology 59, 1944-1953 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1944-1953
-
-
Yang, C.Y.1
-
15
-
-
84924242346
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01430429term=NCT01430429&rank=1 (2012).
-
(2012)
-
-
-
16
-
-
84874967707
-
CXCR3 axis in patients with primary biliary cirrhosis: A possible novel mechanism of the effect of ursodeoxycholic acid
-
Manousou, P. et al. CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin. Exp. Immunol. 172, 9-15 (2013).
-
(2013)
Clin. Exp. Immunol.
, vol.172
, pp. 9-15
-
-
Manousou, P.1
-
17
-
-
84924247186
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02193360 (2014).
-
(2014)
-
-
-
18
-
-
17944381918
-
CD40 activation-induced Fas-dependent apoptosis and NKkB/AP1 signaling in human intrahepatic biliary epithelial cells
-
Afford, S. C. et al. CD40 activation-induced, Fas-dependent apoptosis and NKkB/AP1 signaling in human intrahepatic biliary epithelial cells. FASEB J. 15, 2345-2354 (2001).
-
(2001)
FASEB J.
, vol.15
, pp. 2345-2354
-
-
Afford, S.C.1
-
19
-
-
84924228990
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00364819 (2014).
-
(2014)
-
-
-
20
-
-
84863072278
-
Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
-
Tsuda, M. et al. Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Hepatology 55, 512-521 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 512-521
-
-
Tsuda, M.1
-
21
-
-
84878917142
-
B-cell depletion with rituximab in patients with primary biliary cirrhosis refractory to ursodeoxycholic acid
-
Myers, R. P., Swain, M. G., Lee, S. S., Shaheen, A. A. M. & Burak, K. W. B-cell depletion with rituximab in patients with primary biliary cirrhosis refractory to ursodeoxycholic acid. Am J. Gastroenterol. 108, 933-941 (2014).
-
(2014)
Am J. Gastroenterol.
, vol.108
, pp. 933-941
-
-
Myers, R.P.1
Swain, M.G.2
Lee, S.S.3
Shaheen, A.A.M.4
Burak, K.W.5
-
22
-
-
79251485938
-
B-cell depletion therapy exacerbates murine primary biliary cirrhosis
-
Dhirapong, A. L. et al. B-cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology 53, 527-535 (2011).
-
(2011)
Hepatology
, vol.53
, pp. 527-535
-
-
Dhirapong, A.L.1
-
23
-
-
84860487320
-
Colitis associated with biological agents
-
Freeman, H. J. Colitis associated with biological agents. World J. Gastroenterol. 28, 1871-1874 (2012).
-
(2012)
World J. Gastroenterol.
, vol.28
, pp. 1871-1874
-
-
Freeman, H.J.1
-
24
-
-
84912064693
-
The first primary biliary cirrhosis (PBC) phase 3 trial in two decades-an international study of the FXR agonist obeticholic Acid
-
Nevens, F. et al. The first primary biliary cirrhosis (PBC) phase 3 trial in two decades-an international study of the FXR agonist obeticholic Acid. J. Hepatol. 60 (Suppl.) S525-S526 (2014).
-
(2014)
J. Hepatol.
, vol.60
, pp. S525-S526
-
-
Nevens, F.1
-
25
-
-
84925362562
-
Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
-
Hirschfield, G. M. et al. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2014.12.005.
-
Gastroenterology
-
-
Hirschfield, G.M.1
-
26
-
-
84924245455
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01654731 (2014).
-
(2014)
-
-
-
27
-
-
78650260680
-
Pilot study: Fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxyxcholic acid
-
Levy, C. et al. Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxyxcholic acid. Aliment. Pharmacol. Ther. 33, 235-242 (2011).
-
(2011)
Aliment. Pharmacol. Ther.
, vol.33
, pp. 235-242
-
-
Levy, C.1
-
28
-
-
84891827040
-
Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid
-
Lens, S., Leoz, M., Nazal, L., Bruguera, M. & Pares, A. Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid. Liver Int. 34, 197-203 (2014).
-
(2014)
Liver Int.
, vol.34
, pp. 197-203
-
-
Lens, S.1
Leoz, M.2
Nazal, L.3
Bruguera, M.4
Pares, A.5
-
29
-
-
84924274989
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02026401 (2014).
-
(2014)
-
-
-
30
-
-
84868680318
-
The farnesoid X receptor (FXR) agonist (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC)
-
Marschall, H. U. et al. The farnesoid X receptor (FXR) agonist (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC). J. Hepatol. 56, S377 (2012).
-
(2012)
J. Hepatol.
, vol.56
, pp. S377
-
-
Marschall, H.U.1
-
31
-
-
84930805025
-
Mechanisms of tissue injury in autoimmune liver diseases
-
Liaskou, E., Hirschfield, G. M. & Gershwin, M. E. Mechanisms of tissue injury in autoimmune liver diseases. Semin. Immunopathol. 36, 553-568 (2014).
-
(2014)
Semin. Immunopathol.
, vol.36
, pp. 553-568
-
-
Liaskou, E.1
Hirschfield, G.M.2
Gershwin, M.E.3
-
32
-
-
0034072905
-
Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis
-
Yeaman, S. J., Kirby, J. A. & Jones, D. E. Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. Immunol. Rev. 174, 238-249 (2000).
-
(2000)
Immunol. Rev.
, vol.174
, pp. 238-249
-
-
Yeaman, S.J.1
Kirby, J.A.2
Jones, D.E.3
-
33
-
-
0036246857
-
Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
-
Kita, H. et al. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J. Clin. Invest. 109, 1231-1240 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1231-1240
-
-
Kita, H.1
-
34
-
-
0028936405
-
Heterogeneity of autoreactive T-cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis
-
Van de Water, J. et al. Heterogeneity of autoreactive T-cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J. Exp. Med. 181, 723-733 (1995).
-
(1995)
J. Exp. Med.
, vol.181
, pp. 723-733
-
-
Van De Water, J.1
-
35
-
-
0037033367
-
Identification of HLA-A2-restricted CD8+ cytotoxic T-cell responses in primary biliary cirrhosis: T-cell activation is augmented by immune complexes cross-presented by dendritic cells
-
Kita, H. et al. Identification of HLA-A2-restricted CD8+ cytotoxic T-cell responses in primary biliary cirrhosis: T-cell activation is augmented by immune complexes cross-presented by dendritic cells. J. Exp. Med. 195, 113-123 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 113-123
-
-
Kita, H.1
-
36
-
-
84867577705
-
CDCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
-
Oo, Y. H. et al. CDCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J. Hepatol. 57, 1044-1051 (2012).
-
(2012)
J. Hepatol.
, vol.57
, pp. 1044-1051
-
-
Oo, Y.H.1
-
37
-
-
0026529198
-
Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis
-
Joplin, R. et al. Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis. Lancet 339, 93-94 (1992).
-
(1992)
Lancet
, vol.339
, pp. 93-94
-
-
Joplin, R.1
-
38
-
-
84905036457
-
Animal models of primary biliary cirrhosis
-
Wang, J. et al. Animal models of primary biliary cirrhosis. Semin. Liver Dis. 34, 285-296 (2014).
-
(2014)
Semin. Liver Dis.
, vol.34
, pp. 285-296
-
-
Wang, J.1
-
39
-
-
0038559882
-
Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces anti-mitochondrial antibodies
-
Leung, P. S. et al. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces anti-mitochondrial antibodies. J. Immunol. 170, 5326-5332 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5326-5332
-
-
Leung, P.S.1
-
40
-
-
58149390221
-
Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
-
Walden, H. R. et al. Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway. Hepatology 48, 1874-1884 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 1874-1884
-
-
Walden, H.R.1
-
41
-
-
49649091998
-
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
-
Wakabayashi, K. et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology 48, 531-540 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 531-540
-
-
Wakabayashi, K.1
-
42
-
-
84903935519
-
Innate immunity drives xenobiotic-induced murine autoimmune cholangitis
-
Chang, C. H. et al. Innate immunity drives xenobiotic-induced murine autoimmune cholangitis. Clin. Exp. Immunol. 177, 273-280 (2014).
-
(2014)
Clin. Exp. Immunol.
, vol.177
, pp. 273-280
-
-
Chang, C.H.1
-
43
-
-
77955087537
-
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
-
Hirschfield, G. M. et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat. Genet. 42, 655-657 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 655-657
-
-
Hirschfield, G.M.1
-
44
-
-
84866924593
-
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
-
Liu, J. Z. et al. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat. Genet. 44, 1137-1141 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 1137-1141
-
-
Liu, J.Z.1
-
45
-
-
84924234251
-
P367 Phase 2 study evaluating the efficacy and safety of ustekinumab in patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid
-
Hirschfield. G. M. et al. P367 Phase 2 study evaluating the efficacy and safety of ustekinumab in patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid. J. Hepatol. 60 (Suppl.), S189-S190 (2014).
-
(2014)
J. Hepatol.
, vol.60
, pp. S189-S190
-
-
Hirschfield, G.M.1
-
46
-
-
0038415810
-
Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis
-
Suzuki, A. et al. Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. Dev. Immunol. 9, 55-61 (2002).
-
(2002)
Dev. Immunol.
, vol.9
, pp. 55-61
-
-
Suzuki, A.1
-
47
-
-
35648958686
-
Pathogenesis of primary biliary cirrhosis
-
Jones, D. E. Pathogenesis of primary biliary cirrhosis. Gut 56, 1615-1624 (2007).
-
(2007)
Gut
, vol.56
, pp. 1615-1624
-
-
Jones, D.E.1
-
48
-
-
0037422983
-
Effects of bile acids on biliary epithelial cells: Proliferation, cytotoxicity and cytokine secretion
-
Lamireau, T. et al. Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity and cytokine secretion. Life Sci. 72, 1401-1411 (2003).
-
(2003)
Life Sci.
, vol.72
, pp. 1401-1411
-
-
Lamireau, T.1
-
49
-
-
14944376606
-
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: A possible role in bile duct loss
-
Sasaki, M., Ikeda, H., Haga, H., Manabe, T. & Nakanuma, Y. Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss. J. Pathol. 205, 451-459 (2005).
-
(2005)
J. Pathol.
, vol.205
, pp. 451-459
-
-
Sasaki, M.1
Ikeda, H.2
Haga, H.3
Manabe, T.4
Nakanuma, Y.5
-
50
-
-
0032558588
-
Molecular pathogenesis of cholestasis
-
Trauner, M., Meier, P. J. & Boyer, J. L. Molecular pathogenesis of cholestasis. N. Engl. J. Med. 339, 1217-1227 (1998).
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1217-1227
-
-
Trauner, M.1
Meier, P.J.2
Boyer, J.L.3
-
51
-
-
84865434522
-
Molecular targets for the treatment of fibrosing cholangiopathies Clin
-
Maillette de Buy Wenniger, L. J., Oude Elferink, R. P. & Beuers, U. Molecular targets for the treatment of fibrosing cholangiopathies Clin. Pharmacol. Ther. 92, 381-387 (2012).
-
(2012)
Pharmacol. Ther.
, vol.92
, pp. 381-387
-
-
Maillette De Buy Wenniger, L.J.1
Oude Elferink, R.P.2
Beuers, U.3
-
52
-
-
67649205149
-
EASL practice guidelines on management of cholestatic liver diseases
-
Beuers, U. et al. EASL practice guidelines on management of cholestatic liver diseases. J. Hepatol. 51, 237-267 (2009).
-
(2009)
J. Hepatol.
, vol.51
, pp. 237-267
-
-
Beuers, U.1
-
53
-
-
67651160903
-
Primary biliary cirrhosis
-
Lindor, K. D. et al. Primary biliary cirrhosis. Hepatology 50, 291-308 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 291-308
-
-
Lindor, K.D.1
-
54
-
-
33744920572
-
Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis
-
Beuers, U. Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat. Clin. Pract. Gastroenterol. Hepatol. 3, 318-328 (2006).
-
(2006)
Nat. Clin. Pract. Gastroenterol. Hepatol.
, vol.3
, pp. 318-328
-
-
Beuers, U.1
-
55
-
-
84862663864
-
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health
-
Dilger, K. et al. Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. J. Hepatol. 57, 133-140 (2012).
-
(2012)
J. Hepatol.
, vol.57
, pp. 133-140
-
-
Dilger, K.1
-
56
-
-
0025078256
-
Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine
-
Beuers, U., Thiel, M., Bardenheuer, H. & Paumgartner, G. Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. Biochem. Biophys. Res. Commun. 171, 1115-1121 (1990).
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.171
, pp. 1115-1121
-
-
Beuers, U.1
Thiel, M.2
Bardenheuer, H.3
Paumgartner, G.4
-
57
-
-
0027408588
-
Ursodeoxycholate mobilizes intracellular Ca++ and activates phosphorylase a in isolated hepatocytes
-
Bouscarel, B., Fromm, H. & Nussbaum, R. Ursodeoxycholate mobilizes intracellular Ca++ and activates phosphorylase a in isolated hepatocytes. Am. J. Physiol. 264, G243-G251 (1993).
-
(1993)
Am. J. Physiol.
, vol.264
, pp. G243-G251
-
-
Bouscarel, B.1
Fromm, H.2
Nussbaum, R.3
-
58
-
-
0027510926
-
Effects of tauroursodeoxycholic acid on cytosolic Ca++ signals in isolated rat hepatocytes
-
Beuers, U., Nathanson, M. H. & Boyer, J. L. Effects of tauroursodeoxycholic acid on cytosolic Ca++ signals in isolated rat hepatocytes. Gastroenterology 104, 604-612 (1993).
-
(1993)
Gastroenterology
, vol.104
, pp. 604-612
-
-
Beuers, U.1
Nathanson, M.H.2
Boyer, J.L.3
-
59
-
-
0028954737
-
Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
-
Bouscarel, B., Gettys, T. W., Fromm, H. & Dubner, H. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am. J. Physiol. 268, G300-G310 (1995).
-
(1995)
Am. J. Physiol.
, vol.268
, pp. G300-G310
-
-
Bouscarel, B.1
Gettys, T.W.2
Fromm, H.3
Dubner, H.4
-
60
-
-
0029863466
-
Tauroursodeoxycholic acid activates protein kinase C in isolate hepatocytes
-
Beuers, U. et al. Tauroursodeoxycholic acid activates protein kinase C in isolate hepatocytes. Gastroenterology 110, 1553-1563 (1996).
-
(1996)
Gastroenterology
, vol.110
, pp. 1553-1563
-
-
Beuers, U.1
-
61
-
-
0029792502
-
Hepatocellular protein kinase C activation by bile acids: Implications for regulation of cholesterol 7 alpha-hydroylase
-
Stravitz, R. T. et al. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroylase. Am. J. Physiol. 27, G293-G303 (1996).
-
(1996)
Am. J. Physiol.
, vol.27
, pp. G293-G303
-
-
Stravitz, R.T.1
-
62
-
-
0030829597
-
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
-
Schliess, F., Kurz, A. K., vom Dahl, S. & Haussinger, D. Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 113, 1306-1314 (1997).
-
(1997)
Gastroenterology
, vol.113
, pp. 1306-1314
-
-
Schliess, F.1
Kurz, A.K.2
Vom Dahl, S.3
Haussinger, D.4
-
63
-
-
0034910937
-
Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats
-
Kurz, A. K., Graf, D., Schmitt, M., Vom Dahl, S. & Haussinger, D. T. Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121, 407-419 (2001).
-
(2001)
Gastroenterology
, vol.121
, pp. 407-419
-
-
Kurz, A.K.1
Graf, D.2
Schmitt, M.3
Vom Dahl, S.4
Haussinger, D.T.5
-
64
-
-
3042594002
-
Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
-
Haüssinger, D. et al. Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. Gastroenterology 124, 1476-1487 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1476-1487
-
-
Haüssinger, D.1
-
65
-
-
84874487986
-
5 1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
-
Gohlke, H., Schmitz, B., Sommerfeld, A., Reinehr, R. & Haussinger, D. 5 1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes Hepatology 57, 1117-1129 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 1117-1129
-
-
Gohlke, H.1
Schmitz, B.2
Sommerfeld, A.3
Reinehr, R.4
Haussinger, D.5
-
66
-
-
30944462200
-
Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
-
Dombrowski, F., Stieger, B. & Beuers, U. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab. Invest. 86, 166-174 (2006).
-
(2006)
Lab. Invest.
, vol.86
, pp. 166-174
-
-
Dombrowski, F.1
Stieger, B.2
Beuers, U.3
-
67
-
-
0035038177
-
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
-
Beuers, U. et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33, 1206-1216 (2001).
-
(2001)
Hepatology
, vol.33
, pp. 1206-1216
-
-
Beuers, U.1
-
68
-
-
0027159022
-
Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver
-
Haussinger, D., Saha, N., Hallbrucker, C., Lang, F. & Gerok, W. Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver. Biochem. J. 291, 355-360 (1993).
-
(1993)
Biochem. J.
, vol.291
, pp. 355-360
-
-
Haussinger, D.1
Saha, N.2
Hallbrucker, C.3
Lang, F.4
Gerok, W.5
-
69
-
-
0027141467
-
Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis
-
Beuers, U., Nathanson, M. H., Isales, C. M. & Boyer, J. L. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. J. Clin. Invest. 92, 2984-2993 (1993).
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2984-2993
-
-
Beuers, U.1
Nathanson, M.H.2
Isales, C.M.3
Boyer, J.L.4
-
70
-
-
52649131370
-
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC-/PKA-dependent mechanism in rat liver
-
Wimmer, R. et al. Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC-/PKA-dependent mechanism in rat liver. Gut 57, 1448-1454 (2008).
-
(2008)
Gut
, vol.57
, pp. 1448-1454
-
-
Wimmer, R.1
-
71
-
-
77954223347
-
Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver
-
Cruz, L. N. et al. Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology 52, 327-337 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 327-337
-
-
Cruz, L.N.1
-
73
-
-
77957940106
-
The biliary HCO3-umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
-
Beuers, U. et al. The biliary HCO3-umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 52, 1489-1496 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 1489-1496
-
-
Beuers, U.1
-
74
-
-
84155175630
-
A biliary HCO3-umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
-
Hohenester, S. et al. A biliary HCO3-umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 55, 173-183 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 173-183
-
-
Hohenester, S.1
-
75
-
-
0033033458
-
Assessment of biliary bicarbonate secretion in humans by positron emission tomography
-
Prieto, J. et al. Assessment of biliary bicarbonate secretion in humans by positron emission tomography. Gastroenterology 117, 167-172 (1999).
-
(1999)
Gastroenterology
, vol.117
, pp. 167-172
-
-
Prieto, J.1
-
76
-
-
80053334403
-
Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO3-output
-
Baghdasaryan, A. et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO3-output. Hepatology 54, 1303-1312 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 1303-1312
-
-
Baghdasaryan, A.1
-
77
-
-
0033966156
-
Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid
-
Angulo, P. et al. Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. Hepatology 31, 318-323 (2000).
-
(2000)
Hepatology
, vol.31
, pp. 318-323
-
-
Angulo, P.1
-
78
-
-
38849104576
-
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
-
Arenas, F. et al. Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J. Clin. Invest. 118, 695-709 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 695-709
-
-
Arenas, F.1
-
79
-
-
32044462778
-
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans
-
Hofmann, A. F. et al. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology 42, 1391-1398 (2005).
-
(2005)
Hepatology
, vol.42
, pp. 1391-1398
-
-
Hofmann, A.F.1
-
80
-
-
32044467118
-
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
-
Fickert, P. et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 130, 465-481 (2006).
-
(2006)
Gastroenterology
, vol.130
, pp. 465-481
-
-
Fickert, P.1
-
81
-
-
78049492335
-
Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
-
Denk, G. U. et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology 52, 1758-1768 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 1758-1768
-
-
Denk, G.U.1
-
82
-
-
84896691836
-
Peroxisome proliferator-activated receptor alpha activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion
-
Ghonem, N. S., Ananthanarayanan, M., Soroka, C. J. & Boyer, J. L. Peroxisome proliferator-activated receptor alpha activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology 59, 1030-1042 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1030-1042
-
-
Ghonem, N.S.1
Ananthanarayanan, M.2
Soroka, C.J.3
Boyer, J.L.4
-
83
-
-
0035071514
-
Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: Increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs
-
Lunz, J. G. et al. Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am. J. Pathol. 158, 1379-1390 (2001).
-
(2001)
Am. J. Pathol.
, vol.158
, pp. 1379-1390
-
-
Lunz, J.G.1
-
84
-
-
38549143883
-
Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
-
Rygiel, K. A. et al. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab. Invest. 88, 112-123 (2008).
-
(2008)
Lab. Invest.
, vol.88
, pp. 112-123
-
-
Rygiel, K.A.1
-
85
-
-
77951711854
-
T cell-mediated biliary epithelial-to-mesenchymal transition in liver allograft rejection
-
Rygiel, K. A. et al. T cell-mediated biliary epithelial-to-mesenchymal transition in liver allograft rejection. Liver Transpl. 16, 567-576 (2010).
-
(2010)
Liver Transpl.
, vol.16
, pp. 567-576
-
-
Rygiel, K.A.1
-
86
-
-
84879554094
-
Biliary epithelial senescence and plasticity in acute cellular rejection
-
Brain, J. G. et al. Biliary epithelial senescence and plasticity in acute cellular rejection. Am. J. Transplant. 13, 1688-1702 (2013).
-
(2013)
Am. J. Transplant.
, vol.13
, pp. 1688-1702
-
-
Brain, J.G.1
-
87
-
-
77955304095
-
Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis
-
Sasaki, M., Miyakoshi, M., Sato, Y. & Nakanuma, Y. Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis. J. Hepatol. 53, 318-325 (2010).
-
(2010)
J. Hepatol.
, vol.53
, pp. 318-325
-
-
Sasaki, M.1
Miyakoshi, M.2
Sato, Y.3
Nakanuma, Y.4
-
88
-
-
0037329896
-
The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis
-
Kinnman, N. et al. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab. Invest. 83, 163-173 (2003).
-
(2003)
Lab. Invest.
, vol.83
, pp. 163-173
-
-
Kinnman, N.1
-
90
-
-
0036166579
-
Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
-
Cassiman, D., Libbrecht, L., Desmet, V., Denef, C. & Roskams, T. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J. Hepatol. 36, 200-209 (2002).
-
(2002)
J. Hepatol.
, vol.36
, pp. 200-209
-
-
Cassiman, D.1
Libbrecht, L.2
Desmet, V.3
Denef, C.4
Roskams, T.5
-
91
-
-
33847363203
-
Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
Iredale, J. P. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest. 117, 539-548 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 539-548
-
-
Iredale, J.P.1
-
92
-
-
43549120265
-
Characterization of time-related changes after experimental bile duct ligation
-
Georgiev, P. et al. Characterization of time-related changes after experimental bile duct ligation. Br. J. Surg. 95, 646-656 (2008).
-
(2008)
Br. J. Surg.
, vol.95
, pp. 646-656
-
-
Georgiev, P.1
-
93
-
-
84888339170
-
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
-
Mederacke, I. et al. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat. Commun. 4, 2823 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2823
-
-
Mederacke, I.1
-
94
-
-
84905970880
-
Origin of myofibroblasts in the fibrotic liver in mice
-
Iwaisako, K. et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc. Natl Acad. Sci. USA 111, E3297-E3305 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E3297-E3305
-
-
Iwaisako, K.1
-
95
-
-
27744512904
-
Mdr2 (Abcb4)/mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-and antifibrogenic genes
-
Popov, Y., Patsenker, E., Fickert, P., Trauner, M. & Schuppan, D. Mdr2 (Abcb4)/mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-and antifibrogenic genes. J. Hepatol. 43, 1045-1054 (2005).
-
(2005)
J. Hepatol.
, vol.43
, pp. 1045-1054
-
-
Popov, Y.1
Patsenker, E.2
Fickert, P.3
Trauner, M.4
Schuppan, D.5
-
96
-
-
79551600267
-
Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: Antifibrotis effects in a model of nonsinusoidal fibrosis
-
Strack, I. et al. Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotis effects in a model of nonsinusoidal fibrosis. Lab. Invest. 91, 252-261 (2011).
-
(2011)
Lab. Invest.
, vol.91
, pp. 252-261
-
-
Strack, I.1
-
97
-
-
0033524949
-
The integrin v6 binds and activates latent TGF1: A mechanism for regulating pulmonary inflammation and fibrosis
-
Munger, J. S. et al. The integrin v6 binds and activates latent TGF1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319-328 (1999).
-
(1999)
Cell
, vol.96
, pp. 319-328
-
-
Munger, J.S.1
-
98
-
-
39149111929
-
Integrin v6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
-
Popov, Y. et al. Integrin v6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J. Hepatol. 48, 453-464 (2008).
-
(2008)
J. Hepatol.
, vol.48
, pp. 453-464
-
-
Popov, Y.1
-
99
-
-
48549103201
-
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
-
Patsenker, E. et al. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology 135, 660-670 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 660-670
-
-
Patsenker, E.1
-
100
-
-
84924254551
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01371305 (2014).
-
(2014)
-
-
-
101
-
-
84924247330
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00878761 (2011).
-
(2011)
-
-
-
102
-
-
84888381983
-
Inhibition of v6 promotes acute renal allograft rejection in non-human primates
-
Lo, D. J. et al. Inhibition of v6 promotes acute renal allograft rejection in non-human primates. Am. J. Transplant. 13, 3085-3093 (2013).
-
(2013)
Am. J. Transplant.
, vol.13
, pp. 3085-3093
-
-
Lo, D.J.1
-
103
-
-
77956425361
-
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
-
Barry-Hamilton, V. et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat. Med. 16, 1009-1017 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 1009-1017
-
-
Barry-Hamilton, V.1
-
104
-
-
84924230375
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01672879 (2014).
-
(2014)
-
-
-
105
-
-
84924239067
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01672853 (2014).
-
(2014)
-
-
-
106
-
-
84868698756
-
Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action
-
Poupon, R. Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action. Clin. Res. Hepatol. Gastroenterol. 36, S3-S12 (2012).
-
(2012)
Clin. Res. Hepatol. Gastroenterol.
, vol.36
, pp. S3-S12
-
-
Poupon, R.1
-
107
-
-
0034953329
-
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
-
Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F. & Rosen, A. Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J. Clin. Invest. 108, 223-232 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 223-232
-
-
Odin, J.A.1
Huebert, R.C.2
Casciola-Rosen, L.3
Larusso, N.F.4
Rosen, A.5
-
108
-
-
0036139024
-
Contribution to antimitochondrial antibody production: Cleavage of pyruvate dehydroganse complex-E2 by apoptosis-related proteases
-
Matsumura, S. et al. Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydroganse complex-E2 by apoptosis-related proteases. Hepatology 35, 14-22 (2002).
-
(2002)
Hepatology
, vol.35
, pp. 14-22
-
-
Matsumura, S.1
-
109
-
-
84877924280
-
Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
-
Fickert, P. et al. Differential effects of norUDCA and UDCA in obstructive cholestasis in mice. J. Hepatol. 58, 1201-1208 (2013).
-
(2013)
J. Hepatol.
, vol.58
, pp. 1201-1208
-
-
Fickert, P.1
-
110
-
-
84926421958
-
24-nor-ursodeoxycholic acid ameliorates inflammatry response and liver fibrosis in a murine model of schistosomiasis
-
Sombetzki, M. et al. 24-nor-ursodeoxycholic acid ameliorates inflammatry response and liver fibrosis in a murine model of schistosomiasis. J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2014.11.020.
-
J. Hepatol.
-
-
Sombetzki, M.1
-
111
-
-
67649210759
-
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
-
Zhang, S., Wang, J., Liu, Q. & Harnish, D. C. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J. Hepatol. 51, 380-388 (2009).
-
(2009)
J. Hepatol.
, vol.51
, pp. 380-388
-
-
Zhang, S.1
Wang, J.2
Liu, Q.3
Harnish, D.C.4
-
112
-
-
80052932213
-
New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice
-
Fausther, M. & Dranoff, J. A. New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice. J. Hepatol. 55, 939-940 (2011).
-
(2011)
J. Hepatol.
, vol.55
, pp. 939-940
-
-
Fausther, M.1
Dranoff, J.A.2
-
113
-
-
77955334203
-
Farnesoid-X receptor agonists: A new class of drug for the treatment of PBC An international study evaluating the addition of INT-747 to ursodeoxycholic acid
-
Mason, A. et al. Farnesoid-X receptor agonists: a new class of drug for the treatment of PBC An international study evaluating the addition of INT-747 to ursodeoxycholic acid. J. Hepatol. 52, S1-S2 (2010).
-
(2010)
J. Hepatol.
, vol.52
, pp. S1-S2
-
-
Mason, A.1
-
114
-
-
0036179358
-
Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
-
Prince, M. I., Burt, A. D. & Jones, D. E. J. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut 50, 436-439 (2002).
-
(2002)
Gut
, vol.50
, pp. 436-439
-
-
Prince, M.I.1
Burt, A.D.2
Jones, D.E.J.3
-
115
-
-
33745910873
-
Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence
-
Newton, J. L., Gibson, J. G., Tomlinson, M., Wilton, K. & Jones, D. E. J. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology 44, 91-98 (2006).
-
(2006)
Hepatology
, vol.44
, pp. 91-98
-
-
Newton, J.L.1
Gibson, J.G.2
Tomlinson, M.3
Wilton, K.4
Jones, D.E.J.5
-
116
-
-
84903313532
-
Pruritus in cholestasis: Facts and fiction
-
Beuers, U., Kremer, A. E., Bolier, R. & Elferink, R. P. Pruritus in cholestasis: facts and fiction. Hepatology 60, 399-407 (2014).
-
(2014)
Hepatology
, vol.60
, pp. 399-407
-
-
Beuers, U.1
Kremer, A.E.2
Bolier, R.3
Elferink, R.P.4
-
117
-
-
84924234963
-
-
(eds Lindor, K. D., Heathcote, E. J. & Poupon, R. E.) Springer
-
Bergasa, N. & Jones, E. A. in Primary Biliary Cirrhosis: From Pathogenesis to Clinical Treatment (eds Lindor, K. D., Heathcote, E. J. & Poupon, R. E.) 108-114 (Springer, 2012).
-
(2012)
Primary Biliary Cirrhosis: From Pathogenesis to Clinical Treatment
, pp. 108-114
-
-
Bergasa, N.1
Jones, E.A.2
-
118
-
-
0023846078
-
Treatment of pruritus in primary biliary cirrhosis with rifampicin. Results of a double-blind, cross-over, randomized trial
-
Podesta, A. L. et al. Treatment of pruritus in primary biliary cirrhosis with rifampicin. Results of a double-blind, cross-over, randomized trial. Gastroenterology 94, 488-493 (1991).
-
(1991)
Gastroenterology
, vol.94
, pp. 488-493
-
-
Podesta, A.L.1
-
119
-
-
34250813322
-
The efficacy and safety of bile acid binding agents, opioid antagonists or rifampicin in the treatment of cholestasis-associated pruritus
-
Tandon, P., Rowe, B. H., Vandermeer, B. & Bain, V. G. The efficacy and safety of bile acid binding agents, opioid antagonists or rifampicin in the treatment of cholestasis-associated pruritus. Am. J. Gastroenterol. 102, 1528-1536 (2007).
-
(2007)
Am. J. Gastroenterol.
, vol.102
, pp. 1528-1536
-
-
Tandon, P.1
Rowe, B.H.2
Vandermeer, B.3
Bain, V.G.4
-
120
-
-
33750619889
-
Treatment of refractory cholestatic pruritus with molecular adsorbent recirculating system (MARS)
-
Montero, J. L. et al. Treatment of refractory cholestatic pruritus with molecular adsorbent recirculating system (MARS). Transplant. Proc. 38, 2511-2513 (2006).
-
(2006)
Transplant. Proc.
, vol.38
, pp. 2511-2513
-
-
Montero, J.L.1
-
121
-
-
84863409270
-
Out-patient albumin dialysis for cholestatic patients with intractable itch
-
Leckie, P. et al. 'Out-patient' albumin dialysis for cholestatic patients with intractable itch. Aliment. Pharmacol. Ther. 35, 696-704 (2012).
-
(2012)
Aliment. Pharmacol. Ther.
, vol.35
, pp. 696-704
-
-
Leckie, P.1
-
122
-
-
0013893293
-
Cholestyramine for long term relief of the priritus complicating intrahepatic cholestasis
-
Datta, D. V. & Sherlock, S. Cholestyramine for long term relief of the priritus complicating intrahepatic cholestasis. Gastroenterology 50, 323-332 (1966).
-
(1966)
Gastroenterology
, vol.50
, pp. 323-332
-
-
Datta, D.V.1
Sherlock, S.2
-
123
-
-
33646548609
-
Nasobiliary drainage for cholestatic pruritus
-
Hofmann, A. F. & Huet, P. M. Nasobiliary drainage for cholestatic pruritus. Hepatology 43, 1170-1171 (2006).
-
(2006)
Hepatology
, vol.43
, pp. 1170-1171
-
-
Hofmann, A.F.1
Huet, P.M.2
-
124
-
-
33745907551
-
Biliary drainage transiently relieves intractable pruritus in primary biliary cirrhosis
-
Beuers, U., Gerken, G. & Pusl, T. Biliary drainage transiently relieves intractable pruritus in primary biliary cirrhosis. Hepatology 44, 280-281 (2006).
-
(2006)
Hepatology
, vol.44
, pp. 280-281
-
-
Beuers, U.1
Gerken, G.2
Pusl, T.3
-
125
-
-
84924262558
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01904058 (2014).
-
(2014)
-
-
-
126
-
-
84924256177
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01899703 (2014).
-
(2014)
-
-
-
127
-
-
0030876502
-
Oral naltrexone for cholestatic pruritus: A double-blind, placebo-controlled study
-
Wolfhagen, F. H. J. et al. Oral naltrexone for cholestatic pruritus: a double-blind, placebo-controlled study. Gastroenterology 113, 1264-1269 (1997).
-
(1997)
Gastroenterology
, vol.113
, pp. 1264-1269
-
-
Wolfhagen, F.H.J.1
-
128
-
-
84925581702
-
Lysophosphatidic acid is a potential mediator of cholestatic pruritus
-
Kremer, A. E. et al. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 139, 1008-1018 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 1008-1018
-
-
Kremer, A.E.1
-
129
-
-
84864357786
-
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions
-
Kremer, A. E. et al. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin and responds to therapeutic interventions. Hepatology 56, 1391-1400 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 1391-1400
-
-
Kremer, A.E.1
-
130
-
-
84913533041
-
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice
-
Lieu, T. et al. The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. Gastroenterology 147, 1417-1428 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 1417-1428
-
-
Lieu, T.1
-
131
-
-
84875848761
-
The TGR5 receptor mediated bile acid-induce itch and analgesia
-
Alemi, F. et al. The TGR5 receptor mediated bile acid-induce itch and analgesia. J. Clin. Invest. 123, 1513-1530 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
-
132
-
-
84939815585
-
TGR5: Pathogenetic role and/or therapeutic target in fibrosing cholangitis
-
Keitel, V., Reich, M. & Haussinger, D. TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis. Clin. Rev. Allergy Immunol. http://dx.doi.org/10.1007/s12016-014-8443-x.
-
Clin. Rev. Allergy Immunol.
-
-
Keitel, V.1
Reich, M.2
Haussinger, D.3
-
133
-
-
0036238069
-
The true impact of fatigue in primary biliary cirrhosis: A population study
-
Goldblatt, J. et al. The true impact of fatigue in primary biliary cirrhosis: a population study. Gastroenterology 122, 1235-1241 (2002).
-
(2002)
Gastroenterology
, vol.122
, pp. 1235-1241
-
-
Goldblatt, J.1
-
134
-
-
84879127656
-
The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC Cohort
-
Pells, G. et al. The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC Cohort. J. Hepatol. 59, 67-73 (2013).
-
(2013)
J. Hepatol.
, vol.59
, pp. 67-73
-
-
Pells, G.1
-
135
-
-
34250349573
-
Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis
-
Newton, J. L. et al. Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology 45, 1496-1505 (2007).
-
(2007)
Hepatology
, vol.45
, pp. 1496-1505
-
-
Newton, J.L.1
-
136
-
-
84927660952
-
Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output
-
Dyson, J. K. et al. Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output. Liver Int. http://dx.doi.org/10.1111/liv.12709.
-
Liver Int.
-
-
Dyson, J.K.1
-
137
-
-
0031032710
-
Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment
-
Swain, M. G. & Maric, M. Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. Hepatology 25, 492-494 (1997).
-
(1997)
Hepatology
, vol.25
, pp. 492-494
-
-
Swain, M.G.1
Maric, M.2
-
138
-
-
0036177785
-
Increased sensitivity to the locomotor-activating effects of corticotrophin-releasing hormone in cholestatic rats
-
Burak, K. W., Le, T. & Swain, M. G. Increased sensitivity to the locomotor-activating effects of corticotrophin-releasing hormone in cholestatic rats. Gastroenterology 122, 681-688 (2002).
-
(2002)
Gastroenterology
, vol.122
, pp. 681-688
-
-
Burak, K.W.1
Le, T.2
Swain, M.G.3
-
139
-
-
33644791099
-
TNF-secreting monocytes are recruited into the brain of cholestatic mice
-
Kerfoot, S. M. et al. TNF-secreting monocytes are recruited into the brain of cholestatic mice. Hepatology 43, 154-162 (2006).
-
(2006)
Hepatology
, vol.43
, pp. 154-162
-
-
Kerfoot, S.M.1
-
140
-
-
84883665716
-
P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors
-
D'Mello, C. et al. P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors. J. Neurosci. 33, 14878-14888 (2013).
-
(2013)
J. Neurosci.
, vol.33
, pp. 14878-14888
-
-
D'Mello, C.1
-
141
-
-
78049471863
-
Central nervous system dysfunction in primary biliary cirrhosis patients and its relationship to symptoms
-
McDonald, C., Newton, J. L., Ming Lai, H., Baker, S. N. & Jones, D. E. J. Central nervous system dysfunction in primary biliary cirrhosis patients and its relationship to symptoms. J. Hepatol. 53, 1095-1100 (2010).
-
(2010)
J. Hepatol.
, vol.53
, pp. 1095-1100
-
-
McDonald, C.1
Newton, J.L.2
Ming Lai, H.3
Baker, S.N.4
Jones, D.E.J.5
-
142
-
-
49649129442
-
Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential aetiology
-
Newton, J. L. et al. Cognitive impairment in primary biliary cirrhosis: symptom impact and potential aetiology. Hepatology 48, 541-549 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 541-549
-
-
Newton, J.L.1
-
143
-
-
77954372603
-
Impaired cerebral autoregulation in primary biliary cirrhosis: Implications for the pathogenesis of cognitive decline
-
Hollingsworth, K. G. et al. Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline. Liver Int. 30, 878-885 (2010).
-
(2010)
Liver Int.
, vol.30
, pp. 878-885
-
-
Hollingsworth, K.G.1
-
144
-
-
84920453379
-
Amyloid-pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
-
Dionisio, P. A. et al. Amyloid-pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset. Neurobiol. Aging 36, 228-240 (2015).
-
(2015)
Neurobiol. Aging
, vol.36
, pp. 228-240
-
-
Dionisio, P.A.1
-
145
-
-
50649120124
-
A pilot study of peripheral muscle function in primary biliary cirrhosis: Potential implications for fatigue pathogenesis
-
Hollingsworth, K. G. et al. A pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis. Clin. Gastroenterol. Hepatol. 6, 1041-1048 (2008).
-
(2008)
Clin. Gastroenterol. Hepatol.
, vol.6
, pp. 1041-1048
-
-
Hollingsworth, K.G.1
-
146
-
-
84871815449
-
-
European Medicines Agency [online]
-
European Medicines Agency. EU Clinical Trial Register [online], https://www.clinicaltrialsregister.eu/ctr-search/searchquery=2012-000145-12.
-
EU Clinical Trial Register
-
-
-
147
-
-
7144253117
-
Lactic acid efflux from white skeletal muscle is catalysed by the monocarboxylate transporter isoform MCT4
-
Wilson, M. C. et al. Lactic acid efflux from white skeletal muscle is catalysed by the monocarboxylate transporter isoform MCT4. J. Biol. Chem. 273, 15920-15926 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15920-15926
-
-
Wilson, M.C.1
-
148
-
-
1942517890
-
Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans
-
Juel, C. & Holten, M. K. Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans. J. Physiol. 556, 297-304 (2004).
-
(2004)
J. Physiol.
, vol.556
, pp. 297-304
-
-
Juel, C.1
Holten, M.K.2
-
149
-
-
84905048563
-
Old and novel therapies for primary biliary cirrhosis
-
Pares, A. Old and novel therapies for primary biliary cirrhosis. Semin. Liver Dis. 34, 341-351 (2014).
-
(2014)
Semin. Liver Dis.
, vol.34
, pp. 341-351
-
-
Pares, A.1
-
150
-
-
84924263275
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00746486 (2013).
-
(2013)
-
-
-
151
-
-
84924237171
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02078882 (2014).
-
(2014)
-
-
-
152
-
-
2942733370
-
CTLA4Ig: A novel inhibitor of costimulation
-
Dall'Era, M. & Davis, J. CTLA4Ig: a novel inhibitor of costimulation. Lupus 13, 372-376 (2004).
-
(2004)
Lupus
, vol.13
, pp. 372-376
-
-
Dall'Era, M.1
Davis, J.2
-
153
-
-
84924236423
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01614405 (2014).
-
(2014)
-
-
-
154
-
-
11144294127
-
Pilot studies of single and combination antiretroviral therapy in patients with primary biliary cirrhosis
-
Mason, A. L., Farr, G. H., Xu, L., Hubscher, S. G. & Neuberger, J. M. Pilot studies of single and combination antiretroviral therapy in patients with primary biliary cirrhosis. Am. J. Gastroenterol. 99, 2348-2355 (2004).
-
(2004)
Am. J. Gastroenterol.
, vol.99
, pp. 2348-2355
-
-
Mason, A.L.1
Farr, G.H.2
Xu, L.3
Hubscher, S.G.4
Neuberger, J.M.5
-
155
-
-
77955319590
-
Linking human beta retrovirus infection with primary biliary cirrhosis
-
Mason, A. L. & Zhang, G. Linking human beta retrovirus infection with primary biliary cirrhosis. Gastroenterol. Clin. Biol. 34, 359-366 (2010).
-
(2010)
Gastroenterol. Clin. Biol.
, vol.34
, pp. 359-366
-
-
Mason, A.L.1
Zhang, G.2
-
156
-
-
84924503081
-
Impact of combination antiretroviral therapy in the NOD.c3c4 mouse model of autoimmune biliary disease
-
Sharon, D. et al. Impact of combination antiretroviral therapy in the NOD.c3c4 mouse model of autoimmune biliary disease. Liver Int. http://dx.doi.org/10.1111/liv.12699.
-
Liver Int.
-
-
Sharon, D.1
-
157
-
-
11144308266
-
Proof of principal studies to assess the role of the human betaretrovirus in patients with primary biliary cirrhosis
-
Mason, A., Xu, L. & Neuberger, J. Proof of principal studies to assess the role of the human betaretrovirus in patients with primary biliary cirrhosis. Am. J. Gastroenterol. 99, 2499-2500 (2004).
-
(2004)
Am. J. Gastroenterol.
, vol.99
, pp. 2499-2500
-
-
Mason, A.1
Xu, L.2
Neuberger, J.3
-
158
-
-
84924280849
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00393185 (2012).
-
(2012)
-
-
-
159
-
-
84924274236
-
-
US National Library of Medicine. ClinicalTrials.gov [online]
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01662973 (2013).
-
(2013)
-
-
|