Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: A possible role in bile duct loss

Journal of Pathology

Volumn 205, Issue 4, 2005, Pages 451-459

  Sasaki, Motoko ^a   Ikeda, Hiroko ^a   Haga, Hironori ^b   Manabe, Toshiaki ^b   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cellular senescence; Nitric oxide; Oxidative stress; Primary biliary cirrhosis

Indexed keywords

BETA GALACTOSIDASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; NITRIC OXIDE; PROTEIN P16; PROTEIN P21; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL AGING; CELL CULTURE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CHOLANGITIS; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FREQUENCY ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATORY CELL; LIVER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SAMPLING; TISSUE DISTRIBUTION;

ANIMALS; BETA-GALACTOSIDASE; BILE DUCTS, INTRAHEPATIC; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS, BILIARY; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; OXIDATIVE STRESS; PEROXIDASE;

EID: 14944376606     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1729     Document Type: Article

References (32)

1. Gershwin ME, Mackay IR, Sturgess A, Coppel RL. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987; 138: 3525-3531.
2. Kaplan M. Primary biliary cirrhosis. N Engl J Med 1996; 335: 1570-1580.
3. Portmann B, Nakanuma Y. Diseases of the bile ducts. In Pathology of the Liver (4th edn), MacSween R, Burt A, Portmann BC, Ishak K, Scheuer P, Anthony P (eds). Churchill Livingstone: London, 2001; 435-506.
4. Nakanuma Y, Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology 1979; 76: 1326-1332.
5. Fussey S, Guest J, James O, Bassendine M, Yeaman S. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci USA 1988; 85: 8654-8658.
6. Neuberger J, Thomson R. PBC and AMA: what is the connection? Hepatology 1999; 29: 271-276.
7. Shimoda S, Van de Water J, Ansari A, et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest 1998; 102: 1831-1840.
8. Desmet VJ. Vanishing bile duct syndrome in drug-induced liver disease. J Hepatol 1997; 26(Suppl 1): 31-35.
9. Lunz JG 3rd, Contrucci S, Ruppert K, et al. Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol 2001; 158: 1379-1390.
10. Sigal SH, Rajvanshi P, Gorla GR, et al. Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events. Am J Physiol 1999; 276: G1260-1272.
11. Brodsky WY, Uryvaeva IV. Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol 1977; 50: 275-332.
12. Demetris AJ, Markus BH, Saidman S, et al. Isolation and primary cultures of human intrahepatic bile ductular epithelium. In Vitro Cell Dev Biol 1988; 24: 464-470.
13. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-9367.
14. Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol 2001; 13: 748-753.
15. Wu CT, Eiserich JP, Ansari AA, et al. Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions. Hepatology 2003; 38: 1018-1025.
16. Jaiswal M, LaRusso NF, Shapiro RA, Billiar TR, Gores GJ. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology 2001; 120: 190-199.
17. Gaut JP, Byun J, Tran HD, et al. Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest 2002; 109: 1311-1319.
18. Nakanuma Y, Sasaki M. Expression of blood-group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases. Hepatology 1989; 10 174-178.
19. Demetris AJ, Fung JJ, Todo S, et al. FK 506 used as rescue therapy for human liver allograft recipients. Transplant Proc 1991; 23: 3005-3006.
20. Freese DK, Snover DC, Sharp HL, Gross CR, Savick SK, Payne WD. Chronic rejection after liver transplantation: a study of clinical, histopathological and immunological features. Hepatology 1991; 13: 882-891.
21. Ludwig J. Small-duct primary sclerosing cholangitis. Semin Liver Dis 1991; 11: 11-17.
22. Tsuneyama K, Harada K, Kono N, et al. Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal. J Hepatol 2002; 37: 176-183.
23. Katayanagi K, Kono N, Nakanuma Y. Isolation, culture and characterization of biliary epithelial cells from different anatomical levels of the intrahepatic and extrahepatic biliary tree from a mouse. Liver 1998; 18: 90-98.
24. Zen Y, Harada K, Sasaki M, et al. Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis. Am J Pathol 2002; 161: 1475-1484.
25. Demetris A. Immunopathology of the human biliary tree. In Biliary and Pancreatic Ductal Epithelia, Sirica A, Longnecker D (eds), Marcel Dekker: New York, 1997; 127-180.
26. Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003; 8: 131-144.
27. Aboutwerat A, Pemberton PW, Smith A, et al. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta 2003; 1637: 142-150.
28. Mitsuyoshi H, Nakashima T, Sumida Y, et al. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem Biophys Res Commun 1999; 263 537-542.
29. Serviddio G, Pereda J, Pallardo FV, et al. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 2004; 39: 711-720.
30. Rahman SM, Itakura H, Motoda A. Regenerative pattern of liver cells in primary biliary cirrhosis, alcoholic cirrhosis, posthepatic cirrhosis (HBV-related) and hepatocellular carcinoma: comparative analysis by computerized morphometry. Pathol Int 1996; 46: 267-273.
31. Saxena R, Hytiroglou P, Thung SN, Theise ND. Destruction of canals of Hering in primary biliary cirrhosis. Hum Pathol 2002; 33: 983-988.
32. van den Heuvel MC, de Jong KP, van der Horst ML, Poppema S, Slooff MJ, Gouw AS. Impaired regeneration of biliary cells in human chronic liver allograft rejection: special emphasis on the role of the finest branches of the biliary tree. Liver Transpl 2004; 10: 28-35.