Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

Journal of Hepatology

Volumn 48, Issue 3, 2008, Pages 453-464

  Popov, Yury ^a,b   Patsenker, Eleonora ^b   Stickel, Felix ^b   Zaks, Jessica ^a   Bhaskar, K Ramakrishnan ^a   Niedobitek, Gerald ^c   Kolb, Armin ^d   Friess, Helmut ^d,e   Schuppan, Detlef ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

v 6; Abcb4; Animal model; Antifibrotic therapy; Cirrhosis; Collagenase

Indexed keywords

3 [3 BENZYLOXY 2 [5 (PYRIDIN 2 YLAMINO)PENTANOYLAMINO]PROPIONYLAMINO] 3 (3,5 DICHLOROPHENYL)PROPIONIC ACID; ALPHAVBETA6 INTEGRIN; BETA6 INTEGRIN; EMD 527040; GELATINASE A; MESSENGER RNA; NEUTROPHIL COLLAGENASE; PROCOLLAGEN; PROTEIN INHIBITOR; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLYCOPROTEIN P; INTEGRIN; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2; PYRIDINE DERIVATIVE; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILIARY TRACT FIBROSIS; CELL ACTIVITY; CELL TRANSFORMATION; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG TARGETING; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; FIBROGENESIS; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER FAILURE; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR UPREGULATION; SCLEROSING CHOLANGITIS; SINGLE DRUG DOSE; ADULT; ANIMAL; BILE DUCT; BIOPSY; DISEASE MODEL; DRUG EFFECT; LIVER; LIVER CIRRHOSIS; METABOLISM; MIDDLE AGED; MOUSE MUTANT; PATHOLOGY; WISTAR RAT;

ADULT; ANIMALS; ANTIGENS, NEOPLASM; BILE DUCTS; BIOLOGICAL MARKERS; BIOPSY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EPITHELIAL CELLS; FEMALE; HEPATITIS C, CHRONIC; HEPATOCYTES; HUMANS; INTEGRINS; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; P-GLYCOPROTEINS; PYRIDINES; RATS; RATS, WISTAR;

EID: 39149111929     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.11.021     Document Type: Article

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