메뉴 건너뛰기




Volumn 36, Issue 5, 2014, Pages 553-568

Mechanisms of tissue injury in autoimmune liver diseases

Author keywords

Adaptive immunity; Autoimmune hepatitis; Innate immunity; Primary biliary cirrhosis; Primary sclerosing cholangitis; T regulatory cells; Th17 cells

Indexed keywords

ANIMAL; AUTOIMMUNE DISEASES; DISEASE MODEL; HUMAN; LIVER DISEASES; PATHOLOGY;

EID: 84930805025     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-014-0439-3     Document Type: Review
Times cited : (61)

References (170)
  • 1
    • 84875890982 scopus 로고    scopus 로고
    • The immunobiology and pathophysiology of primary biliary cirrhosis
    • PID: 23347352, COI: 1:CAS:528:DC%2BC3sXltVKqs7w%3D
    • Hirschfield GM, Gershwin ME (2013) The immunobiology and pathophysiology of primary biliary cirrhosis. Annu Rev Pathol 8:303–330
    • (2013) Annu Rev Pathol , vol.8 , pp. 303-330
    • Hirschfield, G.M.1    Gershwin, M.E.2
  • 2
    • 25144474552 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • PID: 16177252, COI: 1:CAS:528:DC%2BD2MXhtVeltLbI
    • Kaplan MM, Gershwin ME (2005) Primary biliary cirrhosis. N Engl J Med 353:1261–1273
    • (2005) N Engl J Med , vol.353 , pp. 1261-1273
    • Kaplan, M.M.1    Gershwin, M.E.2
  • 4
    • 84865517962 scopus 로고    scopus 로고
    • Review article: overlap syndromes and autoimmune liver disease
    • PID: 22817525, COI: 1:CAS:528:DC%2BC38Xhs1CqtbjE
    • Trivedi PJ, Hirschfield GM (2012) Review article: overlap syndromes and autoimmune liver disease. Aliment Pharmacol Ther 36:517–533
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 517-533
    • Trivedi, P.J.1    Hirschfield, G.M.2
  • 5
    • 84886291634 scopus 로고    scopus 로고
    • Mucosal immunity in liver autoimmunity: a comprehensive review
    • PID: 23891169, COI: 1:CAS:528:DC%2BC3sXhtFKltbnL
    • Trivedi PJ, Adams DH (2013) Mucosal immunity in liver autoimmunity: a comprehensive review. J Autoimmun 46:97–111
    • (2013) J Autoimmun , vol.46 , pp. 97-111
    • Trivedi, P.J.1    Adams, D.H.2
  • 6
    • 80054897554 scopus 로고    scopus 로고
    • Cutting edge issues in primary sclerosing cholangitis
    • PID: 21170605, COI: 1:CAS:528:DC%2BC3MXhtFyjs7nI
    • Bowlus CL (2011) Cutting edge issues in primary sclerosing cholangitis. Clin Rev Allergy Immunol 41:139–150
    • (2011) Clin Rev Allergy Immunol , vol.41 , pp. 139-150
    • Bowlus, C.L.1
  • 7
    • 12444260826 scopus 로고    scopus 로고
    • Increased prevalence of primary sclerosing cholangitis among first-degree relatives
    • PID: 15664252
    • Bergquist A, Lindberg G, Saarinen S, Broome U (2005) Increased prevalence of primary sclerosing cholangitis among first-degree relatives. J Hepatol 42:252–256
    • (2005) J Hepatol , vol.42 , pp. 252-256
    • Bergquist, A.1    Lindberg, G.2    Saarinen, S.3    Broome, U.4
  • 8
    • 30944437302 scopus 로고    scopus 로고
    • Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients
    • PID: 16250040
    • Gershwin ME, Selmi C, Worman HJ, Gold EB, Watnik M, Utts J, Lindor KD et al (2005) Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology 42:1194–1202
    • (2005) Hepatology , vol.42 , pp. 1194-1202
    • Gershwin, M.E.1    Selmi, C.2    Worman, H.J.3    Gold, E.B.4    Watnik, M.5    Utts, J.6    Lindor, K.D.7
  • 9
    • 4143103585 scopus 로고    scopus 로고
    • Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment
    • PID: 15300581
    • Selmi C, Mayo MJ, Bach N, Ishibashi H, Invernizzi P, Gish RG, Gordon SC et al (2004) Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment. Gastroenterology 127:485–492
    • (2004) Gastroenterology , vol.127 , pp. 485-492
    • Selmi, C.1    Mayo, M.J.2    Bach, N.3    Ishibashi, H.4    Invernizzi, P.5    Gish, R.G.6    Gordon, S.C.7
  • 12
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    • PID: 19458352, COI: 1:CAS:528:DC%2BD1MXntVKqtrg%3D
    • Hirschfield GM, Liu X, Xu C, Lu Y, Xie G, Lu Y, Gu X et al (2009) Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 360:2544–2555
    • (2009) N Engl J Med , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3    Lu, Y.4    Xie, G.5    Lu, Y.6    Gu, X.7
  • 13
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    • PID: 20639880, COI: 1:CAS:528:DC%2BC3cXovFCnt7k%3D
    • Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M et al (2010) Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet 42:658–660
    • (2010) Nat Genet , vol.42 , pp. 658-660
    • Liu, X.1    Invernizzi, P.2    Lu, Y.3    Kosoy, R.4    Lu, Y.5    Bianchi, I.6    Podda, M.7
  • 14
    • 79953208931 scopus 로고    scopus 로고
    • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    • PID: 21399635, COI: 1:CAS:528:DC%2BC3MXjtVGmt78%3D
    • Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA et al (2011) Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet 43:329–332
    • (2011) Nat Genet , vol.43 , pp. 329-332
    • Mells, G.F.1    Floyd, J.A.2    Morley, K.I.3    Cordell, H.J.4    Franklin, C.S.5    Shin, S.Y.6    Heneghan, M.A.7
  • 15
    • 84867248201 scopus 로고    scopus 로고
    • Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population
    • PID: 23000144, COI: 1:CAS:528:DC%2BC38Xhtl2ktLzO
    • Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H et al (2012) Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet 91:721–728
    • (2012) Am J Hum Genet , vol.91 , pp. 721-728
    • Nakamura, M.1    Nishida, N.2    Kawashima, M.3    Aiba, Y.4    Tanaka, A.5    Yasunami, M.6    Nakamura, H.7
  • 16
    • 84869060864 scopus 로고    scopus 로고
    • Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
    • PID: 22936693, COI: 1:CAS:528:DC%2BC38Xhs1GhsbnE
    • Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R et al (2012) Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet 21:5209–5221
    • (2012) Hum Mol Genet , vol.21 , pp. 5209-5221
    • Juran, B.D.1    Hirschfield, G.M.2    Invernizzi, P.3    Atkinson, E.J.4    Li, Y.5    Xie, G.6    Kosoy, R.7
  • 17
    • 84866924593 scopus 로고    scopus 로고
    • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
    • PID: 22961000, COI: 1:CAS:528:DC%2BC38Xhtlajs7zP
    • Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ et al (2012) Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat Genet 44:1137–1141
    • (2012) Nat Genet , vol.44 , pp. 1137-1141
    • Liu, J.Z.1    Almarri, M.A.2    Gaffney, D.J.3    Mells, G.F.4    Jostins, L.5    Cordell, H.J.6    Ducker, S.J.7
  • 18
    • 77955087537 scopus 로고    scopus 로고
    • Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    • PID: 20639879, COI: 1:CAS:528:DC%2BC3cXovFCns7g%3D
    • Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y et al (2010) Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet 42:655–657
    • (2010) Nat Genet , vol.42 , pp. 655-657
    • Hirschfield, G.M.1    Liu, X.2    Han, Y.3    Gorlov, I.P.4    Lu, Y.5    Xu, C.6    Lu, Y.7
  • 20
    • 78651227093 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    • PID: 21151127, COI: 1:CAS:528:DC%2BC3cXhsFGgtrvE
    • Melum E, Franke A, Schramm C, Weismuller TJ, Gotthardt DN, Offner FA, Juran BD et al (2011) Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 43:17–19
    • (2011) Nat Genet , vol.43 , pp. 17-19
    • Melum, E.1    Franke, A.2    Schramm, C.3    Weismuller, T.J.4    Gotthardt, D.N.5    Offner, F.A.6    Juran, B.D.7
  • 22
    • 79957502386 scopus 로고    scopus 로고
    • Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
    • PID: 21425313, COI: 1:CAS:528:DC%2BC3MXmsFCqurk%3D
    • Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E et al (2011) Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. Hepatology 53:1977–1985
    • (2011) Hepatology , vol.53 , pp. 1977-1985
    • Janse, M.1    Lamberts, L.E.2    Franke, L.3    Raychaudhuri, S.4    Ellinghaus, E.5    Muri Boberg, K.6    Melum, E.7
  • 23
    • 84863981813 scopus 로고    scopus 로고
    • Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
    • PID: 22521342, COI: 1:CAS:528:DC%2BC38XhtVGntb7E
    • Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK et al (2012) Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. J Hepatol 57:366–375
    • (2012) J Hepatol , vol.57 , pp. 366-375
    • Folseraas, T.1    Melum, E.2    Rausch, P.3    Juran, B.D.4    Ellinghaus, E.5    Shiryaev, A.6    Laerdahl, J.K.7
  • 25
    • 84883219528 scopus 로고    scopus 로고
    • Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
    • PID: 22821403, COI: 1:CAS:528:DC%2BC3sXhtlOkt7zE
    • Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK et al (2013) Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology 58:1074–1083
    • (2013) Hepatology , vol.58 , pp. 1074-1083
    • Ellinghaus, D.1    Folseraas, T.2    Holm, K.3    Ellinghaus, E.4    Melum, E.5    Balschun, T.6    Laerdahl, J.K.7
  • 26
    • 84878725018 scopus 로고    scopus 로고
    • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
    • PID: 23603763, COI: 1:CAS:528:DC%2BC3sXmt1Srs70%3D
    • Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA et al (2013) Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet 45:670–675
    • (2013) Nat Genet , vol.45 , pp. 670-675
    • Liu, J.Z.1    Hov, J.R.2    Folseraas, T.3    Ellinghaus, E.4    Rushbrook, S.M.5    Doncheva, N.T.6    Andreassen, O.A.7
  • 27
    • 84890569433 scopus 로고    scopus 로고
    • Autoimmune liver disease, autoimmunity and liver transplantation
    • PID: 24084655, COI: 1:CAS:528:DC%2BC3sXhslGlt77M
    • Carbone M, Neuberger JM (2014) Autoimmune liver disease, autoimmunity and liver transplantation. J Hepatol 60:210–223
    • (2014) J Hepatol , vol.60 , pp. 210-223
    • Carbone, M.1    Neuberger, J.M.2
  • 28
    • 0032907060 scopus 로고    scopus 로고
    • HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations
    • PID: 10372541, COI: 1:STN:280:DyaK1M3pvFOmtA%3D%3D
    • Spurkland A, Saarinen S, Boberg KM, Mitchell S, Broome U, Caballeria L, Ciusani E et al (1999) HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations. Tissue Antigens 53:459–469
    • (1999) Tissue Antigens , vol.53 , pp. 459-469
    • Spurkland, A.1    Saarinen, S.2    Boberg, K.M.3    Mitchell, S.4    Broome, U.5    Caballeria, L.6    Ciusani, E.7
  • 29
    • 0036936696 scopus 로고    scopus 로고
    • Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis
    • PID: 12765483, COI: 1:CAS:528:DC%2BD3sXitVCntLs%3D
    • Donaldson PT, Norris S (2002) Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis. Autoimmunity 35:555–564
    • (2002) Autoimmunity , vol.35 , pp. 555-564
    • Donaldson, P.T.1    Norris, S.2
  • 30
    • 1642318782 scopus 로고    scopus 로고
    • Genetics of liver disease: immunogenetics and disease pathogenesis
    • PID: 15016758, COI: 1:CAS:528:DC%2BD2cXjsVWgu7o%3D
    • Donaldson PT (2004) Genetics of liver disease: immunogenetics and disease pathogenesis. Gut 53:599–608
    • (2004) Gut , vol.53 , pp. 599-608
    • Donaldson, P.T.1
  • 31
    • 33748929827 scopus 로고    scopus 로고
    • HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study
    • PID: 16941709, COI: 1:CAS:528:DC%2BD28XhtVeqt7nF
    • Donaldson PT, Baragiotta A, Heneghan MA, Floreani A, Venturi C, Underhill JA, Jones DE et al (2006) HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study. Hepatology 44:667–674
    • (2006) Hepatology , vol.44 , pp. 667-674
    • Donaldson, P.T.1    Baragiotta, A.2    Heneghan, M.A.3    Floreani, A.4    Venturi, C.5    Underhill, J.A.6    Jones, D.E.7
  • 32
    • 0035116127 scopus 로고    scopus 로고
    • Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus
    • PID: 11182227, COI: 1:CAS:528:DC%2BD3MXhtFeisb4%3D
    • Goldberg AC, Bittencourt PL, Mougin B, Cancado EL, Porta G, Carrilho F, Kalil J (2001) Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus. Hum Immunol 62:165–169
    • (2001) Hum Immunol , vol.62 , pp. 165-169
    • Goldberg, A.C.1    Bittencourt, P.L.2    Mougin, B.3    Cancado, E.L.4    Porta, G.5    Carrilho, F.6    Kalil, J.7
  • 33
    • 0034077771 scopus 로고    scopus 로고
    • Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis
    • PID: 10807521, COI: 1:CAS:528:DC%2BD3cXjtVygs7s%3D
    • Czaja AJ, Donaldson PT (2000) Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. Immunol Rev 174:250–259
    • (2000) Immunol Rev , vol.174 , pp. 250-259
    • Czaja, A.J.1    Donaldson, P.T.2
  • 34
    • 0030833915 scopus 로고    scopus 로고
    • Genetic distinctions between types 1 and 2 autoimmune hepatitis
    • PID: 9399751, COI: 1:STN:280:DyaK1c%2FmtVKksA%3D%3D
    • Czaja AJ, Kruger M, Santrach PJ, Moore SB, Manns MP (1997) Genetic distinctions between types 1 and 2 autoimmune hepatitis. Am J Gastroenterol 92:2197–2200
    • (1997) Am J Gastroenterol , vol.92 , pp. 2197-2200
    • Czaja, A.J.1    Kruger, M.2    Santrach, P.J.3    Moore, S.B.4    Manns, M.P.5
  • 37
    • 84886253518 scopus 로고    scopus 로고
    • Novel insights into autoimmune liver diseases provided by genome-wide association studies
    • PID: 23931959, COI: 1:CAS:528:DC%2BC3sXht1eksLjL
    • Mells GF, Kaser A, Karlsen TH (2013) Novel insights into autoimmune liver diseases provided by genome-wide association studies. J Autoimmun 46:41–54
    • (2013) J Autoimmun , vol.46 , pp. 41-54
    • Mells, G.F.1    Kaser, A.2    Karlsen, T.H.3
  • 38
    • 78651238248 scopus 로고    scopus 로고
    • Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis
    • PID: 20864813, COI: 1:CAS:528:DC%2BC3MXislyht7s%3D
    • Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S et al (2011) Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics 6:95–102
    • (2011) Epigenetics , vol.6 , pp. 95-102
    • Mitchell, M.M.1    Lleo, A.2    Zammataro, L.3    Mayo, M.J.4    Invernizzi, P.5    Bach, N.6    Shimoda, S.7
  • 39
    • 84862820036 scopus 로고    scopus 로고
    • Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    • PID: 22342295
    • Bakalov VK, Gutin L, Cheng CM, Zhou J, Sheth P, Shah K, Arepalli S et al (2012) Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency. J Autoimmun 38:315–321
    • (2012) J Autoimmun , vol.38 , pp. 315-321
    • Bakalov, V.K.1    Gutin, L.2    Cheng, C.M.3    Zhou, J.4    Sheth, P.5    Shah, K.6    Arepalli, S.7
  • 41
    • 84869863290 scopus 로고    scopus 로고
    • Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop
    • PID: 22749494
    • Selmi C, Leung PS, Sherr DH, Diaz M, Nyland JF, Monestier M, Rose NR et al (2012) Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop. J Autoimmun 39:272–284
    • (2012) J Autoimmun , vol.39 , pp. 272-284
    • Selmi, C.1    Leung, P.S.2    Sherr, D.H.3    Diaz, M.4    Nyland, J.F.5    Monestier, M.6    Rose, N.R.7
  • 42
    • 84884350321 scopus 로고    scopus 로고
    • Autoimmune hepatitis: the role of environmental risk factors: a population-based study
    • Ngu JH, Gearry RB, Frampton CM, Stedman CA (2013) Autoimmune hepatitis: the role of environmental risk factors: a population-based study. Hepatol Int 7:869–875
    • (2013) Hepatol Int , vol.7 , pp. 869-875
    • Ngu, J.H.1    Gearry, R.B.2    Frampton, C.M.3    Stedman, C.A.4
  • 43
    • 79957542423 scopus 로고    scopus 로고
    • Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: a meta-analysis
    • PID: 21615644
    • Liang Y, Yang Z, Zhong R (2011) Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: a meta-analysis. Hepatol Res 41:572–578
    • (2011) Hepatol Res , vol.41 , pp. 572-578
    • Liang, Y.1    Yang, Z.2    Zhong, R.3
  • 45
    • 3042521450 scopus 로고    scopus 로고
    • Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases
    • PID: 15194646, COI: 1:STN:280:DC%2BD2czitVCkuw%3D%3D
    • Florin TH, Pandeya N, Radford-Smith GL (2004) Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases. Gut 53:973–979
    • (2004) Gut , vol.53 , pp. 973-979
    • Florin, T.H.1    Pandeya, N.2    Radford-Smith, G.L.3
  • 46
    • 0036786324 scopus 로고    scopus 로고
    • Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study
    • PID: 12235082, COI: 1:STN:280:DC%2BD38vntlSntA%3D%3D
    • Mitchell SA, Thyssen M, Orchard TR, Jewell DP, Fleming KA, Chapman RW (2002) Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study. Gut 51:567–573
    • (2002) Gut , vol.51 , pp. 567-573
    • Mitchell, S.A.1    Thyssen, M.2    Orchard, T.R.3    Jewell, D.P.4    Fleming, K.A.5    Chapman, R.W.6
  • 47
    • 0037309189 scopus 로고    scopus 로고
    • Cytochrome P4502D6(193–212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease
    • PID: 12538711, COI: 1:CAS:528:DC%2BD3sXnvVOrtg%3D%3D
    • Kerkar N, Choudhuri K, Ma Y, Mahmoud A, Bogdanos DP, Muratori L, Bianchi F et al (2003) Cytochrome P4502D6(193–212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J Immunol 170:1481–1489
    • (2003) J Immunol , vol.170 , pp. 1481-1489
    • Kerkar, N.1    Choudhuri, K.2    Ma, Y.3    Mahmoud, A.4    Bogdanos, D.P.5    Muratori, L.6    Bianchi, F.7
  • 48
    • 0024843644 scopus 로고
    • Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis
    • PID: 2574361, COI: 1:STN:280:DyaK3c%2FotFWntA%3D%3D
    • Hopf U, Moller B, Stemerowicz R, Lobeck H, Rodloff A, Freudenberg M, Galanos C et al (1989) Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis. Lancet 2:1419–1422
    • (1989) Lancet , vol.2 , pp. 1419-1422
    • Hopf, U.1    Moller, B.2    Stemerowicz, R.3    Lobeck, H.4    Rodloff, A.5    Freudenberg, M.6    Galanos, C.7
  • 49
    • 0346689993 scopus 로고    scopus 로고
    • Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis
    • PID: 14672611, COI: 1:CAS:528:DC%2BD3sXps1OgsLc%3D
    • Bogdanos DP, Baum H, Grasso A, Okamoto M, Butler P, Ma Y, Rigopoulou E et al (2004) Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis. J Hepatol 40:31–39
    • (2004) J Hepatol , vol.40 , pp. 31-39
    • Bogdanos, D.P.1    Baum, H.2    Grasso, A.3    Okamoto, M.4    Butler, P.5    Ma, Y.6    Rigopoulou, E.7
  • 50
    • 67049119858 scopus 로고    scopus 로고
    • Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis
    • PID: 19638108, COI: 1:CAS:528:DC%2BD1MXovFShs7g%3D
    • Berg CP, Kannan TR, Klein R, Gregor M, Baseman JB, Wesselborg S, Lauber K et al (2009) Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis. Liver Int 29:797–809
    • (2009) Liver Int , vol.29 , pp. 797-809
    • Berg, C.P.1    Kannan, T.R.2    Klein, R.3    Gregor, M.4    Baseman, J.B.5    Wesselborg, S.6    Lauber, K.7
  • 51
    • 17444431516 scopus 로고    scopus 로고
    • Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis
    • PID: 15848043, COI: 1:CAS:528:DC%2BD2MXjsVegur4%3D
    • Padgett KA, Selmi C, Kenny TP, Leung PS, Balkwill DL, Ansari AA, Coppel RL et al (2005) Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis. J Autoimmun 24:209–219
    • (2005) J Autoimmun , vol.24 , pp. 209-219
    • Padgett, K.A.1    Selmi, C.2    Kenny, T.P.3    Leung, P.S.4    Balkwill, D.L.5    Ansari, A.A.6    Coppel, R.L.7
  • 52
    • 34247633493 scopus 로고    scopus 로고
    • The X and why of xenobiotics in primary biliary cirrhosis
    • PID: 17360156, COI: 1:CAS:528:DC%2BD2sXkvFOlsb8%3D
    • Rieger R, Gershwin ME (2007) The X and why of xenobiotics in primary biliary cirrhosis. J Autoimmun 28:76–84
    • (2007) J Autoimmun , vol.28 , pp. 76-84
    • Rieger, R.1    Gershwin, M.E.2
  • 53
    • 33747763332 scopus 로고    scopus 로고
    • Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
    • PID: 16876981, COI: 1:CAS:528:DC%2BD28Xosl2qsL0%3D
    • Rieger R, Leung PS, Jeddeloh MR, Kurth MJ, Nantz MH, Lam KS, Barsky D et al (2006) Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun 27:7–16
    • (2006) J Autoimmun , vol.27 , pp. 7-16
    • Rieger, R.1    Leung, P.S.2    Jeddeloh, M.R.3    Kurth, M.J.4    Nantz, M.H.5    Lam, K.S.6    Barsky, D.7
  • 54
    • 84875923455 scopus 로고    scopus 로고
    • Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA
    • PID: 23352659, COI: 1:CAS:528:DC%2BC3sXhsVOlsLg%3D
    • Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME (2013) Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun 41:79–86
    • (2013) J Autoimmun , vol.41 , pp. 79-86
    • Leung, P.S.1    Wang, J.2    Naiyanetr, P.3    Kenny, T.P.4    Lam, K.S.5    Kurth, M.J.6    Gershwin, M.E.7
  • 55
    • 68849130635 scopus 로고    scopus 로고
    • Autoantibodies and their antigens in autoimmune hepatitis
    • PID: 19675997, COI: 1:CAS:528:DC%2BD1MXhtFans7fK
    • Bogdanos DP, Mieli-Vergani G, Vergani D (2009) Autoantibodies and their antigens in autoimmune hepatitis. Semin Liver Dis 29:241–253
    • (2009) Semin Liver Dis , vol.29 , pp. 241-253
    • Bogdanos, D.P.1    Mieli-Vergani, G.2    Vergani, D.3
  • 56
    • 0023574027 scopus 로고
    • Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage
    • PID: 3437792, COI: 1:STN:280:DyaL1c7kt1enug%3D%3D
    • Vergani D, Mieli-Vergani G, Mondelli M, Portmann B, Eddleston AL (1987) Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage. Liver 7:307–315
    • (1987) Liver , vol.7 , pp. 307-315
    • Vergani, D.1    Mieli-Vergani, G.2    Mondelli, M.3    Portmann, B.4    Eddleston, A.L.5
  • 57
    • 0034071317 scopus 로고    scopus 로고
    • Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane
    • PID: 10716687, COI: 1:CAS:528:DC%2BD3cXis1ems7k%3D
    • Muratori L, Parola M, Ripalti A, Robino G, Muratori P, Bellomo G, Carini R et al (2000) Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane. Gut 46:553–561
    • (2000) Gut , vol.46 , pp. 553-561
    • Muratori, L.1    Parola, M.2    Ripalti, A.3    Robino, G.4    Muratori, P.5    Bellomo, G.6    Carini, R.7
  • 58
    • 84865271115 scopus 로고    scopus 로고
    • Cutting-edge issues in primary biliary cirrhosis
    • PID: 21243445, COI: 1:CAS:528:DC%2BC38Xnt1egtLk%3D
    • Folci M, Meda F, Gershwin ME, Selmi C (2012) Cutting-edge issues in primary biliary cirrhosis. Clin Rev Allergy Immunol 42:342–354
    • (2012) Clin Rev Allergy Immunol , vol.42 , pp. 342-354
    • Folci, M.1    Meda, F.2    Gershwin, M.E.3    Selmi, C.4
  • 59
    • 33947366024 scopus 로고    scopus 로고
    • A sensitive bead assay for antimitochondrial antibodies: chipping away at AMA-negative primary biliary cirrhosis
    • PID: 17326160, COI: 1:CAS:528:DC%2BD2sXjs1Gkurk%3D
    • Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari AA, Coppel RL, Podda M et al (2007) A sensitive bead assay for antimitochondrial antibodies: chipping away at AMA-negative primary biliary cirrhosis. Hepatology 45:659–665
    • (2007) Hepatology , vol.45 , pp. 659-665
    • Oertelt, S.1    Rieger, R.2    Selmi, C.3    Invernizzi, P.4    Ansari, A.A.5    Coppel, R.L.6    Podda, M.7
  • 60
    • 0025286071 scopus 로고
    • The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore
    • PID: 2195063, COI: 1:CAS:528:DyaK3cXltFels7w%3D
    • Courvalin JC, Lassoued K, Bartnik E, Blobel G, Wozniak RW (1990) The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. J Clin Invest 86:279–285
    • (1990) J Clin Invest , vol.86 , pp. 279-285
    • Courvalin, J.C.1    Lassoued, K.2    Bartnik, E.3    Blobel, G.4    Wozniak, R.W.5
  • 61
    • 0030065385 scopus 로고    scopus 로고
    • Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis
    • PID: 8608894, COI: 1:CAS:528:DyaK28XhvFCmtbc%3D
    • Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996) Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis. Gastroenterology 110:840–847
    • (1996) Gastroenterology , vol.110 , pp. 840-847
    • Wesierska-Gadek, J.1    Hohenuer, H.2    Hitchman, E.3    Penner, E.4
  • 62
    • 33646571925 scopus 로고    scopus 로고
    • Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis
    • PID: 16628641, COI: 1:CAS:528:DC%2BD28XkvFGmtb4%3D
    • Wesierska-Gadek J, Penner E, Battezzati PM, Selmi C, Zuin M, Hitchman E, Worman HJ et al (2006) Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis. Hepatology 43:1135–1144
    • (2006) Hepatology , vol.43 , pp. 1135-1144
    • Wesierska-Gadek, J.1    Penner, E.2    Battezzati, P.M.3    Selmi, C.4    Zuin, M.5    Hitchman, E.6    Worman, H.J.7
  • 63
    • 0030965839 scopus 로고    scopus 로고
    • Autoantibodies against “nuclear dots” in primary biliary cirrhosis
    • PID: 9089912, COI: 1:STN:280:DyaK2s3ksFWmsQ%3D%3D
    • Szostecki C, Guldner HH, Will H (1997) Autoantibodies against “nuclear dots” in primary biliary cirrhosis. Semin Liver Dis 17:71–78
    • (1997) Semin Liver Dis , vol.17 , pp. 71-78
    • Szostecki, C.1    Guldner, H.H.2    Will, H.3
  • 64
    • 11144330639 scopus 로고    scopus 로고
    • Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?
    • PID: 15625657
    • Yang WH, Yu JH, Nakajima A, Neuberg D, Lindor K, Bloch DB (2004) Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure? Clin Gastroenterol Hepatol 2:1116–1122
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1116-1122
    • Yang, W.H.1    Yu, J.H.2    Nakajima, A.3    Neuberg, D.4    Lindor, K.5    Bloch, D.B.6
  • 66
    • 0031879553 scopus 로고    scopus 로고
    • Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins
    • PID: 9695994, COI: 1:CAS:528:DyaK1cXlsFGnsro%3D
    • Terjung B, Herzog V, Worman HJ, Gestmann I, Bauer C, Sauerbruch T, Spengler U (1998) Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins. Hepatology 28:332–340
    • (1998) Hepatology , vol.28 , pp. 332-340
    • Terjung, B.1    Herzog, V.2    Worman, H.J.3    Gestmann, I.4    Bauer, C.5    Sauerbruch, T.6    Spengler, U.7
  • 67
    • 77953718694 scopus 로고    scopus 로고
    • p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ
    • PID: 19951907, COI: 1:CAS:528:DC%2BC3cXos1Ghurg%3D
    • Terjung B, Sohne J, Lechtenberg B, Gottwein J, Muennich M, Herzog V, Mahler M et al (2010) p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ. Gut 59:808–816
    • (2010) Gut , vol.59 , pp. 808-816
    • Terjung, B.1    Sohne, J.2    Lechtenberg, B.3    Gottwein, J.4    Muennich, M.5    Herzog, V.6    Mahler, M.7
  • 68
    • 0036296996 scopus 로고    scopus 로고
    • High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6
    • PID: 12077104, COI: 1:CAS:528:DC%2BD38XlslOis70%3D
    • Xu B, Broome U, Ericzon BG, Sumitran-Holgersson S (2002) High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6. Gut 51:120–127
    • (2002) Gut , vol.51 , pp. 120-127
    • Xu, B.1    Broome, U.2    Ericzon, B.G.3    Sumitran-Holgersson, S.4
  • 69
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • PID: 17408653, COI: 1:CAS:528:DC%2BD2sXlslKru7Y%3D
    • Karrar A, Broome U, Sodergren T, Jaksch M, Bergquist A, Bjornstedt M, Sumitran-Holgersson S (2007) Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 132:1504–1514
    • (2007) Gastroenterology , vol.132 , pp. 1504-1514
    • Karrar, A.1    Broome, U.2    Sodergren, T.3    Jaksch, M.4    Bergquist, A.5    Bjornstedt, M.6    Sumitran-Holgersson, S.7
  • 72
    • 54349115416 scopus 로고    scopus 로고
    • Lymphocyte homing and its role in the pathogenesis of IBD
    • PID: 18393377
    • Eksteen B, Liaskou E, Adams DH (2008) Lymphocyte homing and its role in the pathogenesis of IBD. Inflamm Bowel Dis 14:1298–1312
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1298-1312
    • Eksteen, B.1    Liaskou, E.2    Adams, D.H.3
  • 73
    • 33644617718 scopus 로고    scopus 로고
    • Etiopathogenesis of primary sclerosing cholangitis
    • PID: 16496229
    • O’Mahony CA, Vierling JM (2006) Etiopathogenesis of primary sclerosing cholangitis. Semin Liver Dis 26:3–21
    • (2006) Semin Liver Dis , vol.26 , pp. 3-21
    • O’Mahony, C.A.1    Vierling, J.M.2
  • 74
    • 67349123124 scopus 로고    scopus 로고
    • Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis
    • PID: 19410324
    • Rudolph G, Gotthardt D, Kloters-Plachky P, Kulaksiz H, Rost D, Stiehl A (2009) Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis. J Hepatol 51:149–155
    • (2009) J Hepatol , vol.51 , pp. 149-155
    • Rudolph, G.1    Gotthardt, D.2    Kloters-Plachky, P.3    Kulaksiz, H.4    Rost, D.5    Stiehl, A.6
  • 75
    • 84873966954 scopus 로고    scopus 로고
    • Role of gut microbiota in liver diseases
    • PID: 22970713, COI: 1:CAS:528:DC%2BC3sXos1yqsbc%3D
    • Miyake Y, Yamamoto K (2013) Role of gut microbiota in liver diseases. Hepatol Res 43:139–146
    • (2013) Hepatol Res , vol.43 , pp. 139-146
    • Miyake, Y.1    Yamamoto, K.2
  • 76
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • PID: 16497588, COI: 1:CAS:528:DC%2BD28Xit1Kltb8%3D
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 77
    • 84866432939 scopus 로고    scopus 로고
    • Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms
    • PID: 22661952, COI: 1:CAS:528:DC%2BC38XovFSqtb0%3D
    • Yang L, Seki E (2012) Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol 3:138
    • (2012) Front Physiol , vol.3 , pp. 138
    • Yang, L.1    Seki, E.2
  • 78
    • 80052230924 scopus 로고    scopus 로고
    • Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation
    • PID: 21757746
    • O’Hara SP, Splinter PL, Trussoni CE, Gajdos GB, Lineswala PN, LaRusso NF (2011) Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation. J Biol Chem 286:30352–30360
    • (2011) J Biol Chem , vol.286 , pp. 30352-30360
    • O’Hara, S.P.1    Splinter, P.L.2    Trussoni, C.E.3    Gajdos, G.B.4    Lineswala, P.N.5    LaRusso, N.F.6
  • 79
    • 54349125713 scopus 로고    scopus 로고
    • Etiopathogenesis of primary sclerosing cholangitis
    • PID: 18528932, COI: 1:CAS:528:DC%2BD1cXhtFylt7zP
    • Chapman R, Cullen S (2008) Etiopathogenesis of primary sclerosing cholangitis. World J Gastroenterol 14:3350–3359
    • (2008) World J Gastroenterol , vol.14 , pp. 3350-3359
    • Chapman, R.1    Cullen, S.2
  • 80
    • 80053991368 scopus 로고    scopus 로고
    • Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis
    • PID: 22093333, COI: 1:CAS:528:DC%2BC3MXhsVOksbvL
    • Mueller T, Beutler C, Pico AH, Shibolet O, Pratt DS, Pascher A, Neuhaus P et al (2011) Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis. Liver Int 31:1574–1588
    • (2011) Liver Int , vol.31 , pp. 1574-1588
    • Mueller, T.1    Beutler, C.2    Pico, A.H.3    Shibolet, O.4    Pratt, D.S.5    Pascher, A.6    Neuhaus, P.7
  • 81
    • 34547096543 scopus 로고    scopus 로고
    • Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
    • PID: 17446308, COI: 1:CAS:528:DC%2BD2sXosV2mu7Y%3D
    • Sheth P, Delos Santos N, Seth A, LaRusso NF, Rao RK (2007) Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 293:G308–G318
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , pp. G308-G318
    • Sheth, P.1    Delos Santos, N.2    Seth, A.3    LaRusso, N.F.4    Rao, R.K.5
  • 82
    • 84872724877 scopus 로고    scopus 로고
    • Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
    • PID: 23201091, COI: 1:CAS:528:DC%2BC3sXhtFOisL4%3D
    • Guo S, Al-Sadi R, Said HM, Ma TY (2013) Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. Am J Pathol 182:375–387
    • (2013) Am J Pathol , vol.182 , pp. 375-387
    • Guo, S.1    Al-Sadi, R.2    Said, H.M.3    Ma, T.Y.4
  • 83
    • 33144465413 scopus 로고    scopus 로고
    • Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice
    • PID: 16436656, COI: 1:CAS:528:DC%2BD28Xhs1agur4%3D
    • Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K et al (2006) Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am J Pathol 168:410–422
    • (2006) Am J Pathol , vol.168 , pp. 410-422
    • Fickert, P.1    Fuchsbichler, A.2    Marschall, H.U.3    Wagner, M.4    Zollner, G.5    Krause, R.6    Zatloukal, K.7
  • 84
    • 3242727039 scopus 로고    scopus 로고
    • Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • PID: 15236191, COI: 1:CAS:528:DC%2BD2cXmsVShs7c%3D
    • Fickert P, Fuchsbichler A, Wagner M, Zollner G, Kaser A, Tilg H, Krause R et al (2004) Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 127:261–274
    • (2004) Gastroenterology , vol.127 , pp. 261-274
    • Fickert, P.1    Fuchsbichler, A.2    Wagner, M.3    Zollner, G.4    Kaser, A.5    Tilg, H.6    Krause, R.7
  • 85
    • 34447131097 scopus 로고    scopus 로고
    • Mechanisms of disease: a ‘DAMP’ view of inflammatory arthritis
    • PID: 17599072, COI: 1:CAS:528:DC%2BD2sXntVCitr0%3D
    • Foell D, Wittkowski H, Roth J (2007) Mechanisms of disease: a ‘DAMP’ view of inflammatory arthritis. Nat Clin Pract Rheumatol 3:382–390
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 382-390
    • Foell, D.1    Wittkowski, H.2    Roth, J.3
  • 86
    • 84874105072 scopus 로고    scopus 로고
    • The dynamic biliary epithelia: molecules, pathways, and disease
    • PID: 23085249
    • O’Hara SP, Tabibian JH, Splinter PL, LaRusso NF (2013) The dynamic biliary epithelia: molecules, pathways, and disease. J Hepatol 58:575–582
    • (2013) J Hepatol , vol.58 , pp. 575-582
    • O’Hara, S.P.1    Tabibian, J.H.2    Splinter, P.L.3    LaRusso, N.F.4
  • 87
    • 54349124373 scopus 로고    scopus 로고
    • Autoantibodies in primary sclerosing cholangitis
    • PID: 18609700, COI: 1:CAS:528:DC%2BD1cXht1WlsrvI
    • Hov JR, Boberg KM, Karlsen TH (2008) Autoantibodies in primary sclerosing cholangitis. World J Gastroenterol 14:3781–3791
    • (2008) World J Gastroenterol , vol.14 , pp. 3781-3791
    • Hov, J.R.1    Boberg, K.M.2    Karlsen, T.H.3
  • 88
    • 3342946067 scopus 로고    scopus 로고
    • Lymphocyte subpopulations in peripheral blood in primary sclerosing cholangitis
    • PID: 15362735
    • Panasiuk A, Prokopowicz D, Zak J, Panasiuk B, Wysocka J (2004) Lymphocyte subpopulations in peripheral blood in primary sclerosing cholangitis. Hepatogastroenterology 51:1289–1291
    • (2004) Hepatogastroenterology , vol.51 , pp. 1289-1291
    • Panasiuk, A.1    Prokopowicz, D.2    Zak, J.3    Panasiuk, B.4    Wysocka, J.5
  • 89
    • 0034962227 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis
    • PID: 11413121, COI: 1:STN:280:DC%2BD3MzkvFOgtA%3D%3D
    • Bo X, Broome U, Remberger M, Sumitran-Holgersson S (2001) Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis. Gut 49:131–141
    • (2001) Gut , vol.49 , pp. 131-141
    • Bo, X.1    Broome, U.2    Remberger, M.3    Sumitran-Holgersson, S.4
  • 91
    • 25844471675 scopus 로고    scopus 로고
    • Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis
    • PID: 16175622, COI: 1:CAS:528:DC%2BD2MXhtFGlsbjL
    • Mao TK, Lian ZX, Selmi C, Ichiki Y, Ashwood P, Ansari AA, Coppel RL et al (2005) Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology 42:802–808
    • (2005) Hepatology , vol.42 , pp. 802-808
    • Mao, T.K.1    Lian, Z.X.2    Selmi, C.3    Ichiki, Y.4    Ashwood, P.5    Ansari, A.A.6    Coppel, R.L.7
  • 92
    • 33746834534 scopus 로고    scopus 로고
    • Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis
    • PID: 16730427, COI: 1:CAS:528:DC%2BD28XltlKmt7s%3D
    • Chuang YH, Lian ZX, Tsuneyama K, Chiang BL, Ansari AA, Coppel RL, Gershwin ME (2006) Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J Autoimmun 26:232–240
    • (2006) J Autoimmun , vol.26 , pp. 232-240
    • Chuang, Y.H.1    Lian, Z.X.2    Tsuneyama, K.3    Chiang, B.L.4    Ansari, A.A.5    Coppel, R.L.6    Gershwin, M.E.7
  • 93
    • 33344478734 scopus 로고    scopus 로고
    • Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
    • PID: 16498453, COI: 1:CAS:528:DC%2BD28Xhsleltb4%3D
    • Adams DH, Eksteen B (2006) Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease. Nat Rev Immunol 6:244–251
    • (2006) Nat Rev Immunol , vol.6 , pp. 244-251
    • Adams, D.H.1    Eksteen, B.2
  • 94
    • 10644245899 scopus 로고    scopus 로고
    • Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    • PID: 15557349, COI: 1:CAS:528:DC%2BD2cXhtVyiurvM
    • Eksteen B, Grant AJ, Miles A, Curbishley SM, Lalor PF, Hubscher SG, Briskin M et al (2004) Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J Exp Med 200:1511–1517
    • (2004) J Exp Med , vol.200 , pp. 1511-1517
    • Eksteen, B.1    Grant, A.J.2    Miles, A.3    Curbishley, S.M.4    Lalor, P.F.5    Hubscher, S.G.6    Briskin, M.7
  • 95
    • 0035029326 scopus 로고    scopus 로고
    • MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)
    • PID: 11343233, COI: 1:CAS:528:DC%2BD3MXjvVaiu7o%3D
    • Grant AJ, Lalor PF, Hubscher SG, Briskin M, Adams DH (2001) MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease). Hepatology 33:1065–1072
    • (2001) Hepatology , vol.33 , pp. 1065-1072
    • Grant, A.J.1    Lalor, P.F.2    Hubscher, S.G.3    Briskin, M.4    Adams, D.H.5
  • 96
    • 79251516703 scopus 로고    scopus 로고
    • Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity
    • PID: 21225644, COI: 1:CAS:528:DC%2BC3MXisVGisbg%3D
    • Liaskou E, Karikoski M, Reynolds GM, Lalor PF, Weston CJ, Pullen N, Salmi M et al (2011) Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity. Hepatology 53:661–672
    • (2011) Hepatology , vol.53 , pp. 661-672
    • Liaskou, E.1    Karikoski, M.2    Reynolds, G.M.3    Lalor, P.F.4    Weston, C.J.5    Pullen, N.6    Salmi, M.7
  • 97
    • 84855397491 scopus 로고    scopus 로고
    • Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies
    • PID: 22238597, COI: 1:CAS:528:DC%2BC38XptF2lsw%3D%3D
    • Shen SH, Wertz DL, Klinman JP (2012) Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies. PLoS One 7:e29270
    • (2012) PLoS One , vol.7 , pp. e29270
    • Shen, S.H.1    Wertz, D.L.2    Klinman, J.P.3
  • 98
    • 45849130521 scopus 로고    scopus 로고
    • CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
    • PID: 18308860, COI: 1:CAS:528:DC%2BD1cXlvFCisLs%3D
    • Miles A, Liaskou E, Eksteen B, Lalor PF, Adams DH (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am J Physiol Gastrointest Liver Physiol 294:G1257–G1267
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G1257-G1267
    • Miles, A.1    Liaskou, E.2    Eksteen, B.3    Lalor, P.F.4    Adams, D.H.5
  • 99
    • 0037094119 scopus 로고    scopus 로고
    • The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin
    • PID: 11994484, COI: 1:CAS:528:DC%2BD38XjslSjtbo%3D
    • Wright N, Hidalgo A, Rodriguez-Frade JM, Soriano SF, Mellado M, Parmo-Cabanas M, Briskin MJ et al (2002) The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin. J Immunol 168:5268–5277
    • (2002) J Immunol , vol.168 , pp. 5268-5277
    • Wright, N.1    Hidalgo, A.2    Rodriguez-Frade, J.M.3    Soriano, S.F.4    Mellado, M.5    Parmo-Cabanas, M.6    Briskin, M.J.7
  • 100
    • 67649311620 scopus 로고    scopus 로고
    • Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells
    • PID: 19233184, COI: 1:CAS:528:DC%2BD1MXovFOgtbw%3D
    • Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, Curbishley SM et al (2009) Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Gastroenterology 137:320–329
    • (2009) Gastroenterology , vol.137 , pp. 320-329
    • Eksteen, B.1    Mora, J.R.2    Haughton, E.L.3    Henderson, N.C.4    Lee-Turner, L.5    Villablanca, E.J.6    Curbishley, S.M.7
  • 101
    • 84861562120 scopus 로고    scopus 로고
    • Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid
    • PID: 22109893, COI: 1:CAS:528:DC%2BC38XnsFOru7c%3D
    • Neumann K, Kruse N, Szilagyi B, Erben U, Rudolph C, Flach A, Zeitz M et al (2012) Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid. Hepatology 55:1976–1984
    • (2012) Hepatology , vol.55 , pp. 1976-1984
    • Neumann, K.1    Kruse, N.2    Szilagyi, B.3    Erben, U.4    Rudolph, C.5    Flach, A.6    Zeitz, M.7
  • 103
    • 80053294958 scopus 로고    scopus 로고
    • Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis
    • PID: 21735469, COI: 1:CAS:528:DC%2BC3MXht1amtb3N
    • Tsuda M, Ambrosini YM, Zhang W, Yang GX, Ando Y, Rong G, Tsuneyama K et al (2011) Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis. Hepatology 54:1293–1302
    • (2011) Hepatology , vol.54 , pp. 1293-1302
    • Tsuda, M.1    Ambrosini, Y.M.2    Zhang, W.3    Yang, G.X.4    Ando, Y.5    Rong, G.6    Tsuneyama, K.7
  • 104
    • 33748616586 scopus 로고    scopus 로고
    • Abnormal intestinal permeability in primary biliary cirrhosis
    • PID: 16937077
    • Feld JJ, Meddings J, Heathcote EJ (2006) Abnormal intestinal permeability in primary biliary cirrhosis. Dig Dis Sci 51:1607–1613
    • (2006) Dig Dis Sci , vol.51 , pp. 1607-1613
    • Feld, J.J.1    Meddings, J.2    Heathcote, E.J.3
  • 105
    • 84875255974 scopus 로고    scopus 로고
    • Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments
    • Palak J, Trivedi SC (2013) Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments. Hepatol Int 7:28–47
    • (2013) Hepatol Int , vol.7 , pp. 28-47
    • Palak, J.1    Trivedi, S.C.2
  • 106
    • 0026677933 scopus 로고
    • Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis
    • PID: 1489223, COI: 1:STN:280:DyaK3s7ktlersg%3D%3D
    • Senaldi G, Portmann B, Mowat AP, Mieli-Vergani G, Vergani D (1992) Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis. Arch Dis Child 67:1447–1453
    • (1992) Arch Dis Child , vol.67 , pp. 1447-1453
    • Senaldi, G.1    Portmann, B.2    Mowat, A.P.3    Mieli-Vergani, G.4    Vergani, D.5
  • 107
    • 0033048427 scopus 로고    scopus 로고
    • Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis
    • PID: 10029623, COI: 1:CAS:528:DyaK1MXhvVOntL8%3D
    • Lapierre P, Hajoui O, Homberg JC, Alvarez F (1999) Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis. Gastroenterology 116:643–649
    • (1999) Gastroenterology , vol.116 , pp. 643-649
    • Lapierre, P.1    Hajoui, O.2    Homberg, J.C.3    Alvarez, F.4
  • 108
    • 79955416252 scopus 로고    scopus 로고
    • Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression
    • PID: 21526159, COI: 1:CAS:528:DC%2BC3MXlt1aisbk%3D
    • Zhao L, Tang Y, You Z, Wang Q, Liang S, Han X, Qiu D et al (2011) Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PLoS One 6:e18909
    • (2011) PLoS One , vol.6 , pp. e18909
    • Zhao, L.1    Tang, Y.2    You, Z.3    Wang, Q.4    Liang, S.5    Han, X.6    Qiu, D.7
  • 109
    • 77956643943 scopus 로고    scopus 로고
    • A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis
    • PID: 20683931, COI: 1:CAS:528:DC%2BC3cXhtFyitr%2FF
    • Ferri S, Longhi MS, De Molo C, Lalanne C, Muratori P, Granito A, Hussain MJ et al (2010) A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis. Hepatology 52:999–1007
    • (2010) Hepatology , vol.52 , pp. 999-1007
    • Ferri, S.1    Longhi, M.S.2    De Molo, C.3    Lalanne, C.4    Muratori, P.5    Granito, A.6    Hussain, M.J.7
  • 110
    • 0036246857 scopus 로고    scopus 로고
    • Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    • PID: 11994412, COI: 1:CAS:528:DC%2BD38XjsFalsbw%3D
    • Kita H, Matsumura S, He XS, Ansari AA, Lian ZX, Van de Water J, Coppel RL et al (2002) Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest 109:1231–1240
    • (2002) J Clin Invest , vol.109 , pp. 1231-1240
    • Kita, H.1    Matsumura, S.2    He, X.S.3    Ansari, A.A.4    Lian, Z.X.5    Van de Water, J.6    Coppel, R.L.7
  • 111
    • 0028936405 scopus 로고
    • Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis
    • PID: 7836925
    • Van de Water J, Ansari A, Prindiville T, Coppel RL, Ricalton N, Kotzin BL, Liu S et al (1995) Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J Exp Med 181:723–733
    • (1995) J Exp Med , vol.181 , pp. 723-733
    • Van de Water, J.1    Ansari, A.2    Prindiville, T.3    Coppel, R.L.4    Ricalton, N.5    Kotzin, B.L.6    Liu, S.7
  • 112
    • 0028815893 scopus 로고
    • Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis
    • PID: 7806143, COI: 1:CAS:528:DyaK2MXjs1ygsLo%3D
    • Martinez OM, Villanueva JC, Gershwin ME, Krams SM (1995) Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology 21:113–119
    • (1995) Hepatology , vol.21 , pp. 113-119
    • Martinez, O.M.1    Villanueva, J.C.2    Gershwin, M.E.3    Krams, S.M.4
  • 113
    • 46249110385 scopus 로고    scopus 로고
    • Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
    • PID: 18452147
    • Yang GX, Lian ZX, Chuang YH, Moritoki Y, Lan RY, Wakabayashi K, Ansari AA et al (2008) Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology 47:1974–1982
    • (2008) Hepatology , vol.47 , pp. 1974-1982
    • Yang, G.X.1    Lian, Z.X.2    Chuang, Y.H.3    Moritoki, Y.4    Lan, R.Y.5    Wakabayashi, K.6    Ansari, A.A.7
  • 114
    • 0037033367 scopus 로고    scopus 로고
    • Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells
    • PID: 11781370, COI: 1:CAS:528:DC%2BD38XjslOjtA%3D%3D
    • Kita H, Lian ZX, Van de Water J, He XS, Matsumura S, Kaplan M, Luketic V et al (2002) Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med 195:113–123
    • (2002) J Exp Med , vol.195 , pp. 113-123
    • Kita, H.1    Lian, Z.X.2    Van de Water, J.3    He, X.S.4    Matsumura, S.5    Kaplan, M.6    Luketic, V.7
  • 115
    • 0028905099 scopus 로고
    • HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases
    • PID: 7536796, COI: 1:CAS:528:DyaK2MXlsVGhurk%3D
    • Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y (1995) HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J Exp Med 181:1835–1845
    • (1995) J Exp Med , vol.181 , pp. 1835-1845
    • Shimoda, S.1    Nakamura, M.2    Ishibashi, H.3    Hayashida, K.4    Niho, Y.5
  • 116
    • 77953786355 scopus 로고    scopus 로고
    • Two cases of inflammatory bowel disease diagnosed in the course of primary biliary cirrhosis
    • PID: 20530926
    • Arai O, Ikeda H, Mouri H, Notohara K, Matsueda K (2010) Two cases of inflammatory bowel disease diagnosed in the course of primary biliary cirrhosis. Nihon Shokakibyo Gakkai Zasshi 107:900–908
    • (2010) Nihon Shokakibyo Gakkai Zasshi , vol.107 , pp. 900-908
    • Arai, O.1    Ikeda, H.2    Mouri, H.3    Notohara, K.4    Matsueda, K.5
  • 117
    • 0027141317 scopus 로고
    • Immunohistochemical characterization of hepatic lymphocytes in primary biliary cirrhosis in comparison with primary sclerosing cholangitis and autoimmune chronic active hepatitis
    • PID: 8231268, COI: 1:STN:280:DyaK2c%2FkvVanuw%3D%3D
    • Hashimoto E, Lindor KD, Homburger HA, Dickson ER, Czaja AJ, Wiesner RH, Ludwig J (1993) Immunohistochemical characterization of hepatic lymphocytes in primary biliary cirrhosis in comparison with primary sclerosing cholangitis and autoimmune chronic active hepatitis. Mayo Clin Proc 68:1049–1055
    • (1993) Mayo Clin Proc , vol.68 , pp. 1049-1055
    • Hashimoto, E.1    Lindor, K.D.2    Homburger, H.A.3    Dickson, E.R.4    Czaja, A.J.5    Wiesner, R.H.6    Ludwig, J.7
  • 118
    • 0034971844 scopus 로고    scopus 로고
    • Accumulation of macrophages in primary sclerosing cholangitis
    • PID: 11408017, COI: 1:CAS:528:DC%2BD3MXltl2hurY%3D
    • Cameron RG, Blendis LM, Neuman MG (2001) Accumulation of macrophages in primary sclerosing cholangitis. Clin Biochem 34:195–201
    • (2001) Clin Biochem , vol.34 , pp. 195-201
    • Cameron, R.G.1    Blendis, L.M.2    Neuman, M.G.3
  • 120
    • 0029979464 scopus 로고    scopus 로고
    • Elevation of gamma delta T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases
    • PID: 8621180, COI: 1:STN:280:DyaK283gs1GhsA%3D%3D
    • Martins EB, Graham AK, Chapman RW, Fleming KA (1996) Elevation of gamma delta T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases. Hepatology 23:988–993
    • (1996) Hepatology , vol.23 , pp. 988-993
    • Martins, E.B.1    Graham, A.K.2    Chapman, R.W.3    Fleming, K.A.4
  • 121
    • 67650668741 scopus 로고    scopus 로고
    • Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
    • PID: 19604266, COI: 1:CAS:528:DC%2BD1MXhtVSntbzN
    • Harada K, Shimoda S, Sato Y, Isse K, Ikeda H, Nakanuma Y (2009) Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol 157:261–270
    • (2009) Clin Exp Immunol , vol.157 , pp. 261-270
    • Harada, K.1    Shimoda, S.2    Sato, Y.3    Isse, K.4    Ikeda, H.5    Nakanuma, Y.6
  • 122
    • 84883229970 scopus 로고    scopus 로고
    • Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis
    • PID: 23564624, COI: 1:CAS:528:DC%2BC3sXhtlOkt7%2FI
    • Katt J, Schwinge D, Schoknecht T, Quaas A, Sobottka I, Burandt E, Becker C et al (2013) Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis. Hepatology 58:1084–1093
    • (2013) Hepatology , vol.58 , pp. 1084-1093
    • Katt, J.1    Schwinge, D.2    Schoknecht, T.3    Quaas, A.4    Sobottka, I.5    Burandt, E.6    Becker, C.7
  • 123
    • 64649097540 scopus 로고    scopus 로고
    • Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population
    • PID: 19302244, COI: 1:CAS:528:DC%2BD1MXlvVWgt7c%3D
    • Rong G, Zhou Y, Xiong Y, Zhou L, Geng H, Jiang T, Zhu Y et al (2009) Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol 156:217–225
    • (2009) Clin Exp Immunol , vol.156 , pp. 217-225
    • Rong, G.1    Zhou, Y.2    Xiong, Y.3    Zhou, L.4    Geng, H.5    Jiang, T.6    Zhu, Y.7
  • 126
    • 79251585935 scopus 로고    scopus 로고
    • Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells
    • PID: 21084709, COI: 1:CAS:528:DC%2BC3MXhvFGks7w%3D
    • Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, Milder M et al (2011) Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 117:1250–1259
    • (2011) Blood , vol.117 , pp. 1250-1259
    • Dusseaux, M.1    Martin, E.2    Serriari, N.3    Peguillet, I.4    Premel, V.5    Louis, D.6    Milder, M.7
  • 129
    • 84881393577 scopus 로고    scopus 로고
    • IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation
    • PID: 23842754, COI: 1:CAS:528:DC%2BC3sXht1Witb3F
    • Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X et al (2013) IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol 191:1835–1844
    • (2013) J Immunol , vol.191 , pp. 1835-1844
    • Tan, Z.1    Qian, X.2    Jiang, R.3    Liu, Q.4    Wang, Y.5    Chen, C.6    Wang, X.7
  • 130
    • 84865461464 scopus 로고    scopus 로고
    • Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
    • PID: 22687286, COI: 1:CAS:528:DC%2BC38Xht1Kisr%2FM, e761-763
    • Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M et al (2012) Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology 143:765–776, e761-763
    • (2012) Gastroenterology , vol.143 , pp. 765-776
    • Meng, F.1    Wang, K.2    Aoyama, T.3    Grivennikov, S.I.4    Paik, Y.5    Scholten, D.6    Cong, M.7
  • 131
    • 72949106340 scopus 로고    scopus 로고
    • Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
    • PID: 19935807, COI: 1:CAS:528:DC%2BD1MXhsVOhurzF
    • Weaver CT, Hatton RD (2009) Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol 9:883–889
    • (2009) Nat Rev Immunol , vol.9 , pp. 883-889
    • Weaver, C.T.1    Hatton, R.D.2
  • 133
    • 33646052605 scopus 로고    scopus 로고
    • Functional study of CD4 + CD25+ regulatory T cells in health and autoimmune hepatitis
    • PID: 16547287, COI: 1:CAS:528:DC%2BD28Xis1eqsb4%3D
    • Longhi MS, Hussain MJ, Mitry RR, Arora SK, Mieli-Vergani G, Vergani D, Ma Y (2006) Functional study of CD4 + CD25+ regulatory T cells in health and autoimmune hepatitis. J Immunol 176:4484–4491
    • (2006) J Immunol , vol.176 , pp. 4484-4491
    • Longhi, M.S.1    Hussain, M.J.2    Mitry, R.R.3    Arora, S.K.4    Mieli-Vergani, G.5    Vergani, D.6    Ma, Y.7
  • 134
    • 84862658266 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
    • PID: 22425700, COI: 1:CAS:528:DC%2BC38XovV2gurY%3D
    • Peiseler M, Sebode M, Franke B, Wortmann F, Schwinge D, Quaas A, Baron U et al (2012) FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency. J Hepatol 57:125–132
    • (2012) J Hepatol , vol.57 , pp. 125-132
    • Peiseler, M.1    Sebode, M.2    Franke, B.3    Wortmann, F.4    Schwinge, D.5    Quaas, A.6    Baron, U.7
  • 135
    • 3442885909 scopus 로고    scopus 로고
    • Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease
    • PID: 15246204, COI: 1:CAS:528:DC%2BD2cXls1WnsL4%3D
    • Longhi MS, Ma Y, Bogdanos DP, Cheeseman P, Mieli-Vergani G, Vergani D (2004) Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease. J Hepatol 41:31–37
    • (2004) J Hepatol , vol.41 , pp. 31-37
    • Longhi, M.S.1    Ma, Y.2    Bogdanos, D.P.3    Cheeseman, P.4    Mieli-Vergani, G.5    Vergani, D.6
  • 136
    • 67651156354 scopus 로고    scopus 로고
    • Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells
    • PID: 19437492, COI: 1:CAS:528:DC%2BD1MXpt1Shsb4%3D
    • Longhi MS, Mitry RR, Samyn M, Scalori A, Hussain MJ, Quaglia A, Mieli-Vergani G et al (2009) Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells. Hepatology 50:130–142
    • (2009) Hepatology , vol.50 , pp. 130-142
    • Longhi, M.S.1    Mitry, R.R.2    Samyn, M.3    Scalori, A.4    Hussain, M.J.5    Quaglia, A.6    Mieli-Vergani, G.7
  • 137
    • 33646000803 scopus 로고    scopus 로고
    • Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
    • PID: 16557534
    • Lan RY, Cheng C, Lian ZX, Tsuneyama K, Yang GX, Moritoki Y, Chuang YH et al (2006) Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology 43:729–737
    • (2006) Hepatology , vol.43 , pp. 729-737
    • Lan, R.Y.1    Cheng, C.2    Lian, Z.X.3    Tsuneyama, K.4    Yang, G.X.5    Moritoki, Y.6    Chuang, Y.H.7
  • 138
    • 84898828520 scopus 로고    scopus 로고
    • Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL-2RA gene polymorphisms
    • Sebode M, Peiseler M, Franke B, Schwinge D, Schoknecht T, Wortmann F, Quaas A, et al (2014) Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL-2RA gene polymorphisms. J Hepatol
    • (2014) J Hepatol
    • Sebode, M.1    Peiseler, M.2    Franke, B.3    Schwinge, D.4    Schoknecht, T.5    Wortmann, F.6    Quaas, A.7
  • 139
    • 0037422983 scopus 로고    scopus 로고
    • Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion
    • PID: 12527037, COI: 1:CAS:528:DC%2BD3sXivVKntg%3D%3D
    • Lamireau T, Zoltowska M, Levy E, Yousef I, Rosenbaum J, Tuchweber B, Desmouliere A (2003) Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. Life Sci 72:1401–1411
    • (2003) Life Sci , vol.72 , pp. 1401-1411
    • Lamireau, T.1    Zoltowska, M.2    Levy, E.3    Yousef, I.4    Rosenbaum, J.5    Tuchweber, B.6    Desmouliere, A.7
  • 140
    • 33846708192 scopus 로고    scopus 로고
    • Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)
    • PID: 16622704, COI: 1:CAS:528:DC%2BD2sXhtFWjsbc%3D
    • Oude Elferink RP, Paulusma CC (2007) Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch 453:601–610
    • (2007) Pflugers Arch , vol.453 , pp. 601-610
    • Oude Elferink, R.P.1    Paulusma, C.C.2
  • 141
    • 33847064667 scopus 로고    scopus 로고
    • MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes
    • PID: 17295178, COI: 1:CAS:528:DC%2BD2sXjtlWrsLg%3D
    • Trauner M, Fickert P, Wagner M (2007) MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. Semin Liver Dis 27:77–98
    • (2007) Semin Liver Dis , vol.27 , pp. 77-98
    • Trauner, M.1    Fickert, P.2    Wagner, M.3
  • 142
    • 0041563992 scopus 로고    scopus 로고
    • Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis
    • PID: 12783301
    • Sheth S, Shea JC, Bishop MD, Chopra S, Regan MM, Malmberg E, Walker C et al (2003) Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis. Hum Genet 113:286–292
    • (2003) Hum Genet , vol.113 , pp. 286-292
    • Sheth, S.1    Shea, J.C.2    Bishop, M.D.3    Chopra, S.4    Regan, M.M.5    Malmberg, E.6    Walker, C.7
  • 143
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • PID: 8985258, COI: 1:STN:280:DyaK2s7jvVagsA%3D%3D
    • Medina JF, Martinez A, Vazquez JJ, Prieto J (1997) Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 25:12–17
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vazquez, J.J.3    Prieto, J.4
  • 144
    • 18544371193 scopus 로고    scopus 로고
    • Defective regulation of cholangiocyte Cl-/HCO3(−) and Na+/H+ exchanger activities in primary biliary cirrhosis
    • PID: 12029638, COI: 1:CAS:528:DC%2BD38XkvFSntr4%3D
    • Melero S, Spirli C, Zsembery A, Medina JF, Joplin RE, Duner E, Zuin M et al (2002) Defective regulation of cholangiocyte Cl-/HCO3(−) and Na+/H+ exchanger activities in primary biliary cirrhosis. Hepatology 35:1513–1521
    • (2002) Hepatology , vol.35 , pp. 1513-1521
    • Melero, S.1    Spirli, C.2    Zsembery, A.3    Medina, J.F.4    Joplin, R.E.5    Duner, E.6    Zuin, M.7
  • 145
    • 0141483040 scopus 로고    scopus 로고
    • Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis
    • PID: 14517800, COI: 1:CAS:528:DC%2BD3sXosFCltLs%3D
    • Shibao K, Hirata K, Robert ME, Nathanson MH (2003) Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis. Gastroenterology 125:1175–1187
    • (2003) Gastroenterology , vol.125 , pp. 1175-1187
    • Shibao, K.1    Hirata, K.2    Robert, M.E.3    Nathanson, M.H.4
  • 146
    • 77958109069 scopus 로고    scopus 로고
    • Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7alpha-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis
    • PID: 20857261, COI: 1:CAS:528:DC%2BC3cXhtFyis7bJ
    • Takeyama Y, Kanegae K, Inomata S, Takata K, Tanaka T, Ueda S, Yokoyama K et al (2010) Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7alpha-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis. Med Mol Morphol 43:134–138
    • (2010) Med Mol Morphol , vol.43 , pp. 134-138
    • Takeyama, Y.1    Kanegae, K.2    Inomata, S.3    Takata, K.4    Tanaka, T.5    Ueda, S.6    Yokoyama, K.7
  • 147
    • 17744391290 scopus 로고    scopus 로고
    • Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
    • PID: 11230744, COI: 1:CAS:528:DC%2BD3MXit1emtL4%3D
    • Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, Ferenci P et al (2001) Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 33:633–646
    • (2001) Hepatology , vol.33 , pp. 633-646
    • Zollner, G.1    Fickert, P.2    Zenz, R.3    Fuchsbichler, A.4    Stumptner, C.5    Kenner, L.6    Ferenci, P.7
  • 148
    • 32544446183 scopus 로고    scopus 로고
    • Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction
    • PID: 16443736, COI: 1:CAS:528:DC%2BD28XhvV2nsrs%3D
    • Harada K, Isse K, Nakanuma Y (2006) Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. J Clin Pathol 59:184–190
    • (2006) J Clin Pathol , vol.59 , pp. 184-190
    • Harada, K.1    Isse, K.2    Nakanuma, Y.3
  • 149
    • 7644234675 scopus 로고    scopus 로고
    • The cholangiopathies: disorders of biliary epithelia
    • PID: 15521023, COI: 1:CAS:528:DC%2BD2cXhtVKisrrM
    • Lazaridis KN, Strazzabosco M, Larusso NF (2004) The cholangiopathies: disorders of biliary epithelia. Gastroenterology 127:1565–1577
    • (2004) Gastroenterology , vol.127 , pp. 1565-1577
    • Lazaridis, K.N.1    Strazzabosco, M.2    Larusso, N.F.3
  • 150
    • 0034953329 scopus 로고    scopus 로고
    • Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
    • PID: 11457875, COI: 1:CAS:528:DC%2BD3MXlt1KlsbY%3D
    • Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A (2001) Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest 108:223–232
    • (2001) J Clin Invest , vol.108 , pp. 223-232
    • Odin, J.A.1    Huebert, R.C.2    Casciola-Rosen, L.3    LaRusso, N.F.4    Rosen, A.5
  • 151
    • 77956627699 scopus 로고    scopus 로고
    • Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    • PID: 20568301, COI: 1:CAS:528:DC%2BC3cXhtFyitr%2FE
    • Lleo A, Bowlus CL, Yang GX, Invernizzi P, Podda M, Van de Water J, Ansari AA et al (2010) Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 52:987–998
    • (2010) Hepatology , vol.52 , pp. 987-998
    • Lleo, A.1    Bowlus, C.L.2    Yang, G.X.3    Invernizzi, P.4    Podda, M.5    Van de Water, J.6    Ansari, A.A.7
  • 152
    • 33846699177 scopus 로고    scopus 로고
    • T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis
    • PID: 17222534, COI: 1:CAS:528:DC%2BD2sXhs1ChtLk%3D
    • Allina J, Hu B, Sullivan DM, Fiel MI, Thung SN, Bronk SF, Huebert RC et al (2006) T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun 27:232–241
    • (2006) J Autoimmun , vol.27 , pp. 232-241
    • Allina, J.1    Hu, B.2    Sullivan, D.M.3    Fiel, M.I.4    Thung, S.N.5    Bronk, S.F.6    Huebert, R.C.7
  • 153
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: clearance of apoptotic cells regulates immune responses
    • PID: 12461569, COI: 1:CAS:528:DC%2BD38XptFKnu7c%3D
    • Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2:965–975
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 154
    • 67651148521 scopus 로고    scopus 로고
    • Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent
    • PID: 19496180, COI: 1:CAS:528:DC%2BD1MXpt1Shsb8%3D
    • Chamulitrat W, Burhenne J, Rehlen T, Pathil A, Stremmel W (2009) Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent. Hepatology 50:143–154
    • (2009) Hepatology , vol.50 , pp. 143-154
    • Chamulitrat, W.1    Burhenne, J.2    Rehlen, T.3    Pathil, A.4    Stremmel, W.5
  • 155
    • 33745180500 scopus 로고    scopus 로고
    • Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis
    • PID: 16792678, COI: 1:CAS:528:DC%2BD28XpsFGrur8%3D
    • Inamura K, Tsuji H, Nakamoto Y, Suzuki M, Kaneko S (2006) Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis. Clin Exp Immunol 145:93–100
    • (2006) Clin Exp Immunol , vol.145 , pp. 93-100
    • Inamura, K.1    Tsuji, H.2    Nakamoto, Y.3    Suzuki, M.4    Kaneko, S.5
  • 156
    • 14944376606 scopus 로고    scopus 로고
    • Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss
    • PID: 15685690
    • Sasaki M, Ikeda H, Haga H, Manabe T, Nakanuma Y (2005) Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss. J Pathol 205:451–459
    • (2005) J Pathol , vol.205 , pp. 451-459
    • Sasaki, M.1    Ikeda, H.2    Haga, H.3    Manabe, T.4    Nakanuma, Y.5
  • 157
    • 47149088985 scopus 로고    scopus 로고
    • Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence
    • PID: 18536059
    • Sasaki M, Ikeda H, Yamaguchi J, Nakada S, Nakanuma Y (2008) Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. Hepatology 48:186–195
    • (2008) Hepatology , vol.48 , pp. 186-195
    • Sasaki, M.1    Ikeda, H.2    Yamaguchi, J.3    Nakada, S.4    Nakanuma, Y.5
  • 158
    • 84869421637 scopus 로고    scopus 로고
    • Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy
    • PID: 21994884
    • Sasaki M, Nakanuma Y (2012) Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy. Int J Hepatol 2012:452143
    • (2012) Int J Hepatol , vol.2012
    • Sasaki, M.1    Nakanuma, Y.2
  • 159
    • 77955304095 scopus 로고    scopus 로고
    • Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis
    • PID: 20570384
    • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y (2010) Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis. J Hepatol 53:318–325
    • (2010) J Hepatol , vol.53 , pp. 318-325
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 160
    • 0035071514 scopus 로고    scopus 로고
    • Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs
    • PID: 11290556, COI: 1:CAS:528:DC%2BD3MXjtVWhtr8%3D
    • Lunz JG 3rd, Contrucci S, Ruppert K, Murase N, Fung JJ, Starzl TE, Demetris AJ (2001) Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol 158:1379–1390
    • (2001) Am J Pathol , vol.158 , pp. 1379-1390
    • Lunz, J.G.1    Contrucci, S.2    Ruppert, K.3    Murase, N.4    Fung, J.J.5    Starzl, T.E.6    Demetris, A.J.7
  • 161
    • 84883792441 scopus 로고    scopus 로고
    • Increased TERC gene copy number and cells in senescence in primary sclerosing cholangitis compared to colitis and control patients
    • PID: 23933276, COI: 1:CAS:528:DC%2BC3sXhtlGksrrP
    • Laish I, Katz H, Sulayev Y, Liberman M, Naftali T, Benjaminov F, Stein A et al (2013) Increased TERC gene copy number and cells in senescence in primary sclerosing cholangitis compared to colitis and control patients. Gene 529:245–249
    • (2013) Gene , vol.529 , pp. 245-249
    • Laish, I.1    Katz, H.2    Sulayev, Y.3    Liberman, M.4    Naftali, T.5    Benjaminov, F.6    Stein, A.7
  • 162
    • 77954601195 scopus 로고    scopus 로고
    • Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis
    • PID: 20212459, COI: 1:CAS:528:DC%2BC3cXmsFOqtro%3D
    • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y (2010) Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. Lab Investig 90:835–843
    • (2010) Lab Investig , vol.90 , pp. 835-843
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 163
    • 0025969165 scopus 로고
    • Class I and class II major histocompatibility complex antigens on hepatocytes: importance of the method of detection and expression in histologically normal and diseased livers
    • PID: 1864983, COI: 1:STN:280:DyaK3MzisVGisQ%3D%3D
    • Senaldi G, Lobo-Yeo A, Mowat AP, Mieli-Vergani G, Vergani D (1991) Class I and class II major histocompatibility complex antigens on hepatocytes: importance of the method of detection and expression in histologically normal and diseased livers. J Clin Pathol 44:107–114
    • (1991) J Clin Pathol , vol.44 , pp. 107-114
    • Senaldi, G.1    Lobo-Yeo, A.2    Mowat, A.P.3    Mieli-Vergani, G.4    Vergani, D.5
  • 164
    • 0025675497 scopus 로고
    • T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
    • PID: 1979365, COI: 1:STN:280:DyaK3M%2Fntl2htg%3D%3D
    • Wen L, Peakman M, Lobo-Yeo A, McFarlane BM, Mowat AP, Mieli-Vergani G, Vergani D (1990) T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Lancet 336:1527–1530
    • (1990) Lancet , vol.336 , pp. 1527-1530
    • Wen, L.1    Peakman, M.2    Lobo-Yeo, A.3    McFarlane, B.M.4    Mowat, A.P.5    Mieli-Vergani, G.6    Vergani, D.7
  • 165
    • 33751002069 scopus 로고    scopus 로고
    • IL-2 receptor alpha(−/−) mice and the development of primary biliary cirrhosis
    • PID: 17058261, COI: 1:CAS:528:DC%2BD28Xht1aktL%2FK
    • Wakabayashi K, Lian ZX, Moritoki Y, Lan RY, Tsuneyama K, Chuang YH, Yang GX et al (2006) IL-2 receptor alpha(−/−) mice and the development of primary biliary cirrhosis. Hepatology 44:1240–1249
    • (2006) Hepatology , vol.44 , pp. 1240-1249
    • Wakabayashi, K.1    Lian, Z.X.2    Moritoki, Y.3    Lan, R.Y.4    Tsuneyama, K.5    Chuang, Y.H.6    Yang, G.X.7
  • 166
    • 84883244892 scopus 로고    scopus 로고
    • Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFbetaRII mice
    • PID: 23532950, COI: 1:CAS:528:DC%2BC3sXhtlOkt7%2FJ
    • Kawata K, Yang GX, Ando Y, Tanaka H, Zhang W, Kobayashi Y, Tsuneyama K et al (2013) Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFbetaRII mice. Hepatology 58:1094–1104
    • (2013) Hepatology , vol.58 , pp. 1094-1104
    • Kawata, K.1    Yang, G.X.2    Ando, Y.3    Tanaka, H.4    Zhang, W.5    Kobayashi, Y.6    Tsuneyama, K.7
  • 168
    • 84886312305 scopus 로고    scopus 로고
    • Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis
    • PID: 23981074, COI: 1:CAS:528:DC%2BC3sXhs12mtrvE
    • Tanaka H, Yang GX, Iwakoshi N, Knechtle SJ, Kawata K, Tsuneyama K, Leung P et al (2013) Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. Clin Exp Immunol 174:364–371
    • (2013) Clin Exp Immunol , vol.174 , pp. 364-371
    • Tanaka, H.1    Yang, G.X.2    Iwakoshi, N.3    Knechtle, S.J.4    Kawata, K.5    Tsuneyama, K.6    Leung, P.7
  • 169
    • 1842584604 scopus 로고    scopus 로고
    • A murine model of type 2 autoimmune hepatitis: xenoimmunization with human antigens
    • PID: 15057911, COI: 1:CAS:528:DC%2BD2cXjtlCqs7o%3D
    • Lapierre P, Djilali-Saiah I, Vitozzi S, Alvarez F (2004) A murine model of type 2 autoimmune hepatitis: xenoimmunization with human antigens. Hepatology 39:1066–1074
    • (2004) Hepatology , vol.39 , pp. 1066-1074
    • Lapierre, P.1    Djilali-Saiah, I.2    Vitozzi, S.3    Alvarez, F.4
  • 170
    • 45149109642 scopus 로고    scopus 로고
    • Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
    • PID: 18474629, COI: 1:CAS:528:DC%2BD1cXntFant74%3D
    • Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, Johnson EF et al (2008) Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection. J Exp Med 205:1409–1422
    • (2008) J Exp Med , vol.205 , pp. 1409-1422
    • Holdener, M.1    Hintermann, E.2    Bayer, M.3    Rhode, A.4    Rodrigo, E.5    Hintereder, G.6    Johnson, E.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.