The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort

Journal of Hepatology

Volumn 59, Issue 1, 2013, Pages 67-73

  Pells, Greta ^a   Mells, George F ^b,c   Carbone, Marco ^b,c   Newton, Julia L ^d   Bathgate, Andrew J ^e   Burroughs, Andrew K ^f   Heneghan, Michael A ^g   Neuberger, James M ^h   Day, Darren B ^b   Ducker, Samantha J ^a   Sandford, Richard N ^c   Alexander, Graeme J ^b   Jones, David E J ^a,d  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NIHR Biomedical Research Centre in Ageing and Chronic Disease   (United Kingdom)

^e ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^h QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Fatigue; Primary biliary cirrhosis; Quality of life; Transplantation

Indexed keywords

CYCLOSPORIN A; TACROLIMUS;

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DAYTIME SOMNOLENCE; DEPRESSION; DISEASE SEVERITY; FATIGUE; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL; TREATMENT FAILURE;

ADULT; AGE FACTORS; AGED; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FATIGUE; FEMALE; GREAT BRITAIN; HUMANS; LIVER CIRRHOSIS, BILIARY; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PHENOTYPE; QUALITY OF LIFE; RISK FACTORS; SEX FACTORS;

EID: 84879127656     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.02.019     Document Type: Article

References (37)

1. R.F. Liermann Garcia, C. Evangelista Garcia, P. McMaster, and J. Neuberger Transplantation for primary biliary cirrhosis: retrospective analysis of 400 patients in a single center Hepatology 33 2001 22 27
2. D.A. Jacob, U.P. Neumann, M. Bahra, J.M. Langrehr, and P. Neuhaus Liver transplantation for primary biliary cirrhosis: retrospective analysis of results at a single center Dtsch Med Wochenschr 131 2006 2327 2332
3. J. Tinmouth, G. Tomlinson, E.J. Heathcote, and L. Lilly Benefit of transplantation in primary biliary cirrhosis between 1985-1997 Transplantation 73 2002 224 227
4. M.G. Silveira, J.A. Talwalkar, K.D. Lindor, and R.H. Wiesner Recurrent primary biliary cirrhosis after liver transplantation Am J Transplant 10 2010 720 726
5. L. Longworth, T. Young, M.J. Buxton, J. Ratcliffe, J. Neuberger, and A. Burroughs Midterm cost-effectiveness of the liver transplantation program of England and Wales for three disease groups Liver Transpl 9 2003 1295 1307
6. F. Aberg, S. Maklin, P. Rasanen, R.P. Roine, H. Sintonen, and A.M. Koivusalo Cost of a quality-adjusted life year in liver transplantation: the influence of the indication and the model for end-stage liver disease score Liver Transpl 17 2011 1333 1343
7. E.M. Kuiper, B.E. Hansen, H.J. Metselaar, R.A. de Man, E.B. Haagsma, and B. van Hoek Trends in liver transplantation for primary biliary cirrhosis in the Netherlands 1988-2008 BMC Gastroenterol 10 2010 144
8. C.R. Gross, M. Malinchoc, W.R. Kim, R.W. Evans, R.H. Wiesner, and J.L. Petz Quality of life before and after liver transplantation for cholestatic liver disease Hepatology 29 1999 356 364
9. C. Elliott, J. Frith, J. Pairman, D.E. Jones, and J.L. Newton Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls Transpl Int 24 2011 588 595
10. M. Aadahl, B.A. Hansen, P. Kirkegaard, and M. Groenvold Fatigue and physical function after orthotopic liver transplantation Liver Transpl 8 2002 251 259
11. S. Tome, J.T. Wells, A. Said, and M.R. Lucey Quality of life after liver transplantation. A systematic review J Hepatol 48 2008 567 577
12. J.R. Rodrigue, D.R. Nelson, A.I. Reed, D.W. Hanto, and M. Curry Fatigue and sleep quality before and after liver transplantation Prog Transplant 20 2010 221 233
13. G.F. Mells, J.A. Floyd, K.I. Morley, H.J. Cordell, C.S. Franklin, and S.Y. Shin Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nat Genet 43 2011 329 332
14. M. Carbone, G. Mells, G. Pells, M.F. Dawwas, J.L. Newton, and M. Heneghan Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid Gastroenterology 144 2013 560 569
15. C. Corpechot, L. Abenavoli, N. Rabahi, Y. Chretien, T. Andreani, and C. Johanet Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis Hepatology 48 2008 871 877
16. M. Carbone, G.F. Mells, and G.J. Alexander Calcineurin inhibitors and the IL12A locus influence risk of recurrent primary biliary cirrhosis after liver transplantation Am J Transplant 13 2013 1110 1111
17. A. Jacoby, A. Rannard, D. Buck, N. Bhala, J.L. Newton, and O.F. James Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis Gut 54 2005 1622 1629
18. J.L. Newton, G.J. Gibson, M. Tomlinson, K. Wilton, and D. Jones Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence Hepatology 44 2006 91 98
19. J.L. Newton, M. Hudson, P. Tachtatzis, K. Sutcliffe, J. Pairman, and J.A. Burt Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis Hepatology 45 2007 1496 1505
20. P. Blackburn, M. Freeston, C.R. Baker, D.E. Jones, and J.L. Newton The role of psychological factors in the fatigue of primary biliary cirrhosis Liver Int 27 2007 654 661
21. K.G. Hollingsworth, J.L. Newton, R. Taylor, C. McDonald, J.M. Palmer, and A.M. Blamire Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis Clin Gastroenterol Hepatol 6 2008 1041 1048
22. K.G. Hollingsworth, J.L. Newton, L. Robinson, R. Taylor, A.M. Blamire, and D.E. Jones Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis J Hepatol 53 2010 155 161
23. D.E. Jones, K. Hollingsworth, G. Fattakhova, G. MacGowan, R. Taylor, and A. Blamire Impaired cardiovascular function in primary biliary cirrhosis Am J Physiol Gastrointest Liver Physiol 298 2010 G764 773
24. C. McDonald, J. Newton, H.M. Lai, S.N. Baker, and D.E. Jones Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms J Hepatol 53 2010 1095 1100
25. J.L. Newton, K.G. Hollingsworth, R. Taylor, A.M. El-Sharkawy, Z.U. Khan, and R. Pearce Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology Hepatology 48 2008 541 549
26. J.L. Newton, A. Davidson, S. Kerr, N. Bhala, J. Pairman, and J. Burt Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity Eur J Gastroenterol Hepatol 19 2007 125 132
27. K.G. Hollingsworth, D.E. Jones, R. Taylor, J. Frith, A.M. Blamire, and J.L. Newton Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline Liver Int 30 2010 878 885
28. J.M. Morales, E. Varo, and P. Lazaro Immunosuppressant treatment adherence, barriers to adherence and quality of life in renal and liver transplant recipients in Spain Clin Transplant 26 2012 369 376
29. H. Sanchez, B. N'Guessan, F. Ribera, R. Ventura-Clapier, and X. Bigard Cyclosporin A treatment increases rat soleus muscle oxidative capacities Muscle Nerve 28 2003 324 329
30. S. Martinez-Sanchis, M.C. Bernal, J.V. Montagud, G. Candela, J. Crespo, and A. Sancho Effects of immunosuppressive drugs on the cognitive functioning of renal transplant recipients: a pilot study J Clin Exp Neuropsychol 33 2011 1016 1024
31. A. Mouri, Y. Noda, S. Shimizu, Y. Tsujimoto, and T. Nabeshima The role of cyclophilin D in learning and memory Hippocampus 20 2010 293 304
32. G. Russ, N. Jamieson, R. Oberbauer, M. Arias, M.G. Murgia, and G. Blancho Three-year health-related quality-of-life outcomes for sirolimus-treated kidney transplant patients after elimination of cyclosporine Transpl Int 20 2007 875 883
33. W. Rongies, S. Stepniewska, M. Lewandowska, E. Smolis-Bak, W. Dolecki, and J. Sierdzinski Physical activity long-term after liver transplantation yields better quality of life Ann Transplant 16 2011 126 131
34. B.T. van Ginneken, H.J. van den Berg-Emons, H.J. Metselaar, H.W. Tilanus, G. Kazemier, and H.J. Stam Effects of a rehabilitation programme on daily functioning, participation, health-related quality of life, anxiety and depression in liver transplant recipients Disabil Rehabil 32 2010 2107 2112
35. J. Prentis, D.E.J. Jones, M.I. Trenell, and C.P. Snowden Impaired cardiorespiratory reserve in primary biliary cirrhosis patients undergoing liver transplant assessment Hepatology 54 2011 1198A
36. S. Saab, H. Bownik, N. Ayoub, Z. Younossi, F. Durazo, and S. Han Differences in health-related quality of life scores after orthotopic liver transplantation with respect to selected socioeconomic factors Liver Transpl 17 2011 580 590
37. J.N. Lasker, E.D. Sogolow, J.M. Olenik, D.A. Sass, and R.M. Weinrieb Uncertainty and liver transplantation: women with primary biliary cirrhosis before and after transplant Women Health 50 2010 359 375