Effects of bile acids on biliary epithelial cells: Proliferation, cytotoxicity, and cytokine secretion

Life Sciences

Volumn 72, Issue 12, 2003, Pages 1401-1411

  Lamireau, Thierry ^a,b   Zoltowska, Monica ^a   Levy, Emile ^a,c   Yousef, Ibrahim ^a,c   Rosenbaum, Jean ^b   Tuchweber, Beatriz ^a,c   Desmoulière, Alexis ^b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b INSERM   (France)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Apoptosis; Cholestasis; Interleukin 6; Monocyte chemotactic protein 1

Indexed keywords

BILE ACID; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROLITHOCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DOSE RESPONSE; EPITHELIUM CELL; HEPATOBILIARY SYSTEM; HYDROPHOBICITY; MOUSE; NONHUMAN;

ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; BILE DUCTS; CELL DIVISION; CELL LINE, TRANSFORMED; CHEMOKINE CCL2; CYTOKINES; EPITHELIAL CELLS; INTERLEUKIN-6; MICE; MICE, TRANSGENIC; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROLITHOCHOLIC ACID;

EID: 0037422983     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02408-6     Document Type: Article

References (43)

1. Alpini G., Glaser S., Robertson W., Phinizy J.L., Rodgers R.E., Caligiuri A., Lesage G. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. American Journal of Physiology. 273(2 Pt 1):1997;G518-G529.
2. Alpini G., Glaser S., Ueno Y., Rodgers R., Phinizy J.L., Francis H., Baiocchi L., Holcomb L.A., Caligiuri A., Lesage G. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology. 116(1):1999;179-186.
3. Alpini G., Glaser S., Ueno Y. Bile acid depletion and repletion regulate bile duct proliferation and secretion in bile duct ligated (BDL) rats through a phosphatidylinositol 3-kinase (PI3K)-dependent pathway. Hepatology. 30:1999;A1082.
4. Alpini G., Lenzi R., Sarkozi L., Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. Journal of Clinical Investigation. 81(2):1988;569-578.
5. Baiocchi L., Alpini G., Glaser S. The inhibitory effect of ursodeoxycholate (UDCA) on cholangiocyte growth and secretion in bile duct ligated (BDL) rats is not affected by its conjugation with taurine. Gastroenterology. 116:1999;AL0033.
6. Benedetti A., Alvaro D., Bassotti C., Gigliozzi A., Ferretti G., La Rosa T., Di Sario A., Baiocchi L., Jezequel A.M. Cytotoxicity of bile salts against biliary epithelium: a study in isolated bile ductule fragments and isolated perfused rat liver. Hepatology. 26(1):1997;9-21.
7. Carr M.W., Roth S.J., Luther E., Rose S.S., Springer T.A. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proceeddings of Nationall Academy of Science USA. 9(91):1994;3652-3656.
8. Choi I., Kang H.S., Yang Y., Pyun K.H. IL-6 induces hepatic inflammation and collagen synthesis in vivo. Clinical and Experimental Immunology. 3(95):1994;530-535.
9. Deleuze J.F., Jacquemin E., Dubuisson C., Cresteil D., Dumont M., Erlinger S., Bernard O., Hadchouel M. Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. Hepatology. 4(23):1996;904-908.
10. Delzenne N.M., Calderon P.B., Taper H.S., Roberfroid M.B. Comparative hepatotoxicity of cholic acid, deoxycholic acid and lithocholic acid in the rat: in vivo and in vitro studies. Toxicology Letter. 61(2-3):1992;291-304.
11. Diez Ruiz A., Santos Perez J.L., Lopez Martinez G., Gonzalez Calvin J., Gil Extremera B., Gutierrez Gea F. Tumour necrosis factor, interleukin-1 and interleukin-6 in alcoholic cirrhosis. Alcohol and Alcoholism. 28(3):1993;319-323.
12. Ezure T., Sakamoto T., Tsuji H., Lunz J.G., Murase N., Fung J.J., Demetris A.J. The development and compensation of biliary cirrhosis in interleukin-6-deficient mice. American Journal of Pathology. 156(5):2000;1627-1639.
13. Faubion W.A., Guicciardi M.E., Miyoshi H., Bronk S.F., Roberts P.J., Svingen P.A., Kaufmann S.H., Gores G.J. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. Journal of Clinical Investigation. 103(1):1999;137-145.
14. Grappone C., Pinzani M., Parola M., Pellegrini G., Caligiuri A., DeFranco R., Marra F., Herbst H., Alpini G., Milani S. Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats. Journal of Hepatology. 31(1):1999;100-109.
15. Greim H., Czygan P., Schaffner F., Popper H. Determination of bile acids in needle biopsies of human liver. Biochemical Medicine. 8(2):1973;280-286.
16. Gurantz D., Schteingart C.D., Hagey L.R., Steinbach J.H., Grotmol T., Hofmann A.F. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. Hepatology. 13(13):1991;540-550.
17. Heuman D.M., Bajaj R. Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology. 106(5):1994;1333-1341.
18. Hirano F., Tanada H., Makino Y., Okamoto K., Hiramoto M., Handa H., Makino I. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis. 17(3):1996;427-433.
19. Hirano T., Akira S., Taga T., Kishimoto T. Biological and clinical aspects of interleukin 6. Immunology Today. 11(12):1990;443-449.
20. Jones B.A., Rao Y.P., Stravitz R.T., Gores G.J. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. American Journal of Physiology. 272(5 Pt 1):1997;G1109-G1115.
21. Kakumu S., Shinagawa T., Ishikawa T., Yoshioka K., Wakita T., Ito Y., Takayanagi M., Ida N. Serum interleukin 6 levels in patients with chronic hepatitis B. American Journal of Gastroenterology. 86(12):1991;1804-1808.
22. Kanno N., LeSage G., Glaser S., Alvaro D., Alpini G. Functional heterogeneity of the intrahepatic biliary epithelium. Hepatology. 31(3):2000;555-561.
23. Kovalovich K., DeAngelis R.A., Li W., Furth E.E., Ciliberto G., Taub R. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology. 31(1):2000;149-159.
24. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Foline phenol reagent. Journal of Biological Chemistry. 193:1951;265-275.
25. Marra F., DeFranco R., Grappone C., Milani S., Pastacaldi S., Pinzani M., Romanelli R.G., Laffi G., Gentilini P. Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration. American Journal of Pathology. 152(2):1998;423-430.
26. Marra F., Romanelli R.G., Giannini C., Failli P., Pastacaldi S., Arrighi M.C., Pinzani M., Laffi G., Montalto P., Gentilini P. Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells. Hepatology. 29(1):1999;140-148.
27. Mauad T.H., van Nieuwkerk C.M., Dingemans K.P., Smit J.J., Schinkel A.H., Notenboom R.G., van de Bergh Weerman M.A., Verkuisen R.P., Groen A.K., Oude Elferink R.P.J., Van der Valk M.A., Borst P., Offerhaus G.J.A. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. American Journal of Pathology. 145(5):1994;1237-1245.
28. Napoli J., Boishop G.A., McCaughan G.W. Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis. Gastroenterology. 107(3):1994;789-798.
29. Natsume M., Tsuji H., Harada A., Akiyama M., Yano T., Ishikura H., Nakanishi I., Matsushima K., Kaneko S., Mukaida N. Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice. Journal of Leukococyte Biology. 66(4):1999;601-608.
30. Paradis K., Le O.N., Russo P., St-Cyr M., Fournier H., Bu D. Characterization and response to interleukin 1 and tumor necrosis factor of immortalized murine biliary epithelial cells. Gastroenterology. 109(4):1995;1308-1315.
31. Pinzani M., Knauss T.C., Pierce G.F., Hsieh P., Kenney W., Dubyak G.R., Abboud H.E. Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells. American Journal of Physiology. 260(3 Pt 1):1991;C485-C491.
32. Poo J.L., Feldmann G., Erlinger S. Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology. 102(5):1992;1752-1759.
33. Puglielli L., Amigo L., Arrese M., Nunez L., Rigotti A., Garrido J., Gonzalez S., Mingrone G., Greco A.V., Accatino L., Nervi F. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage. Gastroenterology. 107(1):1994;244-254.
34. Roberts S.K., Ludwig J., Larusso N.F. The pathobiology of biliary epithelia. Gastroenterology. 112(1):1997;269-279.
35. Salen G., Batta A.K. Bile acid abnormalities in cholestatic liver diseases. Gastroenterological Clinics of North America. 28(1):1999;173-193.
36. Schlottman K., Wachs F.P., Krieg R.C., Kullmann F., Scholmerich J., Rogler G. Characterization of bile salt-induced apoptosis in colon cancer cell lines. Cancer Research. 60(15):2000;4270-4276.
37. Schmucker D.L., Ohta M., Kanai S., Sato Y., Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology. 12(5):1990;1216-1221.
38. Sedlaczek N., Jia J.D., Bauer M., Herbst H., Ruehl M., Hahn E.G., Schuppan D. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. American Journal of Pathology. 158(4):2001;1239-1244.
39. Stiehl A., Benz C., Sauer P. Mechanism of hepatoprotective action of bile salts in liver disease. Gastroenterological Clinics of North America. 28(1):1999;195-209.
40. Tangkijvanich P., Vimolket T., Theamboonlers A., Kullavanijaya P., Suwangool P., Poovorawan Y. Serum interleukin-6 and interferon-gamma levels in patients with hepatitis B-associated chronic liver disease. Asian and Pacific Journal of Allergy and Immunology. 18(2):2000;109-114.
41. Tuchweber B., Desmouliere A., Bochaton-Piallat M.L., Rubbia-Brandt L., Gabbiani G. Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Laboratory Investigation. 74(1):1996;265-278.
42. Valente A.J., Graves D.T., Vialle-Valentin C.E., Delgado R., Schwartz C.J. Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture. Biochemistry. 27(11):1988;4162-4168.
43. Yasoshima M., Kono N., Sugawara H., Katayanagi K., Harada K., Nakanuma Y. Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study. Laboratory Investigation. 78(1):1998;89-100.