Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression

Gastroenterology

Volumn 135, Issue 2, 2008, Pages 660-670

  Patsenker, Eleonora ^a,b   Popov, Yury ^c   Stickel, Felix ^a   Jonczyk, Alfred ^d   Goodman, Simon L ^d   Schuppan, Detlef ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 BENZYLOXY 2 [5 (PYRIDIN 2 YLAMINO) PENTANOYLAMINO]PROPIONYLAMINO] 3 (3,5 DICHLOROPHENYL)PROPIONIC ACID; ALPHAVBETA6 INTEGRIN; ANTIFIBROTIC AGENT; COLLAGEN; EMD 527040; FIBRONECTIN; TRANSFORMING GROWTH FACTOR BETA1; AUTACOID; GLYCOPROTEIN P; INTEGRIN; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2; PYRIDINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; BILIARY FIBROSIS; BILIARY TRACT DISEASE; CELL ADHESION; CELL PROLIFERATION; CHOLANGIOCYTE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; EPITHELIUM CELL; FIBROGENESIS; GENETIC TRANSCRIPTION; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER FIBROSIS; LIVER FUNCTION; LIVER STRUCTURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; UPREGULATION; ANIMAL; BILE DUCT; BLOOD; CELL CULTURE; CELL LINE; CHOLESTASIS; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIGATION; LIVER; LIVER CIRRHOSIS; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALS; ANTIGENS, NEOPLASM; APOPTOSIS; BILE DUCTS; CELL ADHESION; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTASIS; COLLAGEN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTEGRINS; LIGATION; LIVER; LIVER CIRRHOSIS; MICE; MICE, KNOCKOUT; P-GLYCOPROTEINS; PYRIDINES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 48549103201     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.04.009     Document Type: Article

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