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Volumn 4, Issue , 2013, Pages

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; DISEASE INCIDENCE; DOMINANCE; MORTALITY; RODENT;

EID: 84888339170     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3823     Document Type: Article
Times cited : (1042)

References (55)
  • 1
    • 79955701910 scopus 로고    scopus 로고
    • Scraping fibrosis: Expressway to the core of fibrosis
    • Mehal, W. Z., Iredale, J. & Friedman, S. L. Scraping fibrosis: expressway to the core of fibrosis. Nat. Med. 17, 552-553 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 552-553
    • Mehal, W.Z.1    Iredale, J.2    Friedman, S.L.3
  • 2
    • 0037899249 scopus 로고    scopus 로고
    • The myofibroblast in wound healing and fibrocontractive diseases
    • DOI 10.1002/path.1427
    • Gabbiani, G. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200, 500-503 (2003). (Pubitemid 36818250)
    • (2003) Journal of Pathology , vol.200 , Issue.4 , pp. 500-503
    • Gabbiani, G.1
  • 3
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: Therapeutic translation for fibrotic disease
    • Wynn, T. A. & Ramalingam, T. R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat. Med. 18, 1028-1040 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 5
    • 77950611682 scopus 로고    scopus 로고
    • Portal fibroblasts: Underappreciated mediators of biliary fibrosis
    • Dranoff, J. A. & Wells, R. G. Portal fibroblasts: underappreciated mediators of biliary fibrosis. Hepatology 51, 1438-1444 (2010).
    • (2010) Hepatology , vol.51 , pp. 1438-1444
    • Dranoff, J.A.1    Wells, R.G.2
  • 6
    • 84856976151 scopus 로고    scopus 로고
    • What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis
    • Iwaisako, K., Brenner, D. A. & Kisseleva, T. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J. Gastroenterol. Hepatol. 27, 65-68 (2012).
    • (2012) J. Gastroenterol. Hepatol. , vol.27 , pp. 65-68
    • Iwaisako, K.1    Brenner, D.A.2    Kisseleva, T.3
  • 7
    • 84878235678 scopus 로고    scopus 로고
    • Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
    • Perepelyuk, M. et al. Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G605-G614 (2013).
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.304
    • Perepelyuk, M.1
  • 9
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • Friedman, S. L. Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669 (2008). (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 10
    • 34247619364 scopus 로고    scopus 로고
    • Gene Expression Profiles During Hepatic Stellate Cell Activation in Culture and In Vivo
    • DOI 10.1053/j.gastro.2007.02.033, PII S0016508507003903
    • De Minicis, S. et al. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132, 1937-1946 (2007). (Pubitemid 46677935)
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1937-1946
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3    Kluwe, J.4    Zhang, Y.5    Brenner, D.A.6    Schwabe, R.F.7
  • 12
    • 84862195154 scopus 로고    scopus 로고
    • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
    • Kisseleva, T. et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc. Natl Acad. Sci. USA 109, 9448-9453 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 9448-9453
    • Kisseleva, T.1
  • 13
    • 77956158103 scopus 로고    scopus 로고
    • Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice
    • Scholten, D. et al. Genetic labeling does not detect epithelial-to- mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 139, 987-998 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 987-998
    • Scholten, D.1
  • 14
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • Taura, K. et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51, 1027-1036 (2010).
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, K.1
  • 15
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • Chu, A. S. et al. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 53, 1685-1695 (2011).
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1
  • 16
    • 84873461095 scopus 로고    scopus 로고
    • Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury
    • Li, Y., Wang, J. & Asahina, K. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc. Natl Acad. Sci. USA 110, 2324-2329 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 2324-2329
    • Li, Y.1    Wang, J.2    Asahina, K.3
  • 17
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman, S. L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 88, 125-172 (2008).
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman . S, L.1
  • 18
    • 53449092969 scopus 로고    scopus 로고
    • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers
    • Yang, L. et al. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 26, 2104-2113 (2008).
    • (2008) Stem Cells , vol.26 , pp. 2104-2113
    • Yang, L.1
  • 19
    • 84878527104 scopus 로고    scopus 로고
    • Smoothened is a master regulator of adult liver repair
    • Michelotti, G. A. et al. Smoothened is a master regulator of adult liver repair. J. Clin. Invest. 123, 2380-2394 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 2380-2394
    • Michelotti, G.A.1
  • 20
    • 67349229867 scopus 로고    scopus 로고
    • Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
    • Blaner, W. S. et al. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim. Biophys. Acta 1791, 467-473 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 467-473
    • Blaner, W.S.1
  • 21
    • 57749192055 scopus 로고    scopus 로고
    • Lecithin: Retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver
    • Nagatsuma, K. et al. Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver. Liver Int. 29, 47-54 (2009).
    • (2009) Liver Int. , vol.29 , pp. 47-54
    • Nagatsuma, K.1
  • 24
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik, A., Genove, G. & Betsholtz, C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev. Cell 21, 193-215 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genove, G.2    Betsholtz, C.3
  • 25
    • 79952240154 scopus 로고    scopus 로고
    • Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    • Asahina, K., Zhou, B., Pu, W. T. & Tsukamoto, H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53, 983-995 (2011).
    • (2011) Hepatology , vol.53 , pp. 983-995
    • Asahina, K.1    Zhou, B.2    Pu, W.T.3    Tsukamoto, H.4
  • 28
    • 70349422126 scopus 로고    scopus 로고
    • Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice
    • e1451
    • Higashiyama, R. et al. Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology 137, 1459-1466 e1451 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1459-1466
    • Higashiyama, R.1
  • 31
    • 84877141184 scopus 로고    scopus 로고
    • Evolving therapies for liver fibrosis
    • Schuppan, D. & Kim, Y. O. Evolving therapies for liver fibrosis. J. Clin. Invest. 123, 1887-1901 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1887-1901
    • Schuppan, D.1    Kim, Y.O.2
  • 32
    • 84856461322 scopus 로고    scopus 로고
    • Anti-fibrotic therapy: Lost in translation?
    • Schuppan, D. & Pinzani, M. Anti-fibrotic therapy: lost in translation? J. Hepatol. 56(Suppl 1): S66-S74 (2012).
    • (2012) J. Hepatol. , vol.56 , Issue.SUPPL. 1
    • Schuppan, D.1    Pinzani, M.2
  • 33
    • 33847064667 scopus 로고    scopus 로고
    • MDR3 (ABCB4) defects: A paradigm for the genetics of adult cholestatic syndromes
    • Trauner, M., Fickert, P. & Wagner, M. MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. Semin. Liver Dis. 27, 77-98 (2007).
    • (2007) Semin. Liver Dis. , vol.27 , pp. 77-98
    • Trauner, M.1    Fickert, P.2    Wagner, M.3
  • 34
    • 84869751765 scopus 로고    scopus 로고
    • Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice
    • e1567
    • Espanol-Suner, R. et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology 143, 1564-1575 e1567 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1564-1575
    • Espanol-Suner, R.1
  • 35
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • Malato, Y. et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J. Clin. Invest. 121, 4850-4860 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 4850-4860
    • Malato, Y.1
  • 36
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret, K. S. & Grompe, M. Generation and regeneration of cells of the liver and pancreas. Science 322, 1490-1494 (2008).
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 37
    • 84876291823 scopus 로고    scopus 로고
    • Non-cell-autonomous tumor suppression by p53
    • Lujambio, A. et al. Non-cell-autonomous tumor suppression by p53. Cell 153, 449-460 (2013).
    • (2013) Cell , vol.153 , pp. 449-460
    • Lujambio, A.1
  • 38
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernandez-Gea, V. et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142, 938-946 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernandez-Gea, V.1
  • 39
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • Humphreys, B. D. et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am. J. Pathol. 176, 85-97 (2010).
    • (2010) Am. J. Pathol. , vol.176 , pp. 85-97
    • Humphreys, B.D.1
  • 40
    • 84886304100 scopus 로고    scopus 로고
    • Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis
    • Hung, C. et al. Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 188, 820-830 (2013).
    • (2013) Am. J. Respir. Crit. Care Med. , vol.188 , pp. 820-830
    • Hung, C.1
  • 41
    • 79960099283 scopus 로고    scopus 로고
    • A pericyte origin of spinal cord scar tissue
    • Goritz, C. et al. A pericyte origin of spinal cord scar tissue. Science 333, 238-242 (2011).
    • (2011) Science , vol.333 , pp. 238-242
    • Goritz, C.1
  • 42
    • 84882289111 scopus 로고    scopus 로고
    • Origin and function of myofibroblasts in kidney fibrosis
    • Lebleu, V. S. et al. Origin and function of myofibroblasts in kidney fibrosis. Nat. Med. 19, 1047-1053 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1047-1053
    • Lebleu, V.S.1
  • 43
    • 84855511323 scopus 로고    scopus 로고
    • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    • Rock, J. R. et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc. Natl Acad. Sci. USA 108, E1475-E1483 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108
    • Rock, J.R.1
  • 44
    • 0035170704 scopus 로고    scopus 로고
    • HGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
    • DOI 10.1002/gene.10008
    • Zhuo, L. et al. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31, 85-94 (2001). (Pubitemid 33064319)
    • (2001) Genesis , vol.31 , Issue.2 , pp. 85-94
    • Zhuo, L.1    Theis, M.2    Alvarez-Maya, I.3    Brenner, M.4    Willecke, K.5    Messing, A.6
  • 45
    • 7044233126 scopus 로고    scopus 로고
    • GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
    • DOI 10.1038/nn1340
    • Garcia, A. D., Doan, N. B., Imura, T., Bush, T. G. & Sofroniew, M. V. GFAPexpressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat. Neurosci. 7, 1233-1241 (2004). (Pubitemid 39426243)
    • (2004) Nature Neuroscience , vol.7 , Issue.11 , pp. 1233-1241
    • Garcia, A.D.R.1    Doan, N.B.2    Imura, T.3    Bush, T.G.4    Sofroniew, M.V.5
  • 46
    • 73949140059 scopus 로고    scopus 로고
    • A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    • Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133-140 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 133-140
    • Madisen, L.1
  • 47
    • 35548932872 scopus 로고    scopus 로고
    • A global double-fluorescent cre reporter mouse
    • DOI 10.1002/dvg.20335
    • Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global doublefluorescent Cre reporter mouse. Genesis. 45, 593-605 (2007). (Pubitemid 350013057)
    • (2007) Genesis , vol.45 , Issue.9 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, N.4    Luo, L.5
  • 48
    • 27744512904 scopus 로고    scopus 로고
    • Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
    • DOI 10.1016/j.jhep.2005.06.025, PII S0168827805004885
    • Popov, Y., Patsenker, E., Fickert, P., Trauner, M. & Schuppan, D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J. Hepatol. 43, 1045-1054 (2005). (Pubitemid 41627991)
    • (2005) Journal of Hepatology , vol.43 , Issue.6 , pp. 1045-1054
    • Popov, Y.1    Patsenker, E.2    Fickert, P.3    Trauner, M.4    Schuppan, D.5
  • 49
    • 84866692545 scopus 로고    scopus 로고
    • Deactivation of hepatic stellate cells during liver fibrosis resolution in mice
    • e1022
    • Troeger, J. S. et al. Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology 143, 1073-1083 e1022 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1073-1083
    • Troeger, J.S.1
  • 50
    • 50249150340 scopus 로고    scopus 로고
    • A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
    • Mitchell, C. & Willenbring, H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat. Protoc. 3, 1167-1170 (2008).
    • (2008) Nat. Protoc. , vol.3 , pp. 1167-1170
    • Mitchell, C.1    Willenbring, H.2
  • 51
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1
  • 53
    • 84884984479 scopus 로고    scopus 로고
    • Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells
    • Pradere, J. P. et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells. Hepatology 58, 1461-1473 (2013).
    • (2013) Hepatology , vol.58 , pp. 1461-1473
    • Pradere, J.P.1
  • 54
    • 80051551271 scopus 로고    scopus 로고
    • Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis
    • Kluwe, J. et al. Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis. Gut 60, 1260-1268 (2011).
    • (2011) Gut , vol.60 , pp. 1260-1268
    • Kluwe, J.1


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