-
1
-
-
0029560753
-
Genetic analysis of the multidrug transporter
-
Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. Genetic analysis of the multidrug transporter. Annu Rev Genet 1995;29:607-649.
-
(1995)
Annu Rev Genet
, vol.29
, pp. 607-649
-
-
Gottesman, M.M.1
Hrycyna, C.A.2
Schoenlein, P.V.3
Germann, U.A.4
Pastan, I.5
-
2
-
-
0028799756
-
Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse
-
Oude Elferink RP, Ottenhoff R, van Wijland M, Smit JJ, Schinkel AH, Groen AK. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 1995;95:31-38.
-
(1995)
J Clin Invest
, vol.95
, pp. 31-38
-
-
Oude Elferink, R.P.1
Ottenhoff, R.2
van Wijland, M.3
Smit, J.J.4
Schinkel, A.H.5
Groen, A.K.6
-
3
-
-
0037379362
-
Bile salt transporters: molecular characterization, function, and regulation
-
Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003;83:633-671.
-
(2003)
Physiol Rev
, vol.83
, pp. 633-671
-
-
Trauner, M.1
Boyer, J.L.2
-
4
-
-
0027363563
-
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
-
Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993;75:451-462.
-
(1993)
Cell
, vol.75
, pp. 451-462
-
-
Smit, J.J.1
Schinkel, A.H.2
Oude Elferink, R.P.3
Groen, A.K.4
Wagenaar, E.5
van Deemter, L.6
-
5
-
-
0036788262
-
Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
-
Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Weiglein AH, Lammert F, et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 2002;123:1238-1251.
-
(2002)
Gastroenterology
, vol.123
, pp. 1238-1251
-
-
Fickert, P.1
Zollner, G.2
Fuchsbichler, A.3
Stumptner, C.4
Weiglein, A.H.5
Lammert, F.6
-
6
-
-
55949085226
-
Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases
-
Trauner M, Fickert P, Halilbasic E, Moustafa T. Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. Wien Med Wochenschr 2008;158:542-548.
-
(2008)
Wien Med Wochenschr
, vol.158
, pp. 542-548
-
-
Trauner, M.1
Fickert, P.2
Halilbasic, E.3
Moustafa, T.4
-
7
-
-
0000548749
-
Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging
-
Pineda Torra I, Gervois P, Staels B. Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging. Curr Opin Lipidol 1999;10:151-159.
-
(1999)
Curr Opin Lipidol
, vol.10
, pp. 151-159
-
-
Pineda Torra, I.1
Gervois, P.2
Staels, B.3
-
8
-
-
0032506273
-
Mechanism of action of fibrates on lipid and lipoprotein metabolism
-
Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98:2088-2093.
-
(1998)
Circulation
, vol.98
, pp. 2088-2093
-
-
Staels, B.1
Dallongeville, J.2
Auwerx, J.3
Schoonjans, K.4
Leitersdorf, E.5
Fruchart, J.C.6
-
10
-
-
0037325403
-
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
-
Kok T, Bloks VW, Wolters H, Havinga R, Jansen PL, Staels B, et al. Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem J 2003;369:539-547.
-
(2003)
Biochem J
, vol.369
, pp. 539-547
-
-
Kok, T.1
Bloks, V.W.2
Wolters, H.3
Havinga, R.4
Jansen, P.L.5
Staels, B.6
-
11
-
-
0029922002
-
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse
-
Chianale J, Vollrath V, Wielandt AM, Amigo L, Rigotti A, Nervi F, et al. Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. Biochem J 1996;314(Pt 3):781-786.
-
(1996)
Biochem J
, vol.314
, Issue.PT 3
, pp. 781-786
-
-
Chianale, J.1
Vollrath, V.2
Wielandt, A.M.3
Amigo, L.4
Rigotti, A.5
Nervi, F.6
-
12
-
-
38849137817
-
Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study
-
Cindoruk M, Kerem M, Karakan T, Salman B, Akin O, Alper M, et al. Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study. BMC Gastroenterol 2007;7:44.
-
(2007)
BMC Gastroenterol
, vol.7
, pp. 44
-
-
Cindoruk, M.1
Kerem, M.2
Karakan, T.3
Salman, B.4
Akin, O.5
Alper, M.6
-
13
-
-
0034711185
-
Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
-
Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 2000;275:36703-36707.
-
(2000)
J Biol Chem
, vol.275
, pp. 36703-36707
-
-
Delerive, P.1
Gervois, P.2
Fruchart, J.C.3
Staels, B.4
-
14
-
-
0042858402
-
Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme
-
Barbier O, Duran-Sandoval D, Pineda-Torra I, Kosykh V, Fruchart JC, Staels B. Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J Biol Chem 2003;278:32852-32860.
-
(2003)
J Biol Chem
, vol.278
, pp. 32852-32860
-
-
Barbier, O.1
Duran-Sandoval, D.2
Pineda-Torra, I.3
Kosykh, V.4
Fruchart, J.C.5
Staels, B.6
-
15
-
-
33751007567
-
Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver
-
Trottier J, Verreault M, Grepper S, Monte D, Belanger J, Kaeding J, et al. Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 2006;44:1158-1170.
-
(2006)
Hepatology
, vol.44
, pp. 1158-1170
-
-
Trottier, J.1
Verreault, M.2
Grepper, S.3
Monte, D.4
Belanger, J.5
Kaeding, J.6
-
16
-
-
33847421803
-
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation
-
Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, et al. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2, 3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 2007;35:419-427.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 419-427
-
-
Senekeo-Effenberger, K.1
Chen, S.2
Brace-Sinnokrak, E.3
Bonzo, J.A.4
Yueh, M.F.5
Argikar, U.6
-
17
-
-
78650260680
-
Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
-
Levy C, Peter JA, Nelson DR, Keach J, Petz J, Cabrera R, et al. Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Aliment Pharmacol Ther;33:235-242.
-
Aliment Pharmacol Ther
, vol.33
, pp. 235-242
-
-
Levy, C.1
Peter, J.A.2
Nelson, D.R.3
Keach, J.4
Petz, J.5
Cabrera, R.6
-
18
-
-
0025652361
-
Preparation and specific applications of isolated hepatocyte couplets
-
Boyer JL, Phillips JM, Graf J. Preparation and specific applications of isolated hepatocyte couplets. Methods Enzymol 1990;192:501-516.
-
(1990)
Methods Enzymol
, vol.192
, pp. 501-516
-
-
Boyer, J.L.1
Phillips, J.M.2
Graf, J.3
-
19
-
-
0037163053
-
Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha
-
Jung D, Fried M, Kullak-Ublick GA. Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J Biol Chem 2002;277:30559-30566.
-
(2002)
J Biol Chem
, vol.277
, pp. 30559-30566
-
-
Jung, D.1
Fried, M.2
Kullak-Ublick, G.A.3
-
20
-
-
9144243644
-
Farnesoid X receptor activates transcription of the phospholipid pump MDR3
-
Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, et al. Farnesoid X receptor activates transcription of the phospholipid pump MDR3. J Biol Chem 2003;278:51085-51090.
-
(2003)
J Biol Chem
, vol.278
, pp. 51085-51090
-
-
Huang, L.1
Zhao, A.2
Lew, J.L.3
Zhang, T.4
Hrywna, Y.5
Thompson, J.R.6
-
21
-
-
0031952238
-
Peroxisome proliferator activated receptor-alpha expression in human liver
-
Palmer CN, Hsu MH, Griffin KJ, Raucy JL, Johnson EF. Peroxisome proliferator activated receptor-alpha expression in human liver. Mol Pharmacol 1998;53:14-22.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 14-22
-
-
Palmer, C.N.1
Hsu, M.H.2
Griffin, K.J.3
Raucy, J.L.4
Johnson, E.F.5
-
22
-
-
0030845928
-
Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: a correlation with cell polarity in HepG2 cells
-
Zegers MM, Hoekstra D. Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: a correlation with cell polarity in HepG2 cells. J Cell Biol 1997;138:307-321.
-
(1997)
J Cell Biol
, vol.138
, pp. 307-321
-
-
Zegers, M.M.1
Hoekstra, D.2
-
23
-
-
0033999108
-
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription
-
Marrapodi M, Chiang JY. Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. J Lipid Res 2000;41:514-520.
-
(2000)
J Lipid Res
, vol.41
, pp. 514-520
-
-
Marrapodi, M.1
Chiang, J.Y.2
-
24
-
-
67649482317
-
Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene
-
Nagasawa M, Hara T, Kashino A, Akasaka Y, Ide T, Murakami K. Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. Biochem Pharmacol 2009;78:523-530.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 523-530
-
-
Nagasawa, M.1
Hara, T.2
Kashino, A.3
Akasaka, Y.4
Ide, T.5
Murakami, K.6
-
25
-
-
60449097716
-
ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained
-
Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology 2009;136:1060-1069.
-
(2009)
Gastroenterology
, vol.136
, pp. 1060-1069
-
-
Cai, S.Y.1
Gautam, S.2
Nguyen, T.3
Soroka, C.J.4
Rahner, C.5
Boyer, J.L.6
-
27
-
-
85081455374
-
Fibrates as adjuvant therapy for chronic cholestatic liver disease - it's time has come
-
Ghonem NS, Boyer JL. Fibrates as adjuvant therapy for chronic cholestatic liver disease - it's time has come. Hepatology 2012.
-
(2012)
Hepatology
-
-
Ghonem, N.S.1
Boyer, J.L.2
-
28
-
-
16644368576
-
Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4
-
Shoda J, Inada Y, Tsuji A, Kusama H, Ueda T, Ikegami T, et al. Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. J Lipid Res 2004;45:1813-1825.
-
(2004)
J Lipid Res
, vol.45
, pp. 1813-1825
-
-
Shoda, J.1
Inada, Y.2
Tsuji, A.3
Kusama, H.4
Ueda, T.5
Ikegami, T.6
-
29
-
-
0034666324
-
The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis
-
Hunt MC, Yang YZ, Eggertsen G, Carneheim CM, Gafvels M, Einarsson C, et al. The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis. J Biol Chem 2000;275:28947-28953.
-
(2000)
J Biol Chem
, vol.275
, pp. 28947-28953
-
-
Hunt, M.C.1
Yang, Y.Z.2
Eggertsen, G.3
Carneheim, C.M.4
Gafvels, M.5
Einarsson, C.6
-
30
-
-
84874335908
-
Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARalpha)
-
Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, et al. Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARalpha). Mol Pharmacol 2013;83:709-718.
-
(2013)
Mol Pharmacol
, vol.83
, pp. 709-718
-
-
Thomas, M.1
Burk, O.2
Klumpp, B.3
Kandel, B.A.4
Damm, G.5
Weiss, T.S.6
-
31
-
-
15744395646
-
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
-
Fang HL, Strom SC, Cai H, Falany CN, Kocarek TA, Runge-Morris M. Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol Pharmacol 2005;67:1257-1267.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1257-1267
-
-
Fang, H.L.1
Strom, S.C.2
Cai, H.3
Falany, C.N.4
Kocarek, T.A.5
Runge-Morris, M.6
-
32
-
-
0030834153
-
Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver
-
Miranda S, Vollrath V, Wielandt AM, Loyola G, Bronfman M, Chianale J. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver. J Hepatol 1997;26:1331-1339.
-
(1997)
J Hepatol
, vol.26
, pp. 1331-1339
-
-
Miranda, S.1
Vollrath, V.2
Wielandt, A.M.3
Loyola, G.4
Bronfman, M.5
Chianale, J.6
-
33
-
-
84863804104
-
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
-
Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis. J Lipid Res 2012;53:1625-1635.
-
(2012)
J Lipid Res
, vol.53
, pp. 1625-1635
-
-
Li, F.1
Patterson, A.D.2
Krausz, K.W.3
Tanaka, N.4
Gonzalez, F.J.5
-
34
-
-
12144288053
-
Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients
-
Roglans N, Vazquez-Carrera M, Alegret M, Novell F, Zambon D, Ros E, et al. Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients. Eur J Clin Pharmacol 2004;59:855-861.
-
(2004)
Eur J Clin Pharmacol
, vol.59
, pp. 855-861
-
-
Roglans, N.1
Vazquez-Carrera, M.2
Alegret, M.3
Novell, F.4
Zambon, D.5
Ros, E.6
-
35
-
-
79960608008
-
Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate
-
Trottier J, Caron P, Straka RJ, Barbier O. Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate. Clin Pharmacol Ther 2011;90:279-286.
-
(2011)
Clin Pharmacol Ther
, vol.90
, pp. 279-286
-
-
Trottier, J.1
Caron, P.2
Straka, R.J.3
Barbier, O.4
-
36
-
-
0035570381
-
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression
-
Post SM, Duez H, Gervois PP, Staels B, Kuipers F, Princen HM. Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression. Arterioscler Thromb Vasc Biol 2001;21:1840-1845.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1840-1845
-
-
Post, S.M.1
Duez, H.2
Gervois, P.P.3
Staels, B.4
Kuipers, F.5
Princen, H.M.6
-
37
-
-
33847018050
-
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
-
Hewitt NJ, Lechon MJ, Houston JB, Hallifax D, Brown HS, Maurel P, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 2007;39:159-234.
-
(2007)
Drug Metab Rev
, vol.39
, pp. 159-234
-
-
Hewitt, N.J.1
Lechon, M.J.2
Houston, J.B.3
Hallifax, D.4
Brown, H.S.5
Maurel, P.6
-
38
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
39
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
-
Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol 2003;17:259-272.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 259-272
-
-
Pineda Torra, I.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.C.5
Staels, B.6
-
40
-
-
0038281429
-
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
-
Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology 2003;124:1926-1940.
-
(2003)
Gastroenterology
, vol.124
, pp. 1926-1940
-
-
Barbier, O.1
Torra, I.P.2
Sirvent, A.3
Claudel, T.4
Blanquart, C.5
Duran-Sandoval, D.6
|