Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis

American Journal of Pathology

Volumn 175, Issue 3, 2009, Pages 1167-1177

  Katsifis, Gikas E ^a   Rekka, Sofia ^a   Moutsopoulos, Niki M ^a   Pillemer, Stanley ^a,b   Wahl, Sharon M ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b Analytical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; PLACEBO; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; BIOPSY; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INFLAMMATION; MALE; MINOR SALIVA GLAND; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SJOEGREN SYNDROME; TH17 CELL;

EID: 70349244787     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.090319     Document Type: Article

References (50)

1. Voulgarelis M, Dafni UG, Isenberg DA, Moutsopoulos HM: Malignant lymphoma in primary Sjögren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome. Arthritis Rheum 1999, 42:1765-1772 (Pubitemid 30263648)
2. Katsifis GE, Moutsopoulos NM, Wahl SM: T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology. Clin Rev Allergy Immunol 2007, 32:252-264 (Pubitemid 350242571)
3. Manoussakis MN, Boiu S, Korkolopoulou P, Kapsogeorgou EK, Kavantzas N, Ziakas P, Patsouris E, Moutsopoulos HM: Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleukin-12 in the chronic inflammatory lesions of Sjögren's syndrome: correlation with certain features of immune hyperactivity and factors associated with high risk of lymphoma development. Arthritis Rheum 2007, 56:3977-3988 (Pubitemid 350262325)
4. Boniface K, Blom B, Liu YJ, de Waal Malefyt R: From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev 2008, 226:132-146
5. Sankar V, Brennan MT, Kok MR, Leakan RA, Smith JA, Manny J, Baum BJ, Pillemer SR: Etanercept in Sjögren's syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial. Arthritis Rheum 2004, 50:2240-2245 (Pubitemid 38930815)
6. Moutsopoulos NM, Katsifis GE, Angelov N, Leakan RA, Sankar V, Pillemer S, Wahl SM: Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor α and systemic immune activation. Ann Rheum Dis 2008, 67:1437-1443
7. Mariette X, Ravaud P, Steinfeld S, Baron G, Goetz J, Hachulla E, Combe B, Puechal X, Pennec Y, Sauvezie B, Perdriger A, Hayem G, Janin A, Sibilia J: Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled Trial of Remicade in Primary Sjögren's Syndrome (TRIPSS). Arthritis Rheum 2004, 50:1270-1276 (Pubitemid 38488821)
8. Moutsopoulos NM, Angelov N, Sankar V, Leakan RA, Pillemer S, Wahl SM: Immunological consequences of thalidomide treatment in Sjögren's syndrome. Ann Rheum Dis 2006, 65:112-114 (Pubitemid 41815650)
9. Wahl SM: Transforming growth factor-β: innately bipolar. Curr Opin Immunol 2007, 19:55-62
10. H17 lineage. Nature 2006, 441:231-234
11. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B: TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189 (Pubitemid 43214587)
12. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238
13. H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat Immunol 2008, 9:641-649
14. H-17 responses. Nat Immunol 2008, 9:650-657
15. H17 cells. Nature 2008, 454:350-352
16. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886
17. Mavragani CP, Niewold TB, Moutsopoulos NM, Pillemer SR, Wahl SM, Crow MK: Augmented interferon-α pathway activation in patients with Sjögren's syndrome treated with etanercept. Arthritis Rheum 2007, 56:3995-4004
18. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH: Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002, 61:554-558 (Pubitemid 34539104)
19. Daniels TE, Whitcher JP: Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca: analysis of 618 patients with suspected Sjögren's syndrome, Arthritis Rheum 1994, 37:869-877 (Pubitemid 24184539)
20. Tarpley TM Jr, Anderson LG, White CL: Minor salivary gland involvement in Sjögren's syndrome. Oral Surg Oral Med Oral Pathol 1974, 37:64-74
21. Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S: Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol 2008, 181:2898-2906
22. Nguyen CQ, Hu MH, Li Y, Stewart C, Peck AB: Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice. Arthritis Rheum 2008, 58:734-743
23. Lee YK, Turner H, Maynard CL, Oliver J, Chen D, Elson CO, Weaver CT: Late developmental plasticity in the T helper 17 lineage. Immunity 2009, 30:92-107
24. + T-regulatory cells in Sjögren's syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am J Pathol 2008, 173:1389-1396
25. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C: CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 2008, 181:8391-8401
26. + T helper cells. Cell 2006, 126:1121-1133
27. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C: T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 2008, 28:29-39
28. Fox RI: Sjögren's syndrome. Lancet 2005, 366:321-331
29. Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP: IL-17 stimulates the production and expression of proinflammatory cytokines. IL-β and TNF-α, by human macrophages, J Immunol 1998, 160:3513-3521 (Pubitemid 28164746)
30. Moseley TA, Haudenschild DR, Rose L, Reddi AH: Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 2003, 14:155-174
31. Kolls JK, Linden A: Interleukin-17 family members and inflammation. Immunity 2004, 21:467-476
32. Ferraccioli GF, De Vita S: Cytokine expression in the salivary glands of Sjögren's syndrome patients in relation to tissue infiltration and lymphoepithelial lesions. Arthritis Rheum 1997, 40:987-990
33. Isaksen K, Jonsson R, Omdal R: Anti-CD20 treatment in primary Sjögren's syndrome. Scand J Immunol 2008, 68:554-564
34. Mitsias DI, Tzioufas AG, Veiopoulou C, Zintzaras E, Tassios IK, Kogopoulou O, Moutsopoulos HM, Thyphronitis G: The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome. Clin Exp Immunol 2002, 128:562-568 (Pubitemid 34639321)
35. Fox RI, Kang HI, Ando D, Abrams J, Pisa E: Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994, 152:5532-5539 (Pubitemid 24153003)
36. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, Yamada A, Itoh K, Nomoto K: Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996, 39:1376-1384 (Pubitemid 26270098)
37. H-17 cell-mediated pathology. Nat Immunol 2007, 8:1390-1397
38. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Fili L, Ferri S, Frosali F, Giudici F, Romagnani P, Parronchi P, Tonelli F, Maggi E, Romagnani S: Phenotypic and functional features of human Th17 cells. J Exp Med 2007, 204:1849-1861 (Pubitemid 47240944)
39. Gottenberg JE, Lavie F, Abbed K, Gasnault J, Le Nevot E, Delfraissy JF, Taoufik Y, Mariette X: CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome. J Autoimmun 2005, 24:235-242 (Pubitemid 40545886)
40. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M: Imbalance of regulatory T cells in human autoimmune diseases. Immunology 2006, 117:289-300
41. Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank R, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'Shea J: Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007, 26:371-381 (Pubitemid 46413906)
42. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H: Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317:256-260 (Pubitemid 47076203)
43. H17 cell differentiation by antagonizing RORγt function. Nature 2008, 453:236-240
44. Spachidou MP, Bourazopoulou E, Maratheftis CI, Kapsogeorgou EK, Moutsopoulos HM, Tzioufas AG, Manoussakis MN: Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndrome. Clin Exp Immunol 2007, 147:497-503 (Pubitemid 46208051)
45. + T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036
46. Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT: Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol 2004, 173:7249-7258 (Pubitemid 39628161)
47. Woo P, Wilkinson N, Prieur AM, Southwood T, Leone V, Livermore P, Wythe H, Thomson D, Kishimoto T: Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. Arthritis Res Ther 2005, 7:R1281-R1288
48. Maini RN, Taylor PC, Szechinski J, Pavelka K, Broll J, Balint G, Emery P, Raemen F, Petersen J, Smolen J, Thomson D, Kishimoto T: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006, 54:2817-2829 (Pubitemid 44497760)
49. Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl M: A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 2007, 356:580-592 (Pubitemid 46220818)
50. Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, Dolin B, Goodman N, Groden C, Hornung RL, Quezado M, Yang Z, Neurath MF, Salfeld J, Veldman GM, Schwertschlag U, Strober W: Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004, 351:2069-2079 (Pubitemid 39482500)