High-resolution fluorodeoxyglucose positron emission tomography shows both global and regional cerebral hypometabolism in multiple sclerosis

Journal of Neuroimaging

Volumn 8, Issue 4, 1998, Pages 228-234

  Bakshi, Rohit ^a,c   Miletrch, Robert S ^a   Kinkel, Peter R ^a   Emmet, Marja L ^b   Kinkel, William R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b Dent Neurologic Institute

^c Millard Fillmore Gates Circle Hospital   (United States)

Author keywords

Brain; Demyelination; Hypometabolism; Multiple sclerosis; Positron emission tomography; White matter disease

Indexed keywords

FLUORODEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18;

ARTICLE; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; GRAY MATTER; HUMAN; IMAGE ANALYSIS; MULTIPLE SCLEROSIS; OCCIPITAL CORTEX; PARIETAL LOBE; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; RADIODIAGNOSIS; ADULT; BASAL GANGLION; BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN REGION; COMPARATIVE STUDY; FEMALE; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; LATERAL OCCIPITAL CORTEX; MALE; MESIAL OCCIPITAL CORTEX; PET SCANNER; PONS; QUALITATIVE ANALYSIS; SUPERIOR DORSOLATERAL FRONTAL CORTEX; SUPERIOR MESIAL FRONTAL CORTEX; SUPRATENTORIAL WHITE MATTER; WHITE MATTER;

EID: 0031717172     PISSN: 10512284     EISSN: None     Source Type: Journal    
DOI: 10.1111/jon199884228     Document Type: Article

References (32)

1. Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 1996;39:6-16
2. Koopmans RA, Li DKB, Grochowski E, Cutler PJ, Paty DW. Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 1989;25: 74-81
3. Truyen L, Gheuens J, Parizel PM, Van de Vyer FL, Martin JJ. Long term follow-up of multiple sclerosis by standardized. non-contrast-enhanced magnetic resonance imaging. J Neurol Sci 1991;106:35-40
4. Barkhof F, Scheltens P, Frequin STFM, et al. Relapsing-remitting multiple sclerosis: sequential enhanced MR imaging vs clinical findings in determining disease activity. AJR Am J Roentgenol 1992;159:1041-1047
5. Isaac C, Li DKB, Genton M, et al. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 1988;38:1511-1515
6. Sinnige LGF, Teeuwissen E, Hew JM, Minderhoud JM. Correlation between magnetic resonance imaging and clinical parameters in multiple sclerosis. Acta Neurol Scand 1995;91:188-191
7. Thompson AJ, Kermode AG, MacManus DG, et al. Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ 1990;300:631-634
8. Willoughby EW, Grochowski E, Li DKB, Oger J, Kastrukoff LF, Paty DW. Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 1989;25:43-49
9. Baumhefner RW, Tourtellotte WW, Syndulko K, et al. Quantitative multiple sclerosis plaque assessment with magnetic resonance imaging. Arch Neurol 1990;47:19-26
10. Russo C, Smoker WRK, Kubal W. Cortical and subcortical T2 shortening in multiple sclerosis. AJNR Am J Neuroradiol 1996;18:124-126
11. McDonald WI, Miller DH, Thompson AJ. Are magnetic resonance findings predictive of clinical outcome in therapeutic trials in multiple sclerosis? The dilemma of interferon-B. Ann Neurol 1995;37:611-619
12. Miller DH. Magnetic resonance in monitoring the treatment of multiple sclerosis. Ann Neurol 1994;36:S91-S94
13. Thorpe JW, Miller DH. MRI: its application and impact. Int MSJ 1994;1:7-16
14. Hanemann CO, Kleinschmidt A, Reifenberger G, Freund H-J, Seitz RJ. Balo's concentric sclerosis followed by MRI and positron emission tomography. Neuroradiology 1993; 35:578-580
15. Roelcke U, Kappos L, Lechner-Scott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxy-glucose positron emission tomography study. Neurology 1997;48:1566-1571
16. Blinkenberg M, Rune K, Jonsson A, et al. Cerebral metabolism in a case of multiple sclerosis with acute mental disorder. Acta Neurol Scand 1996;94:310-313
17. Pozzilli C, Fieschi C, Perani D, et al. Relationship between corpus callosum atrophy and cerebral metabolic asymmetries in multiple sclerosis. J Neurol Sci 1992;112:51-57
18. Pozzilli C, Passafiume D, Bernardi S, et al. SPECT, MRI and cognitive functions in multiple sclerosis. J Neurol Neurosurg Psychiatry 1991;54:110-115
19. Lycke J, Wikkelso C, Bergh A-C, Jacobsson L, Andersen O. Regional cerebral blood flow in multiple sclerosis measured by single photon emission tomography with technetium-99m hexamethylpropyleneamine oxime. Eur Neurol 1993;33:163-167
20. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231
21. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444-1452
22. Wienhard K, Dahlbom M, Eriksson L, et al. The ECAT EXACT HR: performance of a new high resolution positron scanner. J Comput Assist Tomogr 1994;18:110-118
23. Blesa R, Mohr E, Miletich RS, Hildebrand K, Sampson M, Chase TN. Cerebral metabolic changes in Alzheimer's disease: neurobehavioral patterns. Dementia 1996;7:239-245
24. Blesa R, Mohr E, Miletich RS, et al. Changes in cerebral glucose metabolism with normal aging. Eur J Neurol 1997; 4:8-14
25. Miletich RS, Bankiewicz KS, Quarantelli M, et al. MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in hemiparkinsonian monkeys. Ann Neurol 1994;35:689-697
26. Brooks DJ, Leenders KL, Head G, Marshall J, Legg NJ, Jones T. Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis. J Neurol Neurosurg Psychiatry 1984;47:1182-1191
27. Jansen HML, Willemsen ATM, Sinnige LGF, et al. Cobalt-55 positron emission tomography in relapsing-progressive multiple sclerosis. J Neurol Sci 1995;132:139-145
28. Brownell B, Hughes TJ. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 1962;25:315-320
29. Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873-880
30. Stuss DT, Benson DF. The frontal lobes. New York: Raven Press, 1986:12-38
31. Pandya DN, Barnes CL. Architecture and connections of the frontal lobe. In: Perecman E, ed. The frontal lobes revisited. New York: IRBN Press, 1987:41-72
32. Tohgi H, Chiba K, Sasaki K, Hiroi S, Ishibashi Y. Cerebral perfusion patterns in vascular dementia of Binswanger type compared with senile dementia of Alzheimer type: a SPECT study. J Neurol 1991;238:365-370