Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment

Journal of Immunology Research

Volumn 2014, Issue , 2014, Pages

  Gironi, Maira ^a,b   Borgiani, Bruno ^a,b   Mariani, Enrica ^b   Cursano, Cristina ^b   Mendozzi, Laura ^c   Cavarretta, Rossella ^c   Saresella, Marina ^c   Clerici, Mario ^c   Comi, Giancarlo ^a   Rovaris, Marco ^c   Furlan, Roberto ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b CAM   (Italy)

^c IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; AZATHIOPRINE; BETA INTERFERON; GLATIRAMER; GLUTATHIONE; MALONALDEHYDE; NALTREXONE; NATALIZUMAB; OXIDIZED LOW DENSITY LIPOPROTEIN ANTIBODY; REACTIVE OXYGEN METABOLITE; UBIDECARENONE; ANTIBODY; IMMUNOLOGIC FACTOR; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PEPTIDE; UBIQUINONE;

ADULT; AGED; ANTIBODY TITER; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME BLOOD LEVEL; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; OXIDATIVE STRESS; PHENOTYPE; SEX DIFFERENCE; AGE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BLOOD; CASE CONTROL STUDY; IMMUNOLOGY; OXIDATION REDUCTION REACTION; PATHOLOGY; PILOT STUDY;

ADULT; AGE FACTORS; AGED; ANTIBODIES; CASE-CONTROL STUDIES; FEMALE; GLUTATHIONE; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-BETA; LIPOPROTEINS, LDL; MALE; MALONDIALDEHYDE; MIDDLE AGED; MULTIPLE SCLEROSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDES; PILOT PROJECTS; REACTIVE OXYGEN SPECIES; SEX FACTORS; UBIQUINONE;

EID: 84899519853     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2014/961863     Document Type: Article

References (57)

1. Gh Popescu B. F., Lucchinetti C. F., Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurology 2012 12, article 11 2-s2.0-84859100978 10.1186/1471-2377-12-11
2. Lassmann H., Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease. Journal of Neural Transmission 2011 118 5 747 752 2-s2.0-79956198149 10.1007/s00702-011-0607-8
3. Centonze D., Muzio L., Rossi S., Cavasinni F., De Chiara V., Bergami A., Musella A., D'Amelio M., Cavallucci V., Martorana A., Bergamaschi A., Cencioni M. T., Diamantini A., Butti E., Comi G., Bernardi G., Cecconi F., Battistini L., Furlan R., Martino G., Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. Journal of Neuroscience 2009 29 11 3442 3452 2-s2.0-63849213783 10.1523/JNEUROSCI.5804-08. 2009
4. Campbell G., Mahad D., Clonal expansion of mitochondrial DNA deletions and the progression of multiple sclerosis. CNS & Neurological Disorders-Drug Targets 2012 11 589 597
5. Centonze D., Muzio L., Rossi S., Furlan R., Bernardi G., Martino G., The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis. Cell Death and Differentiation 2010 17 7 1083 1091 2-s2.0-77953611373 10.1038/cdd.2009.179
6. Kidd P. M., Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Alternative Medicine Review 2005 10 4 268 293 2-s2.0-29144495573
7. Witte M., Nijland P., Drexhage J., Reduced expression of PGC-1 α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathologica 2013 125 2 231 243 10.1007/s00401-012-1052-y
8. Blokhin A., Vyshkina T., Komoly S., Kalman B., Variations in mitochondrial DNA copy numbers in MS brains. Journal of Molecular Neuroscience 2008 35 3 283 287 2-s2.0-51649107779 10.1007/s12031-008-9115-1
9. Fischer M. T., Sharma R., Lim J. L., Haider L., Frischer J. M., Drexhage J., Mahad D., Bradl M., Van Horssen J., Lassmann H., NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012 135 3 886 899 2-s2.0-84857538385 10.1093/brain/aws012
10. Tasset I., Agüera E., Sanchez-Lopez F., Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clinical Biochemistry 2012 45 440 444
11. Nikić I., Merkler D., Sorbara C., Brinkoetter M., Kreutzfeldt M., Bareyre F. M., Brück W., Bishop D., Misgeld T., Kerschensteiner M., A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 2011 17 4 495 499 2-s2.0-79953761792 10.1038/nm.2324
12. Oliveira S., Kallaur A., Simao A., Oxidative stress in multiple sclerosis patients in clinical remission: association with the expanded disability status scale. Journal of the Neurological Sciences 2012 321 49 53
13. Kalman B., Laitinen K., Komoly S., The involvement of mitochondria in the pathogenesis of multiple sclerosis. Journal of Neuroimmunology 2007 188 1-2 1 12 2-s2.0-34447640526 10.1016/j.jneuroim.2007.03.020
14. Song Y., Pinniger G. J., Bakker A. J., Lipopolysaccharide-induced weakness in the preterm diaphragm is associated with mitochondrial electron transport chain dysfunction and oxidative stress. PloS ONE 2013 8 734 757
15. Gilgun-Sherki Y., Melamed E., Offen D., The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. Journal of Neurology 2004 251 3 261 268 2-s2.0-1642264093 10.1007/s00415-004-0348-9
16. Poyton R. O., Ball K. A., Castello P. R., Mitochondrial generation of free radicals and hypoxic signaling. Trends in Endocrinology and Metabolism 2009 20 7 332 340 2-s2.0-69849097192 10.1016/j.tem.2009.04.001
17. Surace M., Block M., Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors. Cellular and Molecular Life Sciences 2012 69 14 2409 2427 10.1007/s00018-012-1015-4
18. Leto T. L., Geiszt M., Role of Nox family NADPH oxidases in host defense. Antioxidants and Redox Signaling 2006 8 9-10 1549 1561 2-s2.0-33750926794 10.1089/ars.2006.8.1549
19. Honorat J. A., Kinoshita M., Okuno T., Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis. PloS ONE 2013 8 713 729
20. Ortiz G. G., Pacheco-Moisés F. P., Bitzer-Quintero O. K., Immunology and oxidative stress in multiple sclerosis: clinical and basic approach. Clinical and Developmental Immunology 2013 2013 14 708659 10.1155/2013/708659
21. Reuter S., Gupta S. C., Chaturvedi M. M., Aggarwal B. B., Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biology and Medicine 2010 49 11 1603 1616 2-s2.0-78049370987 10.1016/j.freeradbiomed.2010. 09.006
22. Acar A., Ugur C. M., Evliyaoglu O., Evaluation of serum oxidant/antioxidant balance in multiple sclerosis. Acta Neurologica Belgica 2012 112 275 280
23. Ghabaee M., Jabedari B., Al-E-Eshagh N., Ghaffarpour M., Asadi F., Serum and cerebrospinal fluid antioxidant activity and lipid peroxidation in GuillainBarre syndrome and multiple sclerosis patients. International Journal of Neuroscience 2010 120 4 301 304 2-s2.0-77950847084 10.3109/00207451003695690
24. Di Giuseppe D., Ulivelli M., Bartalini S., Battistini S., Cerase A., Passero S., Summa D., Frosali S., Priora R., Margaritis A., Di Simplicio P., Regulation of redox forms of plasma thiols by albumin in multiple sclerosis after fasting and methionine loading test. Amino Acids 2010 38 5 1461 1471 2-s2.0-77955866737 10.1007/s00726-009-0350-8
25. Kastenbauer S., Kieseier B. C., Becker B. F., No evidence of increased oxidative degradation of urate to allantoin in the CSF and serum of patients with multiple sclerosis. Journal of Neurology 2005 252 5 611 612 2-s2.0-20044390760 10.1007/s00415-005-0697-z
26. Miller E., Walczak A., Saluk J., Ponczek M. B., Majsterek I., Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis. Clinical Biochemistry 2012 45 1-2 26 30 2-s2.0-84855301917 10.1016/j.clinbiochem.2011.09.021
27. Amorini A. M., Petzold A., Tavazzi B., Eikelenboom J., Keir G., Belli A., Giovannoni G., Di Pietro V., Polman C., D'Urso S., Vagnozzi R., Uitdehaag B., Lazzarino G., Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clinical Biochemistry 2009 42 10-11 1001 1006 2-s2.0-67349252457 10.1016/j.clinbiochem.2009.03.020
28. Lassmann H., Van Horssen J., Mahad D., Progressive multiple sclerosis: pathology and pathogenesis. Nature Reviews Neurology 2012 8 647 656
29. Gironi M., Bianchi A., Russo A., Alberoni M., Ceresa L., Angelini A., Cursano C., Mariani E., Nemni R., Kullmann C., Farina E., Martinelli Boneschi F., Oxidative imbalance in different neurodegenerative diseases with memory impairment. Neurodegenerative Diseases 2011 8 3 129 137 2-s2.0-79953325097 10.1159/000319452
30. Polman C. H., Reingold S. C., Banwell B., Clanet M., Cohen J. A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F. D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A. J., Waubant E., Weinshenker B., Wolinsky J. S., Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology 2011 69 2 292 302 2-s2.0-79952501096 10.1002/ana.22366
31. Benedetti B., Rovaris M., Rocca M. A., Caputo D., Zaffaroni M., Capra R., Bertolotto A., Martinelli V., Comi G., Filippi M., In-vivo evidence for stable neuroaxonal damage in the brain of patients with benign multiple sclerosis. Multiple Sclerosis 2009 15 7 789 794 2-s2.0-67649304790 10.1177/1352458509103714
32. Wei Y.-H., Lu C.-Y., Lee H.-C., Pang C.-Y., Ma Y.-S., Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Annals of the New York Academy of Sciences 1998 854 155 170 2-s2.0-0032436502 10.1111/j.1749-6632.1998.tb09899.x
33. Tiidus P. M., Estrogen and gender effects on muscle damage, inflammation, and oxidative stress. Canadian Journal of Applied Physiology 2000 25 4 274 287 2-s2.0-0034251875
34. Ren J., Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2007 34 5-6 432 438 2-s2.0-33947674281 10.1111/j.1440-1681.2007.04591.x
35. Dikici I., Mehmetoglu I., Dikici N., Bitirgen M., Kurban S., Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon- α treatment. Clinical Biochemistry 2005 38 12 1141 1144 2-s2.0-29144475091 10.1016/j.clinbiochem.2005.10.006
36. Pennisi G., Cornelius C., Cavallaro M. M., Salinaro A. T., Cambria M. T., Pennisi M., Bella R., Milone P., Ventimiglia B., Migliore M. R., Di Renzo L., De Lorenzo A., Calabrese V., Redox regulation of cellular stress response in multiple sclerosis. Biochemical Pharmacology 2011 82 10 1490 1499 2-s2.0-80054684930 10.1016/j.bcp.2011.07.092
37. Van der Walt A., Butzkueven H., Kolbe S., Marriott M., Alexandrou E., Gresle M., Egan G., Kilpatrick T., Neuroprotection in multiple sclerosis: a therapeutic challenge for the next decade. Pharmacology and Therapeutics 2010 126 1 82 93 2-s2.0-77649274969 10.1016/j.pharmthera.2010.01.006
38. Lassmann H., Multiple sclerosis: lessons from molecular neuropathology. Experimental Neurology 2013 10.1016/j.expneurol.2013.12.003
39. Haider L., Fischer M. T., Frischer J. M., Bauer J., Höftberger R., Botond G., Esterbauer H., Binder C. J., Witztum J. L., Lassmann H., Oxidative damage in multiple sclerosis lesions. Brain 2011 134 7 1914 1924 2-s2.0-79959723400 10.1093/brain/awr128
40. Barnett M. H., Prineas J. W., Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Annals of Neurology 2004 55 4 458 468 2-s2.0-1642281535 10.1002/ana.20016
41. Littarru G. P., Tiano L., Clinical aspects of coenzyme Q10: an update. Nutrition 2010 26 3 250 254 2-s2.0-75749150806 10.1016/j.nut.2009.08.008
42. Groneberg D. A., Kindermann B., Althammer M., Klapper M., Vormann J., Littarru G. P., Döring F., Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. International Journal of Biochemistry and Cell Biology 2005 37 6 1208 1218 2-s2.0-15044348677 10.1016/j.biocel.2004.11.017
43. Inui M., Ooe M., Fujii K., Matsunaka H., Yoshida M., Ichihashi M., Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. BioFactors 2008 32 1-4 237 243 2-s2.0-58149377630
44. Sanoobar M., Eghtesadi S., Azimi A., Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. International Journal of Neuroscience 2013 123 776 782
45. Voskuhl R. R., Gold S. M., Sex-related factors in multiple sclerosis susceptibility and progression. Nature Reviews Neurology 2012 8 255 263 2-s2.0-84858732796 10.1038/nrneurol.2012.43
46. De Bustos F., Jiménez-Jiménez F., Molina J., Serum levels of coenzyme Q10 in patients with multiple sclerosis. Acta Neurologica Scandinavica 2000 101 209 211
47. Glass C. K., Witztum J. L., Atherosclerosis: the road ahead. Cell 2001 104 4 503 516 2-s2.0-0035936802 10.1016/S0092-8674(01)00238-0
48. Shoji T., Nishizawa Y., Fukumoto M., Shimamura K., Kimura J., Kanda H., Emoto M., Kawagishi T., Morii H., Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis 2000 148 1 171 177 2-s2.0-0033990553 10.1016/S0021-9150(99)00218-X
49. Sjöberg B. G., Su J., Dahlbom I., Grönlund H., Wikström M., Hedblad B., Berglund G., de Faire U., Frostegård J., Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men. Atherosclerosis 2009 203 2 528 532 2-s2.0-62649133717 10.1016/j.atherosclerosis.2008.07.009
50. Binder C. J., Chang M.-K., Shaw P. X., Miller Y. I., Hartvigsen K., Dewan A., Witztum J. L., Innate and acquired immunity in atherogenesis. Nature Medicine 2002 8 11 1218 1226 2-s2.0-0036852824 10.1038/nm1102-1218
51. Usatyuk P. V., Natarajan V., Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvascular Research 2012 83 1 45 55 2-s2.0-82955237301 10.1016/j.mvr.2011.04.012
52. Mitra S., Khaidakov M., Lu J., Ayyadevara S., Szwedo J., Wang X. W., Chen C., Khaidakov S., Kasula S. R., Stone A., Pogribny I., Mehta J. L., Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. American Journal of Physiology 2011 301 2 H506 H513 2-s2.0-79961041729 10.1152/ajpheart.00252.2011
53. Ding Z., Wang X., Schnackenberg L., Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g. International Journal of Cardiology 2013 168 1378 1385
54. Wei D., Jia X., Liu Y., Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis. International Journal of Molecular Medicine 2013 31 2 400 406 10.3892/ijmm.2012.1201
55. Steinberg D., Lewis A. Conner Memorial Lecture: oxidative modification of LDL and atherogenesis. Circulation 1997 95 4 1062 1071 2-s2.0-0031048299
56. Besler H. T., Çomolu S., Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutritional Neuroscience 2003 6 3 189 196 2-s2.0-0038412627 10.1080/1028415031000115945
57. van Horssen J., Schreibelt G., Drexhage J., Hazes T., Dijkstra C. D., van der Valk P., de Vries H. E., Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radical Biology and Medicine 2008 45 12 1729 1737 2-s2.0-56349160121 10.1016/j.freeradbiomed.2008.09.023