Chronic fatigue syndrome is associated with diminished intracellular perforin

Clinical and Experimental Immunology

Volumn 142, Issue 3, 2005, Pages 505-511

  Maher, K J ^a   Klimas, N G ^a,b   Fletcher, Mary Ann ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chronic fatigue syndrome; Cytoplasmic granules; Flow cytometry; Killer cells natural; Perforin

Indexed keywords

BIOLOGICAL MARKER; PERFORIN;

ADULT; ARTICLE; CELL GRANULE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENDOCRINE FUNCTION; FATIGUE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANTIGENS, CD; COHORT STUDIES; CYTOPLASMIC GRANULES; CYTOTOXICITY TESTS, IMMUNOLOGIC; FATIGUE SYNDROME, CHRONIC; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 28344433673     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02935.x     Document Type: Article

References (37)

1. Fukuda K, Straus SE, Hickie I et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994; 121:953-9.
2. Reyes M, Nisenbaum R, Hoaglin DC et al. Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas. Arch Intern Med 2003; 163:1530-6.
3. Jason LA, Richman JA, Rademaker AW et al. A community-based study of chronic fatigue syndrome. Arch Intern Med 1999; 159:2129-37.
4. Reyes M, Dobbins JG, Nisenbaum R, Subedar NS, Randall B, Reeves WC. Chronic fatigue syndrome progression and self-defined recovery: evidence from the CDC surveillance system. J Chronic Fatigue Syndrome 1999; 5:17-27.
5. Hill NF, Tiersky LA, Scavalla VR, Lavietes M, Natelson BH. Natural history of severe chronic fatigue syndrome. Arch Phys Med Rehabil 1999; 80:1090-4.
6. Klimas NG, Salvato FR, Morgan R, Fletcher MA. Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol 1990; 28:1403-10.
7. Maher K, Klimas NG, Fletcher MA. Immunology. In: Jason L, Fennell P, Taylor R, eds. Handbook of chronic fatigue syndrome. Hoboken, NJ: John Wiley and Sons, 2003:124-51.
8. Caligiuri M, Murray C, Buchwald D et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol 1987; 139:3306-13.
9. Fletcher MA, Maher K, Klimas NG. Natural killer cell function in chronic fatigue syndrome. Clin Appl Immunol Rev 2002; 2:129-39.
10. + T-cell determinations in persons infected with human immunodeficiency virus (HIV). MMWR 1997; 46:1-29.
11. Maher KJ, Klimas NG, Hurwitz B, Schiff R, Fletcher MA. Quantitative fluorescence measures for the determination of intracellular perform content. Clin Diagn Lab Immunol 2002; 9:1248-52.
12. Patarca R, Fletcher MA, Podack E. Cytotoxic lymphocytes. In: Rose N, deMacario E, Folds J, Lane HC, Nakamura R, eds. Manual of clinical laboratory immunology, 5th edn. Washington, DC: ASM Press, 1997:29-303.
13. Plioplys A. Differential diagnosis in medical assessment. In: Jason L, Fennell P, Taylor R, eds. Handbook of chronic fatigue syndrome. Hoboken, NJ: John Wiley and Sons, 2003:26-41.
14. Landay AL, Jessop C, Lennette ET, Levy JA. Chronic fatigue syndrome: clinical condition associated with immune activation. Lancet 1991; 338:707-12.
15. Skowera A, Cleare A, Blair D, Bevis L, Wessely SC, Peakman M. High levels of type 2 cytokine-producing cells in chronic fatigue syndrome. Clin Exp Immunol 2004; 135:294-302.
16. Gupta S, Aggarwal S, See D, Starr A. Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome. J Psych Res 1997; 31:149-56.
17. Patarca R, Klimas NG, Lugtendorf S et al. Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression. Clin Infect Dis 1994; 18:8147-53.
18. Kameoka J, Tanaka T, Nojima Y, et al. Direct association of adenocine diaminase with T cell activation antigen, CD26. Science 1994; 261:466-70.
19. Boonacker E, Van Noorden CJ. The multifunctional or moonlighting protein CD26/DPPIV. Eur J Cell Biol 2003; 82:53-73.
20. Moretta L, Bottino D, Pende MC et al. Human natural killer cells: their origin, receptors and function. Eur J Immunol 2002; 32:1205-11.
21. Barry M, Bleackley R. Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol 2002; 2:401-9.
22. Steinau M, Unger ER, Vernon SD et al. Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome. J Mol Med 2004; 82:750-5.
23. Kagi D, Ledermann B, Burki K et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994; 369:31-7.
24. + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur J Immunol 1994; 24:3068-72.
25. + T cells or perform. J Virol 1997; 71:1808-13.
26. + T cells by perform. Eur J Immunol 1999; 29:3262-72.
27. Sambhara S, Switzer I, Kurichh A et al. Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice. Cell Immunol 1998; 187:13-18.
28. Kehren J, Desvignes C, Krasteva M et al. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. J Exp Med 1999; 189:779-86.
29. + T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med 1998; 187:1903-20.
30. Sower LE, Klimpel GR, Hanna W et al. Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell Immunol 1996; 171:159-63.
31. Stepp SE, Dufourcq-Lagelouse R, Le Deist F et al. Perform gene defects in familial hemophagocytic lymphohistiocytosis. Science 1999; 286:1957-9.
32. Henter JI, Elinder G, Soder O et al. Hypercytokinemia in familial hemophagocytic lymphohistiocytosis. Blood 1991; 78:2918-22.
33. Arico M, Janka G, Fischer A et al. Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry. FHL Study Group of the Histiocyte Society. Leukemia 1996; 10:197-203.
34. Sullivan KE, Delaar CA, Douglas S et al. Defective natural killer cell function in patients with hemophagocytic lymphohistiocytosis and in first degree relatives. Pediatr Res 1998; 44:465-8.
35. + peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection. J Hepatol 2002; 37:514-22.
36. Matloubian M, Suresh M, Glass A et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol 1999; 73:2527-36.
37. Henter JI, Ehrnst A, Andersson J et al. Familial hemophagocytic lymphohistiocytosis and viral infections. Acta Pediatr 1993; 82:369-72.