The C609T inborn polymorphism in NAD(P)H: Quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease

Free Radical Biology and Medicine

Volumn 51, Issue 3, 2011, Pages 713-718

  Stavropoulou, Chrysa ^a   Zachaki, Sophia ^a   Alexoudi, Athanasia ^b   Chatzi, Ioanna ^b   Georgakakos, Vasileios N ^a   Terzoudi, Georgia I ^a   Pantelias, Gabriel E ^a   Karageorgiou, Clementine E ^b   Sambani, Constantina ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b G GENNIMATAS GENERAL HOSPITAL   (Greece)

Author keywords

Free radicals; Genetic polymorphism; Multiple sclerosis; NAD(P)H:quinone oxidoreductase 1; Oxidative stress; Susceptibility

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); NQO1 PROTEIN, HUMAN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE PREDISPOSITION; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; CASE CONTROL STUDY; ENZYMOLOGY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RISK; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MUTATION; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATIVE STRESS; POLYMORPHISM, GENETIC; RISK; SEX FACTORS;

EID: 79960012015     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.043     Document Type: Article

References (30)

1. G.C. Ebers, and A.D. Sadovnick Epidemiology D.W. Paty, G.C. Ebers, Multiple Sclerosis 1998 Davis Philadelphia 16
2. L.M. Sayre, G. Perry, and M.A. Smith Oxidative stress and neurotoxicity Chem. Res. Toxicol. 21 2008 172 188 (Pubitemid 351219718)
3. Y. Liu, B. Zhu, P. Li, D.W. Patty, and M.S. Cynader Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis Neuroreport 12 2001 1841 1845 (Pubitemid 32553694)
4. J.M. Lee, M.J. Calkins, K. Chan, Y.W. Kan, and J.A. Johnson Identification of the NF-E2-related factor-2 dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis J. Biol. Chem. 278 2003 12029 12038 (Pubitemid 36800179)
5. Y. Gilgun-Sherki, E. Melamed, and D. Offen The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy J. Neurol. 251 2004 261 268 (Pubitemid 38387142)
6. A. Sidoti, C. Antognelli, C. Rinaldi, R. D'Angelo, V. Dattola, P. Girlanda, V. Talesa, and A. Amato Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility factors of multiple sclerosis? Mult. Scler. 13 2007 446 453 (Pubitemid 46796504)
7. G. Schreibelt, J.V. van Horssen, S. van Rossum, C.D. Dijkstra, B. Drukarch, and H.H. de Vries Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology Brain Res. Rev. 56 2007 322 330 (Pubitemid 350166526)
8. R.E. Gonsette Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity J. Neurol. Sci. 274 2008 48 53
9. J. Van Horssen, G. Schreibelt, L. Bö, L. Montagne, B. Drukarch, F.L. van Muiswinkel, and H.E. de Vries NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis Free Radic. Biol. 41 2006 311 317 (Pubitemid 43928505)
10. E. Niki Assessment of antioxidant capacity in vitro and in vivo Free Radic. Biol. 49 2010 503 515
11. F.L. Van Muiswinkel, and H.B. Kuiperij The Nrf2-ARE signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders Curr. Drug Targets CNS Neurol. Disord. 4 2005 267 281 (Pubitemid 40754162)
12. D. Siegel, D.L. Gustafson, D.L. Dehn, J.Y. Han, P. Boonchoong, L.J. Berliner, and D. Ross NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger Mol. Pharmacol. 65 2004 1238 1247 (Pubitemid 38543494)
13. D. Ross, J.K. Kepa, S.L. Winski, H.D. Beall, A. Anwar, and D. Siegel NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms Chem. Biol. Interact. 129 2000 77 97 (Pubitemid 32061055)
14. K.S. SantaCruz, E. Yazlovitskaya, J. Collins, J. Johnson, and C. DeCarli Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease Neurobiol. Aging 25 2004 63 69 (Pubitemid 37522194)
15. R.D. Traver, T. Horikoshi, K.D. Danenberg, T.H. Stadlbauer, P.V. Danenberg, D. Ross, and N.W. Gibson NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity Cancer Res. 52 1992 797 802
16. B.L. Kuehl, J.W. Paterson, J.W. Peacock, M.C. Paterson, and A.M. Rauth Presence of a heterozygous substitution and its relationship to DT-diaphorase activity Br. J. Cancer 72 1995 555 561
17. D.W. Nebert, A.L. Roe, S.E. Vandale, E. Bingham, and G.G. Oakley NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review Genet. Med. 4 2002 62 70 (Pubitemid 44698580)
18. A.T. Dinkova-Kostova, and P. Talalay Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen Free Radic. Biol. Med. 29 2000 231 240
19. J.T. Bian, H.L. Zhao, Z.X. Zhang, X.H. Bi, and J.W. Zhang Association of NAD(P)H:quinone oxidoreductase 1 polymorphism and Alzheimer's disease in Chinese J. Mol. Neurosci. 34 2008 235 240
20. M. Shao, Z. Liu, E. Tao, and B. Chen Polymorphism of MAO-B gene and NAD(P)H:quinone oxidoreductase gene in Parkinson's disease [in Chinese] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18 2001 122 124
21. W.I. McDonald, A. Comptson, G. Edan, D. Goodkin, H.P. Hartung, F.D. Lublin, H.F. McFarland, D.W. Paty, C.S.C. Polman, M. Sandberg-Wollheim, W. Sibley, A. Thomptson, S. van den Noort, B.Y. Weinshenker, and J.S. Wolinsky Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis Ann. Neurol. 50 2001 121 127
22. J.F. Kurtzke Disability rating scales in multiple sclerosis Ann. N. Y. Acad. Sci. 436 1984 347 360 (Pubitemid 15102057)
23. F.D. Lublin, and S.C. Reingold Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis Neurology 46 1996 907 911
24. A.K. Raina, D.J. Templeton, J.C. Deak, G. Perry, and M.A. Smith Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease Redox Rep. 4 1999 23 27 (Pubitemid 29296777)
25. L. Tajouri, A.S. Mellick, K.J. Ashton, A.E. Tannenberg, R.M. Nagra, W.W. Tourtellote, and L.R. Griffiths Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis Brain Res. Mol. Brain Res. 119 2003 170 183 (Pubitemid 37415090)
26. M. Koch, G.S.M. Ramsaransing, A.V. Arutjunyan, M. Stepanov, A. Teelken, D.J. Heersema, and J. De Keyser Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis J. Neurol. 253 2006 483 487 (Pubitemid 43965614)
27. M. Koch, J. Mostert, A.V. Arutjunyan, M. Stepanov, A. Teelken, and D. Heersema Plasma lipid peroxidation and progression of disability in multiple sclerosis Eur. J. Neurol. 14 2007 529 533 (Pubitemid 46587841)
28. M. Koch, J. Mostert, A.V. Arutjunyan, M. Stepanov, A. Teelken, D. Heersema, and J. De Keyser Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis Mult. Scler. 14 2008 159 165 (Pubitemid 351639623)
29. K.S. Ahn, G. Sethi, A.K. Jain, A.K. Jaiswal, and B.B. Aggarwal Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-κB, IκBα kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis J. Biol. Chem. 281 2006 19798 19808 (Pubitemid 44065754)
30. C.C. Whitacre, S.C. Reingold, and P.A. O'Looney A gender gap in autoimmunity Science 283 1999 1277 1278 (Pubitemid 129507205)