Sex steroids in Sjögren's syndrome

Journal of Autoimmunity

Volumn 39, Issue 1-2, 2012, Pages 49-56

  Konttinen, Yrjö T ^a,b,c   Fuellen, Georg ^d   Bing, Yan ^e   Porola, Pauliina ^a,f   Stegaev, Vasily ^a,f   Trokovic, Nina ^a,f   Falk, Steffi S I ^d   Liu, Yi ^e   Szodoray, Peter ^g   Takakubo, Yuya ^a,h  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b ORTON ORTHOPAEDIC HOSPITAL   (Finland)

^c COXA Hospital for Joint Replacement ^*  (Finland)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e SICHUAN UNIVERSITY   (China)

^f UNIVERSITY OF HELSINKI   (Finland)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

^h YAMAGATA UNIVERSITY   (Japan)

Author keywords

17 Estradiol; Dehydroepiandrosterone; Dihydrotestosterone; Intracrinology; T cell receptors; Toll like receptors

Indexed keywords

ANDROGEN; ANDROSTANOLONE; B LYMPHOCYTE RECEPTOR; ESTROGEN; LAMININ; LAMININ 111; LAMININ 211; PRASTERONE; SEX HORMONE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 2;

ACINAR CELL; ADRENAL GLAND; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CATALYSIS; CLIMACTERIUM; EXOCRINE GLAND; GONAD; HUMAN; MENOPAUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY CELL; SJOEGREN SYNDROME;

ACINAR CELLS; ANIMALS; APOPTOSIS; DEHYDROEPIANDROSTERONE; DIHYDROTESTOSTERONE; ESTROGENS; EXOCRINE GLANDS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MICE; PROTEIN ISOFORMS; SJOGREN'S SYNDROME;

EID: 84862807929     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.01.004     Document Type: Article

References (31)

1. Konttinen Y.T., Spaan M., Stegaev V., Porola P., Lorés M., Vivó A., et al. Female dominance in Sjögren's syndrome - a paradox and a new paradigm. Sjögren's syndrome and associated disorders 2009, 59-77. Transworld Research Network, Kerala. M. Zeher, P. Szodoray (Eds.).
2. Konttinen Y.T., Käsnä-Ronkainen L. Sjögren's syndrome: viewpoint on pathogenesis. One of the reasons I was never asked to write a textbook chapter on it. Scand J Rheumatol 2002, 116:15-22.
3. Båve U., Nordmark G., Lövgren T., Rönnelid J., Cajander S., Eloranta M.-L., et al. Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum 2005, 52:1185-1195.
4. Gottenberg J.E., Cagnard N., Lucchesi C., Letourneur F., Mistou S., Lazure T., et al. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. Proc Natl Acad Sci U S A 2006, 103:2770-2775.
5. Lövgren T., Eloranta M.L., Kastner B., Wahren-Herlenius M., Alm G.V., Rönnblom L. Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. Arthritis Rheum 2006, 54:1917-1927.
6. Mavragani C.P., Crow M.K. Activation of the type I interferon pathway in primary Sjogren's syndrome. J Autoimmun 2010, 35:225-231.
7. Crow M.K. Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res Ther 2010, 12(Suppl. 1):S5.
8. Shim G.J., Warner M., Kim H.J., Andersson S., Liu L., Ekman J., et al. Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome. Proc Natl Acad Sci U S A 2004, 101:12628-12633.
9. Ishimaru N., Arakaki R., Watanabe M., Kobayashi M., Miyazaki K., Hayashi Y. Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background. Am J Pathol 2003, 163:1481-1490.
10. Laroche M., Borg S., Lassoued S., De Lafontan B., Roché H. Joint pain with aromatase inhibitors: abnormal frequency of Sjögren's syndrome. J Rheumatol 2007, 34:2259-2263.
11. Valtysdóttir S.T., Wide L., Hällgren R. Low serum dehydroepiandrosterone sulfate in women with primary Sjögren's syndrome as an isolated sign of impaired HPA axis function. J Rheumatol 2001, 28:1259-1265.
12. Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog Brain Res 2010, 182:97-148.
13. Re R.N., Cook J.L. Noncanonical intracrine action. J Am Soc Hypertens 2011, 5:435-448.
14. Werman A., Werman-Venkert R., White R., Lee J.K., Werman B., Krelin Y., et al. The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A 2004, 101:2434-2439.
15. Hammes A., Andreassen T.K., Spoelgen R., Raila J., Hubner N., Schulz H., et al. Role of endocytosis in cellular uptake of sex steroids. Cell 2005, 122:751-762.
16. Grube M., Reuther S., Meyer Zu, Schwabedissen H., Köck K., Draber K., et al. Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug Metab Dispos 2007, 35:30-35.
17. Spaan M., Porola P., Laine M., Rozman B., Azuma M., Konttinen Y.T. Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjögren's syndrome. J Cell Mol Med 2009, 13:1261-1270.
18. Välimaa H., Savolainen S., Soukka T., Silvoniemi P., Mäkelä S., Kujari H., et al. Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. J Endocrinol 2004, 180:55-62.
19. Agha-Hosseini F., Mirzaii-Dizgah I., Mansourian A., Khayamzadeh M. Relationship of stimulated saliva 17beta-estradiol and oral dryness feeling in menopause. Maturitas 2009, 62:197-199.
20. Konttinen Y.T., Porola P., Konttinen L., Laine M., Poduval P. Immunohistopathology of Sjögren's syndrome. Autoimmun Rev 2006, 6:16-20.
21. Hartkamp A., Geenen R., Godaert G.L., Bootsma H., Kruize A.A., Bijlsma J.W., et al. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. Ann Rheum Dis 2008, 67:91-97.
22. Virkki L.M., Porola P., Forsblad D'Elia H., Valtysdottir S., Solovieva S.A., Konttinen Y.T. Dehydroepiandrosterone (DHEA) substitution treatment in severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome. Arthritis Care Res 2010, 62:118-124.
23. Nussey S.S., Whitehead S.A. Endocrinology: an integrated approach 2001, Taylor Francis, London.
24. Porola P., Virkki L., Przybyla B.D., Laine L., Pattersson T.A., Pihakari A., et al. Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjögren's syndrome. J Rheumatol 2008, 35:2229-2235.
25. Porola P., Straub R.H., Virkki L., Konttinen Y.T., Nordström D. Ineffectiveness of DHEA-S replacement therapy to improve local androgen deficiency in salivary glands of female patients with primary Sjögren's syndrome. Scand J Rheumatol 2011, 40:387-390.
26. Laine M., Virtanen I., Salo T., Konttinen Y.T. Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 2004, 50:3968-3973.
27. Poduval P., Sillat T., Virtanen I., Porola P., Konttinen Y.T. Abnormal basement membrane type IV collagen alpha chain composition in labial salivary glands in Sjögren's syndrome. Arthritis Rheum 2009, 60:938-945.
28. Porola P., Mackiewicz Z., Laine M., Barretto G., Stegaev V., Takakubo Y., et al. Laminin isoform profiles in salivary glands in Sjögren's syndrome. Adv Clin Chem 2011, vol. 55:35-59. Academic Press. G.S. Makowski (Ed.).
29. Porola P., Laine M., Virtanen I., Pöllänen R., Przybyla B.D., Konttinen Y.T. Androgens and integrins in salivary glands in Sjögren's syndrome. J Rheumatol 2010, 37:1181-1187.
30. De Gendt K., Swinnen J.V., Saunders P.T., Schoonjans L., Dewerchin M., Devos A., et al. Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A 2004, 101:1327-1332.
31. Routsias J.G., Tzioufas A.G. Autoimmune response and target autoantigens in Sjogren's syndrome. Eur J Clin Invest 2010, 40:1026-1036.