메뉴 건너뛰기




Volumn 13, Issue 4, 2011, Pages

Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR; ADALIMUMAB; ANTIRHEUMATIC AGENT; CYTOKINE; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; TNFR FC FUSION PROTEIN; TNFR-FC FUSION PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 79960883879     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3431     Document Type: Article
Times cited : (181)

References (52)
  • 1
    • 33645130483 scopus 로고    scopus 로고
    • Joint inflammation and cytokine inhibition in rheumatoid arthritis
    • 10.1007/s10238-006-0088-5, 16550339
    • Christodoulou C, Choy EH. Joint inflammation and cytokine inhibition in rheumatoid arthritis. Clin Exp Med 2006, 6:13-19. 10.1007/s10238-006-0088-5, 16550339.
    • (2006) Clin Exp Med , vol.6 , pp. 13-19
    • Christodoulou, C.1    Choy, E.H.2
  • 2
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • 10.1056/NEJM200103223441207, 11259725
    • Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001, 344:907-916. 10.1056/NEJM200103223441207, 11259725.
    • (2001) N Engl J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 3
    • 0142041982 scopus 로고    scopus 로고
    • TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    • 10.1038/nm939, 14520364
    • Feldmann M, Maini RN. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003, 9:1245-1250. 10.1038/nm939, 14520364.
    • (2003) Nat Med , vol.9 , pp. 1245-1250
    • Feldmann, M.1    Maini, R.N.2
  • 4
    • 33646365588 scopus 로고    scopus 로고
    • Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: Two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial
    • 10.1002/art.21655, 16572441, TEMPO Study Investigators
    • van der Heijde D, Klareskog L, Rodriguez-Valverde V, Codreanu C, Bolosiu H, Melo-Gomes J, Tornero-Molina J, Wajdula J, Pedersen R, Fatenejad S, . TEMPO Study Investigators Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: Two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. Arthritis Rheum 2006, 54:1063-1074. 10.1002/art.21655, 16572441, TEMPO Study Investigators.
    • (2006) Arthritis Rheum , vol.54 , pp. 1063-1074
    • van der Heijde, D.1    Klareskog, L.2    Rodriguez-Valverde, V.3    Codreanu, C.4    Bolosiu, H.5    Melo-Gomes, J.6    Tornero-Molina, J.7    Wajdula, J.8    Pedersen, R.9    Fatenejad, S.10
  • 5
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • 10.1002/art.21519, 16385520
    • Breedveld FC, Weisman MH, Kavanaugh AF, Cohen SB, Pavelka K, van Vollenhoven R, Sharp J, Perez JL, Spencer-Green GT. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006, 54:26-37. 10.1002/art.21519, 16385520.
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3    Cohen, S.B.4    Pavelka, K.5    van Vollenhoven, R.6    Sharp, J.7    Perez, J.L.8    Spencer-Green, G.T.9
  • 6
    • 79951689117 scopus 로고    scopus 로고
    • Long-term effectiveness and safety of TNF-blocking agents in daily clinical practive: results from the Dutch rheumatoid arthritis monitoring register
    • 10.1093/rheumatology/keq325, 21078625
    • Kievit W, Fransen J, Adang EMM, den Broeder AA, Moens HJB, Visser H, van de Laar MA, van Riel PL. Long-term effectiveness and safety of TNF-blocking agents in daily clinical practive: results from the Dutch rheumatoid arthritis monitoring register. Rheumatology 2011, 50:196-203. 10.1093/rheumatology/keq325, 21078625.
    • (2011) Rheumatology , vol.50 , pp. 196-203
    • Kievit, W.1    Fransen, J.2    Adang, E.M.M.3    den Broeder, A.A.4    Moens, H.J.B.5    Visser, H.6    van de Laar, M.A.7    van Riel, P.L.8
  • 7
    • 64549161956 scopus 로고    scopus 로고
    • Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review
    • 10.1186/ar2666, 2669237, 19368701
    • Rubbert-Roth A, Finckh A. Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review. Arthritis Res Ther 2009, 11:S1. 10.1186/ar2666, 2669237, 19368701.
    • (2009) Arthritis Res Ther , vol.11
    • Rubbert-Roth, A.1    Finckh, A.2
  • 8
    • 34248572345 scopus 로고    scopus 로고
    • Th-17 cells in the circle of immunity and autoimmunity
    • Bettelli E, Oukka M, Kuchroo VK. Th-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007, 8:345-350.
    • (2007) Nat Immunol , vol.8 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 9
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineage
    • 10.1038/ni1254, 16200070
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineage. Nat Immunol 2005, 6:1123-1132. 10.1038/ni1254, 16200070.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 10
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • 10.1038/ni1261, 1618871, 16200068
    • Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141. 10.1038/ni1261, 1618871, 16200068.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6    Wang, Y.7    Hood, L.8    Zhu, Z.9    Tian, Q.10    Dong, C.11
  • 12
    • 40649083317 scopus 로고    scopus 로고
    • Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases
    • Agarwal S, Misra R, Aggarwal A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol 2008, 35:515-519.
    • (2008) J Rheumatol , vol.35 , pp. 515-519
    • Agarwal, S.1    Misra, R.2    Aggarwal, A.3
  • 13
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • 10.1002/art.24568, 19479869
    • Shen H, Goodall JC, Gaston JSH. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum 2009, 60:1647-1656. 10.1002/art.24568, 19479869.
    • (2009) Arthritis Rheum , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Gaston, J.S.H.3
  • 14
    • 74849095189 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamn D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis
    • 10.1002/art.25043, 20039421
    • Colin EM, Asmawidjaja PS, van Hamburg JP, Mus AMC, van Driel M, Hazes JMW, van Leeuwen JP, Lubberts E. 1,25-Dihydroxyvitamn D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 2010, 62:132-42. 10.1002/art.25043, 20039421.
    • (2010) Arthritis Rheum , vol.62 , pp. 132-142
    • Colin, E.M.1    Asmawidjaja, P.S.2    van Hamburg, J.P.3    Mus, A.M.C.4    van Driel, M.5    Hazes, J.M.W.6    van Leeuwen, J.P.7    Lubberts, E.8
  • 15
    • 0035048597 scopus 로고    scopus 로고
    • IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
    • Chabaud M, Lubberts E, Joosten L, van den Berg W, Miossec P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res Ther 2001, 3:168-177.
    • (2001) Arthritis Res Ther , vol.3 , pp. 168-177
    • Chabaud, M.1    Lubberts, E.2    Joosten, L.3    van den Berg, W.4    Miossec, P.5
  • 16
    • 21644479222 scopus 로고    scopus 로고
    • Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cells and stromal cell origin
    • 10.1186/ar1733, 1175027, 15987480
    • Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, Akbar AN, Lord JM, Gordon C, Buckley CD, Salmon M. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cells and stromal cell origin. Arthritis Res Ther 2005, 7:R784-795. 10.1186/ar1733, 1175027, 15987480.
    • (2005) Arthritis Res Ther , vol.7
    • Raza, K.1    Falciani, F.2    Curnow, S.J.3    Ross, E.J.4    Lee, C.Y.5    Akbar, A.N.6    Lord, J.M.7    Gordon, C.8    Buckley, C.D.9    Salmon, M.10
  • 17
    • 0035465260 scopus 로고    scopus 로고
    • Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins1, 6, and 8 in skin and synovial fibroblasts: a possible role as a "fine-tuning cytokine" in inflammation processes
    • 10.1002/1529-0131(200109)44:9<2176::AID-ART371>3.0.CO;2-4, 11592383
    • Katz Y, Nadiv O, Beer Y. Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins1, 6, and 8 in skin and synovial fibroblasts: a possible role as a "fine-tuning cytokine" in inflammation processes. Arthritis Rheum 2001, 44:2176-2184. 10.1002/1529-0131(200109)44:9<2176::AID-ART371>3.0.CO;2-4, 11592383.
    • (2001) Arthritis Rheum , vol.44 , pp. 2176-2184
    • Katz, Y.1    Nadiv, O.2    Beer, Y.3
  • 18
    • 0036785194 scopus 로고    scopus 로고
    • Interleukin 17 synergies with tumor necrosis factor alpha to induce cartilage destruction in vitro
    • 10.1136/ard.61.10.870, 1753923, 12228154
    • Van Bezooijen RL, Van Der Wee-Pals L, Papapoulos SE, Lowik CW. Interleukin 17 synergies with tumor necrosis factor alpha to induce cartilage destruction in vitro. Ann Rheum Dis 2002, 61:870-876. 10.1136/ard.61.10.870, 1753923, 12228154.
    • (2002) Ann Rheum Dis , vol.61 , pp. 870-876
    • Van Bezooijen, R.L.1    Van Der Wee-Pals, L.2    Papapoulos, S.E.3    Lowik, C.W.4
  • 19
    • 78650764391 scopus 로고    scopus 로고
    • Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    • 10.1002/art.30093, 20954258
    • Van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AMC, Colin EM, Hazes JMW, Dolhain RJ, Lubberts E. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 2011, 63:73-83. 10.1002/art.30093, 20954258.
    • (2011) Arthritis Rheum , vol.63 , pp. 73-83
    • Van Hamburg, J.P.1    Asmawidjaja, P.S.2    Davelaar, N.3    Mus, A.M.C.4    Colin, E.M.5    Hazes, J.M.W.6    Dolhain, R.J.7    Lubberts, E.8
  • 20
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • 10.1002/art.20001, 14872510
    • Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004, 50:650-659. 10.1002/art.20001, 14872510.
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6    van den Berg, W.B.7
  • 22
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, A humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase 1 randomized double-blind, placebo-controlled, proof of concept study
    • 10.1002/art.27334, 20131262
    • Genovese MC, Van den Bosch F, Roberson SA, Bojin S, Biagini IM, Ryan P, Sloan-Lancaster J. LY2439821, A humanized anti-IL-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase 1 randomized double-blind, placebo-controlled, proof of concept study. Arthritis Rheum 2010, 62:929-939. 10.1002/art.27334, 20131262.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1    Van den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5    Ryan, P.6    Sloan-Lancaster, J.7
  • 24
    • 75749129902 scopus 로고    scopus 로고
    • Tumor necrosis factor α blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells
    • Ma HL, Napierata L, Stedman N, Benoit S, Collins M, Nickerson-Nutter C, Young DA. Tumor necrosis factor α blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. Arthritis Rheum 2010, 62:430-440.
    • (2010) Arthritis Rheum , vol.62 , pp. 430-440
    • Ma, H.L.1    Napierata, L.2    Stedman, N.3    Benoit, S.4    Collins, M.5    Nickerson-Nutter, C.6    Young, D.A.7
  • 25
    • 58149166804 scopus 로고    scopus 로고
    • Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    • 10.1084/jem.20072707, 2571924, 18936235
    • Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 2008, 205:2491-2497. 10.1084/jem.20072707, 2571924, 18936235.
    • (2008) J Exp Med , vol.205 , pp. 2491-2497
    • Notley, C.A.1    Inglis, J.J.2    Alzabin, S.3    McCann, F.E.4    McNamee, K.E.5    Williams, R.O.6
  • 27
    • 36148976803 scopus 로고    scopus 로고
    • Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis
    • 10.1007/s00296-007-0388-4, 17619881
    • Kageyama Y, Ichikawa T, Nagafusa T, Torikai E, Shimazu M, Nagano A. Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis. Rheumatol Int 2007, 28:137-143. 10.1007/s00296-007-0388-4, 17619881.
    • (2007) Rheumatol Int , vol.28 , pp. 137-143
    • Kageyama, Y.1    Ichikawa, T.2    Nagafusa, T.3    Torikai, E.4    Shimazu, M.5    Nagano, A.6
  • 28
    • 78449267111 scopus 로고    scopus 로고
    • The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in the rheumatoid arthritis patients
    • Yue C, You X, Zhao L, Wang H, Tang F, Zhang F, Zhang X, He W. The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in the rheumatoid arthritis patients. Rheumatol Int 2009, 30:1553-1557.
    • (2009) Rheumatol Int , vol.30 , pp. 1553-1557
    • Yue, C.1    You, X.2    Zhao, L.3    Wang, H.4    Tang, F.5    Zhang, F.6    Zhang, X.7    He, W.8
  • 29
    • 78549271154 scopus 로고    scopus 로고
    • Increased IL-17 production by peripheral T helper cells after tumor necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression
    • 10.1093/rheumatology/keq224, 20724433
    • Aerts NE, De Knop KJ, Leysen J, Ebo DG, Bridts CH, Weyler JJ, Stevens WJ, De Clerck LS. Increased IL-17 production by peripheral T helper cells after tumor necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression. Rheumatology 2010, 49:2264-2272. 10.1093/rheumatology/keq224, 20724433.
    • (2010) Rheumatology , vol.49 , pp. 2264-2272
    • Aerts, N.E.1    De Knop, K.J.2    Leysen, J.3    Ebo, D.G.4    Bridts, C.H.5    Weyler, J.J.6    Stevens, W.J.7    De Clerck, L.S.8
  • 31
    • 14044260093 scopus 로고    scopus 로고
    • Update on the British Society for Rheumatology guidelines for prescribing TNFalpha blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001)
    • British Society for Rheumatology Standards, Guidelines and Audit Working Group
    • Ledingham J, Deighton C, . British Society for Rheumatology Standards, Guidelines and Audit Working Group Update on the British Society for Rheumatology guidelines for prescribing TNFalpha blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001). Rheumatology (Oxford) 2005, 44:157-163. British Society for Rheumatology Standards, Guidelines and Audit Working Group.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 157-163
    • Ledingham, J.1    Deighton, C.2
  • 32
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • 10.1002/art.1780380107, 7818570
    • Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LBA, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:44-48. 10.1002/art.1780380107, 7818570.
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    van't Hof, M.A.2    Kuper, H.H.3    van Leeuwen, M.A.4    van de Putte, L.B.A.5    van Riel, P.L.6
  • 33
    • 0030068817 scopus 로고    scopus 로고
    • Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria
    • 10.1002/art.1780390105, 8546736
    • Van Gestel AM, Prevoo ML, van't Hof MA, van Rijswijk MH, van de Putte LB, van Riel PL. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria. Arthritis Rheum 1996, 39:34-40. 10.1002/art.1780390105, 8546736.
    • (1996) Arthritis Rheum , vol.39 , pp. 34-40
    • Van Gestel, A.M.1    Prevoo, M.L.2    van't Hof, M.A.3    van Rijswijk, M.H.4    van de Putte, L.B.5    van Riel, P.L.6
  • 35
    • 78549270112 scopus 로고    scopus 로고
    • Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease
    • 10.1093/rheumatology/keq284, 20837500
    • Chen DY, Lan JL, Chen YM, Lin CC, Chen HH, Hsieh CW. Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease. Rheumatology 2010, 49:2305-2312. 10.1093/rheumatology/keq284, 20837500.
    • (2010) Rheumatology , vol.49 , pp. 2305-2312
    • Chen, D.Y.1    Lan, J.L.2    Chen, Y.M.3    Lin, C.C.4    Chen, H.H.5    Hsieh, C.W.6
  • 37
    • 78049495342 scopus 로고    scopus 로고
    • Etanercept (ETN) with methotrexate (MTX) is better than ETN monotherapy in patients with active rheumatoid arthritis despite MTX therapy: a randomized trial
    • 10.1007/s10165-010-0324-4, 20574649, Japan Biological Agent Study Integrated Consortium
    • Kameda H, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Takeuchi T, . Japan Biological Agent Study Integrated Consortium Etanercept (ETN) with methotrexate (MTX) is better than ETN monotherapy in patients with active rheumatoid arthritis despite MTX therapy: a randomized trial. Mod Rheumatol 2010, 20:531-538. 10.1007/s10165-010-0324-4, 20574649, Japan Biological Agent Study Integrated Consortium.
    • (2010) Mod Rheumatol , vol.20 , pp. 531-538
    • Kameda, H.1    Ueki, Y.2    Saito, K.3    Nagaoka, S.4    Hidaka, T.5    Atsumi, T.6    Tsukano, M.7    Kasama, T.8    Shiozawa, S.9    Tanaka, Y.10    Takeuchi, T.11
  • 41
    • 27644575496 scopus 로고    scopus 로고
    • Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis
    • 10.1186/ar1470, 1064895, 15642134
    • Kim KW, Cho ML, Park MK, Yoon CH, Park SH, Lee SH, Kim HY. Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis. Arthritis Res Ther 2005, 7:R139-148. 10.1186/ar1470, 1064895, 15642134.
    • (2005) Arthritis Res Ther , vol.7
    • Kim, K.W.1    Cho, M.L.2    Park, M.K.3    Yoon, C.H.4    Park, S.H.5    Lee, S.H.6    Kim, H.Y.7
  • 42
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • 10.1038/ni1488, 17581537
    • Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974. 10.1038/ni1488, 17581537.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6    Levy, D.E.7    Leonard, W.J.8    Littman, D.R.9
  • 44
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukn-17 in human T helper lymphocytes
    • 10.1002/art.22866, 2323677, 17763419
    • Chen Z, Tato CM, Muul L, Laurence A, ÓShea JJ. Distinct regulation of interleukn-17 in human T helper lymphocytes. Arthritis Rheum 2007, 56:2936-2946. 10.1002/art.22866, 2323677, 17763419.
    • (2007) Arthritis Rheum , vol.56 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    ÓShea, J.J.5
  • 45
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumor necrosis factor biologicals: results from a 24-week multicentre randomized placebo-controlled trial
    • Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, Sanchez A, Alecock E, Lee J, Kremer J. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumor necrosis factor biologicals: results from a 24-week multicentre randomized placebo-controlled trial. Ann Rheum Dis 2008, 67:1516-1523.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    van Vollenhoven, R.5    Sanchez, A.6    Alecock, E.7    Lee, J.8    Kremer, J.9
  • 46
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • 10.1038/nature05970, 17581588
    • Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448:484-487. 10.1038/nature05970, 17581588.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jäger, A.5    Strom, T.B.6    Oukka, M.7    Kuchroo, V.K.8
  • 47
    • 58749105841 scopus 로고    scopus 로고
    • IL-23 promotes maintenance but not commitment to the Th17 lineage
    • 2678905, 18941183
    • Stritesky GL, Yeh N, Kaplan MH. IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol 2008, 181:5948-5955. 2678905, 18941183.
    • (2008) J Immunol , vol.181 , pp. 5948-5955
    • Stritesky, G.L.1    Yeh, N.2    Kaplan, M.H.3
  • 48
    • 34547852171 scopus 로고    scopus 로고
    • Interleukin (IL)-23 p19 expression induced by IL-1β in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-κB and AP-1 dependent pathway
    • 10.1093/rheumatology/kem055, 17569750
    • Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM. Interleukin (IL)-23 p19 expression induced by IL-1β in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-κB and AP-1 dependent pathway. Rheumatology 2007, 46:1266-1273. 10.1093/rheumatology/kem055, 17569750.
    • (2007) Rheumatology , vol.46 , pp. 1266-1273
    • Liu, F.L.1    Chen, C.H.2    Chu, S.J.3    Chen, J.H.4    Lai, J.H.5    Sytwu, H.K.6    Chang, D.M.7
  • 49
    • 34247570854 scopus 로고    scopus 로고
    • Cells of the synovium in rheumatoid arthritis. T lymphocytes
    • 10.1186/ar2107, 1860060, 17306038
    • Lundy SK, Sarkar S, Tesmer LA, Fox DA. Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther 2007, 9:202-212. 10.1186/ar2107, 1860060, 17306038.
    • (2007) Arthritis Res Ther , vol.9 , pp. 202-212
    • Lundy, S.K.1    Sarkar, S.2    Tesmer, L.A.3    Fox, D.A.4
  • 50
    • 76649096907 scopus 로고    scopus 로고
    • Role of TL1A in the pathogenesis of rheumatoid arthritis
    • 10.4049/jimmunol.0802645, 19786547
    • Zhang J, Wang X, Fahmi H, Wojcik S, Fikes J, Yu Y, Wu J, Luo H. Role of TL1A in the pathogenesis of rheumatoid arthritis. J Immunol 2009, 183:5350-5357. 10.4049/jimmunol.0802645, 19786547.
    • (2009) J Immunol , vol.183 , pp. 5350-5357
    • Zhang, J.1    Wang, X.2    Fahmi, H.3    Wojcik, S.4    Fikes, J.5    Yu, Y.6    Wu, J.7    Luo, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.