메뉴 건너뛰기




Volumn 5, Issue FEB, 2015, Pages

Pericytes as targets in hereditary hemorrhagic telangiectasia

Author keywords

Angiogenesis; Pericyte; Rare vascular disease; Thalidomide; Transforming growth factor signaling

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; ENDOGLIN; GAP JUNCTION PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

EID: 84923608016     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2015.00037     Document Type: Review
Times cited : (44)

References (165)
  • 1
    • 33144462810 scopus 로고    scopus 로고
    • Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease
    • Abdalla, S. A., and Letarte, M. (2006). Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease. J. Med. Genet. 43, 97-110. doi: 10.1136/jmg.2005.030833
    • (2006) J. Med. Genet , vol.43 , pp. 97-110
    • Abdalla, S.A.1    Letarte, M.2
  • 2
    • 81055130456 scopus 로고    scopus 로고
    • Successful treatment of bleeding gastro intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide
    • bcr0820114585
    • Alam, M. A., Sami, S., and Babu, S. (2011). Successful treatment of bleeding gastro intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. BMJ Case Rep. 2011:bcr0820114585. doi: 10.1136/bcr.08.2011.4585
    • (2011) BMJ Case Rep , vol.2011
    • Alam, M.A.1    Sami, S.2    Babu, S.3
  • 4
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • Armulik, A., Abramsson, A., and Betsholtz, C. (2005). Endothelial/pericyte interactions. Circ. Res. 97, 512-523. doi: 10.1161/01.RES.0000182903.16652.d7
    • (2005) Circ. Res , vol.97 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 6
    • 79954461354 scopus 로고    scopus 로고
    • Pericytes and the blood-brain barrier: recent advances and implications for the delivery of CNS therapy
    • Armulik, A., Mäe, M., and Betsholtz, C. (2011). Pericytes and the blood-brain barrier: recent advances and implications for the delivery of CNS therapy. Ther. Deliv. 2, 419-422. doi: 10.4155/tde.11.23
    • (2011) Ther. Deliv , vol.2 , pp. 419-422
    • Armulik, A.1    Mäe, M.2    Betsholtz, C.3
  • 7
    • 84911484660 scopus 로고    scopus 로고
    • Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
    • Arnold, T. D., Niaudet, C., Pang, M. F., Siegenthaler, J., Gaengel, K., Jung, B., et al. (2014). Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development 141, 4489-4499. doi: 10.1242/dev.107193
    • (2014) Development , vol.141 , pp. 4489-4499
    • Arnold, T.D.1    Niaudet, C.2    Pang, M.F.3    Siegenthaler, J.4    Gaengel, K.5    Jung, B.6
  • 8
    • 0033621804 scopus 로고    scopus 로고
    • Endoglin, an ancillary TGFb receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
    • Arthur, H. M., Ure, J., Smith, A. J., Renforth, G., Wilson, D. I., Torsney, E., et al. (2000). Endoglin, an ancillary TGFb receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev. Biol. 217, 42-53. doi: 10.1006/dbio.1999.9534
    • (2000) Dev. Biol , vol.217 , pp. 42-53
    • Arthur, H.M.1    Ure, J.2    Smith, A.J.3    Renforth, G.4    Wilson, D.I.5    Torsney, E.6
  • 9
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    • Bader, B. L., Rayburn, H., Crowley, D., and Hynes, R. O. (1998). Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95, 507-519. doi: 10.1016/S0092-8674(00)81618-9
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 11
    • 33644870430 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations
    • Bayrak-Toydemir, P., McDonald, J., Markewitz, B., Lewin, S., Miller, F., Chou, L. S., et al. (2006b). Genotype-phenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations. Am. J. Med. Genet. A 140, 463-470. doi: 10.1002/ajmg.a.31101
    • (2006) Am. J. Med. Genet. A , vol.140 , pp. 463-470
    • Bayrak-Toydemir, P.1    McDonald, J.2    Markewitz, B.3    Lewin, S.4    Miller, F.5    Chou, L.S.6
  • 12
    • 84883229556 scopus 로고    scopus 로고
    • Pericyte loss in diabetic retinopathy: mechanisms and consequences
    • Beltramo, E., and Porta, M. (2013). Pericyte loss in diabetic retinopathy: mechanisms and consequences. Curr. Med. Chem. 20, 3218-3225. doi: 10.2174/09298673113209990022
    • (2013) Curr. Med. Chem , vol.20 , pp. 3218-3225
    • Beltramo, E.1    Porta, M.2
  • 13
    • 84859453770 scopus 로고    scopus 로고
    • Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling
    • Benedito, R., Rocha, S. F., Woeste, M., Zamykal, M., Radtke, F., Casanovas, O., et al. (2012). Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 484, 110-114. doi: 10.1038/nature10908
    • (2012) Nature , vol.484 , pp. 110-114
    • Benedito, R.1    Rocha, S.F.2    Woeste, M.3    Zamykal, M.4    Radtke, F.5    Casanovas, O.6
  • 14
    • 21644452716 scopus 로고    scopus 로고
    • Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
    • Blanco, F. J., Santibanez, J. F., Guerrero-Esteo, M., Langa, C., Vary, C. P., and Bernabeu, C. (2005). Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J. Cell. Physiol. 204, 574-584. doi: 10.1002/jcp.20311
    • (2005) J. Cell. Physiol , vol.204 , pp. 574-584
    • Blanco, F.J.1    Santibanez, J.F.2    Guerrero-Esteo, M.3    Langa, C.4    Vary, C.P.5    Bernabeu, C.6
  • 15
    • 8644256840 scopus 로고    scopus 로고
    • BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    • Beppu, H., Ichinose, F., Kawai, N., Jones, R. C., Yu, P. B., Zapol, W. M., et al. (2004). BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L1241-L1247. doi: 10.1152/ajplung.00239.2004
    • (2004) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.287 , pp. L1241-L1247
    • Beppu, H.1    Ichinose, F.2    Kawai, N.3    Jones, R.C.4    Yu, P.B.5    Zapol, W.M.6
  • 16
    • 33745700371 scopus 로고    scopus 로고
    • Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype
    • Bossler, A. D., Richards, J., George, C., Godmilow, L., and Ganguly, A. (2006). Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Hum. Mutat. 27, 667-675. doi: 10.1002/humu.20342
    • (2006) Hum. Mutat , vol.27 , pp. 667-675
    • Bossler, A.D.1    Richards, J.2    George, C.3    Godmilow, L.4    Ganguly, A.5
  • 17
    • 0032720393 scopus 로고    scopus 로고
    • A murine model of hereditary hemorrhagic telangiectasia
    • Bourdeau, A., Dumont, D. J., and Letarte, M. (1999). A murine model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 104, 1343-1351. doi: 10.1172/JCI8088
    • (1999) J. Clin. Invest , vol.104 , pp. 1343-1351
    • Bourdeau, A.1    Dumont, D.J.2    Letarte, M.3
  • 18
    • 0034443720 scopus 로고    scopus 로고
    • Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia
    • Bourdeau, A., Faughnan, M. E., and Letarte, M. (2000). Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia. Trends Cardiovasc. Med. 10, 279-285. doi: 10.1016/S1050-1738(01)00062-7
    • (2000) Trends Cardiovasc. Med , vol.10 , pp. 279-285
    • Bourdeau, A.1    Faughnan, M.E.2    Letarte, M.3
  • 19
    • 0034970744 scopus 로고    scopus 로고
    • Potential role of modifier genes influencing transforming growth factor-β1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia
    • Bourdeau, A., Faughnan, M. E., McDonald, M. L., Paterson, A. D., Wanless, I. R., and Letarte, M. (2001). Potential role of modifier genes influencing transforming growth factor-β1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia. Am. J. Pathol. 158, 2011-2020. doi: 10.1016/S0002-9440(10)64673-1
    • (2001) Am. J. Pathol , vol.158 , pp. 2011-2020
    • Bourdeau, A.1    Faughnan, M.E.2    McDonald, M.L.3    Paterson, A.D.4    Wanless, I.R.5    Letarte, M.6
  • 20
  • 21
    • 19544368642 scopus 로고    scopus 로고
    • Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch
    • Cambier, S., Gline, S., Mu, D., Collins, R., Araya, J., Dolganov, G., et al. (2005). Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am. J. Pathol. 166, 1883-1894. doi: 10.1016/S0002-9440(10)62497-2
    • (2005) Am. J. Pathol , vol.166 , pp. 1883-1894
    • Cambier, S.1    Gline, S.2    Mu, D.3    Collins, R.4    Araya, J.5    Dolganov, G.6
  • 22
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet, P., and Jain, R. K. (2011). Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-307. doi: 10.1038/nature10144
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 24
    • 38349008641 scopus 로고    scopus 로고
    • Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    • Carvalho, R. L., Itoh, F., Goumans, M. J., Lebrin, F., Kato, M., Takahashi, S., et al. (2007). Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. J. Cell Sci. 120, 4269-4277. doi: 10.1242/jcs.013169
    • (2007) J. Cell Sci , vol.120 , pp. 4269-4277
    • Carvalho, R.L.1    Itoh, F.2    Goumans, M.J.3    Lebrin, F.4    Kato, M.5    Takahashi, S.6
  • 25
    • 12344255297 scopus 로고    scopus 로고
    • Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
    • Carvalho, R. L., Jonker, L., Goumans, M. J., Larsson, J., Bouwman, P., Karlsson, S., et al. (2004). Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development 131, 6237-6247. doi: 10.1242/dev.01529
    • (2004) Development , vol.131 , pp. 6237-6247
    • Carvalho, R.L.1    Jonker, L.2    Goumans, M.J.3    Larsson, J.4    Bouwman, P.5    Karlsson, S.6
  • 26
    • 0032908432 scopus 로고    scopus 로고
    • Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    • Chang, H., Huylebroeck, D., Verschueren, K., Guo, Q., Matzuk, M. M., and Zwijsen, A. (1999). Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126, 1631-1642.
    • (1999) Development , vol.126 , pp. 1631-1642
    • Chang, H.1    Huylebroeck, D.2    Verschueren, K.3    Guo, Q.4    Matzuk, M.M.5    Zwijsen, A.6
  • 27
    • 2042462926 scopus 로고    scopus 로고
    • BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    • Chen, H., Shi, S., Acosta, L., Li, W., Lu, J., Bao, S., et al. (2004). BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development 131, 2219-2231. doi: 10.1242/dev.01094
    • (2004) Development , vol.131 , pp. 2219-2231
    • Chen, H.1    Shi, S.2    Acosta, L.3    Li, W.4    Lu, J.5    Bao, S.6
  • 28
    • 84872936093 scopus 로고    scopus 로고
    • Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain
    • Chen, W., Guo, Y., Walker, E. J., Shen, F., Jun, K., Oh, S. P., et al. (2013). Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain. Arterioscler. Thromb. Vasc. Biol. 3, 305-310. doi: 10.1161/ATVBAHA.112.300485
    • (2013) Arterioscler. Thromb. Vasc. Biol , vol.3 , pp. 305-310
    • Chen, W.1    Guo, Y.2    Walker, E.J.3    Shen, F.4    Jun, K.5    Oh, S.P.6
  • 29
    • 84877635803 scopus 로고    scopus 로고
    • Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2
    • Choi, E. J., Kim, Y. H., Choe, S. W., Tak, Y. G., Garrido-Martin, E. M., Chang, M., et al. (2013). Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2. PLoS ONE 8:e63138. doi: 10.1371/journal.pone.0063138
    • (2013) PLoS ONE , vol.8 , pp. e63138
    • Choi, E.J.1    Kim, Y.H.2    Choe, S.W.3    Tak, Y.G.4    Garrido-Martin, E.M.5    Chang, M.6
  • 30
    • 84860852036 scopus 로고    scopus 로고
    • Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse
    • Choi, E. J., Walker, E. J., Shen, F., Oh, S. P., Arthur, H. M., Young, W. L., et al. (2012). Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc. Dis. 33, 540-547. doi: 10.1159/000337762
    • (2012) Cerebrovasc. Dis , vol.33 , pp. 540-547
    • Choi, E.J.1    Walker, E.J.2    Shen, F.3    Oh, S.P.4    Arthur, H.M.5    Young, W.L.6
  • 31
    • 0141453477 scopus 로고    scopus 로고
    • Vascular endothelial growth factor serum levels are elevated in patients with hereditary hemorrhagic telangiectasia
    • Cirulli, A., Liso, A., D'Ovidio, F., Mestice, A., Pasculli, G., and Gallitelli, M. (2003). Vascular endothelial growth factor serum levels are elevated in patients with hereditary hemorrhagic telangiectasia. Acta Haematol. 110, 29-32. doi: 10.1159/000072411
    • (2003) Acta Haematol , vol.110 , pp. 29-32
    • Cirulli, A.1    Liso, A.2    D'Ovidio, F.3    Mestice, A.4    Pasculli, G.5    Gallitelli, M.6
  • 32
    • 22244449292 scopus 로고    scopus 로고
    • A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5
    • Cole, S. G., Begbie, M. E., Wallace, G. M., and Shovlin, C. L. (2005). A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5. J. Med. Genet. 42, 577-582. doi: 10.1136/jmg.2004.028712
    • (2005) J. Med. Genet , vol.42 , pp. 577-582
    • Cole, S.G.1    Begbie, M.E.2    Wallace, G.M.3    Shovlin, C.L.4
  • 33
    • 33646228404 scopus 로고    scopus 로고
    • Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish
    • Covassin, L. D., Villefranc, J. A., Kacergis, M. C., Weinstein, B. M., and Lawson, N. D. (2006). Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 103, 6554-6559. doi: 10.1073/pnas.0506886103
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 6554-6559
    • Covassin, L.D.1    Villefranc, J.A.2    Kacergis, M.C.3    Weinstein, B.M.4    Lawson, N.D.5
  • 35
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman, R., Zhou, L., Kebede, A. A., and Barres, B. A. (2010). Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468, 562-566. doi: 10.1038/nature09513
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 36
    • 42549158413 scopus 로고    scopus 로고
    • Bone morphogenetic protein-9 is a circulating vascular quiescence factor
    • David, L., Mallet, C., Keramidas, M., Lamandé, N., Gasc, J. M., Dupuis-Girod, S., et al. (2008). Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ. Res. 102, 914-922. doi: 10.1161/CIRCRESAHA.107.165530
    • (2008) Circ. Res , vol.102 , pp. 914-922
    • David, L.1    Mallet, C.2    Keramidas, M.3    Lamandé, N.4    Gasc, J.M.5    Dupuis-Girod, S.6
  • 37
    • 33847369980 scopus 로고    scopus 로고
    • Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
    • David, L., Mallet, C., Mazerbourg, S., Feige, J. J., and Bailly, S. (2007). Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109, 1953-1961. doi: 10.1182/blood-2006-07-034124
    • (2007) Blood , vol.109 , pp. 1953-1961
    • David, L.1    Mallet, C.2    Mazerbourg, S.3    Feige, J.J.4    Bailly, S.5
  • 38
    • 62649172211 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine on epistaxis and quality of life in patients with HHT: a pilot study
    • de Gussem, E. M., Snijder, R. J., Disch, F. J., Zanen, P., Westermann, C. J., and Mager, J. J. (2009). The effect of N-acetylcysteine on epistaxis and quality of life in patients with HHT: a pilot study. Rhinology 47, 85-88.
    • (2009) Rhinology , vol.47 , pp. 85-88
    • de Gussem, E.M.1    Snijder, R.J.2    Disch, F.J.3    Zanen, P.4    Westermann, C.J.5    Mager, J.J.6
  • 39
    • 68849128539 scopus 로고    scopus 로고
    • Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche
    • Díaz-Flores, L., Gutiérrez, R., Madrid, J. F., Varela, H., Valladares, F., Acosta, E., et al. (2009). Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol. Histopathol. 24, 909-969.
    • (2009) Histol. Histopathol , vol.24 , pp. 909-969
    • Díaz-Flores, L.1    Gutiérrez, R.2    Madrid, J.F.3    Varela, H.4    Valladares, F.5    Acosta, E.6
  • 40
    • 0029074681 scopus 로고
    • Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
    • Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., and Akhurst, R. J. (1995). Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121, 1845-1854.
    • (1995) Development , vol.121 , pp. 1845-1854
    • Dickson, M.C.1    Martin, J.S.2    Cousins, F.M.3    Kulkarni, A.B.4    Karlsson, S.5    Akhurst, R.J.6
  • 41
    • 84899713100 scopus 로고    scopus 로고
    • ELLIPSE Study: a Phase 1 study evaluating the tolerance of bevacizumab nasal spray in the treatment of epistaxis in hereditary hemorrhagic telangiectasia
    • Dupuis-Girod, S., Ambrun, A., Decullier, E., Samson, G., Roux, A., Fargeton, A. E., et al. (2014). ELLIPSE Study: a Phase 1 study evaluating the tolerance of bevacizumab nasal spray in the treatment of epistaxis in hereditary hemorrhagic telangiectasia. MAbs 6, 794-799. doi: 10.4161/mabs.28025
    • (2014) MAbs , vol.6 , pp. 794-799
    • Dupuis-Girod, S.1    Ambrun, A.2    Decullier, E.3    Samson, G.4    Roux, A.5    Fargeton, A.E.6
  • 42
    • 84857865784 scopus 로고    scopus 로고
    • Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output
    • Dupuis-Girod, S., Ginon, I., Saurin, J. C., Marion, D., Guillot, E., Decullier, E., et al. (2012). Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output. JAMA 307, 948-955. doi: 10.1001/jama.2012.250
    • (2012) JAMA , vol.307 , pp. 948-955
    • Dupuis-Girod, S.1    Ginon, I.2    Saurin, J.C.3    Marion, D.4    Guillot, E.5    Decullier, E.6
  • 43
    • 77957241701 scopus 로고    scopus 로고
    • Dynamics of endothelial cell behavior in sprouting angiogenesis
    • Eilken, H. M., and Adams, R. H. (2010). Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr. Opin. Cell Biol. 22, 617-625. doi: 10.1016/j.ceb.2010.08.010
    • (2010) Curr. Opin. Cell Biol , vol.22 , pp. 617-625
    • Eilken, H.M.1    Adams, R.H.2
  • 44
    • 53349108638 scopus 로고    scopus 로고
    • SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    • El-Bizri, N., Guignabert, C., Wang, L., Cheng, A., Stankunas, K., Chang, C. P., et al. (2008). SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135, 2981-2991. doi: 10.1242/dev.017863
    • (2008) Development , vol.135 , pp. 2981-2991
    • El-Bizri, N.1    Guignabert, C.2    Wang, L.3    Cheng, A.4    Stankunas, K.5    Chang, C.P.6
  • 45
    • 84872969075 scopus 로고    scopus 로고
    • Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype
    • Fang, J. S., Dai, C., Kurjiaka, D. T., Burt, J. M., and Hirschi, K. K. (2013). Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype. Arterioscler. Thromb. Vasc. Biol. 33, 362-368. doi: 10.1161/ATVBAHA.112.255950
    • (2013) Arterioscler. Thromb. Vasc. Biol , vol.33 , pp. 362-368
    • Fang, J.S.1    Dai, C.2    Kurjiaka, D.T.3    Burt, J.M.4    Hirschi, K.K.5
  • 46
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in tgf-beta signaling through Smads
    • Feng, X. H., and Derynck, R. (2005). Specificity and versatility in tgf-beta signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693. doi: 10.1146/annurev.cellbio.21.022404.142018
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 47
    • 26444609583 scopus 로고    scopus 로고
    • Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions
    • Fernandez-L, A., Sanz-Rodriguez, F., Zarrabeitia, R., Pérez-Molino, A., Hebbel, R. P., Nguyen, J., et al. (2005). Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions. Cardiovasc. Res. 68, 235-248. doi: 10.1016/j.cardiores.2005.06.009
    • (2005) Cardiovasc. Res , vol.68 , pp. 235-248
    • Fernandez-L, A.1    Sanz-Rodriguez, F.2    Zarrabeitia, R.3    Pérez-Molino, A.4    Hebbel, R.P.5    Nguyen, J.6
  • 48
    • 78650645093 scopus 로고    scopus 로고
    • Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
    • Fernández-Klett, F., Offenhauser, N., Dirnagl, U., Priller, J., and Lindauer, U. (2010). Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc. Natl. Acad. Sci. U.S.A. 107, 22290-22295. doi: 10.1073/pnas.1011321108
    • (2010) Proc. Natl. Acad. Sci. U. S. A , vol.107 , pp. 22290-22295
    • Fernández-Klett, F.1    Offenhauser, N.2    Dirnagl, U.3    Priller, J.4    Lindauer, U.5
  • 49
    • 65249173169 scopus 로고    scopus 로고
    • Endothelial-mural cell signaling in vascular development and angiogenesis
    • Gaengel, K., Genové, G., Armulik, A., and Betsholtz, C. (2009). Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 29, 630-638. doi: 10.1161/ATVBAHA.107.161521
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , pp. 630-638
    • Gaengel, K.1    Genové, G.2    Armulik, A.3    Betsholtz, C.4
  • 50
    • 84908503787 scopus 로고    scopus 로고
    • Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease
    • Gaillard, S., Dupuis-Girod, S., Boutitie, F., Rivière, S., Morinière, S., Hatron, P. Y., et al. (2014). Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease. J. Thromb. Haemost. 12, 1494-1502. doi: 10.1111/jth.12654
    • (2014) J. Thromb. Haemost , vol.12 , pp. 1494-1502
    • Gaillard, S.1    Dupuis-Girod, S.2    Boutitie, F.3    Rivière, S.4    Morinière, S.5    Hatron, P.Y.6
  • 51
    • 12144286738 scopus 로고    scopus 로고
    • A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)
    • Gallione, C. J., Repetto, G. M., Legius, E., Rustgi, A. K., Schelley, S. L., Tejpar, S., et al. (2004). A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet 363, 852-859. doi: 10.1016/S0140-6736(04)15732-2
    • (2004) Lancet , vol.363 , pp. 852-859
    • Gallione, C.J.1    Repetto, G.M.2    Legius, E.3    Rustgi, A.K.4    Schelley, S.L.5    Tejpar, S.6
  • 53
    • 84914171026 scopus 로고    scopus 로고
    • Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models-brief report
    • Garrido-Martin, E. M., Nguyen, H. L., Cunningham, T. A., Choe, S. W., Jiang, Z., Arthur, H. M., et al. (2014). Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models-brief report. Arterioscler. Thromb. Vasc. Biol. 34, 2232-2236. doi: 10.1161/ATVBAHA.114.303984
    • (2014) Arterioscler. Thromb. Vasc. Biol , vol.34 , pp. 2232-2236
    • Garrido-Martin, E.M.1    Nguyen, H.L.2    Cunningham, T.A.3    Choe, S.W.4    Jiang, Z.5    Arthur, H.M.6
  • 54
    • 84923608476 scopus 로고    scopus 로고
    • Treatment of epistaxis in hereditary hemorrhagic telangiectasia with tranexamic acid - a double-blind placebo-controlled cross-over phase IIIB study
    • Geisthoff, U. W., Seyfert, U. T., Kübler, M., Bieg, B., Plinkert, P. K., and König, J. (2014). Treatment of epistaxis in hereditary hemorrhagic telangiectasia with tranexamic acid - a double-blind placebo-controlled cross-over phase IIIB study. Thromb. Res. 134, 565-571. doi: 10.1016/j.thromres.2014.06.012
    • (2014) Thromb. Res , vol.134 , pp. 565-571
    • Geisthoff, U.W.1    Seyfert, U.T.2    Kübler, M.3    Bieg, B.4    Plinkert, P.K.5    König, J.6
  • 55
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • Gerhardt, H., and Betsholtz, C. (2003). Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 314, 15-23. doi: 10.1007/s00441-003-0745-x
    • (2003) Cell Tissue Res , vol.314 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 56
    • 0037815292 scopus 로고    scopus 로고
    • VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    • Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., et al. (2003). VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177. doi: 10.1083/jcb.200302047
    • (2003) J. Cell Biol , vol.161 , pp. 1163-1177
    • Gerhardt, H.1    Golding, M.2    Fruttiger, M.3    Ruhrberg, C.4    Lundkvist, A.5    Abramsson, A.6
  • 57
    • 0033927061 scopus 로고    scopus 로고
    • N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken
    • Gerhardt, H., Wolburg, H., and Redies, C. (2000). N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev. Dyn. 218, 472-479. doi: 10.1002/1097-0177(200007)218:3<472::AID-DVDY1008>3.0.CO;2-
    • (2000) Dev. Dyn , vol.218 , pp. 472-479
    • Gerhardt, H.1    Wolburg, H.2    Redies, C.3
  • 58
    • 80054000495 scopus 로고    scopus 로고
    • Coordinating cell behaviour during blood vessel formation
    • Geudens, I., and Gerhardt, H. (2011). Coordinating cell behaviour during blood vessel formation. Development 138, 4569-4583. doi: 10.1242/dev.062323
    • (2011) Development , vol.138 , pp. 4569-4583
    • Geudens, I.1    Gerhardt, H.2
  • 59
    • 77953067153 scopus 로고    scopus 로고
    • Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation
    • Girerd, B., Montani, D., Coulet, F., Sztrymf, B., Yaici, A., Jaïs, X., et al. (2010). Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation. Am. J. Respir. Crit. Care Med. 181, 851-861. doi: 10.1164/rccm.200908-1284OC
    • (2010) Am. J. Respir. Crit. Care Med , vol.181 , pp. 851-861
    • Girerd, B.1    Montani, D.2    Coulet, F.3    Sztrymf, B.4    Yaici, A.5    Jaïs, X.6
  • 60
    • 84903535162 scopus 로고    scopus 로고
    • Key role of the endothelial TGF-b/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension
    • Gore, B., Izikki, M., Mercier, O., Dewachter, L., Fadel, E., Humbert, M., et al. (2014). Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension. PLoS ONE 29:e100310. doi: 10.1371/journal.pone.0100310
    • (2014) PLoS ONE , vol.29 , pp. e100310
    • Gore, B.1    Izikki, M.2    Mercier, O.3    Dewachter, L.4    Fadel, E.5    Humbert, M.6
  • 61
    • 84885682688 scopus 로고    scopus 로고
    • An interim report of thalidomide for treatment of recurrent angioectasia related gastrointestinal bleeding
    • Gossage, J. R., Chamberlain, S. M., Sridhar, S., and Kumar, A. (2009). An interim report of thalidomide for treatment of recurrent angioectasia related gastrointestinal bleeding. Hemat. Meet. Rep. 2009, 3.
    • (2009) Hemat. Meet. Rep. , vol.2009 , pp. 3
    • Gossage, J.R.1    Chamberlain, S.M.2    Sridhar, S.3    Kumar, A.4
  • 62
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    • Goumans, M. J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., et al. (2003). Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol. Cell 12, 817-828. doi: 10.1016/S1097-2765(03)00386-1
    • (2003) Mol. Cell , vol.12 , pp. 817-828
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Lebrin, F.4    Larsson, J.5    Mummery, C.6
  • 63
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    • Goumans, M. J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P., and ten Dijke, P. (2002). Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 21, 1743-1753. doi: 10.1093/emboj/21.7.1743
    • (2002) EMBO J , vol.21 , pp. 1743-1753
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    ten Dijke, P.6
  • 64
    • 77955854944 scopus 로고    scopus 로고
    • Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2 Sprouty4 and other interval genes
    • Govani, F. S., and Shovlin, C. L. (2010). Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes. J. Angiogenes. Res. 2:15. doi: 10.1186/2040-2384-2-15
    • (2010) J. Angiogenes. Res. , vol.2 , pp. 15
    • Govani, F.S.1    Shovlin, C.L.2
  • 65
    • 84897564199 scopus 로고    scopus 로고
    • Capillary pericytes regulate cerebral blood flow in health and disease
    • Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., et al. (2014). Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508, 55-60. doi: 10.1038/nature13165
    • (2014) Nature , vol.508 , pp. 55-60
    • Hall, C.N.1    Reynell, C.2    Gesslein, B.3    Hamilton, N.B.4    Mishra, A.5    Sutherland, B.A.6
  • 66
    • 78049253786 scopus 로고    scopus 로고
    • Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease
    • Hamilton, N. B., Attwell, D., and Hall, C. N. (2010). Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front. Neuroenergetics 2:5. doi: 10.3389/fnene.2010.00005
    • (2010) Front. Neuroenergetics. , vol.2 , pp. 5
    • Hamilton, N.B.1    Attwell, D.2    Hall, C.N.3
  • 67
    • 84907591199 scopus 로고    scopus 로고
    • VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2
    • Han, C., Choe, S. W., Kim, Y. H., Acharya, A. P., Keselowsky, B. G., Sorg, B. S., et al. (2014). VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2. Angiogenesis 17, 823-830. doi: 10.1007/s10456-014-9436-3
    • (2014) Angiogenesis , vol.17 , pp. 823-830
    • Han, C.1    Choe, S.W.2    Kim, Y.H.3    Acharya, A.P.4    Keselowsky, B.G.5    Sorg, B.S.6
  • 68
    • 58249091885 scopus 로고    scopus 로고
    • VEGF and Notch signaling: the yin and yang of angiogenic sprouting
    • Hellström, M., Phng, L. K., and Gerhardt, H. (2007). VEGF and Notch signaling: the yin and yang of angiogenic sprouting. Cell Adh. Migr. 1, 133-136. doi: 10.4161/cam.1.3.4978
    • (2007) Cell Adh. Migr , vol.1 , pp. 133-136
    • Hellström, M.1    Phng, L.K.2    Gerhardt, H.3
  • 69
    • 0042917501 scopus 로고    scopus 로고
    • Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation
    • Hirschi, K. K., Burt, J. M., Hirschi, K. D., and Dai, C. (2003). Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation. Circ. Res. 93, 429-437. doi: 10.1161/01.RES.0000091259.84556.D5
    • (2003) Circ. Res , vol.93 , pp. 429-437
    • Hirschi, K.K.1    Burt, J.M.2    Hirschi, K.D.3    Dai, C.4
  • 70
    • 50349096148 scopus 로고    scopus 로고
    • Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    • Hong, K. H., Lee, Y. J., Lee, E., Park, S. O., Han, C., Beppu, H., et al. (2008). Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 118, 722-730. doi: 10.1161/CIRCULATIONAHA.107.736801
    • (2008) Circulation , vol.118 , pp. 722-730
    • Hong, K.H.1    Lee, Y.J.2    Lee, E.3    Park, S.O.4    Han, C.5    Beppu, H.6
  • 71
    • 77949350034 scopus 로고    scopus 로고
    • Identification of a primary target of thalidomide teratogenicity
    • Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., et al. (2010). Identification of a primary target of thalidomide teratogenicity. Science 327, 1345-1350. doi: 10.1126/science.1177319
    • (2010) Science , vol.327 , pp. 1345-1350
    • Ito, T.1    Ando, H.2    Suzuki, T.3    Ogura, T.4    Hotta, K.5    Imamura, Y.6
  • 72
    • 84861810420 scopus 로고    scopus 로고
    • Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions
    • Itoh, F., Itoh, S., Adachi, T., Ichikawa, K., Matsumura, Y., Takagi, T., et al. (2012). Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. Blood 119, 5320-5328. doi: 10.1182/blood-2011-12-395772
    • (2012) Blood , vol.119 , pp. 5320-5328
    • Itoh, F.1    Itoh, S.2    Adachi, T.3    Ichikawa, K.4    Matsumura, Y.5    Takagi, T.6
  • 73
    • 67649877882 scopus 로고    scopus 로고
    • Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation
    • Itoh, F., Itoh, S., Carvalho, R. L., Adachi, T., Ema, M., Goumans, M. J., et al. (2009). Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation. Lab. Invest. 89, 800-810. doi: 10.1038/labinvest.2009.37
    • (2009) Lab. Invest , vol.89 , pp. 800-810
    • Itoh, F.1    Itoh, S.2    Carvalho, R.L.3    Adachi, T.4    Ema, M.5    Goumans, M.J.6
  • 74
    • 77957607057 scopus 로고    scopus 로고
    • Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
    • Jakobsson, L., Franco, C. A., Bentley, K., Collins, R. T., Ponsioen, B., Aspalter, I. M., et al. (2010). Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat. Cell Biol. 12, 943-953. doi: 10.1038/ncb2103
    • (2010) Nat. Cell Biol , vol.12 , pp. 943-953
    • Jakobsson, L.1    Franco, C.A.2    Bentley, K.3    Collins, R.T.4    Ponsioen, B.5    Aspalter, I.M.6
  • 75
    • 84877110299 scopus 로고    scopus 로고
    • Transforming growth factor b family members in regulation of vascular function: in the light of vascular conditional knockouts
    • Jakobsson, L., and van Meeteren, L. A. (2013). Transforming growth factor β family members in regulation of vascular function: in the light of vascular conditional knockouts. Exp. Cell Res. 319, 1264-1270. doi: 10.1016/j.yexcr.2013.02.015
    • (2013) Exp. Cell Res , vol.319 , pp. 1264-1270
    • Jakobsson, L.1    van Meeteren, L.A.2
  • 76
    • 0030050973 scopus 로고    scopus 로고
    • Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
    • Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S. J., et al. (1996). Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat. Genet. 13, 189-195. doi: 10.1038/ng0696-189
    • (1996) Nat. Genet , vol.13 , pp. 189-195
    • Johnson, D.W.1    Berg, J.N.2    Baldwin, M.A.3    Gallione, C.J.4    Marondel, I.5    Yoon, S.J.6
  • 77
    • 84883463387 scopus 로고    scopus 로고
    • Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
    • Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., et al. (2013). Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat. Genet. 45, 1077-1082. doi: 10.1038/ng.2723
    • (2013) Nat. Genet , vol.45 , pp. 1077-1082
    • Keller, A.1    Westenberger, A.2    Sobrido, M.J.3    García-Murias, M.4    Domingo, A.5    Sears, R.L.6
  • 78
    • 84865118378 scopus 로고    scopus 로고
    • BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II
    • Kim, J. H., Peacock, M. R., George, S. C., and Hughes, C. C. (2012). BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis 15, 497-509. doi: 10.1007/s10456-012-9277-x
    • (2012) Angiogenesis , vol.15 , pp. 497-509
    • Kim, J.H.1    Peacock, M.R.2    George, S.C.3    Hughes, C.C.4
  • 79
    • 73349140140 scopus 로고    scopus 로고
    • CNS pericytes: concepts, misconceptions, and a way out
    • Krueger, M., and Bechmann, I. (2010). CNS pericytes: concepts, misconceptions, and a way out. Glia 58, 1-10. doi: 10.1002/glia.20898
    • (2010) Glia , vol.58 , pp. 1-10
    • Krueger, M.1    Bechmann, I.2
  • 81
    • 0036365786 scopus 로고    scopus 로고
    • Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease
    • Kurstin, R. (2002). Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. Oncology 16, 21-24.
    • (2002) Oncology , vol.16 , pp. 21-24
    • Kurstin, R.1
  • 82
    • 84858176226 scopus 로고    scopus 로고
    • ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway
    • Larrivée, B., Prahst, C., Gordon, E., del Toro, R., Mathivet, T., Duarte, A., et al. (2012). ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev. Cell 22, 489-500. doi: 10.1016/j.devcel.2012.02.005
    • (2012) Dev. Cell , vol.22 , pp. 489-500
    • Larrivée, B.1    Prahst, C.2    Gordon, E.3    del Toro, R.4    Mathivet, T.5    Duarte, A.6
  • 83
    • 17744397294 scopus 로고    scopus 로고
    • Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
    • Larsson, J., Goumans, M. J., Sjöstrand, L. J., van Rooijen, M. A., Ward, D., and Levéen, P. (2001). Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 20, 1663-1673. doi: 10.1093/emboj/20.7.1663
    • (2001) EMBO J , vol.20 , pp. 1663-1673
    • Larsson, J.1    Goumans, M.J.2    Sjöstrand, L.J.3    van Rooijen, M.A.4    Ward, D.5    Levéen, P.6
  • 84
    • 8144230707 scopus 로고    scopus 로고
    • Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    • Lebrin, F., Goumans, M. J., Jonker, L., Carvalho, R. L., Valdimarsdottir, G., Thorikay, M., et al. (2004). Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J. 23, 4018-4028. doi: 10.1038/sj.emboj.7600386
    • (2004) EMBO J , vol.23 , pp. 4018-4028
    • Lebrin, F.1    Goumans, M.J.2    Jonker, L.3    Carvalho, R.L.4    Valdimarsdottir, G.5    Thorikay, M.6
  • 85
    • 77950538918 scopus 로고    scopus 로고
    • Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia
    • Lebrin, F., Srun, S., Raymond, K., Martin, S., van den Brink, S., Freitas, C., et al. (2010). Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat. Med. 16, 420-428. doi: 10.1038/nm.2131
    • (2010) Nat. Med , vol.16 , pp. 420-428
    • Lebrin, F.1    Srun, S.2    Raymond, K.3    Martin, S.4    van den Brink, S.5    Freitas, C.6
  • 86
    • 33846208639 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network
    • Lesca, G., Olivieri, C., Burnichon, N., Pagella, F., Carette, M. F., Gilbert-Dussardier, B., et al. (2007). Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network. Genet. Med. 9, 14-22. doi: 10.1097/GIM.0b013e31802d8373
    • (2007) Genet. Med , vol.9 , pp. 14-22
    • Lesca, G.1    Olivieri, C.2    Burnichon, N.3    Pagella, F.4    Carette, M.F.5    Gilbert-Dussardier, B.6
  • 87
    • 34250877840 scopus 로고    scopus 로고
    • Septectomy and septal dermoplasty for the treatment of severe transfusion-dependent epistaxis in patients with hereditary hemorrhagic telangiectasia and septal perforation
    • Lesnik, G. T., Ross, D. A., Henderson, K. J., Joe, J. K., Leder, S. B., White, R. I., et al. (2007). Septectomy and septal dermoplasty for the treatment of severe transfusion-dependent epistaxis in patients with hereditary hemorrhagic telangiectasia and septal perforation. Am. J. Rhinol. 21, 312-315. doi: 10.2500/ajr.2007.21.3017
    • (2007) Am. J. Rhinol , vol.21 , pp. 312-315
    • Lesnik, G.T.1    Ross, D.A.2    Henderson, K.J.3    Joe, J.K.4    Leder, S.B.5    White, R.I.6
  • 88
    • 24344461857 scopus 로고    scopus 로고
    • Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1
    • Letarte, M., McDonald, M. L., Li, C., Kathirkamathamby, K., Vera, S., Pece-Barbara, N., et al. (2005). Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1. Cardiovasc. Res. 68, 155-164. doi: 10.1016/j.cardiores.2005.04.028
    • (2005) Cardiovasc. Res , vol.68 , pp. 155-164
    • Letarte, M.1    McDonald, M.L.2    Li, C.3    Kathirkamathamby, K.4    Vera, S.5    Pece-Barbara, N.6
  • 90
    • 0033612141 scopus 로고    scopus 로고
    • Defective angiogenesis in mice lacking endoglin
    • Li, D. Y., Sorensen, L. K., Brooke, B. S., Urness, L. D., Davis, E. C., Taylor, D. G., et al. (1999). Defective angiogenesis in mice lacking endoglin. Science 284, 1534-1537. doi: 10.1126/science.284.5419.1534
    • (1999) Science , vol.284 , pp. 1534-1537
    • Li, D.Y.1    Sorensen, L.K.2    Brooke, B.S.3    Urness, L.D.4    Davis, E.C.5    Taylor, D.G.6
  • 91
    • 79952525332 scopus 로고    scopus 로고
    • Endothelial Smad4 maintains cerebrovascular integrity by activating N-Cadherin through cooperation with notch
    • Li, F., Lan, Y., Wang, Y., Wang, J., Yang, G., Meng, F., et al. (2011). Endothelial Smad4 maintains cerebrovascular integrity by activating N-Cadherin through cooperation with notch. Dev. Cell. 20, 291-302. doi: 10.1016/j.devcel.2011.01.011
    • (2011) Dev. Cell , vol.20 , pp. 291-302
    • Li, F.1    Lan, Y.2    Wang, Y.3    Wang, J.4    Yang, G.5    Meng, F.6
  • 92
    • 34548853386 scopus 로고    scopus 로고
    • Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity
    • Liu, D., Wang, J., Kinzel, B., Müeller, M., Mao, X., Valdez, R., et al. (2007). Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity. Blood 110, 1502-1510. doi: 10.1182/blood-2006-11-058594
    • (2007) Blood , vol.110 , pp. 1502-1510
    • Liu, D.1    Wang, J.2    Kinzel, B.3    Müeller, M.4    Mao, X.5    Valdez, R.6
  • 94
    • 79959409816 scopus 로고    scopus 로고
    • Msx genes define a population of mural cell precursors required for head blood vessel maturation
    • Lopes, M., Goupille, O., Saint Cloment, C., Lallemand, Y., Cumano, A., and Robert, B. (2011). Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development 138, 3055-3066. doi: 10.1242/dev.063214
    • (2011) Development , vol.138 , pp. 3055-3066
    • Lopes, M.1    Goupille, O.2    Saint Cloment, C.3    Lallemand, Y.4    Cumano, A.5    Robert, B.6
  • 95
    • 77952478858 scopus 로고    scopus 로고
    • Pathogenesis of arteriovenous malformations in the absence of endoglin
    • Mahmoud, M., Allinson, K. R., Zhai, Z., Oakenfull, R., Ghandi, P., Adams, R. H., et al. (2010). Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ. Res. 106, 1425-1433. doi: 10.1161/CIRCRESAHA.109.211037
    • (2010) Circ. Res , vol.106 , pp. 1425-1433
    • Mahmoud, M.1    Allinson, K.R.2    Zhai, Z.3    Oakenfull, R.4    Ghandi, P.5    Adams, R.H.6
  • 96
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massagué, J., and Gomis, R. R. (2006). The logic of TGFbeta signaling. FEBS Lett. 580, 2811-2820. doi: 10.1016/j.febslet.2006.04.033
    • (2006) FEBS Lett , vol.580 , pp. 2811-2820
    • Massagué, J.1    Gomis, R.R.2
  • 97
    • 77954394706 scopus 로고    scopus 로고
    • The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction
    • Mathiisen, T. M., Lehre, K. P., Danbolt, N. C., and Ottersen, O. P. (2010). The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 58, 1094-1103. doi: 10.1002/glia.20990
    • (2010) Glia , vol.58 , pp. 1094-1103
    • Mathiisen, T.M.1    Lehre, K.P.2    Danbolt, N.C.3    Ottersen, O.P.4
  • 98
    • 0028171579 scopus 로고
    • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
    • McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., et al. (1994). Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat. Genet. 8, 345-351. doi: 10.1038/ng1294-345
    • (1994) Nat. Genet , vol.8 , pp. 345-351
    • McAllister, K.A.1    Grogg, K.M.2    Johnson, D.W.3    Gallione, C.J.4    Baldwin, M.A.5    Jackson, C.E.6
  • 99
    • 34447097729 scopus 로고    scopus 로고
    • The thalidomide saga
    • Melchert, M., and List, A. (2007). The thalidomide saga. Int. J. Biochem. Cell Biol. 39, 1489-1499. doi: 10.1016/j.biocel.2007.01.022
    • (2007) Int. J. Biochem. Cell Biol , vol.39 , pp. 1489-1499
    • Melchert, M.1    List, A.2
  • 100
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas, A., and Heldin, C. H. (2005). Non-Smad TGF-beta signals. J. Cell Sci. 118, 3573-3584. doi: 10.1242/jcs.02554
    • (2005) J. Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 101
    • 84858286273 scopus 로고    scopus 로고
    • Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades
    • Moya, I. M., Umans, L., Maas, E., Pereira, P. N., Beets, K., Francis, A., et al. (2012). Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev. Cell 22, 501-514. doi: 10.1016/j.devcel.2012.01.007
    • (2012) Dev. Cell , vol.22 , pp. 501-514
    • Moya, I.M.1    Umans, L.2    Maas, E.3    Pereira, P.N.4    Beets, K.5    Francis, A.6
  • 102
    • 0037192933 scopus 로고    scopus 로고
    • The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
    • Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., et al. (2002). The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J. Cell Biol. 157, 493-507. doi: 10.1083/jcb.200109100
    • (2002) J. Cell Biol , vol.157 , pp. 493-507
    • Mu, D.1    Cambier, S.2    Fjellbirkeland, L.3    Baron, J.L.4    Munger, J.S.5    Kawakatsu, H.6
  • 103
    • 0027474157 scopus 로고
    • The versatility of microvascular pericytes: from mesenchyme to smooth muscle?
    • Nehls, V., and Drenckhahn, D. (1993). The versatility of microvascular pericytes: from mesenchyme to smooth muscle? Histochemistry 99, 1-12. doi: 10.1007/BF00268014
    • (1993) Histochemistry , vol.99 , pp. 1-12
    • Nehls, V.1    Drenckhahn, D.2
  • 104
    • 80155177915 scopus 로고    scopus 로고
    • TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development
    • Nguyen, H. L., Lee, Y. J., Shin, J., Lee, E., Park, S. O., McCarty, J. H., et al. (2011). TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab. Invest. 91, 1554-1563. doi: 10.1038/labinvest.2011.124
    • (2011) Lab. Invest , vol.91 , pp. 1554-1563
    • Nguyen, H.L.1    Lee, Y.J.2    Shin, J.3    Lee, E.4    Park, S.O.5    McCarty, J.H.6
  • 105
    • 84873693930 scopus 로고    scopus 로고
    • Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification
    • Nicolas, G., Pottier, C., Maltête, D., Coutant, S., Rovelet-Lecrux, A., Legallic, S., et al. (2013). Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification. Neurology 80, 181-187. doi: 10.1212/WNL.0b013e31827ccf34
    • (2013) Neurology , vol.80 , pp. 181-187
    • Nicolas, G.1    Pottier, C.2    Maltête, D.3    Coutant, S.4    Rovelet-Lecrux, A.5    Legallic, S.6
  • 106
    • 12944273545 scopus 로고    scopus 로고
    • Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    • Oh, S. P., Seki, T., Goss, K. A., Imamura, T., Yi, Y., Donahoe, P. K., et al. (2000). Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97, 2626-2631 doi: 10.1073/pnas.97.6.2626
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 2626-2631
    • Oh, S.P.1    Seki, T.2    Goss, K.A.3    Imamura, T.4    Yi, Y.5    Donahoe, P.K.6
  • 107
    • 0030579203 scopus 로고    scopus 로고
    • TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima, M., Oshima, H., and Taketo, M. M. (1996). TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179, 297-302. doi: 10.1006/dbio.1996.0259
    • (1996) Dev. Biol , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 108
    • 0032443086 scopus 로고    scopus 로고
    • Molecular control of vascular smooth muscle cell differentiation
    • Owens, G. K. (1998). Molecular control of vascular smooth muscle cell differentiation. Acta Physiol. Scand. 164, 623-635. doi: 10.1111/j.1365-201X.1998.tb10706.x
    • (1998) Acta Physiol. Scand , vol.164 , pp. 623-635
    • Owens, G.K.1
  • 109
    • 33749379585 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation
    • Park, C., Lavine, K., Mishina, Y., Deng, C. X., Ornitz, D. M., and Choi, K. (2006). Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development 133, 3473-3484. doi: 10.1242/dev.02499
    • (2006) Development , vol.133 , pp. 3473-3484
    • Park, C.1    Lavine, K.2    Mishina, Y.3    Deng, C.X.4    Ornitz, D.M.5    Choi, K.6
  • 110
    • 38349173601 scopus 로고    scopus 로고
    • ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
    • Park, S. O., Lee, Y. J., Seki, T., Hong, K. H., Fliess, N., Jiang, Z., et al. (2008). ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 111, 633-642. doi: 10.1182/blood-2007-08-107359
    • (2008) Blood , vol.111 , pp. 633-642
    • Park, S.O.1    Lee, Y.J.2    Seki, T.3    Hong, K.H.4    Fliess, N.5    Jiang, Z.6
  • 111
    • 70449392400 scopus 로고    scopus 로고
    • Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia
    • Park, S. O., Wankhede, M., Lee, Y. J., Choi, E. J., Fliess, N., Choe, S. W., et al. (2009). Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 119, 3487-3496. doi: 10.1172/JCI39482
    • (2009) J. Clin. Invest , vol.119 , pp. 3487-3496
    • Park, S.O.1    Wankhede, M.2    Lee, Y.J.3    Choi, E.J.4    Fliess, N.5    Choe, S.W.6
  • 112
    • 80053582147 scopus 로고    scopus 로고
    • Deep vein thrombosis induced by thalidomide to control epistaxis secondary to hereditary haemorrhagic telangiectasia
    • Penaloza, A., Vekemans, M. C., Lambert, C., and Hermans, C. (2011). Deep vein thrombosis induced by thalidomide to control epistaxis secondary to hereditary haemorrhagic telangiectasia. Blood Coagul. Fibrinolysis. 22, 616-618. doi: 10.1097/MBC.0b013e32834a040c
    • (2011) Blood Coagul. Fibrinolysis , vol.22 , pp. 616-618
    • Penaloza, A.1    Vekemans, M.C.2    Lambert, C.3    Hermans, C.4
  • 113
    • 33749860102 scopus 로고    scopus 로고
    • Bidirectional control of CNS capillary diameter by pericytes
    • Peppiatt, C. M., Howarth, C., Mobbs, P., and Attwell, D. (2006). Bidirectional control of CNS capillary diameter by pericytes. Nature 443, 700-704. doi: 10.1038/nature05193
    • (2006) Nature , vol.443 , pp. 700-704
    • Peppiatt, C.M.1    Howarth, C.2    Mobbs, P.3    Attwell, D.4
  • 114
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente, M., Gerhardt, H., and Carmeliet, P. (2011). Basic and therapeutic aspects of angiogenesis. Cell 146, 873-887. doi: 10.1016/j.cell.2011.08.039
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 115
    • 84868301370 scopus 로고    scopus 로고
    • "Sprouting angiogenesis," a reappraisal
    • Ribatti, D., and Crivellato, E. (2012). "Sprouting angiogenesis," a reappraisal. Dev. Biol. 372, 157-165. doi: 10.1016/j.ydbio.2012.09.018
    • (2012) Dev. Biol , vol.372 , pp. 157-165
    • Ribatti, D.1    Crivellato, E.2
  • 116
    • 77956563351 scopus 로고    scopus 로고
    • Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations
    • Ricard, N., Bidart, M., Mallet, C., Lesca, G., Giraud, S., Prudent, R., et al. (2010). Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations. Blood 116, 1604-1612. doi: 10.1182/blood-2010-03-276881
    • (2010) Blood , vol.116 , pp. 1604-1612
    • Ricard, N.1    Bidart, M.2    Mallet, C.3    Lesca, G.4    Giraud, S.5    Prudent, R.6
  • 117
    • 84862727268 scopus 로고    scopus 로고
    • BMP9 and BMP10 are critical for postnatal retinal vascular remodeling
    • Ricard, N., Ciais, D., Levet, S., Subileau, M., Mallet, C., Zimmers, T. A., et al. (2012). BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood 119, 6162-6171. doi: 10.1182/blood-2012-01-407593
    • (2012) Blood , vol.119 , pp. 6162-6171
    • Ricard, N.1    Ciais, D.2    Levet, S.3    Subileau, M.4    Mallet, C.5    Zimmers, T.A.6
  • 118
    • 84929931605 scopus 로고    scopus 로고
    • Intranasal submucosal bevacizumab for epistaxis in hereditary hemorrhagic telangiectasia: a double-blind, randomized, placebo-controlled trial
    • [Epub ahead of print]
    • Riss, D., Burian, M., Wolf, A., Kranebitter, V., Kaider, A., and Arnoldner, C. (2014). Intranasal submucosal bevacizumab for epistaxis in hereditary hemorrhagic telangiectasia: a double-blind, randomized, placebo-controlled trial. Head Neck. doi: 10.1002/hed.23655. [Epub ahead of print].
    • (2014) Head Neck
    • Riss, D.1    Burian, M.2    Wolf, A.3    Kranebitter, V.4    Kaider, A.5    Arnoldner, C.6
  • 119
    • 0037108152 scopus 로고    scopus 로고
    • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    • Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., et al. (2002). Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16, 2684-2698. doi: 10.1101/gad.242002
    • (2002) Genes Dev , vol.16 , pp. 2684-2698
    • Ruhrberg, C.1    Gerhardt, H.2    Golding, M.3    Watson, R.4    Ioannidou, S.5    Fujisawa, H.6
  • 120
    • 0028290625 scopus 로고
    • Brief report: treatment of bleeding in hereditary hemorrhagic telangiectasia with aminocaproic acid
    • Saba, H. I., Morelli, G. A., and Logrono, L. A. (1994). Brief report: treatment of bleeding in hereditary hemorrhagic telangiectasia with aminocaproic acid. N. Engl. J. Med. 330, 1789-1790. doi: 10.1056/NEJM199406233302504
    • (1994) N. Engl. J. Med , vol.330 , pp. 1789-1790
    • Saba, H.I.1    Morelli, G.A.2    Logrono, L.A.3
  • 121
    • 59149089645 scopus 로고    scopus 로고
    • Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? Int
    • Sadick, H., Hage, J., Goessler, U., Bran, G., Riedel, F., Bugert, P., et al. (2008). Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? Int. J. Mol. Med. 22, 575-580.
    • (2008) J. Mol. Med. , vol.22 , pp. 575-580
    • Sadick, H.1    Hage, J.2    Goessler, U.3    Bran, G.4    Riedel, F.5    Bugert, P.6
  • 122
    • 21244466505 scopus 로고    scopus 로고
    • Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density
    • Sadick, H., Naim, R., Gössler, U., Hörmann, K., and Riedel, F. (2005a). Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density. Int. J. Mol. Med. 15, 15-19.
    • (2005) Int. J. Mol. Med. , vol.15 , pp. 15-19
    • Sadick, H.1    Naim, R.2    Gössler, U.3    Hörmann, K.4    Riedel, F.5
  • 123
    • 21244483045 scopus 로고    scopus 로고
    • Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression
    • Sadick, H., Riedel, F., Naim, R., Göessler, U., Hörmann, K., Hafner, M., et al. (2005b). Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression. Haematologica 90, 818-828.
    • (2005) Haematologica , vol.90 , pp. 818-828
    • Sadick, H.1    Riedel, F.2    Naim, R.3    Göessler, U.4    Hörmann, K.5    Hafner, M.6
  • 124
    • 0038049059 scopus 로고    scopus 로고
    • [Argon plasma coagulation and topically applied estriol Long-term results in the treatment of hereditary hemorrhagic telangiectasia of the nasal mucosa]
    • Sadick, H., Riedel, F., Oulmi, J., Hörmann, K., and Bergler, W. F. (2003). [Argon plasma coagulation and topically applied estriol. Long-term results in the treatment of hereditary hemorrhagic telangiectasia of the nasal mucosa]. HNO 51, 118-124. doi: 10.1007/s00106-002-0666-0
    • (2003) HNO , vol.51 , pp. 118-124
    • Sadick, H.1    Riedel, F.2    Oulmi, J.3    Hörmann, K.4    Bergler, W.F.5
  • 125
    • 84890576583 scopus 로고    scopus 로고
    • Pericyte loss influences Alzheimer-like neurodegeneration in mice
    • Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., et al. (2013). Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat. Commun. 4, 2932. doi: 10.1038/ncomms3932
    • (2013) Nat. Commun. , vol.4 , pp. 2932
    • Sagare, A.P.1    Bell, R.D.2    Zhao, Z.3    Ma, Q.4    Winkler, E.A.5    Ramanathan, A.6
  • 126
    • 0024382711 scopus 로고
    • Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture
    • Sato, Y., and Rifkin, D. B. (1989). Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J. Cell Biol. 109, 309-315. doi: 10.1083/jcb.109.1.309
    • (1989) J. Cell Biol , vol.109 , pp. 309-315
    • Sato, Y.1    Rifkin, D.B.2
  • 127
    • 34247331476 scopus 로고    scopus 로고
    • BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    • Scharpfenecker, M., van Dinther, M., Liu, Z., van Bezooijen, R. L., Zhao, Q., Pukac, L., et al. (2007). BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J. Cell Sci. 120, 964-972. doi: 10.1242/jcs.002949
    • (2007) J. Cell Sci , vol.120 , pp. 964-972
    • Scharpfenecker, M.1    van Dinther, M.2    Liu, Z.3    van Bezooijen, R.L.4    Zhao, Q.5    Pukac, L.6
  • 128
    • 27744494454 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent
    • Seay, U., Sedding, D., Krick, S., Hecker, M., Seeger, W., and Eickelberg, O. (2005). Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent. J. Pharmacol. Exp. Ther. 315, 1005-1012. doi: 10.1124/jpet.105.091249
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , pp. 1005-1012
    • Seay, U.1    Sedding, D.2    Krick, S.3    Hecker, M.4    Seeger, W.5    Eickelberg, O.6
  • 129
    • 30944436695 scopus 로고    scopus 로고
    • Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development
    • Seki, T., Hong, K. H., and Oh, S. P. (2006). Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab. Invest. 86, 116-129. doi: 10.1038/labinvest.3700376
    • (2006) Lab. Invest , vol.86 , pp. 116-129
    • Seki, T.1    Hong, K.H.2    Oh, S.P.3
  • 130
    • 79959250326 scopus 로고    scopus 로고
    • Latent TGF-β structure and activation
    • Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., et al. (2011). Latent TGF-β structure and activation. Nature 474, 343-349. doi: 10.1038/nature10152
    • (2011) Nature , vol.474 , pp. 343-349
    • Shi, M.1    Zhu, J.2    Wang, R.3    Chen, X.4    Mi, L.5    Walz, T.6
  • 131
    • 84876571810 scopus 로고    scopus 로고
    • Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy
    • Shortt, J., Hsu, A. K., and Johnstone, R. W. (2013). Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy. Oncogene 32, 4191-4202. doi: 10.1038/onc.2012.599
    • (2013) Oncogene , vol.32 , pp. 4191-4202
    • Shortt, J.1    Hsu, A.K.2    Johnstone, R.W.3
  • 132
    • 77955880114 scopus 로고    scopus 로고
    • Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment
    • Shovlin, C. L. (2010). Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev. 24, 203-219. doi: 10.1016/j.blre.2010.07.001
    • (2010) Blood Rev , vol.24 , pp. 203-219
    • Shovlin, C.L.1
  • 133
    • 0022567611 scopus 로고
    • The pericyte-a review
    • Sims, M. E. (1986). The pericyte-a review. Tissue Cell 18, 53-174. doi: 10.1016/0040-8166(86)90026-1
    • (1986) Tissue Cell , vol.18 , pp. 53-174
    • Sims, M.E.1
  • 134
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal, S., Mehta, J., Desikan, R., Ayers, D., Roberson, P., Eddlemon, P., et al. (1999). Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. 341, 1565-1571. doi: 10.1056/NEJM199911183412102
    • (1999) N. Engl. J. Med , vol.341 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3    Ayers, D.4    Roberson, P.5    Eddlemon, P.6
  • 135
    • 0344111641 scopus 로고
    • Thalidomide and congenital abnormalities
    • Speirs, A. L. (1962). Thalidomide and congenital abnormalities. Lancet 1, 303-305. doi: 10.1016/S0140-6736(62)91248-5
    • (1962) Lancet , vol.1 , pp. 303-305
    • Speirs, A.L.1
  • 136
    • 52049084102 scopus 로고    scopus 로고
    • Signaling via the Tgf-β type I receptor Alk5 in heart development
    • Sridurongrit, S., Larsson, J., Schwartz, R., Ruiz-Lozano, P., and Kaartinen, V. (2008). Signaling via the Tgf-β type I receptor Alk5 in heart development. Dev. Biol. 322, 208-218. doi: 10.1016/j.ydbio.2008.07.038
    • (2008) Dev. Biol , vol.322 , pp. 208-218
    • Sridurongrit, S.1    Larsson, J.2    Schwartz, R.3    Ruiz-Lozano, P.4    Kaartinen, V.5
  • 137
    • 0037341510 scopus 로고    scopus 로고
    • A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2
    • Srinivasan, S., Hanes, M. A., Dickens, T., Porteous, M. E., Oh, S. P., Hale, L. P., et al. (2003). A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum. Mol. Genet. 12, 473-482. doi: 10.1093/hmg/ddg050
    • (2003) Hum. Mol. Genet , vol.12 , pp. 473-482
    • Srinivasan, S.1    Hanes, M.A.2    Dickens, T.3    Porteous, M.E.4    Oh, S.P.5    Hale, L.P.6
  • 138
    • 84900889870 scopus 로고    scopus 로고
    • Pericyte dynamics during angiogenesis: new insights from new identities
    • Stapor, P. C., Sweat, R. S., Dashti, D. C., Betancourt, A. M., and Murfee, W. L. (2014). Pericyte dynamics during angiogenesis: new insights from new identities. J. Vasc. Res. 51, 163-174. doi: 10.1159/000362276
    • (2014) J. Vasc. Res , vol.51 , pp. 163-174
    • Stapor, P.C.1    Sweat, R.S.2    Dashti, D.C.3    Betancourt, A.M.4    Murfee, W.L.5
  • 139
    • 84871189221 scopus 로고    scopus 로고
    • Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    • Stark, K., Eckart, A., Haidari, S., Tirniceriu, A., Lorenz, M., von Brühl, M. L., et al. (2013). Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs. Nat. Immunol. 14, 41-51. doi: 10.1038/ni.2477
    • (2013) Nat. Immunol , vol.14 , pp. 41-51
    • Stark, K.1    Eckart, A.2    Haidari, S.3    Tirniceriu, A.4    Lorenz, M.5    von Brühl, M.L.6
  • 140
    • 33847607880 scopus 로고    scopus 로고
    • The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    • Suchting, S., Freitas, C., le Noble, F., Benedito, R., Bréant, C., Duarte, A., et al. (2007). The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. U.S.A. 104, 3225-3230. doi: 10.1073/pnas.0611177104
    • (2007) Proc. Natl. Acad. Sci. U. S. A , vol.104 , pp. 3225-3230
    • Suchting, S.1    Freitas, C.2    le Noble, F.3    Benedito, R.4    Bréant, C.5    Duarte, A.6
  • 141
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., et al. (2008). Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454, 656-660. doi: 10.1038/nature07083
    • (2008) Nature , vol.454 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3    Murtomäki, A.4    Suchting, S.5    Wirzenius, M.6
  • 142
    • 66649093493 scopus 로고    scopus 로고
    • Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
    • Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D., and Vargesson, N. (2009). Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. Proc. Natl. Acad. Sci. U.S.A. 106, 8573-8578. doi: 10.1073/pnas.0901505106
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 8573-8578
    • Therapontos, C.1    Erskine, L.2    Gardner, E.R.3    Figg, W.D.4    Vargesson, N.5
  • 143
    • 0037380583 scopus 로고    scopus 로고
    • Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality
    • Torsney, E., Charlton, R., Diamond, A. G., Burn, J., Soames, J. V., and Arthur, H. M. (2003). Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality. Circulation 107, 1653-1657. doi: 10.1161/01.CIR.0000058170.92267.00
    • (2003) Circulation , vol.107 , pp. 1653-1657
    • Torsney, E.1    Charlton, R.2    Diamond, A.G.3    Burn, J.4    Soames, J.V.5    Arthur, H.M.6
  • 144
    • 84902504267 scopus 로고    scopus 로고
    • Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression
    • Tual-Chalot, S., Mahmoud, M., Allinson, K. R., Redgrave, R. E., Zhai, Z., Oh, S. P., et al. (2014). Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression. PLoS ONE 9:e98646. doi: 10.1371/journal.pone.0098646
    • (2014) PLoS ONE , vol.9 , pp. e98646
    • Tual-Chalot, S.1    Mahmoud, M.2    Allinson, K.R.3    Redgrave, R.E.4    Zhai, Z.5    Oh, S.P.6
  • 145
    • 34250844456 scopus 로고    scopus 로고
    • Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis
    • Umans, L., Cox, L., Tjwa, M., Bito, V., Vermeire, L., Laperre, K., et al. (2007). Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am. J. Pathol. 170, 1460-1472. doi: 10.2353/ajpath.2007.060839
    • (2007) Am. J. Pathol , vol.170 , pp. 1460-1472
    • Umans, L.1    Cox, L.2    Tjwa, M.3    Bito, V.4    Vermeire, L.5    Laperre, K.6
  • 146
    • 0141884395 scopus 로고    scopus 로고
    • Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse
    • Umans, L., Vermeire, L., Francis, A., Chang, H., Huylebroeck, D., and Zwijsen, A. (2003). Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis 37, 5-11. doi: 10.1002/gene.10219
    • (2003) Genesis , vol.37 , pp. 5-11
    • Umans, L.1    Vermeire, L.2    Francis, A.3    Chang, H.4    Huylebroeck, D.5    Zwijsen, A.6
  • 147
    • 0033757655 scopus 로고    scopus 로고
    • Arteriovenous malformations in mice lacking activin receptor-like kinase-1
    • Urness, L. D., Sorensen, L. K., and Li, D. Y. (2000). Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat. Genet. 26, 328-331. doi: 10.1038/81634
    • (2000) Nat. Genet , vol.26 , pp. 328-331
    • Urness, L.D.1    Sorensen, L.K.2    Li, D.Y.3
  • 149
    • 0025230351 scopus 로고
    • Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone
    • van Cutsem, E., Rutgeerts, P., and Vantrappen, G. (1990). Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone. Lancet 335, 953-955. doi: 10.1016/0140-6736(90)91010-8
    • (1990) Lancet , vol.335 , pp. 953-955
    • van Cutsem, E.1    Rutgeerts, P.2    Vantrappen, G.3
  • 151
    • 77957841685 scopus 로고    scopus 로고
    • Real prevalence of pulmonary right-to-left shunt according to genotype in patients with hereditary hemorrhagic telangiectasia: a transthoracic contrast echocardiography study
    • van Gent, M. W., Post, M. C., Snijder, R. J., Westermann, C. J., Plokker, H. W., and Mager, J. J. (2010). Real prevalence of pulmonary right-to-left shunt according to genotype in patients with hereditary hemorrhagic telangiectasia: a transthoracic contrast echocardiography study. Chest 138, 833-839. doi: 10.1378/chest.09-1849
    • (2010) Chest , vol.138 , pp. 833-839
    • van Gent, M.W.1    Post, M.C.2    Snijder, R.J.3    Westermann, C.J.4    Plokker, H.W.5    Mager, J.J.6
  • 152
  • 153
    • 82555176570 scopus 로고    scopus 로고
    • Endothelial development taking shape
    • Wacker, A., and Gerhardt, H. (2011). Endothelial development taking shape. Curr. Opin. Cell Biol. 23, 676-685. doi: 10.1016/j.ceb.2011.10.002
    • (2011) Curr. Opin. Cell Biol , vol.23 , pp. 676-685
    • Wacker, A.1    Gerhardt, H.2
  • 154
    • 84863314451 scopus 로고    scopus 로고
    • Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain
    • Walker, E. J., Su, H., Shen, F., Degos, V., Amend, G., Jun, K., et al. (2012). Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Stroke 43, 1925-1930. doi: 10.1161/STROKEAHA.111.647982
    • (2012) Stroke , vol.43 , pp. 1925-1930
    • Walker, E.J.1    Su, H.2    Shen, F.3    Degos, V.4    Amend, G.5    Jun, K.6
  • 155
    • 79952502411 scopus 로고    scopus 로고
    • Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch
    • Winkler, E. A., Bell, R. D., and Zlokovic, B. V. (2011). Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev. Cell 20, 279-280. doi: 10.1016/j.devcel.2011.03.002
    • (2011) Dev. Cell , vol.20 , pp. 279-280
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 156
    • 84902652960 scopus 로고    scopus 로고
    • The pericyte: a forgotten cell type with important implications for Alzheimer's disease?
    • Winkler, E. A., Sagare, A. P., and Zlokovic, B. V. (2014). The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 24, 371-386. doi: 10.1111/bpa.12152
    • (2014) Brain Pathol , vol.24 , pp. 371-386
    • Winkler, E.A.1    Sagare, A.P.2    Zlokovic, B.V.3
  • 157
    • 84883825716 scopus 로고    scopus 로고
    • BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia
    • Wooderchak-Donahue, W. L., McDonald, J., O'Fallon, B., Upton, P. D., Li, W., Roman, B. L., et al. (2013). BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia. Am. J. Hum. Genet. 93, 530-537. doi: 10.1016/j.ajhg.2013.07.004
    • (2013) Am. J. Hum. Genet , vol.93 , pp. 530-537
    • Wooderchak-Donahue, W.L.1    McDonald, J.2    O'Fallon, B.3    Upton, P.D.4    Li, W.5    Roman, B.L.6
  • 158
    • 1042266621 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain
    • Xu, B., Wu, Y. Q., Huey, M., Arthur, H. M., Marchuk, D. A., and Hashimoto, T. (2004). Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J. Cereb. Blood Flow Metab. 24, 237-244. doi: 10.1097/01.WCB.0000107730.66603.51
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 237-244
    • Xu, B.1    Wu, Y.Q.2    Huey, M.3    Arthur, H.M.4    Marchuk, D.A.5    Hashimoto, T.6
  • 159
    • 0032960886 scopus 로고    scopus 로고
    • Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
    • Yang, X., Castilla, L. H., Xu, X., Li, C., Gotay, J., Weinstein, M., et al. (1999). Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development 126, 1571-1580.
    • (1999) Development , vol.126 , pp. 1571-1580
    • Yang, X.1    Castilla, L.H.2    Xu, X.3    Li, C.4    Gotay, J.5    Weinstein, M.6
  • 160
    • 63249096929 scopus 로고    scopus 로고
    • Antiestrogen therapy for hereditary hemorrhagic telangiectasia: a double-blind placebo-controlled clinical trial
    • Yaniv, E., Preis, M., Hadar, T., Shvero, J., and Haddad, M. (2009). Antiestrogen therapy for hereditary hemorrhagic telangiectasia: a double-blind placebo-controlled clinical trial. Laryngoscope 119, 284-288. doi: 10.1002/lary.20065
    • (2009) Laryngoscope , vol.119 , pp. 284-288
    • Yaniv, E.1    Preis, M.2    Hadar, T.3    Shvero, J.4    Haddad, M.5
  • 161
    • 84869835182 scopus 로고    scopus 로고
    • BMP9 regulates endoglin-dependent chemokine responses in endothelial cells
    • Young, K., Conley, B., Romero, D., Tweedie, E., O'Neill, C., Pinz, I., et al. (2012). BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood 120, 4263-4273. doi: 10.1182/blood-2012-07-440784
    • (2012) Blood , vol.120 , pp. 4263-4273
    • Young, K.1    Conley, B.2    Romero, D.3    Tweedie, E.4    O'Neill, C.5    Pinz, I.6
  • 162
    • 21644447416 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    • Yu, P. B., Beppu, H., Kawai, N., Li, E., and Bloch, K. D. (2005). Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J. Biol. Chem. 280, 24443-24450. doi: 10.1074/jbc.M502825200
    • (2005) J. Biol. Chem , vol.280 , pp. 24443-24450
    • Yu, P.B.1    Beppu, H.2    Kawai, N.3    Li, E.4    Bloch, K.D.5
  • 163
    • 42949178711 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    • Yu, P. B., Deng, D. Y., Beppu, H., Hong, C. C., Lai, C., Hoyng, S. A., et al. (2008). Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J. Biol. Chem. 283, 3877-3888. doi: 10.1074/jbc.M706797200
    • (2008) J. Biol. Chem , vol.283 , pp. 3877-3888
    • Yu, P.B.1    Deng, D.Y.2    Beppu, H.3    Hong, C.C.4    Lai, C.5    Hoyng, S.A.6
  • 164
    • 0035984003 scopus 로고    scopus 로고
    • beta8 integrins are required for vascular morphogenesis in mouse embryos
    • Zhu, J., Motejlek, K., Wang, D., Zang, K., Schmidt, A., and Reichardt, L. F. (2002). beta8 integrins are required for vascular morphogenesis in mouse embryos. Development 129, 2891-2903.
    • (2002) Development , vol.129 , pp. 2891-2903
    • Zhu, J.1    Motejlek, K.2    Wang, D.3    Zang, K.4    Schmidt, A.5    Reichardt, L.F.6
  • 165
    • 84876724199 scopus 로고    scopus 로고
    • Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma
    • Zhu, Y. X., Kortuem, K. M., and Stewart, A. K. (2013). Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk. Lymphoma 54, 683-687. doi: 10.3109/10428194.2012.728597
    • (2013) Leuk. Lymphoma , vol.54 , pp. 683-687
    • Zhu, Y.X.1    Kortuem, K.M.2    Stewart, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.