The integrin ανβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1

Journal of Cell Biology

Volumn 157, Issue 3, 2002, Pages 493-507

  Mu, Dezhi ^a,d   Cambier, Stephanie ^a,d   Fjellbirkeland, Lars ^a,d   Baron, Jody L ^b   Munger, John S ^c   Kawakatsu, Hisaaki ^d   Sheppard, Dean ^a,d   Courtney Broaddus, V ^a,d   Nishimura, Stephen L ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Cell cycle; Homeostasis; Integrins; Metalloprotease; Transforming growth factor

Indexed keywords

ALPHAVBETA8 INTEGRIN; INTEGRIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; INTEGRIN ALPHAVBETA8; METALLOPROTEINASE; MMP14 PROTEIN, MOUSE; OLIGOPEPTIDE; PROTEIN; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; EPITHELIUM CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; NERVE CELL; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL DIVISION; CELL LINE; GENETIC TRANSFECTION; LUNG TUMOR; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

ANIMALS; CELL DIVISION; CELL LINE; HOMEOSTASIS; HUMANS; INTEGRINS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TNF RECEPTOR-ASSOCIATED FACTOR 2; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED;

EID: 0037192933     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109100     Document Type: Article

References (54)

1. An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
2. Cell-associated activation of latent transforming growth factor-β by catpain
3. Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model
4. Role of transforming growth factor-β in human disease
5. Transforming growth facror-β in tissue fibrosis
6. Restricted distribution of integrin β6 mRNA in primate epithelial tissues
7. Tissue inhibitors of metalloproteinases: Evolution, structure and function
8. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin ανβ3
9. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction
10. A role for the integrin ανβ8 in the negative regulation of epithelial cell growth
11. Thrombospondin-1 is a major activator of TGF-β1 in vivo
12. Functional activation of integrin αΝβ3 in tumor cells expressing membrane-type 1 matrix metalloproteinase
13. MT1-MMP initiates activation of proMMP-2 and integrin αΝβ3 promotes maturation of MMP-2 in breast carcinoma cells
14. The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
15. Low molecular weight inhibitors in corneal ulceration
16. Overview of matrix metalloproteinase expression in cultured human cells
17. Integrin signaling: Specificity and control of cell survival and cell cycle progression
18. Isolation and characterization of basal cells from human upper respiratory epithelium
19. The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma
20. Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-β1 during liver regeneration
21. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
22. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
23. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation
24. Feedback regulators in normal and tumour tissues
25. Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium
26. Mechanism of activation of latent recombinant transforming growth factor-β1 by plasmin
27. The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
28. Developmental analysis of oligodendroglial integrins in primary cells: Changes in αν-associated β subunits during differentiation
29. Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids
30. Advanced mammalian gene transfer: High titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging line
31. Cloning and expression of a divergent integrin subunit β8
32. Latent transforming growth factor-β: Structural features and mechanisms of activation
33. Interactions between growth factors and integrins: Latent forms of transforming growth factor-β are ligands for the integrin ανβ1
34. The integrin ανβ6 binds and activates latent TGF-β1: A mechanism for regulating pulmonary inflammation and fibrosis
35. Activation of latent TGF-β by thrombospondin-1: Mechanisms and physiology
36. Integrin ανβ8: Interaction with vitronectin and functional divergence of the β8 cytoplasmic domain
37. Synaptic and glial localization of the integrin ανβ8 in mouse and rat brain
38. Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
39. Monoclonal antibodies against the CD44 [In(Lu)-related p80], and Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors
40. Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo
41. Probabilistic aspects of the human cybernetic machine
42. The ADAM gene family: Surface proteins with adhesion and protease activity
43. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets
44. A matrix metalloproteinase expressed on the surface of invasive tumour cells
45. Integrins, oncogenes and anchorage independence
46. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
47. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease
48. Correlation of intrinsic chemoresistance of nonsmall-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations
49. Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets
50. Role of the integrin ανβ6 in cell attachment to fibronectin, heterologous expression of intact and secreted forms of the receptor
51. Novel purification of vitronectin from human plasma by heparin affinity chromatography
52. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
53. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
54. Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7)