Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Tual Chalot, Simon ^a   Mahmoud, Marwa ^a,d   Allinson, Kathleen R ^a   Redgrave, Rachael E ^a   Zhai, Zhenhua ^a,e   Oh, S Paul ^b   Fruttiger, Marcus ^c   Arthur, Helen M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^e JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ENDOGLIN; JAGGED1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; ACTIVIN RECEPTOR 1; ENDOGLIN PROTEIN, MOUSE; SIGNAL PEPTIDE; SMAD PROTEIN;

ADULT; ADULT ANIMAL; ANEMIA; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOVENOUS MALFORMATION; ARTICLE; CAECAL HEMORRHAGE; CECUM DISEASE; CELL PROLIFERATION; CONGENITAL BLOOD VESSEL MALFORMATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME DEFICIENCY; FETUS DISEASE; IN VIVO STUDY; LUNG HEMORRHAGE; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PERINATAL PERIOD; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA BLOOD VESSEL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR HYPERBRANCHING; VEIN MALFORMATION; ANIMAL; BLEEDING; ENDOTHELIUM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; ANIMALS, NEWBORN; ARTERIOVENOUS MALFORMATIONS; ENDOTHELIAL CELLS; ENDOTHELIUM; GENE EXPRESSION REGULATION; HEMORRHAGE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; RETINAL VESSELS; SMAD PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84902504267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098646     Document Type: Article

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