Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain

Development (Cambridge)

Volumn 141, Issue 23, 2014, Pages 4489-4499

  Arnold, Thomas D ^a,b   Niaudet, Colin ^b,e   Pang, Mei Fong ^b,f   Siegenthaler, Julie ^a   Gaengel, Konstantin ^b,e   Jung, Bongnam ^b,e   Ferrero, Gina M ^c   Mukouyama, Yoh Suke ^d,g   Fuxe, Jonas ^b   Akhurst, Rosemary ^c   Betsholtz, Christer ^b,e   Sheppard, Dean ^a   Reichardt, Louis F ^c,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

^f Princeton University   (United States)

^g Children's Hospital Colorado   (United States)

^h FLATIRON INSTITUTE   (United States)

Author keywords

Angiogenesis; Brain; CNS; Hemorrhage; Integrin V 8; Mouse; Sprouting; TGF

Indexed keywords

ALPHAVBETA5 INTEGRIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; INTEGRIN; INTEGRIN ALPHAVBETA8;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; MOUSE; NERVE SPROUTING; NEUROEPITHELIUM; NONHUMAN; PERICYTE; SIGNAL TRANSDUCTION; ANALYSIS OF VARIANCE; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; CELL COUNT; CEREBRAL HEMORRHAGE; COMPLICATION; CONFOCAL MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY; VASCULARIZATION;

MUS;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL COUNT; CEREBRAL HEMORRHAGE; ENDOTHELIAL CELLS; IMMUNOHISTOCHEMISTRY; INTEGRINS; MICE; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84911484660     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.107193     Document Type: Article

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