Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation

Laboratory Investigation

Volumn 89, Issue 7, 2009, Pages 800-810

  Itoh, Fumiko ^a   Itoh, Susumu ^a   Carvalho, Rita L C ^b   Adachi, Tomomi ^a   Ema, Masatsugu ^a   Goumans, Marie José ^c,d   Larsson, Jonas ^e   Karlsson, Stefan ^e   Takahashi, Satoru ^a   Mummery, Christine L ^b,d   Dijke, Peter Ten ^d   Kato, Mitsuyasu ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b HUBRECHT INSTITUTE   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e LUND UNIVERSITY   (Sweden)

Author keywords

ALK1; ALK5; Endothelium; TGF ; Vasculature; Yolk sac

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR LIKE KINASE 1; ALANINE; ASPARTIC ACID; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BLOOD VESSEL INJURY; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; ERYTHROID CELL; GENOTYPE; HEART DEVELOPMENT; HEMATOPOIETIC STEM CELL; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PLACENTA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; YOLK SAC;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; BLOOD VESSELS; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; FEMALE; HEART DEFECTS, CONGENITAL; HEMATOPOIETIC STEM CELLS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; YOLK SAC;

EID: 67649877882     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.37     Document Type: Article

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