Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia

Trends in Cardiovascular Medicine

Volumn 10, Issue 7, 2000, Pages 279-285

  Bourdeau, Annie ^a   Faughnan, Marie E ^b   Letarte, Michelle ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONGENITAL BLOOD VESSEL MALFORMATION; CONTROLLED STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RENDU OSLER WEBER DISEASE; SHORT SURVEY;

EID: 0034443720     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(01)00062-7     Document Type: Review

References (29)

1. Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2
2. Endoglin, an ancillary TGF beta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
3. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily
4. The activin receptor-like kinase 1 gene; genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2
5. Clinical heterogeneity in hereditary haemorrhagic telangiectasia; are pulmonary arteriovenous malformations more common in families linked to endoglin?
6. Endoglin expression is reduced in normal vessels but still detectable in arteriovenous malformations of patients with hereditary hemorrhagic telangiectasia type 1
7. A murine model of hereditary hemorrhagic telangiectasia
8. Potential role of modifier genes influencing TGF-β1 levels in the development of vascular defects in endoglin heterozygous mice with Hereditary Hemorrhagic Telangiectasia
9. Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia
10. Portal shunting and resistance to Schistosoma mansoni in 129 strain mice
11. Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin
12. Schistosoma mansoni; evidence that vascular abnormalities correlate with the 'non-permissive' trait in 129/Ola mice
13. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
14. Hereditary hemorrhagic telangiectasia
15. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
16. Endoglin modulates cellular responses to TGF-β1
17. Defective angiogenesis in mice lacking endoglin
18. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
19. Pulmonary arteriovenous malformations; cerebral ischemia and neurologic manifestations
20. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
21. Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative
22. Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1
23. Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population
24. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)
25. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia
26. Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations; issues in clinical management and review of pathogenic mechanisms
27. Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-β binding protein of endothelial and stromal cells