Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 51, 2010, Pages 22290-22295

  Fernández Klett, Francisco ^a   Offenhauser, Nikolas ^a   Dirnagl, Ulrich ^a,b   Priller, Josef ^a,b   Lindauer, Ute ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NeuroCure Research Center   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cerebral blood flow; Cortical spreading depolarization; Electrophysiology; Neurovascular coupling

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; BICUCULLINE; THROMBOXANE A2;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD FLOW; BLOOD VESSEL DIAMETER; BRAIN BLOOD FLOW; BRAIN CORTEX; CAPILLARY; DEPOLARIZATION; DRUG ACTIVITY; ERYTHROCYTE; FEMALE; HYPEREMIA; IN VIVO CULTURE; IN VIVO STUDY; MALE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PERICYTE; PRIORITY JOURNAL; SEIZURE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ARTERIOLES; BICUCULLINE; BLOOD FLOW VELOCITY; BRAIN; CAPILLARIES; CEREBROVASCULAR DISORDERS; FEMALE; GABA-A RECEPTOR ANTAGONISTS; HYPEREMIA; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PERICYTES; RECEPTORS, GABA-A; THROMBOXANE A2; VASOCONSTRICTOR AGENTS; VASODILATION;

MUS;

EID: 78650645093     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011321108     Document Type: Article

References (31)

1. Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21:1133-1145.
2. Raichle ME (1998) Behind the scenes of functional brain imaging: A historical and physiological perspective. Proc Natl Acad Sci USA 95:765-772.
3. Krogh A (1924) The Anatomy and Physiology of Capillaries (Yale Univ Press, New Haven).
4. Shepro D, Morel NM (1993) Pericyte physiology. FASEB J 7:1031-1038.
5. Schönfelder U, Hofer A, Paul M, Funk RH (1998) In situ observation of living pericytes in rat retinal capillaries. Microvasc Res 56:22-29.
6. Peppiatt CM, Howarth C, Mobbs P, Attwell D (2006) Bidirectional control of CNS capillary diameter by pericytes. Nature 443:700-704.
7. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y (1997) 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407:313-319.
8. Krueger M, Bechmann I (2010) CNS pericytes: Concepts, misconceptions, and a way out. Glia 58:1-10.
9. Hirase H, Creso J, Buzsáki G (2004) Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci. Neuroscience 128:209-216.
10. Obrig H, et al. (2000) Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults. Neuroimage 12:623-639.
11. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711.
12. Yemisci M, et al. (2009) Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 15:1031-1037.
13. Fischer EG, Ames A, 3rd, Hedley-Whyte ET, O'Gorman S (1977) Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the "noreflow phenomenon". Stroke 8:36-39.
14. Pries AR, et al. (1994) Resistance to blood flow in microvessels in vivo. Circ Res 75: 904-915.
15. Koudstaal PJ, et al. (1993) Increased thromboxane biosynthesis in patients with acute cerebral ischemia. Stroke 24:219-223.
16. Stefanovic B, et al. (2008) Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab 28:961-972.
17. Iadecola C, Yang G, Ebner TJ, Chen G (1997) Local and propagated vascular responses evoked by focal synaptic activity in cerebellar cortex. J Neurophysiol 78:651-659. (Pubitemid 27353533)
18. Erinjeri JP, Woolsey TA (2002) Spatial integration of vascular changes with neural activity in mouse cortex. J Cereb Blood Flow Metab 22:353-360.
19. Kleinfeld D, Mitra PP, Helmchen F, Denk W (1998) Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci USA 95:15741-15746.
20. Chaigneau E, Oheim M, Audinat E, Charpak S (2003) Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. Proc Natl Acad Sci USA 100:13081-13086.
21. Sheth SA, et al. (2004) Columnar specificity of microvascular oxygenation and volume responses: Implications for functional brain mapping. J Neurosci 24:634-641.
22. Woolsey TA, et al. (1996) Neuronal units linked to microvascular modules in cerebral cortex: Response elements for imaging the brain. Cereb Cortex 6:647-660.
23. Fergus A, Lee KS (1997) GABAergic regulation of cerebral microvascular tone in the rat. J Cereb Blood Flow Metab 17:992-1003.
24. Kocharyan A, Fernandes P, Tong XK, Vaucher E, Hamel E (2008) Specific subtypes of cortical GABA interneurons contribute to the neurovascular coupling response to basal forebrain stimulation. J Cereb Blood Flow Metab 28:221-231.
25. Vaucher E, Tong XK, Cholet N, Lantin S, Hamel E (2000) GABA neurons provide a rich input to microvessels but not nitric oxide neurons in the rat cerebral cortex: A means for direct regulation of local cerebral blood flow. J Comp Neurol 421:161-171.
26. Rosenblum WI (1969) Erythrocyte velocity and a velocitypulse in minute blood vessels on the surface of the mouse brain. Circ Res 24:887-892.
27. Gragera RR, Muniz E, Martínez-Rodriguez R (1993) Electron microscopic immunolocalization of GABA and glutamicacid decarboxylase (GAD) in cerebellar capillaries and their microenvironment. Cell Mol Biol (Noisy-le-grand) 39:809-817.
28. Li J, Iadecola C (1994) Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 33:1453-1461.
29. Thomsen K, Offenhauser N, Lauritzen M (2004) Principal neuron spiking: Neither necessary nor sufficient for cerebral blood flow in rat cerebellum. J Physiol 560: 181-189.
30. Dirnagl U, Villringer A, Einhäupl KM (1992) In-vivo confocal scanning laser microscopy of the cerebral microcirculation. J Microsc 165:147-157.
31. Schaffer CB, et al. (2006) Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol 4:e22.