메뉴 건너뛰기




Volumn 94, Issue 3, 2015, Pages 193-205

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

Author keywords

LYN; B cell; B cell receptor; Bruton tyrosine kinase; Ibrutinib; MiRNA; NF B; PI(3)K; Spleen tyrosine kinase; ZAP 70

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; IBRUTINIB; IDELALISIB; INTERLEUKIN 1 RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; NATALIZUMAB; PLERIXAFOR; PROTEIN KINASE LYN; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; RITUXIMAB; ANTINEOPLASTIC AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

EID: 84923407069     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12427     Document Type: Review
Times cited : (158)

References (133)
  • 1
    • 84893414788 scopus 로고    scopus 로고
    • Signaling circuits in early B-cell development
    • Reth M, Nielsen P. Signaling circuits in early B-cell development. Adv Immunol 2014;122:129-75.
    • (2014) Adv Immunol , vol.122 , pp. 129-175
    • Reth, M.1    Nielsen, P.2
  • 3
    • 33645310982 scopus 로고    scopus 로고
    • ITAM-mediated tonic signalling through pre-BCR and BCR complexes
    • Monroe JG. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat Rev Immunol 2006;6:283-94.
    • (2006) Nat Rev Immunol , vol.6 , pp. 283-294
    • Monroe, J.G.1
  • 4
    • 0027305921 scopus 로고
    • Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
    • Rawlings DJ, Saffran DC, Tsukada S, et al. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 1993;261:358-61.
    • (1993) Science , vol.261 , pp. 358-361
    • Rawlings, D.J.1    Saffran, D.C.2    Tsukada, S.3
  • 5
    • 2342667375 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling
    • Fruman DA. Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr Opin Immunol 2004;16:314-20.
    • (2004) Curr Opin Immunol , vol.16 , pp. 314-320
    • Fruman, D.A.1
  • 6
    • 0034507903 scopus 로고    scopus 로고
    • BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    • Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000;13:817-27.
    • (2000) Immunity , vol.13 , pp. 817-827
    • Okada, T.1    Maeda, A.2    Iwamatsu, A.3    Gotoh, K.4    Kurosaki, T.5
  • 7
    • 0036584284 scopus 로고    scopus 로고
    • Regulation of B-cell signal transduction by adaptor proteins
    • Kurosaki T. Regulation of B-cell signal transduction by adaptor proteins. Nat Rev Immunol 2002;2:354-63.
    • (2002) Nat Rev Immunol , vol.2 , pp. 354-363
    • Kurosaki, T.1
  • 8
    • 0032748581 scopus 로고    scopus 로고
    • Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
    • Craxton A, Jiang A, Kurosaki T, Clark EA. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt. J Biol Chem 1999;274:30644-50.
    • (1999) J Biol Chem , vol.274 , pp. 30644-30650
    • Craxton, A.1    Jiang, A.2    Kurosaki, T.3    Clark, E.A.4
  • 9
    • 0028346563 scopus 로고
    • Signal transduction by the B cell antigen receptor and its coreceptors
    • Cambier JC, Pleiman CM, Clark MR. Signal transduction by the B cell antigen receptor and its coreceptors. Annu Rev Immunol 1994;12:457-86.
    • (1994) Annu Rev Immunol , vol.12 , pp. 457-486
    • Cambier, J.C.1    Pleiman, C.M.2    Clark, M.R.3
  • 10
    • 65349191248 scopus 로고    scopus 로고
    • The role of PI3K signalling in the B cell response to antigen
    • Hodson DJ, Turner M. The role of PI3K signalling in the B cell response to antigen. Adv Exp Med Biol 2009;633:43-53.
    • (2009) Adv Exp Med Biol , vol.633 , pp. 43-53
    • Hodson, D.J.1    Turner, M.2
  • 11
    • 61849141064 scopus 로고    scopus 로고
    • Tyrosine kinases and their substrates in B lymphocytes
    • Kurosaki T, Hikida M. Tyrosine kinases and their substrates in B lymphocytes. Immunol Rev 2009;228:132-48.
    • (2009) Immunol Rev , vol.228 , pp. 132-148
    • Kurosaki, T.1    Hikida, M.2
  • 13
    • 0028073936 scopus 로고
    • Functional analysis of Csk in signal transduction through the B-cell antigen receptor
    • Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H. Functional analysis of Csk in signal transduction through the B-cell antigen receptor. Mol Cell Biol 1994;14:7306-13.
    • (1994) Mol Cell Biol , vol.14 , pp. 7306-7313
    • Hata, A.1    Sabe, H.2    Kurosaki, T.3    Takata, M.4    Hanafusa, H.5
  • 14
    • 0031569176 scopus 로고    scopus 로고
    • Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells
    • Pao LI, Cambier JC. Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. J Immunol 1997;158:2663-9.
    • (1997) J Immunol , vol.158 , pp. 2663-2669
    • Pao, L.I.1    Cambier, J.C.2
  • 15
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo LD, Donner DB. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci 2002;27:462-7.
    • (2002) Trends Biochem Sci , vol.27 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 16
    • 0034194516 scopus 로고    scopus 로고
    • Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5′ inositol phosphatase (SHIP)
    • Brauweiler A, Tamir I, Dal Porto J, Benschop RJ, Helgason CD, Humphries RK, Freed JH, Cambier JC. Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5′ inositol phosphatase (SHIP). J Exp Med 2000;191:1545-54.
    • (2000) J Exp Med , vol.191 , pp. 1545-1554
    • Brauweiler, A.1    Tamir, I.2    Dal Porto, J.3    Benschop, R.J.4    Helgason, C.D.5    Humphries, R.K.6    Freed, J.H.7    Cambier, J.C.8
  • 17
    • 0031172446 scopus 로고    scopus 로고
    • Immunoreceptor tyrosine-based inhibition motifs
    • Vivier E, Daeron M. Immunoreceptor tyrosine-based inhibition motifs. Immunol Today 1997;18:286-91.
    • (1997) Immunol Today , vol.18 , pp. 286-291
    • Vivier, E.1    Daeron, M.2
  • 18
    • 0035127225 scopus 로고    scopus 로고
    • New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs
    • Nitschke L, Floyd H, Crocker PR. New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs. Scand J Immunol 2001;53:227-34.
    • (2001) Scand J Immunol , vol.53 , pp. 227-234
    • Nitschke, L.1    Floyd, H.2    Crocker, P.R.3
  • 19
    • 77953897004 scopus 로고    scopus 로고
    • Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling
    • Liu W, Meckel T, Tolar P, Sohn HW, Pierce SK. Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling. Immunity 2010;32:778-89.
    • (2010) Immunity , vol.32 , pp. 778-789
    • Liu, W.1    Meckel, T.2    Tolar, P.3    Sohn, H.W.4    Pierce, S.K.5
  • 21
    • 77953536657 scopus 로고    scopus 로고
    • Organisation and dynamics of antigen receptors: implications for lymphocyte signalling
    • Treanor B, Batista FD. Organisation and dynamics of antigen receptors: implications for lymphocyte signalling. Curr Opin Immunol 2010;22:299-307.
    • (2010) Curr Opin Immunol , vol.22 , pp. 299-307
    • Treanor, B.1    Batista, F.D.2
  • 22
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam KP, Kuhn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997;90:1073-83.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 24
    • 0028946385 scopus 로고
    • Differential binding activity of ARH1/TAM motifs
    • Cambier JC, Johnson SA. Differential binding activity of ARH1/TAM motifs. Immunol Lett 1995;44:77-80.
    • (1995) Immunol Lett , vol.44 , pp. 77-80
    • Cambier, J.C.1    Johnson, S.A.2
  • 26
    • 0032572720 scopus 로고    scopus 로고
    • Csk controls antigen receptor-mediated development and selection of T-lineage cells
    • Schmedt C, Saijo K, Niidome T, Kuhn R, Aizawa S, Tarakhovsky A. Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 1998;394:901-4.
    • (1998) Nature , vol.394 , pp. 901-904
    • Schmedt, C.1    Saijo, K.2    Niidome, T.3    Kuhn, R.4    Aizawa, S.5    Tarakhovsky, A.6
  • 27
    • 0029847936 scopus 로고    scopus 로고
    • Evidence for a preformed transducer complex organized by the B cell antigen receptor
    • Wienands J, Larbolette O, Reth M. Evidence for a preformed transducer complex organized by the B cell antigen receptor. Proc Natl Acad Sci USA 1996;93:7865-70.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7865-7870
    • Wienands, J.1    Larbolette, O.2    Reth, M.3
  • 28
    • 0043192901 scopus 로고    scopus 로고
    • A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
    • Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA 2003;100:9991-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9991-9996
    • Wright, G.1    Tan, B.2    Rosenwald, A.3    Hurt, E.H.4    Wiestner, A.5    Staudt, L.M.6
  • 29
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010;463:88-92.
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 30
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Duhren-von Minden M, Ubelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012;489:309-12.
    • (2012) Nature , vol.489 , pp. 309-312
    • Duhren-von Minden, M.1    Ubelhart, R.2    Schneider, D.3
  • 31
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med 2010;362:1417-29.
    • (2010) N Engl J Med , vol.362 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 32
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-62.
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 33
    • 33947403981 scopus 로고    scopus 로고
    • Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
    • Lenz G, Nagel I, Siebert R, et al. Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. J Exp Med 2007;204:633-43.
    • (2007) J Exp Med , vol.204 , pp. 633-643
    • Lenz, G.1    Nagel, I.2    Siebert, R.3
  • 34
    • 69049105207 scopus 로고    scopus 로고
    • Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells
    • Engels N, Konig LM, Heemann C, Lutz J, Tsubata T, Griep S, Schrader V, Wienands J. Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nat Immunol 2009;10:1018-25.
    • (2009) Nat Immunol , vol.10 , pp. 1018-1025
    • Engels, N.1    Konig, L.M.2    Heemann, C.3    Lutz, J.4    Tsubata, T.5    Griep, S.6    Schrader, V.7    Wienands, J.8
  • 35
    • 0037147182 scopus 로고    scopus 로고
    • A distinct signaling pathway used by the IgG-containing B cell antigen receptor
    • Wakabayashi C, Adachi T, Wienands J, Tsubata T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 2002;298:2392-5.
    • (2002) Science , vol.298 , pp. 2392-2395
    • Wakabayashi, C.1    Adachi, T.2    Wienands, J.3    Tsubata, T.4
  • 36
    • 34247340435 scopus 로고    scopus 로고
    • Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
    • Horikawa K, Martin SW, Pogue SL, Silver K, Peng K, Takatsu K, Goodnow CC. Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J Exp Med 2007;204:759-69.
    • (2007) J Exp Med , vol.204 , pp. 759-769
    • Horikawa, K.1    Martin, S.W.2    Pogue, S.L.3    Silver, K.4    Peng, K.5    Takatsu, K.6    Goodnow, C.C.7
  • 37
    • 0036171910 scopus 로고    scopus 로고
    • Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
    • Martin SW, Goodnow CC. Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nat Immunol 2002;3:182-8.
    • (2002) Nat Immunol , vol.3 , pp. 182-188
    • Martin, S.W.1    Goodnow, C.C.2
  • 38
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Lymphoma/Leukemia Molecular Profiling Project.
    • Rosenwald A, Wright G, Chan WC, et al., Lymphoma/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002;346:1937-47.
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3
  • 39
    • 41149136296 scopus 로고    scopus 로고
    • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    • Lenz G, Davis RE, Ngo VN, et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008;319:1676-9.
    • (2008) Science , vol.319 , pp. 1676-1679
    • Lenz, G.1    Davis, R.E.2    Ngo, V.N.3
  • 40
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • Ngo VN, Davis RE, Lamy L, et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006;441:106-10.
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1    Davis, R.E.2    Lamy, L.3
  • 41
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-54.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 42
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007;109:259-70.
    • (2007) Blood , vol.109 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 43
    • 11144356992 scopus 로고    scopus 로고
    • Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    • Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004;113:1008-16.
    • (2004) J Clin Invest , vol.113 , pp. 1008-1016
    • Ghiotto, F.1    Fais, F.2    Valetto, A.3
  • 44
    • 80052929598 scopus 로고    scopus 로고
    • Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases
    • Hadzidimitriou A, Agathangelidis A, Darzentas N, et al. Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood 2011;118:3088-95.
    • (2011) Blood , vol.118 , pp. 3088-3095
    • Hadzidimitriou, A.1    Agathangelidis, A.2    Darzentas, N.3
  • 45
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, Chiorazzi N, Meffre E. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005;115:1636-43.
    • (2005) J Clin Invest , vol.115 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3    Wardemann, H.4    Albesiano, E.5    Messmer, B.T.6    Chiorazzi, N.7    Meffre, E.8
  • 46
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R, Silverman GJ, Hatzi K, et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 2008;14:665-74.
    • (2008) Mol Med , vol.14 , pp. 665-674
    • Catera, R.1    Silverman, G.J.2    Hatzi, K.3
  • 47
    • 55749091407 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    • Chu CC, Catera R, Hatzi K, et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 2008;112:5122-9.
    • (2008) Blood , vol.112 , pp. 5122-5129
    • Chu, C.C.1    Catera, R.2    Hatzi, K.3
  • 48
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A, Hellqvist E, Sidorova E, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008;111:3838-48.
    • (2008) Blood , vol.111 , pp. 3838-3848
    • Lanemo Myhrinder, A.1    Hellqvist, E.2    Sidorova, E.3
  • 51
    • 84879255556 scopus 로고    scopus 로고
    • IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope
    • Que X, Widhopf GF 2nd, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS ONE 2013;8:e65203.
    • (2013) PLoS ONE , vol.8 , pp. e65203
    • Que, X.1    Widhopf 2nd, G.F.2    Amir, S.3    Hartvigsen, K.4    Hansen, L.F.5    Woelkers, D.6    Tsimikas, S.7    Binder, C.J.8    Kipps, T.J.9    Witztum, J.L.10
  • 52
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011;365:2497-506.
    • (2011) N Engl J Med , vol.365 , pp. 2497-2506
    • Wang, L.1    Lawrence, M.S.2    Wan, Y.3
  • 53
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011;475:101-5.
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 54
    • 84869088009 scopus 로고    scopus 로고
    • Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients
    • Blix ES, Irish JM, Husebekk A, Delabie J, Tierens AM, Myklebust JH, Kolstad A. Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients. Br J Haematol 2012;159:604-8.
    • (2012) Br J Haematol , vol.159 , pp. 604-608
    • Blix, E.S.1    Irish, J.M.2    Husebekk, A.3    Delabie, J.4    Tierens, A.M.5    Myklebust, J.H.6    Kolstad, A.7
  • 55
    • 84900457748 scopus 로고    scopus 로고
    • Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells
    • Palomba ML, Piersanti K, Ziegler CG, et al. Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells. PLoS ONE 2014;9:e79987.
    • (2014) PLoS ONE , vol.9 , pp. e79987
    • Palomba, M.L.1    Piersanti, K.2    Ziegler, C.G.3
  • 57
    • 84880293043 scopus 로고    scopus 로고
    • MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
    • Mraz M, Kipps TJ. MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia. Leuk Lymphoma 2013;54:1836-9.
    • (2013) Leuk Lymphoma , vol.54 , pp. 1836-1839
    • Mraz, M.1    Kipps, T.J.2
  • 58
    • 84904887947 scopus 로고    scopus 로고
    • MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia
    • Cui B, Chen L, Zhang S, et al. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood 2014;124:546-54.
    • (2014) Blood , vol.124 , pp. 546-554
    • Cui, B.1    Chen, L.2    Zhang, S.3
  • 61
    • 33644851486 scopus 로고    scopus 로고
    • Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma
    • Rinaldi A, Kwee I, Taborelli M, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol 2006;132:303-16.
    • (2006) Br J Haematol , vol.132 , pp. 303-316
    • Rinaldi, A.1    Kwee, I.2    Taborelli, M.3
  • 62
    • 84867163670 scopus 로고    scopus 로고
    • Molecular pathogenesis of mantle cell lymphoma
    • Jares P, Colomer D, Campo E. Molecular pathogenesis of mantle cell lymphoma. J Clin Invest 2012;122:3416-23.
    • (2012) J Clin Invest , vol.122 , pp. 3416-3423
    • Jares, P.1    Colomer, D.2    Campo, E.3
  • 63
  • 64
    • 33745863907 scopus 로고    scopus 로고
    • Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
    • Gazumyan A, Reichlin A, Nussenzweig MC. Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. J Exp Med 2006;203:1785-94.
    • (2006) J Exp Med , vol.203 , pp. 1785-1794
    • Gazumyan, A.1    Reichlin, A.2    Nussenzweig, M.C.3
  • 65
    • 0035253720 scopus 로고    scopus 로고
    • Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization
    • Ma H, Yankee TM, Hu J, Asai DJ, Harrison ML, Geahlen RL. Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol 2001;166:1507-16.
    • (2001) J Immunol , vol.166 , pp. 1507-1516
    • Ma, H.1    Yankee, T.M.2    Hu, J.3    Asai, D.J.4    Harrison, M.L.5    Geahlen, R.L.6
  • 66
    • 66949130737 scopus 로고    scopus 로고
    • Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance
    • Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol 2009;182:5382-92.
    • (2009) J Immunol , vol.182 , pp. 5382-5392
    • Gross, A.J.1    Lyandres, J.R.2    Panigrahi, A.K.3    Prak, E.T.4    DeFranco, A.L.5
  • 67
    • 27544458293 scopus 로고    scopus 로고
    • Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling
    • Gauld SB, Benschop RJ, Merrell KT, Cambier JC. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol 2005;6:1160-7.
    • (2005) Nat Immunol , vol.6 , pp. 1160-1167
    • Gauld, S.B.1    Benschop, R.J.2    Merrell, K.T.3    Cambier, J.C.4
  • 69
    • 77955916272 scopus 로고    scopus 로고
    • Molecular underpinning of B-cell anergy
    • Yarkoni Y, Getahun A, Cambier JC. Molecular underpinning of B-cell anergy. Immunol Rev 2010;237:249-63.
    • (2010) Immunol Rev , vol.237 , pp. 249-263
    • Yarkoni, Y.1    Getahun, A.2    Cambier, J.C.3
  • 71
    • 84897575209 scopus 로고    scopus 로고
    • Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia
    • Zonta F, Pagano MA, Trentin L, et al. Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia. Blood 2014;123:875-83.
    • (2014) Blood , vol.123 , pp. 875-883
    • Zonta, F.1    Pagano, M.A.2    Trentin, L.3
  • 72
    • 79551686422 scopus 로고    scopus 로고
    • Oncogenically active MYD88 mutations in human lymphoma
    • Ngo VN, Young RM, Schmitz R, et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 2011;470:115-9.
    • (2011) Nature , vol.470 , pp. 115-119
    • Ngo, V.N.1    Young, R.M.2    Schmitz, R.3
  • 73
    • 77953714711 scopus 로고    scopus 로고
    • Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
    • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010;465:885-90.
    • (2010) Nature , vol.465 , pp. 885-890
    • Lin, S.C.1    Lo, Y.C.2    Wu, H.3
  • 74
    • 38949165127 scopus 로고    scopus 로고
    • Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
    • Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G, Ye BH. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood 2008;111:1515-23.
    • (2008) Blood , vol.111 , pp. 1515-1523
    • Ding, B.B.1    Yu, J.J.2    Yu, R.Y.3    Mendez, L.M.4    Shaknovich, R.5    Zhang, Y.6    Cattoretti, G.7    Ye, B.H.8
  • 75
    • 0033559311 scopus 로고    scopus 로고
    • Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
    • Nishida K, Yoshida Y, Itoh M, et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 1999;93:1809-16.
    • (1999) Blood , vol.93 , pp. 1809-1816
    • Nishida, K.1    Yoshida, Y.2    Itoh, M.3
  • 76
    • 0037333264 scopus 로고    scopus 로고
    • The "Gab" in signal transduction
    • Gu H, Neel BG. The "Gab" in signal transduction. Trends Cell Biol 2003;13:122-30.
    • (2003) Trends Cell Biol , vol.13 , pp. 122-130
    • Gu, H.1    Neel, B.G.2
  • 78
    • 0032514897 scopus 로고    scopus 로고
    • The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor
    • Ingham RJ, Holgado-Madruga M, Siu C, Wong AJ, Gold MR. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor. J Biol Chem 1998;273:30630-7.
    • (1998) J Biol Chem , vol.273 , pp. 30630-30637
    • Ingham, R.J.1    Holgado-Madruga, M.2    Siu, C.3    Wong, A.J.4    Gold, M.R.5
  • 79
    • 33644694711 scopus 로고    scopus 로고
    • The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling
    • Sarmay G, Angyal A, Kertesz A, Maus M, Medgyesi D. The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol Lett 2006;104:76-82.
    • (2006) Immunol Lett , vol.104 , pp. 76-82
    • Sarmay, G.1    Angyal, A.2    Kertesz, A.3    Maus, M.4    Medgyesi, D.5
  • 80
    • 0035853673 scopus 로고    scopus 로고
    • The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
    • Ingham RJ, Santos L, Dang-Lawson M, Holgado-Madruga M, Dudek P, Maroun CR, Wong AJ, Matsuuchi L, Gold MR. The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. J Biol Chem 2001;276:12257-65.
    • (2001) J Biol Chem , vol.276 , pp. 12257-12265
    • Ingham, R.J.1    Santos, L.2    Dang-Lawson, M.3    Holgado-Madruga, M.4    Dudek, P.5    Maroun, C.R.6    Wong, A.J.7    Matsuuchi, L.8    Gold, M.R.9
  • 81
  • 82
    • 0030943398 scopus 로고    scopus 로고
    • T cell antigen receptor signal transduction
    • Qian D, Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol 1997;9:205-12.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 205-212
    • Qian, D.1    Weiss, A.2
  • 84
    • 34547930555 scopus 로고    scopus 로고
    • The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia
    • Kipps TJ. The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia. Best Pract Res Clin Haematol 2007;20:415-24.
    • (2007) Best Pract Res Clin Haematol , vol.20 , pp. 415-424
    • Kipps, T.J.1
  • 85
    • 10744222814 scopus 로고    scopus 로고
    • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003;101:4944-51.
    • (2003) Blood , vol.101 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 87
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004;351:893-901.
    • (2004) N Engl J Med , vol.351 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 88
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L, Huynh L, Apgar J, Tang L, Rassenti L, Weiss A, Kipps TJ. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2008;111:2685-92.
    • (2008) Blood , vol.111 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3    Tang, L.4    Rassenti, L.5    Weiss, A.6    Kipps, T.J.7
  • 89
    • 0029076731 scopus 로고
    • Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase
    • Kong GH, Bu JY, Kurosaki T, Shaw AS, Chan AC. Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. Immunity 1995;2:485-92.
    • (1995) Immunity , vol.2 , pp. 485-492
    • Kong, G.H.1    Bu, J.Y.2    Kurosaki, T.3    Shaw, A.S.4    Chan, A.C.5
  • 90
    • 0033526058 scopus 로고    scopus 로고
    • ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck)
    • Ashe JM, Wiest DL, Abe R, Singer A. ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck). J Exp Med 1999;189:1163-8.
    • (1999) J Exp Med , vol.189 , pp. 1163-1168
    • Ashe, J.M.1    Wiest, D.L.2    Abe, R.3    Singer, A.4
  • 91
    • 0029788103 scopus 로고    scopus 로고
    • Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
    • Latour S, Chow LM, Veillette A. Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem 1996;271:22782-90.
    • (1996) J Biol Chem , vol.271 , pp. 22782-22790
    • Latour, S.1    Chow, L.M.2    Veillette, A.3
  • 92
    • 0037126634 scopus 로고    scopus 로고
    • The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation
    • Rao N, Ghosh AK, Ota S, Zhou P, Reddi AL, Hakezi K, Druker BK, Wu J, Band H. The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation. EMBO J 2001;20:7085-95.
    • (2001) EMBO J , vol.20 , pp. 7085-7095
    • Rao, N.1    Ghosh, A.K.2    Ota, S.3    Zhou, P.4    Reddi, A.L.5    Hakezi, K.6    Druker, B.K.7    Wu, J.8    Band, H.9
  • 93
    • 0033602144 scopus 로고    scopus 로고
    • A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells
    • Zhang Z, Elly C, Qiu L, Altman A, Liu YC. A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells. Curr Biol 1999;9:203-6.
    • (1999) Curr Biol , vol.9 , pp. 203-206
    • Zhang, Z.1    Elly, C.2    Qiu, L.3    Altman, A.4    Liu, Y.C.5
  • 94
    • 0032567438 scopus 로고    scopus 로고
    • Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
    • Lupher ML Jr., Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H. Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. J Biol Chem 1998;273:35273-81.
    • (1998) J Biol Chem , vol.273 , pp. 35273-35281
    • Lupher, M.L.1    Rao, N.2    Lill, N.L.3    Andoniou, C.E.4    Miyake, S.5    Clark, E.A.6    Druker, B.7    Band, H.8
  • 96
    • 84897055483 scopus 로고    scopus 로고
    • Targeting Bruton's tyrosine kinase in B cell malignancies
    • Hendriks RW, Yuvaraj S, Kil LP. Targeting Bruton's tyrosine kinase in B cell malignancies. Nat Rev Cancer 2014;14:219-32.
    • (2014) Nat Rev Cancer , vol.14 , pp. 219-232
    • Hendriks, R.W.1    Yuvaraj, S.2    Kil, L.P.3
  • 97
    • 84868211774 scopus 로고    scopus 로고
    • Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape
    • Burger JA. Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape. Curr Opin Oncol 2012;24:643-9.
    • (2012) Curr Opin Oncol , vol.24 , pp. 643-649
    • Burger, J.A.1
  • 98
    • 84857844598 scopus 로고    scopus 로고
    • PI3Kdelta inhibitors in cancer: rationale and serendipity merge in the clinic
    • Fruman DA, Rommel C. PI3Kdelta inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov 2011;1:562-72.
    • (2011) Cancer Discov , vol.1 , pp. 562-572
    • Fruman, D.A.1    Rommel, C.2
  • 99
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32-42.
    • (2013) N Engl J Med , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 100
    • 0027358430 scopus 로고
    • The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages
    • de Weers M, Verschuren MC, Kraakman ME, Mensink RG, Schuurman RK, van Dongen JJ, Hendriks RW. The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages. Eur J Immunol 1993;23:3109-14.
    • (1993) Eur J Immunol , vol.23 , pp. 3109-3114
    • de Weers, M.1    Verschuren, M.C.2    Kraakman, M.E.3    Mensink, R.G.4    Schuurman, R.K.5    van Dongen, J.J.6    Hendriks, R.W.7
  • 102
    • 4444335344 scopus 로고    scopus 로고
    • Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing
    • Nombela-Arrieta C, Lacalle RA, Montoya MC, et al. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 2004;21:429-41.
    • (2004) Immunity , vol.21 , pp. 429-441
    • Nombela-Arrieta, C.1    Lacalle, R.A.2    Montoya, M.C.3
  • 103
    • 0141456120 scopus 로고    scopus 로고
    • CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase
    • Smit MJ, Verdijk P, van der Raaij-Helmer EM, Navis M, Hensbergen PJ, Leurs R, Tensen CP. CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase. Blood 2003;102:1959-65.
    • (2003) Blood , vol.102 , pp. 1959-1965
    • Smit, M.J.1    Verdijk, P.2    van der Raaij-Helmer, E.M.3    Navis, M.4    Hensbergen, P.J.5    Leurs, R.6    Tensen, C.P.7
  • 104
    • 0842346270 scopus 로고    scopus 로고
    • Do phosphoinositide 3-kinases direct lymphocyte navigation?
    • Ward SG. Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 2004;25:67-74.
    • (2004) Trends Immunol , vol.25 , pp. 67-74
    • Ward, S.G.1
  • 106
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: a target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367-75.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 107
    • 0345161418 scopus 로고    scopus 로고
    • Accelerated emigration of B lymphocytes in the Xid mouse
    • Cariappa A, Kim TJ, Pillai S. Accelerated emigration of B lymphocytes in the Xid mouse. J Immunol 1999;162:4417-23.
    • (1999) J Immunol , vol.162 , pp. 4417-4423
    • Cariappa, A.1    Kim, T.J.2    Pillai, S.3
  • 111
    • 0033216389 scopus 로고    scopus 로고
    • Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo
    • Arroyo AG, Yang JT, Rayburn H, Hynes RO. Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 1999;11:555-66.
    • (1999) Immunity , vol.11 , pp. 555-566
    • Arroyo, A.G.1    Yang, J.T.2    Rayburn, H.3    Hynes, R.O.4
  • 112
    • 0035911255 scopus 로고    scopus 로고
    • Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response
    • Leuker CE, Labow M, Muller W, Wagner N. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response. J Exp Med 2001;193:755-68.
    • (2001) J Exp Med , vol.193 , pp. 755-768
    • Leuker, C.E.1    Labow, M.2    Muller, W.3    Wagner, N.4
  • 113
    • 0033119201 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment
    • Ma Q, Jones D, Springer TA. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 1999;10:463-71.
    • (1999) Immunity , vol.10 , pp. 463-471
    • Ma, Q.1    Jones, D.2    Springer, T.A.3
  • 115
    • 8644227902 scopus 로고    scopus 로고
    • The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
    • Nie Y, Waite J, Brewer F, Sunshine MJ, Littman DR, Zou YR. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med 2004;200:1145-56.
    • (2004) J Exp Med , vol.200 , pp. 1145-1156
    • Nie, Y.1    Waite, J.2    Brewer, F.3    Sunshine, M.J.4    Littman, D.R.5    Zou, Y.R.6
  • 117
    • 24144489347 scopus 로고    scopus 로고
    • Two independent retrotransposon insertions at the same site within the coding region of BTK
    • Conley ME, Partain JD, Norland SM, Shurtleff SA, Kazazian HH Jr. Two independent retrotransposon insertions at the same site within the coding region of BTK. Hum Mutat 2005;25:324-5.
    • (2005) Hum Mutat , vol.25 , pp. 324-325
    • Conley, M.E.1    Partain, J.D.2    Norland, S.M.3    Shurtleff, S.A.4    Kazazian, H.H.5
  • 119
    • 0029792213 scopus 로고    scopus 로고
    • Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
    • Hendriks RW, de Bruijn MF, Maas A, Dingjan GM, Karis A, Grosveld F. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J 1996;15:4862-72.
    • (1996) EMBO J , vol.15 , pp. 4862-4872
    • Hendriks, R.W.1    de Bruijn, M.F.2    Maas, A.3    Dingjan, G.M.4    Karis, A.5    Grosveld, F.6
  • 120
    • 0028847329 scopus 로고
    • Defective B cell development and function in Btk-deficient mice
    • Khan WN, Alt FW, Gerstein RM, et al. Defective B cell development and function in Btk-deficient mice. Immunity 1995;3:283-99.
    • (1995) Immunity , vol.3 , pp. 283-299
    • Khan, W.N.1    Alt, F.W.2    Gerstein, R.M.3
  • 121
    • 0037087339 scopus 로고    scopus 로고
    • Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice
    • Middendorp S, Dingjan GM, Hendriks RW. Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice. J Immunol 2002;168:2695-703.
    • (2002) J Immunol , vol.168 , pp. 2695-2703
    • Middendorp, S.1    Dingjan, G.M.2    Hendriks, R.W.3
  • 122
    • 0034662198 scopus 로고    scopus 로고
    • Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway
    • Nomura K, Kanegane H, Karasuyama H, et al. Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood 2000;96:610-7.
    • (2000) Blood , vol.96 , pp. 610-617
    • Nomura, K.1    Kanegane, H.2    Karasuyama, H.3
  • 123
    • 33644542737 scopus 로고    scopus 로고
    • B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1
    • Carrasco YR, Batista FD. B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1. EMBO J 2006;25:889-99.
    • (2006) EMBO J , vol.25 , pp. 889-899
    • Carrasco, Y.R.1    Batista, F.D.2
  • 124
    • 80052570271 scopus 로고    scopus 로고
    • Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance
    • Mraz M, Zent CS, Church AK, et al. Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance. Br J Haematol 2011;155:53-64.
    • (2011) Br J Haematol , vol.155 , pp. 53-64
    • Mraz, M.1    Zent, C.S.2    Church, A.K.3
  • 125
    • 84859398461 scopus 로고    scopus 로고
    • Nurture versus nature: the microenvironment in chronic lymphocytic leukemia
    • Burger JA. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2011;2011:96-103.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 96-103
    • Burger, J.A.1
  • 126
    • 66549113998 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting
    • Kurtova AV, Tamayo AT, Ford RJ, Burger JA. Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting. Blood 2009;113:4604-13.
    • (2009) Blood , vol.113 , pp. 4604-4613
    • Kurtova, A.V.1    Tamayo, A.T.2    Ford, R.J.3    Burger, J.A.4
  • 128
    • 84888216911 scopus 로고    scopus 로고
    • Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
    • Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood 2013;122:2539-49.
    • (2013) Blood , vol.122 , pp. 2539-2549
    • Dubovsky, J.A.1    Beckwith, K.A.2    Natarajan, G.3
  • 129
    • 22144489127 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
    • Gorgun G, Holderried TA, Zahrieh D, Neuberg D, Gribben JG. Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest 2005;115:1797-805.
    • (2005) J Clin Invest , vol.115 , pp. 1797-1805
    • Gorgun, G.1    Holderried, T.A.2    Zahrieh, D.3    Neuberg, D.4    Gribben, J.G.5
  • 130
    • 84897069190 scopus 로고    scopus 로고
    • Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
    • Woyach JA, Smucker K, Smith LL, et al. Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. Blood 2014;123:1810-7.
    • (2014) Blood , vol.123 , pp. 1810-1817
    • Woyach, J.A.1    Smucker, K.2    Smith, L.L.3
  • 131
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • RESONATE Investigators.
    • Byrd JC, Brown JR, O'Brien S, et al., RESONATE Investigators. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med 2014;371:213-23.
    • (2014) N Engl J Med , vol.371 , pp. 213-223
    • Byrd, J.C.1    Brown, J.R.2    O'Brien, S.3
  • 132
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997-1007.
    • (2014) N Engl J Med , vol.370 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 133
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011;118:3603-12.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.