IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde-Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Que, Xuchu ^a   Widhopf II, George F ^a,b   Amir, Shahzada ^c   Hartvigsen, Karsten ^a,d   Hansen, Lotte F ^a   Woelkers, Douglas ^e   Tsimikas, Sotirios ^a   Binder, Christoph J ^a,c,f   Kipps, Thomas J ^a,b   Witztum, Joseph L ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MALONALDEHYDE; MALONDIALDEHYDE ACETALDEHYDE ADDUCT; OXIDATION SPECIFIC EPITOPE; RECOMBINANT ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IGHD3-3 GENE; IGHJ6 GENE; IGHV1-69 GENE; IGLV3-9 GENE; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN LIGHT CHAIN GENE; INFLAMMATION; LIPID PEROXIDATION; MACROPHAGE; NONHUMAN; PHAGE DISPLAY;

ACETALDEHYDE; ADULT; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; APOPTOSIS; B-LYMPHOCYTES; BASE SEQUENCE; EPITOPES; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALONDIALDEHYDE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PLAQUE, ATHEROSCLEROTIC; PROTEIN BINDING; RABBITS;

EID: 84879255556     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065203     Document Type: Article

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